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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20223287The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling.J Steroid Biochem Mol Biol2010 JulOrd??ez-Mor??n Pdoi: 10.1016/j.jsbmb.2010.02.031
26458302MicroRNA144 inhibits migration and proliferation in rectal cancer by downregulating ROCK1.Mol Med Rep2015 NovCai SDdoi: 10.3892/mmr.2015.4391
23615712MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway.Mol Cell Biochem2013 AugLi Ndoi: 10.1007/s11010-013-1664-0
26292662Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression.J Pineal Res2016 JanBorin TFdoi: 10.1111/jpi.12270
28031255ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.EMBO Mol Med2017 FebRath Ndoi: 10.15252/emmm.201606743.
18922892Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion.Cancer Res2008 Oct 15Joshi Bdoi: 10.1158/0008-5472.CAN-08-0343.
23872151MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1.Biochem Biophys Res Commun2013 Aug 9Zhou Xdoi: 10.1016/j.bbrc.2013.07.033
26615424MiR-145 suppresses cell proliferation and motility by inhibiting ROCK1 in hepatocellular carcinoma.Tumour Biol2016 MayDing Wdoi: 10.1007/s13277-015-4462-3
23298303Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma.Asia Pac J Clin Oncol2014 JunWu YJdoi: 10.1111/ajco.12052
26474697MiR-506 suppresses cell proliferation and tumor growth by targeting Rho-associated protein kinase 1 in hepatocellular carcinoma.Biochem Biophys Res Commun2015 Nov 27Deng Qdoi: 10.1016/j.bbrc.2015.10.043
14716844Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.World J Gastroenterol2004 Jan 15Wang DS-
22563075Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility.J Biol Chem2012 Jun 22Rana MKdoi: 10.1074/jbc.M112.346114
25448675FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1.FEBS Lett2014 Nov 28Hu Jdoi: 10.1016/j.febslet.2014.10.012
26081423MicroRNA-144 acts as a tumor suppressor by targeting Rho-associated coiled-coil containing protein kinase 1 in osteosarcoma cells.Mol Med Rep2015 SepHuang Jdoi: 10.3892/mmr.2015.3937
24317511ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc.Oncogene2014 Dec 4Zhang Cdoi: 10.1038/onc.2013.505
17344417Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.Genes Dev2007 Mar 1Lefort K-
16371346Inhibition of motile and invasive properties of ovarian cancer cells by ASODN against Rho-associated protein kinase.Cell Commun Adhes2005 Jan-AprHan Z-
20364104Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.Cancer Biol Ther2010 Jun 1Deng L-
25755711Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.Int J Clin Exp Pathol2015 Jan 1Zhang J-
20053635Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion events.J Cell Sci2010 Feb 1Struckhoff APdoi: 10.1242/jcs.052167
25831237miR-340 suppresses glioblastoma multiforme.Oncotarget2015 Apr 20Huang D-
26026086ROCK I Has More Accurate Prognostic Value than MET in Predicting Patient Survival in Colorectal Cancer.Anticancer Res2015 JunLi J-
24801908MiR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1.Tumour Biol2014 AugLi Edoi: 10.1007/s13277-014-2031-9
28081735miR-214-5p Targets ROCK1 and Suppresses Proliferation and Invasion of Human Osteosarcoma Cells.Oncol Res2017 Jan 2Zhang Mdoi: 10.3727/096504016X14719078133401.
28709411Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.BMC Cancer2017 Jul 14Amaya CNdoi: 10.1186/s12885-017-3470-7.
28117029MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase.Oncol Res2017 Sep 21Yang Hdoi: 10.3727/096504017X14850134190255
28848996Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma.Int J Oncol2017 OctLuo Ddoi: 10.3892/ijo.2017.4100
22232555Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins.J Biol Chem2012 Feb 24Shields MAdoi: 10.1074/jbc.M111.308940
11893932Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro.Pancreas2002 AprKaneko K-
24180482MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1.J Transl Med2013 Nov 2Xu Xdoi: 10.1186/1479-5876-11-276.
