EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20223287	The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling.	J Steroid Biochem Mol Biol	2010 Jul	Ord??ez-Mor??n P	doi: 10.1016/j.jsbmb.2010.02.031
26458302	MicroRNA144 inhibits migration and proliferation in rectal cancer by downregulating ROCK1.	Mol Med Rep	2015 Nov	Cai SD	doi: 10.3892/mmr.2015.4391
23615712	MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway.	Mol Cell Biochem	2013 Aug	Li N	doi: 10.1007/s11010-013-1664-0
26292662	Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression.	J Pineal Res	2016 Jan	Borin TF	doi: 10.1111/jpi.12270
28031255	ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.	EMBO Mol Med	2017 Feb	Rath N	doi: 10.15252/emmm.201606743.
18922892	Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion.	Cancer Res	2008 Oct 15	Joshi B	doi: 10.1158/0008-5472.CAN-08-0343.
23872151	MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1.	Biochem Biophys Res Commun	2013 Aug 9	Zhou X	doi: 10.1016/j.bbrc.2013.07.033
26615424	MiR-145 suppresses cell proliferation and motility by inhibiting ROCK1 in hepatocellular carcinoma.	Tumour Biol	2016 May	Ding W	doi: 10.1007/s13277-015-4462-3
23298303	Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma.	Asia Pac J Clin Oncol	2014 Jun	Wu YJ	doi: 10.1111/ajco.12052
26474697	MiR-506 suppresses cell proliferation and tumor growth by targeting Rho-associated protein kinase 1 in hepatocellular carcinoma.	Biochem Biophys Res Commun	2015 Nov 27	Deng Q	doi: 10.1016/j.bbrc.2015.10.043
14716844	Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.	World J Gastroenterol	2004 Jan 15	Wang DS	-
22563075	Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility.	J Biol Chem	2012 Jun 22	Rana MK	doi: 10.1074/jbc.M112.346114
25448675	FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1.	FEBS Lett	2014 Nov 28	Hu J	doi: 10.1016/j.febslet.2014.10.012
26081423	MicroRNA-144 acts as a tumor suppressor by targeting Rho-associated coiled-coil containing protein kinase 1 in osteosarcoma cells.	Mol Med Rep	2015 Sep	Huang J	doi: 10.3892/mmr.2015.3937
24317511	ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc.	Oncogene	2014 Dec 4	Zhang C	doi: 10.1038/onc.2013.505
17344417	Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.	Genes Dev	2007 Mar 1	Lefort K	-
16371346	Inhibition of motile and invasive properties of ovarian cancer cells by ASODN against Rho-associated protein kinase.	Cell Commun Adhes	2005 Jan-Apr	Han Z	-
20364104	Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.	Cancer Biol Ther	2010 Jun 1	Deng L	-
25755711	Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.	Int J Clin Exp Pathol	2015 Jan 1	Zhang J	-
20053635	Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion events.	J Cell Sci	2010 Feb 1	Struckhoff AP	doi: 10.1242/jcs.052167
25831237	miR-340 suppresses glioblastoma multiforme.	Oncotarget	2015 Apr 20	Huang D	-
26026086	ROCK I Has More Accurate Prognostic Value than MET in Predicting Patient Survival in Colorectal Cancer.	Anticancer Res	2015 Jun	Li J	-
24801908	MiR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1.	Tumour Biol	2014 Aug	Li E	doi: 10.1007/s13277-014-2031-9
28081735	miR-214-5p Targets ROCK1 and Suppresses Proliferation and Invasion of Human Osteosarcoma Cells.	Oncol Res	2017 Jan 2	Zhang M	doi: 10.3727/096504016X14719078133401.
28709411	Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.	BMC Cancer	2017 Jul 14	Amaya CN	doi: 10.1186/s12885-017-3470-7.
28117029	MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase.	Oncol Res	2017 Sep 21	Yang H	doi: 10.3727/096504017X14850134190255
28848996	Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma.	Int J Oncol	2017 Oct	Luo D	doi: 10.3892/ijo.2017.4100
22232555	Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins.	J Biol Chem	2012 Feb 24	Shields MA	doi: 10.1074/jbc.M111.308940
11893932	Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro.	Pancreas	2002 Apr	Kaneko K	-
24180482	MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1.	J Transl Med	2013 Nov 2	Xu X	doi: 10.1186/1479-5876-11-276.
21994419	MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer.	Clin Cancer Res	2011 Dec 15	Zheng B	doi: 10.1158/1078-0432.CCR-11-1714
20140017	Activating ROCK1 somatic mutations in human cancer.	Oncogene	2010 Apr 29	Lochhead PA	doi: 10.1038/onc.2010.3
22584506	Inhibition of RhoA/ROCK signaling pathway promotes the apoptosis of gastric cancer cells.	Hepatogastroenterology	2012 Nov-Dec	Xu XT	-
18615591	Placenta growth factor, PLGF, influences the motility of lung cancer cells, the role of Rho associated kinase, Rock1.	J Cell Biochem	2008 Sep 1	Chen J	doi: 10.1002/jcb.21831.
27035227	MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1.	Mol Med Rep	2016 May	Wu D	doi: 10.3892/mmr.2016.5055
18780293	Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells.	Prostate	2008 Dec 1	Shi XB	doi: 10.1002/pros.20849.