21994419MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer.Clin Cancer Res2011 Dec 15Zheng Bdoi: 10.1158/1078-0432.CCR-11-1714
20140017Activating ROCK1 somatic mutations in human cancer.Oncogene2010 Apr 29Lochhead PAdoi: 10.1038/onc.2010.3
22584506Inhibition of RhoA/ROCK signaling pathway promotes the apoptosis of gastric cancer cells.Hepatogastroenterology2012 Nov-DecXu XT-
18615591Placenta growth factor, PLGF, influences the motility of lung cancer cells, the role of Rho associated kinase, Rock1.J Cell Biochem2008 Sep 1Chen Jdoi: 10.1002/jcb.21831.
27035227MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1.Mol Med Rep2016 MayWu Ddoi: 10.3892/mmr.2016.5055
18780293Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells.Prostate2008 Dec 1Shi XBdoi: 10.1002/pros.20849.
25677806RhoC and ROCKs regulate cancer cell interactions with endothelial cells.Mol Oncol2015 JunReymond Ndoi: 10.1016/j.molonc.2015.01.004
19667069ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK.J Biol Chem2009 Oct 23Xiao Ldoi: 10.1074/jbc.M109.007971
23328676Role of rho-kinase gene polymorphisms and protein expressions in colorectal cancer development.Pathobiology2013Sari Idoi: 10.1159/000341395
24324133Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.Proc Natl Acad Sci U S A2014 Jan 21Gilkes DMdoi: 10.1073/pnas.1321510111
23649168CCR4 mediates CCL17 (TARC)-induced migration of human colon cancer cells via RhoA/Rho-kinase signaling.Int J Colorectal Dis2013 NovAl-haidari AAdoi: 10.1007/s00384-013-1712-y
26715279MicroRNA-145 inhibits growth and migration of breast cancer cells through targeting oncoprotein ROCK1.Tumour Biol2016 JunZheng Mdoi: 10.1007/s13277-015-4722-2
26562026Possible Gender-Related Modulation by the ROCK1 Gene in Colorectal Cancer Susceptibility.Pathobiology2015Zucchini Cdoi: 10.1159/000439405
16543245Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.J Biol Chem2006 May 19Mizukami Y-
25218053Immunoexpression of ROCK-1 and MMP-9 as prognostic markers in breast cancer.Acta Histochem2014 OctBottino Jdoi: 10.1016/j.acthis.2014.08.009
24894676MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells.Tumour Biol2014 SepCui Gdoi: 10.1007/s13277-014-2168-6
17044646Induction of apoptosis by L-NMMA, via FKHRL1/ROCK pathway in human gastric cancer cells.Biomed Environ Sci2006 AugWang YZ-
18695890The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.Int J Oncol2008 SepLane J-
25987767Downregulation of rho-associated protein kinase 1 by miR-124 in colorectal cancer.World J Gastroenterol2015 May 14Xi ZWdoi: 10.3748/wjg.v21.i18.5454.
24587343An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.PLoS One2014 Feb 28Pettee KMdoi: 10.1371/journal.pone.0090371
23775364Androgen receptor enhances entosis, a non-apoptotic cell death, through modulation of Rho/ROCK pathway in prostate cancer cells.Prostate2013 SepWen Sdoi: 10.1002/pros.22676
26306811Hsa-miR-146a-5p modulates androgen-independent prostate cancer cells apoptosis by targeting ROCK1.Prostate2015 DecXu Bdoi: 10.1002/pros.23068
15843433Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.Mol Biol Cell2005 JulCardone RA-
18396681[Effect of blocking of ROCK-1, an effector of small G protein Rho, on the malignant behavior of ovarian tumor cells in vitro].Zhonghua Zhong Liu Za Zhi2007 OctHan ZQ-
24465504MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer.PLoS One2014 Jan 21Shin JYdoi: 10.1371/journal.pone.0085205
20126978Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation.Int J Oncol2010 MarNakashima M-
28184030Genetic variants in RhoA and ROCK1 genes are associated with the development, progression and prognosis of prostate cancer.Oncotarget2017 Mar 21Liu Kdoi: 10.18632/oncotarget.15197.