25677806	RhoC and ROCKs regulate cancer cell interactions with endothelial cells.	Mol Oncol	2015 Jun	Reymond N	doi: 10.1016/j.molonc.2015.01.004
19667069	ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK.	J Biol Chem	2009 Oct 23	Xiao L	doi: 10.1074/jbc.M109.007971
23328676	Role of rho-kinase gene polymorphisms and protein expressions in colorectal cancer development.	Pathobiology	2013	Sari I	doi: 10.1159/000341395
24324133	Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.	Proc Natl Acad Sci U S A	2014 Jan 21	Gilkes DM	doi: 10.1073/pnas.1321510111
23649168	CCR4 mediates CCL17 (TARC)-induced migration of human colon cancer cells via RhoA/Rho-kinase signaling.	Int J Colorectal Dis	2013 Nov	Al-haidari AA	doi: 10.1007/s00384-013-1712-y
26715279	MicroRNA-145 inhibits growth and migration of breast cancer cells through targeting oncoprotein ROCK1.	Tumour Biol	2016 Jun	Zheng M	doi: 10.1007/s13277-015-4722-2
26562026	Possible Gender-Related Modulation by the ROCK1 Gene in Colorectal Cancer Susceptibility.	Pathobiology	2015	Zucchini C	doi: 10.1159/000439405
16543245	Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.	J Biol Chem	2006 May 19	Mizukami Y	-
25218053	Immunoexpression of ROCK-1 and MMP-9 as prognostic markers in breast cancer.	Acta Histochem	2014 Oct	Bottino J	doi: 10.1016/j.acthis.2014.08.009
24894676	MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells.	Tumour Biol	2014 Sep	Cui G	doi: 10.1007/s13277-014-2168-6
17044646	Induction of apoptosis by L-NMMA, via FKHRL1/ROCK pathway in human gastric cancer cells.	Biomed Environ Sci	2006 Aug	Wang YZ	-
18695890	The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.	Int J Oncol	2008 Sep	Lane J	-
25987767	Downregulation of rho-associated protein kinase 1 by miR-124 in colorectal cancer.	World J Gastroenterol	2015 May 14	Xi ZW	doi: 10.3748/wjg.v21.i18.5454.
24587343	An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.	PLoS One	2014 Feb 28	Pettee KM	doi: 10.1371/journal.pone.0090371
23775364	Androgen receptor enhances entosis, a non-apoptotic cell death, through modulation of Rho/ROCK pathway in prostate cancer cells.	Prostate	2013 Sep	Wen S	doi: 10.1002/pros.22676
26306811	Hsa-miR-146a-5p modulates androgen-independent prostate cancer cells apoptosis by targeting ROCK1.	Prostate	2015 Dec	Xu B	doi: 10.1002/pros.23068
15843433	Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.	Mol Biol Cell	2005 Jul	Cardone RA	-
18396681	[Effect of blocking of ROCK-1, an effector of small G protein Rho, on the malignant behavior of ovarian tumor cells in vitro].	Zhonghua Zhong Liu Za Zhi	2007 Oct	Han ZQ	-
24465504	MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer.	PLoS One	2014 Jan 21	Shin JY	doi: 10.1371/journal.pone.0085205
20126978	Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation.	Int J Oncol	2010 Mar	Nakashima M	-
28184030	Genetic variants in RhoA and ROCK1 genes are associated with the development, progression and prognosis of prostate cancer.	Oncotarget	2017 Mar 21	Liu K	doi: 10.18632/oncotarget.15197.
28841710	Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.	PLoS One	2017 Aug 25	Whatcott CJ	doi: 10.1371/journal.pone.0183871
27203208	Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context.	Oncotarget	2016 May 31	Matsubara M	doi: 10.18632/oncotarget.9395.
27374095	Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer.	Oncotarget	2016 Jul 12	Iskit S	doi: 10.18632/oncotarget.10230.
29790629	Long non-coding RNA NEAT1 promoted ovarian cancer cells' metastasis through regulation of miR-382-3p/ROCK1 axial.	Cancer Sci	2018 Jul	Liu Y	doi: 10.1111/cas.13647
29441962	MiR-139 prompts the development of osteosarcomas mainly through targeting ROCK1.	Pharmazie	2017 Dec 1	Su S	doi: 10.1691/ph.2017.7439.
29710554	MicroRNA-361-5p inhibits papillary thyroid carcinoma progression by targeting ROCK1.	Biomed Pharmacother	2018 Jun	Li R	doi: 10.1016/j.biopha.2018.03.122
29544562	Long non-coding RNA NEAT1 regulates the proliferation, migration and invasion of gastric cancer cells via targeting miR-335-5p/ROCK1 axis.	Pharmazie	2018 Mar 5	Wang H	doi: 10.1691/ph.2018.7877.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr18	21049170	Missense_Mutation	novel	M112I	0.34
BLCA	chr18	21015477	Missense_Mutation	novel	T455N	0.88
BLCA	chr18	20967909	Missense_Mutation	NA	R1012Q	0.41
BLCA	chr18	20969162	Missense_Mutation	NA	R956T	0.3
BLCA	chr18	21110882	Missense_Mutation	novel	R10Q	0.06
BLCA	chr18	21049827	Missense_Mutation	NA	E77K	0.42
BLCA	chr18	20992925	Missense_Mutation	novel	S633C	0.1
BLCA	chr18	21042139	Nonsense_Mutation	NA	S306*	0.28
BLCA	chr18	21045296	Missense_Mutation	NA	H196Y	0.15
BLCA	chr18	21110979	5'UTR	novel		0.19
BLCA	chr18	20966978	Silent	novel	L1097L	0.3
BRCA	chr18	20967798	Missense_Mutation	rs761438534	N1049S	0.09
BRCA	chr18	20950686	3'UTR	novel		0.23
BRCA	chr18	20950826	3'UTR	novel		0.35
BRCA	chr18	20954889	Silent	novel	L1249L	0.09
BRCA	chr18	20992930	Silent	NA	I631I	0.31
BRCA	chr18	20955029	Missense_Mutation	NA	E1203K	0.16
BRCA	chr18	20959862	Missense_Mutation	NA	P1164S	0.18
BRCA	chr18	21006423	Nonsense_Mutation	NA	Q605*	0.42
BRCA	chr18	20953650	Missense_Mutation	NA	R1330Q	0.15
BRCA	chr18	21042577	Missense_Mutation	NA	E270K	0.18
BRCA	chr18	20992888	Silent	novel	L645L	0.08
BRCA	chr18	20967932	Frame_Shift_Ins	novel	*N1004Kfs7**	0.04
BRCA	chr18	20967935	Frame_Shift_Del	novel	*V1003Efs13**	0.03
BRCA	chr18	20967001	Silent	NA	L1090L	0.28
BRCA	chr18	21006495	Missense_Mutation	NA	L581V	0.36
BRCA	chr18	21045373	Missense_Mutation	NA	V170A	0.11
CESC	chr18	20991212	Missense_Mutation	rs764295785	Q703E	0.42
CESC	chr18	20950013	3'UTR	novel		0.27
CESC	chr18	20950686	3'UTR	novel		0.26
CESC	chr18	21006507	Nonsense_Mutation	NA	Q577*	0.24
CESC	chr18	20950173	3'UTR	novel		0.4
CESC	chr18	20950808	3'UTR	novel		0.23
CESC	chr18	20954829	Silent	novel	H1269H	0.45
CESC	chr18	20969202	Nonsense_Mutation	novel	E943*	0.48
CESC	chr18	20953582	Frame_Shift_Del	NA	*T1353Lfs71**	0.14
CESC	chr18	20982766	Silent	NA	F852F	0.28
CESC	chr18	20953735	Nonsense_Mutation	novel	Q1302*	0.3
CESC	chr18	20953747	Silent	novel	L1298L	0.23
CESC	chr18	21111215	5'UTR	novel		0.83
CESC	chr18	20950686	3'UTR	novel		0.21
CESC	chr18	20953613	Silent	NA	F1342F	0.2
CESC	chr18	20959841	Missense_Mutation	NA	D1171H	0.38
CESC	chr18	20954811	Silent	NA	K1275K	0.15
CHOL	chr18	21049866	Missense_Mutation	novel	N64Y	0.37
COAD	chr18	20951220	3'UTR	novel		0.37
COAD	chr18	20959886	Missense_Mutation	rs747883475	E1156K	0.36
COAD	chr18	20967064	Missense_Mutation	NA	E1069K	0.44
COAD	chr18	20991217	Missense_Mutation	NA	K701T	0.35
COAD	chr18	20960178	Silent	NA	V1127V	0.27
COAD	chr18	20967840	Missense_Mutation	NA	R1035Q	0.21
COAD	chr18	20992934	Missense_Mutation	NA	R630Q	0.12
COAD	chr18	20954848	Missense_Mutation	novel	R1263I	0.37
COAD	chr18	20953724	Missense_Mutation	NA	Q1305H	0.24
COAD	chr18	20991313	Missense_Mutation	novel	L669S	0.05
COAD	chr18	21028852	Missense_Mutation	novel	E379K	0.07
COAD	chr18	20959903	Frame_Shift_Ins	NA	*I1150Nfs5**	0.23
COAD	chr18	20979952	Frame_Shift_Del	NA	*N871Tfs5**	0.29
COAD	chr18	20991173	Splice_Region	novel		0.41
COAD	chr18	21042582	Frame_Shift_Del	NA	*L268Yfs6**	0.3
COAD	chr18	20984387	Frame_Shift_Del	novel	*K818Efs6**	0.51
COAD	chr18	20987024	Missense_Mutation	novel	L744I	0.36
COAD	chr18	20968799	Silent	rs375431349	I992I	0.45
COAD	chr18	20967939	Missense_Mutation	novel	A1002D	0.12
COAD	chr18	20967753	Missense_Mutation	rs771167832	A1064V	0.42
COAD	chr18	20953718	Frame_Shift_Del	rs752898741	*K1307Nfs3**	0.28
COAD	chr18	20984490	Silent	novel	L784L	0.28
COAD	chr18	20967904	Missense_Mutation	novel	D1014N	0.11
COAD	chr18	20967077	Splice_Site	NA	X1065_splice	0.26
COAD	chr18	20979941	Missense_Mutation	NA	L875V	0.22
COAD	chr18	21042577	Missense_Mutation	NA	E270K	0.07
COAD	chr18	20954864	Missense_Mutation	novel	A1258S	0.4
COAD	chr18	20951263	3'UTR	novel		0.38
COAD	chr18	20954852	Nonsense_Mutation	rs763334480	R1262*	0.24
COAD	chr18	21015445	Nonsense_Mutation	NA	E466*	0.36
COAD	chr18	20979951	Frame_Shift_Ins	NA	*N871Kfs14**	0.07
COAD	chr18	21023638	Silent	NA	S418S	0.25
COAD	chr18	20954866	Frame_Shift_Del	NA	*P1257Lfs3**	0.21
COAD	chr18	21039560	Missense_Mutation	novel	E321D	0.24
COAD	chr18	21049143	Frame_Shift_Ins	NA	*W122Lfs25**	0.4
ESCA	chr18	20950387	3'UTR	novel		0.33
ESCA	chr18	21042680	Silent	novel	V235V	0.18
ESCA	chr18	20967889	Missense_Mutation	novel	R1019G	0.31
ESCA	chr18	20979952	Missense_Mutation	NA	N871T	0.27
ESCA	chr18	20950846	3'UTR	novel		0.59
GBM	chr18	20968788	Missense_Mutation	NA	R996Q	0.45
GBM	chr18	20969141	Missense_Mutation	novel	T963R	0.26
GBM	chr18	21028853	Silent	novel	E378E	0.24
GBM	chr18	21049197	Silent	novel	A103A	0.21
GBM	chr18	20953612	Missense_Mutation	NA	R1343W	0.04
GBM	chr18	20967784	Nonsense_Mutation	NA	K1054*	0.1
HNSC	chr18	21049131	Missense_Mutation	novel	R125S	0.77
HNSC	chr18	20967767	Silent	NA	L1059L	0.32
HNSC	chr18	20968770	Splice_Site	novel	X1001_splice	0.18
HNSC	chr18	21028895	Silent	rs370231055	D364D	0.22
HNSC	chr18	21020237	Missense_Mutation	novel	Q425H	0.31
HNSC	chr18	20967057	Missense_Mutation	novel	A1071V	0.38