28841710Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.PLoS One2017 Aug 25Whatcott CJdoi: 10.1371/journal.pone.0183871
27203208Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context.Oncotarget2016 May 31Matsubara Mdoi: 10.18632/oncotarget.9395.
27374095Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer.Oncotarget2016 Jul 12Iskit Sdoi: 10.18632/oncotarget.10230.
29790629Long non-coding RNA NEAT1 promoted ovarian cancer cells' metastasis through regulation of miR-382-3p/ROCK1 axial.Cancer Sci2018 JulLiu Ydoi: 10.1111/cas.13647
29441962MiR-139 prompts the development of osteosarcomas mainly through targeting ROCK1.Pharmazie2017 Dec 1Su Sdoi: 10.1691/ph.2017.7439.
29710554MicroRNA-361-5p inhibits papillary thyroid carcinoma progression by targeting ROCK1.Biomed Pharmacother2018 JunLi Rdoi: 10.1016/j.biopha.2018.03.122
29544562Long non-coding RNA NEAT1 regulates the proliferation, migration and invasion of gastric cancer cells via targeting miR-335-5p/ROCK1 axis.Pharmazie2018 Mar 5Wang Hdoi: 10.1691/ph.2018.7877.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1821049170Missense_MutationnovelM112I0.34
BLCAchr1821015477Missense_MutationnovelT455N0.88
BLCAchr1820967909Missense_MutationNAR1012Q0.41
BLCAchr1820969162Missense_MutationNAR956T0.3
BLCAchr1821110882Missense_MutationnovelR10Q0.06
BLCAchr1821049827Missense_MutationNAE77K0.42
BLCAchr1820992925Missense_MutationnovelS633C0.1
BLCAchr1821042139Nonsense_MutationNAS306*0.28
BLCAchr1821045296Missense_MutationNAH196Y0.15
BLCAchr18211109795'UTRnovel0.19
BLCAchr1820966978SilentnovelL1097L0.3
BRCAchr1820967798Missense_Mutationrs761438534N1049S0.09
BRCAchr18209506863'UTRnovel0.23
BRCAchr18209508263'UTRnovel0.35
BRCAchr1820954889SilentnovelL1249L0.09
BRCAchr1820992930SilentNAI631I0.31
BRCAchr1820955029Missense_MutationNAE1203K0.16
BRCAchr1820959862Missense_MutationNAP1164S0.18
BRCAchr1821006423Nonsense_MutationNAQ605*0.42
BRCAchr1820953650Missense_MutationNAR1330Q0.15
BRCAchr1821042577Missense_MutationNAE270K0.18
BRCAchr1820992888SilentnovelL645L0.08
BRCAchr1820967932Frame_Shift_InsnovelN1004Kfs*70.04
BRCAchr1820967935Frame_Shift_DelnovelV1003Efs*130.03
BRCAchr1820967001SilentNAL1090L0.28
BRCAchr1821006495Missense_MutationNAL581V0.36
BRCAchr1821045373Missense_MutationNAV170A0.11
CESCchr1820991212Missense_Mutationrs764295785Q703E0.42
CESCchr18209500133'UTRnovel0.27
CESCchr18209506863'UTRnovel0.26
CESCchr1821006507Nonsense_MutationNAQ577*0.24
CESCchr18209501733'UTRnovel0.4
CESCchr18209508083'UTRnovel0.23
CESCchr1820954829SilentnovelH1269H0.45
CESCchr1820969202Nonsense_MutationnovelE943*0.48
CESCchr1820953582Frame_Shift_DelNAT1353Lfs*710.14
CESCchr1820982766SilentNAF852F0.28
CESCchr1820953735Nonsense_MutationnovelQ1302*0.3
CESCchr1820953747SilentnovelL1298L0.23
CESCchr18211112155'UTRnovel0.83
CESCchr18209506863'UTRnovel0.21
CESCchr1820953613SilentNAF1342F0.2