HNSC	chr18	21049181	Missense_Mutation	novel	K109E	0.14
HNSC	chr18	21044168	Frame_Shift_Del	novel	*D202Cfs9**	0.26
HNSC	chr18	20992838	Missense_Mutation	novel	S662L	0.49
HNSC	chr18	20954950	Missense_Mutation	NA	H1229R	0.23
HNSC	chr18	20969155	Missense_Mutation	novel	E958D	0.14
HNSC	chr18	21045346	Missense_Mutation	novel	T179N	0.19
HNSC	chr18	20986980	Missense_Mutation	novel	L758F	0.07
HNSC	chr18	21006515	Missense_Mutation	novel	S574L	0.28
HNSC	chr18	21042664	Missense_Mutation	novel	I241V	0.28
HNSC	chr18	21049153	Missense_Mutation	novel	S118F	0.12
HNSC	chr18	20955233	Missense_Mutation	novel	H1175Q	0.39
HNSC	chr18	20954822	Missense_Mutation	novel	H1272N	0.07
KIRC	chr18	21028900	Missense_Mutation	rs775903956	I363V	0.37
KIRC	chr18	21006577	Missense_Mutation	NA	L553F	0.36
KIRC	chr18	21049143	Frame_Shift_Ins	NA	*W122Lfs25**	0.22
KIRC	chr18	20967034	Nonsense_Mutation	NA	Q1079*	0.29
KIRC	chr18	20969179	Missense_Mutation	NA	K950N	0.39
KIRC	chr18	21044134	Missense_Mutation	novel	A215T	0.23
KIRC	chr18	21006548	Frame_Shift_Del	novel	*A561Dfs2**	0.15
KIRP	chr18	21044157	Missense_Mutation	novel	D207V	0.27
LGG	chr18	20970384	Silent	novel	R928R	0.37
LGG	chr18	20967017	Silent	novel	E1084E	0.05
LGG	chr18	21006569	Nonsense_Mutation	novel	*T556delinsILPRSPIIS**	0.07
LIHC	chr18	21045359	Missense_Mutation	novel	A175T	0.34
LIHC	chr18	21006437	Missense_Mutation	NA	D600A	0.41
LIHC	chr18	20980004	Missense_Mutation	NA	T854A	0.43
LIHC	chr18	21045403	Missense_Mutation	novel	D160G	0.38
LIHC	chr18	21049143	Frame_Shift_Ins	NA	*W122Lfs25**	0.11
LUAD	chr18	20959856	Missense_Mutation	rs748810091	M1166V	0.4
LUAD	chr18	21044131	Missense_Mutation	NA	D216Y	0.59
LUAD	chr18	21110985	5'UTR	novel		0.16
LUAD	chr18	21020207	Silent	novel	L435L	0.26
LUAD	chr18	21042678	Frame_Shift_Ins	novel	*G236Dfs12**	0.06
LUAD	chr18	21042679	Frame_Shift_Ins	novel	*G236Lfs5**	0.06
LUAD	chr18	21042577	Missense_Mutation	NA	E270K	0.36
LUAD	chr18	20967843	Missense_Mutation	novel	N1034I	0.07
LUAD	chr18	21049879	Nonsense_Mutation	novel	Y59delins*	0.17
LUAD	chr18	21049143	Frame_Shift_Ins	NA	*W122Lfs25**	0.32
LUAD	chr18	20951340	3'UTR	novel		0.23
LUAD	chr18	21049092	Missense_Mutation	NA	Q138H	0.22
LUAD	chr18	20967935	In_Frame_Ins	novel	V1003_N1004insD	0.13
LUAD	chr18	21049122	Missense_Mutation	NA	M128I	0.42
LUAD	chr18	21006572	Missense_Mutation	NA	R555T	0.19
LUAD	chr18	21110883	Nonsense_Mutation	novel	R10*	0.11
LUAD	chr18	21070551	In_Frame_Del	novel	L46_I52del	0.16
LUAD	chr18	20954862	Silent	NA	A1258A	0.1
LUAD	chr18	20987018	Frame_Shift_Del	novel	M743*	0.07
LUAD	chr18	20970492	Missense_Mutation	NA	L892F	0.37
LUAD	chr18	21006725	Missense_Mutation	novel	E538K	0.83
LUAD	chr18	21070595	Missense_Mutation	NA	V38L	0.17
LUAD	chr18	21042589	Frame_Shift_Del	novel	*V266Yfs8**	0.19
LUAD	chr18	20968849	Nonsense_Mutation	NA	E976*	0.12
LUAD	chr18	20969192	Missense_Mutation	rs377651671	S946N	0.3
LUAD	chr18	20987105	Nonsense_Mutation	novel	E717*	0.4
LUAD	chr18	21042688	Missense_Mutation	NA	T233A	0.26
LUSC	chr18	20987072	Missense_Mutation	novel	E728K	0.35
LUSC	chr18	21042694	Missense_Mutation	novel	C231R	0.39
LUSC	chr18	21006500	Missense_Mutation	novel	E579G	0.12
LUSC	chr18	20951381	3'UTR	novel		0.39
LUSC	chr18	20954856	Missense_Mutation	novel	E1260D	0.37
LUSC	chr18	20967050	Missense_Mutation	novel	R1073S	0.07
LUSC	chr18	20967790	Missense_Mutation	novel	V1052L	0.42
LUSC	chr18	20991233	Missense_Mutation	NA	A696T	0.17
LUSC	chr18	21008158	Missense_Mutation	NA	Q483E	0.07
LUSC	chr18	20953589	Silent	novel	S1350S	0.17
LUSC	chr18	20991258	Silent	novel	E687E	0.12
LUSC	chr18	21006772	Missense_Mutation	novel	Q522R	0.22
LUSC	chr18	20991180	Missense_Mutation	NA	M713I	0.59
LUSC	chr18	20967056	Silent	rs773377004	A1071A	0.21
LUSC	chr18	21070531	Splice_Site	novel	X59_splice	0.82
LUSC	chr18	20966970	Missense_Mutation	NA	S1100C	0.14
MESO	chr18	20992855	Frame_Shift_Del	NA	*Q656Rfs4**	0.51
MESO	chr18	21042613	Missense_Mutation	novel	E258K	0.3
OV	chr18	20970507	Splice_Site	novel	X885_splice	0.19
OV	chr18	20950688	3'UTR	novel		0.63
OV	chr18	20950689	3'UTR	novel		0.63
OV	chr18	20970367	Missense_Mutation	novel	K934T	0.05
OV	chr18	21020209	In_Frame_Del	novel	Q425_K434del	0.13
PAAD	chr18	21028841	Frame_Shift_Del	novel	*I383Ffs13**	0.17
PAAD	chr18	21008124	Missense_Mutation	novel	R494I	0.17
PAAD	chr18	21042146	Missense_Mutation	novel	D304N	0.04
PAAD	chr18	21045437	Missense_Mutation	novel	L149F	0.1
PAAD	chr18	20982824	Missense_Mutation	novel	R833K	0.12
PRAD	chr18	21045367	Missense_Mutation	NA	E172G	0.6
PRAD	chr18	21110877	In_Frame_Ins	novel	F11dup	0.28
PRAD	chr18	20966985	Missense_Mutation	NA	L1095S	0.08
PRAD	chr18	20953646	Silent	novel	T1331T	0.41
PRAD	chr18	20982798	Silent	novel	L842L	0.54
READ	chr18	21049180	Missense_Mutation	NA	K109I	0.58
READ	chr18	21006467	Missense_Mutation	rs141266099	R590Q	0.23
READ	chr18	20991312	Silent	novel	L669L	0.07
READ	chr18	20951212	3'UTR	novel		0.29
READ	chr18	20967027	Missense_Mutation	NA	A1081D	0.28
READ	chr18	20970451	Missense_Mutation	novel	R906Q	0.34
READ	chr18	21110834	Missense_Mutation	NA	N26T	0.29
READ	chr18	20967909	Missense_Mutation	NA	R1012Q	0.43
READ	chr18	20970405	Missense_Mutation	NA	K921N	0.37
READ	chr18	20991305	Missense_Mutation	NA	D672Y	0.09
READ	chr18	21006360	Missense_Mutation	novel	D626Y	0.04
READ	chr18	21049219	Missense_Mutation	NA	K96T	0.4
READ	chr18	20967772	Nonsense_Mutation	novel	E1058*	0.2
READ	chr18	20953724	Missense_Mutation	NA	Q1305H	0.11
READ	chr18	20970405	Missense_Mutation	NA	K921N	0.33
READ	chr18	21070558	Missense_Mutation	NA	K50T	0.09
SARC	chr18	20987014	Missense_Mutation	novel	D747G	0.3
SARC	chr18	20955046	Splice_Site	novel	X1198_splice	0.08
SKCM	chr18	21006563	Nonsense_Mutation	NA	S558*	0.24
SKCM	chr18	20954843	Missense_Mutation	NA	H1265Y	0.28
SKCM	chr18	20959858	Missense_Mutation	NA	S1165F	0.2
SKCM	chr18	20954836	Missense_Mutation	NA	K1267M	0.3
SKCM	chr18	21015476	Silent	rs150844243	T455T	0.2
SKCM	chr18	21015477	Missense_Mutation	novel	T455I	0.2
SKCM	chr18	21028836	Missense_Mutation	novel	P384L	0.43
SKCM	chr18	21028837	Missense_Mutation	novel	P384S	0.42
SKCM	chr18	20959875	Silent	NA	K1159K	0.22
SKCM	chr18	20953612	Missense_Mutation	NA	R1343W	0.36
SKCM	chr18	20953613	Silent	NA	F1342F	0.35
SKCM	chr18	20984399	Missense_Mutation	NA	L814S	0.46
SKCM	chr18	20970362	Missense_Mutation	NA	H936Y	0.51
SKCM	chr18	21049216	Missense_Mutation	NA	S97F	0.71
SKCM	chr18	21008111	Silent	NA	Y498Y	0.24
SKCM	chr18	21042641	Silent	NA	S248S	0.4
SKCM	chr18	21045351	Silent	NA	F177F	0.21
STAD	chr18	21049143	Frame_Shift_Ins	NA	*W122Lfs25**	0.48
STAD	chr18	21049814	Missense_Mutation	novel	V81A	0.19
STAD	chr18	20953718	Frame_Shift_Del	rs752898741	*K1307Nfs3**	0.43
STAD	chr18	21006592	Missense_Mutation	NA	E548D	0.25
STAD	chr18	21049143	Frame_Shift_Del	novel	*W122Gfs31**	0.29
STAD	chr18	21042613	Nonsense_Mutation	NA	E258*	0.34
STAD	chr18	21049779	Splice_Site	NA	X92_splice	0.31
STAD	chr18	21042685	Missense_Mutation	NA	A234T	0.21
STAD	chr18	20959900	Frame_Shift_Del	novel	*L1151Cfs20**	0.18
STAD	chr18	21045324	In_Frame_Ins	novel	A185_L186insF	0.13
STAD	chr18	21006696	Splice_Region	novel		0.32
STAD	chr18	20953718	Frame_Shift_Del	novel	*K1307Mfs11**	0.37
STAD	chr18	20991283	Nonsense_Mutation	novel	S679*	0.09
STAD	chr18	20967758	Missense_Mutation	NA	M1062I	0.09
STAD	chr18	20984358	Missense_Mutation	NA	L828F	0.37
STAD	chr18	20982822	Nonsense_Mutation	NA	G834*	0.16
STAD	chr18	21045461	Frame_Shift_Del	novel	*Y141Mfs12**	0.25
STAD	chr18	20953718	Frame_Shift_Del	rs752898741	*K1307Nfs3**	0.52
STAD	chr18	20986950	Missense_Mutation	NA	E768D	0.22
STAD	chr18	21008070	Missense_Mutation	NA	V512A	0.25
STAD	chr18	20984491	Silent	NA	R783R	0.1
STAD	chr18	20955226	Missense_Mutation	novel	P1178S	0.23
STAD	chr18	20953718	Frame_Shift_Del	rs752898741	*K1307Nfs3**	0.42
STAD	chr18	20984395	Silent	NA	L815L	0.32
STAD	chr18	21006591	Nonsense_Mutation	NA	E549*	0.25
STAD	chr18	20959868	Missense_Mutation	NA	S1162P	0.11
STAD	chr18	21042171	Missense_Mutation	NA	N295K	0.08
THCA	chr18	20991260	Frame_Shift_Ins	novel	*E687Ffs10**	0.05
THYM	chr18	20950931	3'UTR	novel		0.34
UCEC	chr18	20951212	3'UTR	novel		0.28
UCEC	chr18	20951379	3'UTR	novel		0.11
UCEC	chr18	20953650	Missense_Mutation	NA	R1330Q	0.36
UCEC	chr18	20959886	Missense_Mutation	rs747883475	E1156K	0.21
UCEC	chr18	20967019	Nonsense_Mutation	NA	E1084*	0.35
UCEC	chr18	20992934	Missense_Mutation	NA	R630Q	0.25
UCEC	chr18	20959869	Missense_Mutation	novel	Q1161H	0.43
UCEC	chr18	20967909	Missense_Mutation	NA	R1012Q	0.13
UCEC	chr18	21111520	5'UTR	novel		0.25
UCEC	chr18	21111036	5'UTR	novel		0.4
UCEC	chr18	20967909	Missense_Mutation	NA	R1012Q	0.36
UCEC	chr18	21023648	Missense_Mutation	NA	R415I	0.35
UCEC	chr18	20959885	Missense_Mutation	novel	E1156A	0.3
UCEC	chr18	21028920	Missense_Mutation	novel	V356A	0.27
UCEC	chr18	20950931	3'UTR	novel		0.46
UCEC	chr18	20950931	3'UTR	novel		0.39
UCEC	chr18	20953718	Frame_Shift_Del	rs752898741	*K1307Nfs3**	0.46
UCEC	chr18	21045315	Silent	novel	I189I	0.81
UCEC	chr18	21006591	Nonsense_Mutation	NA	E549*	0.49
UCEC	chr18	20967757	Nonsense_Mutation	novel	Q1063*	0.36