CESCchr1820959841Missense_MutationNAD1171H0.38
CESCchr1820954811SilentNAK1275K0.15
CHOLchr1821049866Missense_MutationnovelN64Y0.37
COADchr18209512203'UTRnovel0.37
COADchr1820959886Missense_Mutationrs747883475E1156K0.36
COADchr1820967064Missense_MutationNAE1069K0.44
COADchr1820991217Missense_MutationNAK701T0.35
COADchr1820960178SilentNAV1127V0.27
COADchr1820967840Missense_MutationNAR1035Q0.21
COADchr1820992934Missense_MutationNAR630Q0.12
COADchr1820954848Missense_MutationnovelR1263I0.37
COADchr1820953724Missense_MutationNAQ1305H0.24
COADchr1820991313Missense_MutationnovelL669S0.05
COADchr1821028852Missense_MutationnovelE379K0.07
COADchr1820959903Frame_Shift_InsNAI1150Nfs*50.23
COADchr1820979952Frame_Shift_DelNAN871Tfs*50.29
COADchr1820991173Splice_Regionnovel0.41
COADchr1821042582Frame_Shift_DelNAL268Yfs*60.3
COADchr1820984387Frame_Shift_DelnovelK818Efs*60.51
COADchr1820987024Missense_MutationnovelL744I0.36
COADchr1820968799Silentrs375431349I992I0.45
COADchr1820967939Missense_MutationnovelA1002D0.12
COADchr1820967753Missense_Mutationrs771167832A1064V0.42
COADchr1820953718Frame_Shift_Delrs752898741K1307Nfs*30.28
COADchr1820984490SilentnovelL784L0.28
COADchr1820967904Missense_MutationnovelD1014N0.11
COADchr1820967077Splice_SiteNAX1065_splice0.26
COADchr1820979941Missense_MutationNAL875V0.22
COADchr1821042577Missense_MutationNAE270K0.07
COADchr1820954864Missense_MutationnovelA1258S0.4
COADchr18209512633'UTRnovel0.38
COADchr1820954852Nonsense_Mutationrs763334480R1262*0.24
COADchr1821015445Nonsense_MutationNAE466*0.36
COADchr1820979951Frame_Shift_InsNAN871Kfs*140.07
COADchr1821023638SilentNAS418S0.25
COADchr1820954866Frame_Shift_DelNAP1257Lfs*30.21
COADchr1821039560Missense_MutationnovelE321D0.24
COADchr1821049143Frame_Shift_InsNAW122Lfs*250.4
ESCAchr18209503873'UTRnovel0.33
ESCAchr1821042680SilentnovelV235V0.18
ESCAchr1820967889Missense_MutationnovelR1019G0.31
ESCAchr1820979952Missense_MutationNAN871T0.27
ESCAchr18209508463'UTRnovel0.59
GBMchr1820968788Missense_MutationNAR996Q0.45
GBMchr1820969141Missense_MutationnovelT963R0.26
GBMchr1821028853SilentnovelE378E0.24
GBMchr1821049197SilentnovelA103A0.21
GBMchr1820953612Missense_MutationNAR1343W0.04
GBMchr1820967784Nonsense_MutationNAK1054*0.1
HNSCchr1821049131Missense_MutationnovelR125S0.77
HNSCchr1820967767SilentNAL1059L0.32
HNSCchr1820968770Splice_SitenovelX1001_splice0.18
HNSCchr1821028895Silentrs370231055D364D0.22
HNSCchr1821020237Missense_MutationnovelQ425H0.31
HNSCchr1820967057Missense_MutationnovelA1071V0.38
HNSCchr1821049181Missense_MutationnovelK109E0.14
HNSCchr1821044168Frame_Shift_DelnovelD202Cfs*90.26
HNSCchr1820992838Missense_MutationnovelS662L0.49
HNSCchr1820954950Missense_MutationNAH1229R0.23
HNSCchr1820969155Missense_MutationnovelE958D0.14
HNSCchr1821045346Missense_MutationnovelT179N0.19
HNSCchr1820986980Missense_MutationnovelL758F0.07
HNSCchr1821006515Missense_MutationnovelS574L0.28