UCEC	chr18	20951099	3'UTR	novel		0.4
UCEC	chr18	20951207	3'UTR	novel		0.33
UCEC	chr18	20955041	Silent	novel	L1199L	0.27
UCEC	chr18	21110915	5'UTR	novel		0.48
UCEC	chr18	21111688	5'UTR	novel		0.55
UCEC	chr18	20970511	Missense_Mutation	novel	E886A	0.33
UCEC	chr18	20979959	Nonsense_Mutation	novel	E869*	0.15
UCEC	chr18	20967935	Frame_Shift_Ins	novel	*L1006Ifs4**	0.04
UCEC	chr18	20992920	Nonsense_Mutation	NA	Q635*	0.22
UCEC	chr18	21039473	Splice_Region	NA	D350D	0.16
UCEC	chr18	20953718	Frame_Shift_Del	rs752898741	*K1307Nfs3**	0.41
UCEC	chr18	20953598	Missense_Mutation	NA	K1347N	0.26
UCEC	chr18	20991242	Missense_Mutation	NA	V693L	0.21
UCEC	chr18	21006467	Missense_Mutation	rs141266099	R590Q	0.33
UCEC	chr18	21039522	Missense_Mutation	NA	R334Q	0.23
UCEC	chr18	21049863	Missense_Mutation	rs763280401	K65E	0.25
UCEC	chr18	21039535	Nonsense_Mutation	novel	E330*	0.2
UCEC	chr18	20980003	Missense_Mutation	novel	T854R	0.1
UCEC	chr18	20984353	Splice_Region	rs372187123	T829T	0.45
UCEC	chr18	21008129	Missense_Mutation	novel	Q492H	0.45
UCEC	chr18	20960196	Silent	novel	I1121I	0.46
UCEC	chr18	20959903	Frame_Shift_Ins	NA	*I1150Nfs5**	0.43
UCEC	chr18	20953650	Missense_Mutation	NA	R1330Q	0.36
UCEC	chr18	20967904	Missense_Mutation	NA	D1014Y	0.29
UCEC	chr18	20979993	Missense_Mutation	novel	K857N	0.07
UCEC	chr18	21006467	Missense_Mutation	rs141266099	R590Q	0.09
UCEC	chr18	21023648	Missense_Mutation	NA	R415I	0.35
UCEC	chr18	20967904	Missense_Mutation	NA	D1014Y	0.37
UCEC	chr18	20968861	Splice_Site	novel	X972_splice	0.32
UCEC	chr18	20992934	Missense_Mutation	NA	R630Q	0.4
UCEC	chr18	21006467	Missense_Mutation	rs141266099	R590Q	0.13
UCEC	chr18	21006591	Nonsense_Mutation	NA	E549*	0.4
UCEC	chr18	21110836	Silent	novel	V25V	0.15
UCEC	chr18	20966962	Missense_Mutation	novel	V1103I	0.38
UCEC	chr18	21049195	Missense_Mutation	novel	M104R	0.39
UCEC	chr18	20982803	Missense_Mutation	NA	R840Q	0.47
UCEC	chr18	21028831	Missense_Mutation	novel	A386P	0.06
UCEC	chr18	20967912	Missense_Mutation	novel	N1011T	0.4
UCEC	chr18	20979994	Missense_Mutation	novel	K857T	0.14
UCEC	chr18	20992934	Missense_Mutation	NA	R630Q	0.18
UCEC	chr18	20950916	3'UTR	novel		0.38
UCEC	chr18	21015445	Nonsense_Mutation	NA	E466*	0.47
UCEC	chr18	21042577	Missense_Mutation	NA	E270K	0.32
UCEC	chr18	20955011	Missense_Mutation	NA	D1209Y	0.28
UCEC	chr18	20967034	Nonsense_Mutation	NA	Q1079*	0.51
UCEC	chr18	21023633	Missense_Mutation	novel	A420V	0.28
UCEC	chr18	20950592	3'UTR	novel		0.57
UCEC	chr18	20967912	Missense_Mutation	novel	N1011I	0.3
UCEC	chr18	20969137	Missense_Mutation	novel	E964D	0.48
UCEC	chr18	20991321	Missense_Mutation	rs770190015	K666N	0.22
UCEC	chr18	21039477	Missense_Mutation	novel	R349Q	0.38
UCEC	chr18	21049847	Nonsense_Mutation	novel	*R70Lfs6**	0.05
UCEC	chr18	20950089	3'UTR	novel		0.3
UCEC	chr18	20950713	3'UTR	novel		0.5
UCEC	chr18	20953650	Missense_Mutation	NA	R1330Q	0.35
UCEC	chr18	20959886	Missense_Mutation	rs747883475	E1156K	0.4
UCEC	chr18	21049194	Missense_Mutation	novel	M104I	0.48
UCEC	chr18	20950496	3'UTR	novel		0.35
UCEC	chr18	20953603	Missense_Mutation	novel	V1346L	0.21
UCEC	chr18	20953596	Frame_Shift_Del	novel	*N1348Ifs76**	0.37
UCEC	chr18	20954866	Frame_Shift_Del	NA	*P1257Lfs3**	0.28
UCEC	chr18	20970381	Frame_Shift_Del	novel	*Q929Rfs5**	0.27
UCEC	chr18	20950975	3'UTR	novel		0.29
UCEC	chr18	20967909	Missense_Mutation	NA	R1012Q	0.2
UCEC	chr18	20984428	Missense_Mutation	novel	E804D	0.16
UCEC	chr18	21042134	Nonsense_Mutation	novel	E308*	0.15
UCEC	chr18	20950931	3'UTR	novel		0.82
UCEC	chr18	21110991	5'UTR	novel		0.44
UCEC	chr18	20950931	3'UTR	novel		0.54
UCEC	chr18	20950099	3'UTR	novel		0.24
UCEC	chr18	21023648	Missense_Mutation	NA	R415I	0.37
UCEC	chr18	21049847	Missense_Mutation	NA	R70Q	0.17
UCEC	chr18	20951121	3'UTR	novel		0.29
UCEC	chr18	21070609	Missense_Mutation	novel	G33E	0.33
UCEC	chr18	20950179	3'UTR	novel		0.29
UCEC	chr18	20951121	3'UTR	novel		0.45
UCEC	chr18	20970385	Missense_Mutation	novel	R928I	0.31
UCEC	chr18	20968788	Missense_Mutation	NA	R996Q	0.3
UCEC	chr18	21006591	Missense_Mutation	novel	E549K	0.43
UCEC	chr18	20953718	Frame_Shift_Del	rs752898741	*K1307Nfs3**	0.42
UCEC	chr18	21015449	Missense_Mutation	novel	M464I	0.4
UCEC	chr18	21044111	Missense_Mutation	novel	K222N	0.25
UCEC	chr18	21028915	Missense_Mutation	rs569522637	D358N	0.26
UCEC	chr18	20991235	Missense_Mutation	novel	K695T	0.1
UCEC	chr18	21042577	Nonsense_Mutation	novel	E270*	0.19
UCEC	chr18	20950409	3'UTR	novel		0.13
UCEC	chr18	21008124	Missense_Mutation	novel	R494I	0.22
UCEC	chr18	21028779	Missense_Mutation	rs374052961	R403H	0.38
UCEC	chr18	20953646	Silent	novel	T1331T	0.05
UCEC	chr18	20959904	Frame_Shift_Del	novel	*I1150Ffs21**	0.11
UCEC	chr18	21028825	Missense_Mutation	NA	V388I	0.27
UCEC	chr18	21045442	Missense_Mutation	rs755247871	R147H	0.1
UCEC	chr18	21049121	Missense_Mutation	NA	A129T	0.37
UCEC	chr18	20954865	Frame_Shift_Ins	novel	*A1258Cfs10**	0.3
UCEC	chr18	20950729	3'UTR	novel		0.4
UCEC	chr18	20984376	Nonsense_Mutation	NA	E822*	0.44
UCEC	chr18	20986954	Missense_Mutation	NA	D767G	0.37
UCEC	chr18	21015445	Nonsense_Mutation	NA	E466*	0.43
UCEC	chr18	20950931	3'UTR	novel		0.6
UCEC	chr18	20950931	3'UTR	novel		0.53
UCEC	chr18	20959904	Frame_Shift_Del	novel	*I1150Ffs21**	0.47
UCEC	chr18	20984437	Frame_Shift_Del	novel	*G802Vfs2**	0.26
UCEC	chr18	21042134	Nonsense_Mutation	novel	E308*	0.19
UCEC	chr18	21049847	Missense_Mutation	NA	R70Q	0.05
UCEC	chr18	21039532	Nonsense_Mutation	NA	E331*	0.06
UCEC	chr18	21049862	Missense_Mutation	NA	K65I	0.22
UCEC	chr18	20953635	Missense_Mutation	novel	R1335I	0.19
UCEC	chr18	20991233	Missense_Mutation	novel	A696S	0.21
UCEC	chr18	21006396	Nonsense_Mutation	novel	R614*	0.12
UCEC	chr18	20950931	3'UTR	novel		0.58
UCEC	chr18	20951211	3'UTR	rs200547604		0.41
UCEC	chr18	20979951	Frame_Shift_Ins	NA	*N871Kfs14**	0.21
UCEC	chr18	21042626	Silent	novel	G253G	0.09
UCEC	chr18	20966981	Silent	rs757035057	D1096D	0.33
UCEC	chr18	20967904	Missense_Mutation	NA	D1014Y	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
THYM	0.014	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.036	Kaplan-Meier Survival Analysis
MESO	0.016	Kaplan-Meier Survival Analysis
ACC	0.039	Kaplan-Meier Survival Analysis
SKCM	0.003	Kaplan-Meier Survival Analysis
PAAD	0.0099	Kaplan-Meier Survival Analysis
LGG	0.014	Kaplan-Meier Survival Analysis
OV	0.011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000067900 (Gene tree)
Gene ID: 6093
Gene Symbol: ROCK1
Alias: p160ROCK
Full Name: Rho associated coiled-coil containing protein kinase 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 164,946 bases
Position: chr18:20,946,906-21,111,851
Accession: 10251
Summary: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30674565	MiR-144 Inhibits Tumor Growth and Metastasis in Osteosarcoma via Dual-suppressing RhoA/ROCK1 Signaling Pathway.	Mol Pharmacol	2019 Apr	Liu JL	doi: 10.1124/mol.118.114207

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000635540	ROCK1-207	5656	-	ENSP00000489185	1137 (aa)	-	A0A0U1RQV4
ENST00000584687	ROCK1-205	492	-	-	- (aa)	-	-
ENST00000584875	ROCK1-206	616	-	-	- (aa)	-	-
ENST00000583556	ROCK1-204	672	-	-	- (aa)	-	-
ENST00000582445	ROCK1-203	543	-	-	- (aa)	-	-
ENST00000399799	ROCK1-201	9484	XM_011526137	ENSP00000382697	1354 (aa)	XP_011524439	Q13464
ENST00000578051	ROCK1-202	584	-	ENSP00000462004	99 (aa)	-	J3KRH6

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04062	Chemokine signaling pathway	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04350	TGF-beta signaling pathway	KEGG
hsa04360	Axon guidance	KEGG
hsa04510	Focal adhesion	KEGG
hsa04530	Tight junction	KEGG
hsa04611	Platelet activation	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05131	Shigellosis	KEGG
hsa05132	Salmonella infection	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05205	Proteoglycans in cancer	KEGG
hsa05206	MicroRNAs in cancer	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000067900's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000067900	ROCK1	99	65.132	ENSG00000134318	ROCK2	100	94.118	Homo_sapiens
ENSG00000067900	ROCK1	78	34.295	ENSG00000198752	CDC42BPB	88	52.632	Homo_sapiens
ENSG00000067900	ROCK1	69	32.371	ENSG00000122966	CIT	83	43.956	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0001726	ruffle	-	ISS	Component
GO:0003180	aortic valve morphogenesis	-	ISS	Process
GO:0003383	apical constriction	-	IEA	Process
GO:0004672	protein kinase activity	8798490.10436159.	TAS	Function
GO:0004674	protein serine/threonine kinase activity	10652353.11018042.18694941.19036714.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	27853422.	NAS	Function
GO:0004674	protein serine/threonine kinase activity	-	TAS	Function
GO:0005515	protein binding	10652353.14660612.17853893.20230755.21281639.22085929.25416956.25448675.27853422.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005814	centriole	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	-	ISS	Component
GO:0005886	plasma membrane	-	ISS	Component
GO:0006468	protein phosphorylation	10436159.	TAS	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0006939	smooth muscle contraction	12778124.	TAS	Process
GO:0007159	leukocyte cell-cell adhesion	12082081.	IDA	Process
GO:0007165	signal transduction	10436159.	TAS	Process
GO:0007186	G protein-coupled receptor signaling pathway	-	TAS	Process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	25816133.	IMP	Process
GO:0007266	Rho protein signal transduction	27160703.	IGI	Process
GO:0010494	cytoplasmic stress granule	-	ISS	Component
GO:0010506	regulation of autophagy	27853422.	TAS	Process
GO:0010508	positive regulation of autophagy	27853422.	IGI	Process
GO:0010613	positive regulation of cardiac muscle hypertrophy	28679962.	IMP	Process
GO:0010628	positive regulation of gene expression	27853422.28679962.	IMP	Process
GO:0010628	positive regulation of gene expression	-	ISS	Process
GO:0016525	negative regulation of angiogenesis	19181962.	IMP	Process
GO:0017049	GTP-Rho binding	-	IEA	Function
GO:0018105	peptidyl-serine phosphorylation	18573880.	IDA	Process
GO:0022614	membrane to membrane docking	12082081.	IDA	Process
GO:0030027	lamellipodium	-	ISS	Component
GO:0030036	actin cytoskeleton organization	10436159.	TAS	Process
GO:0030155	regulation of cell adhesion	12778124.	TAS	Process
GO:0030866	cortical actin cytoskeleton organization	25816133.	IGI	Process
GO:0030866	cortical actin cytoskeleton organization	25816133.	IMP	Process
GO:0031175	neuron projection development	27160703.	IGI	Process
GO:0032059	bleb	-	IEA	Component
GO:0032060	bleb assembly	-	IEA	Process
GO:0032091	negative regulation of protein binding	18573880.	IDA	Process
GO:0032956	regulation of actin cytoskeleton organization	25911094.	IDA	Process
GO:0032956	regulation of actin cytoskeleton organization	12778124.	TAS	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	25816133.	IGI	Process
GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	25816133.	IMP	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043410	positive regulation of MAPK cascade	28679962.	IMP	Process
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	Process
GO:0045616	regulation of keratinocyte differentiation	19997641.	IMP	Process
GO:0045664	regulation of neuron differentiation	27160703.	IGI	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	Process
GO:0048013	ephrin receptor signaling pathway	-	TAS	Process
GO:0048156	tau protein binding	28386764.	NAS	Function
GO:0050321	tau-protein kinase activity	28386764.	NAS	Function
GO:0050900	leukocyte migration	12082081.	IDA	Process
GO:0050901	leukocyte tethering or rolling	12082081.	IDA	Process
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	27853422.	TAS	Process
GO:0051451	myoblast migration	-	ISS	Process
GO:0051492	regulation of stress fiber assembly	12778124.	TAS	Process
GO:0051893	regulation of focal adhesion assembly	12778124.	TAS	Process
GO:0051894	positive regulation of focal adhesion assembly	-	ISS	Process
GO:0061157	mRNA destabilization	-	ISS	Process
GO:0070168	negative regulation of biomineral tissue development	-	ISS	Process
GO:0071559	response to transforming growth factor beta	-	ISS	Process
GO:0072518	Rho-dependent protein serine/threonine kinase activity	18573880.	IDA	Function
GO:0072659	protein localization to plasma membrane	25816133.	IGI	Process
GO:0072659	protein localization to plasma membrane	25816133.	IMP	Process
GO:0097746	regulation of blood vessel diameter	-	ISS	Process
GO:0106003	amyloid-beta complex	27853422.	IDA	Component
GO:0110061	regulation of angiotensin-activated signaling pathway	28679962.	IMP	Process
GO:0140058	neuron projection arborization	27160703.	IGI	Process
GO:1900223	positive regulation of amyloid-beta clearance	27853422.	IGI	Process
GO:1900242	regulation of synaptic vesicle endocytosis	27160703.	IGI	Process
GO:1902003	regulation of amyloid-beta formation	27853422.	TAS	Process
GO:1902430	negative regulation of amyloid-beta formation	24305806.27853422.	IMP	Process
GO:1902992	negative regulation of amyloid precursor protein catabolic process	24305806.27853422.	IMP	Process
GO:1903140	regulation of establishment of endothelial barrier	25816133.	IGI	Process
GO:1903140	regulation of establishment of endothelial barrier	25816133.	IMP	Process
GO:1903347	negative regulation of bicellular tight junction assembly	25816133.	IGI	Process
GO:1905205	positive regulation of connective tissue replacement	28679962.	IMP	Process
GO:1990776	response to angiotensin	-	ISS	Process
GO:2000114	regulation of establishment of cell polarity	20803696.	TAS	Process
GO:2000145	regulation of cell motility	12778124.	TAS	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.