HNSCchr1821042664Missense_MutationnovelI241V0.28
HNSCchr1821049153Missense_MutationnovelS118F0.12
HNSCchr1820955233Missense_MutationnovelH1175Q0.39
HNSCchr1820954822Missense_MutationnovelH1272N0.07
KIRCchr1821028900Missense_Mutationrs775903956I363V0.37
KIRCchr1821006577Missense_MutationNAL553F0.36
KIRCchr1821049143Frame_Shift_InsNAW122Lfs*250.22
KIRCchr1820967034Nonsense_MutationNAQ1079*0.29
KIRCchr1820969179Missense_MutationNAK950N0.39
KIRCchr1821044134Missense_MutationnovelA215T0.23
KIRCchr1821006548Frame_Shift_DelnovelA561Dfs*20.15
KIRPchr1821044157Missense_MutationnovelD207V0.27
LGGchr1820970384SilentnovelR928R0.37
LGGchr1820967017SilentnovelE1084E0.05
LGGchr1821006569Nonsense_MutationnovelT556delinsILP*RSPIIS0.07
LIHCchr1821045359Missense_MutationnovelA175T0.34
LIHCchr1821006437Missense_MutationNAD600A0.41
LIHCchr1820980004Missense_MutationNAT854A0.43
LIHCchr1821045403Missense_MutationnovelD160G0.38
LIHCchr1821049143Frame_Shift_InsNAW122Lfs*250.11
LUADchr1820959856Missense_Mutationrs748810091M1166V0.4
LUADchr1821044131Missense_MutationNAD216Y0.59
LUADchr18211109855'UTRnovel0.16
LUADchr1821020207SilentnovelL435L0.26
LUADchr1821042678Frame_Shift_InsnovelG236Dfs*120.06
LUADchr1821042679Frame_Shift_InsnovelG236Lfs*50.06
LUADchr1821042577Missense_MutationNAE270K0.36
LUADchr1820967843Missense_MutationnovelN1034I0.07
LUADchr1821049879Nonsense_MutationnovelY59delins*0.17
LUADchr1821049143Frame_Shift_InsNAW122Lfs*250.32
LUADchr18209513403'UTRnovel0.23
LUADchr1821049092Missense_MutationNAQ138H0.22
LUADchr1820967935In_Frame_InsnovelV1003_N1004insD0.13
LUADchr1821049122Missense_MutationNAM128I0.42
LUADchr1821006572Missense_MutationNAR555T0.19
LUADchr1821110883Nonsense_MutationnovelR10*0.11
LUADchr1821070551In_Frame_DelnovelL46_I52del0.16
LUADchr1820954862SilentNAA1258A0.1
LUADchr1820987018Frame_Shift_DelnovelM743*0.07
LUADchr1820970492Missense_MutationNAL892F0.37
LUADchr1821006725Missense_MutationnovelE538K0.83
LUADchr1821070595Missense_MutationNAV38L0.17
LUADchr1821042589Frame_Shift_DelnovelV266Yfs*80.19
LUADchr1820968849Nonsense_MutationNAE976*0.12
LUADchr1820969192Missense_Mutationrs377651671S946N0.3
LUADchr1820987105Nonsense_MutationnovelE717*0.4
LUADchr1821042688Missense_MutationNAT233A0.26
LUSCchr1820987072Missense_MutationnovelE728K0.35
LUSCchr1821042694Missense_MutationnovelC231R0.39
LUSCchr1821006500Missense_MutationnovelE579G0.12
LUSCchr18209513813'UTRnovel0.39
LUSCchr1820954856Missense_MutationnovelE1260D0.37
LUSCchr1820967050Missense_MutationnovelR1073S0.07
LUSCchr1820967790Missense_MutationnovelV1052L0.42
LUSCchr1820991233Missense_MutationNAA696T0.17
LUSCchr1821008158Missense_MutationNAQ483E0.07
LUSCchr1820953589SilentnovelS1350S0.17
LUSCchr1820991258SilentnovelE687E0.12
LUSCchr1821006772Missense_MutationnovelQ522R0.22
LUSCchr1820991180Missense_MutationNAM713I0.59
LUSCchr1820967056Silentrs773377004A1071A0.21
LUSCchr1821070531Splice_SitenovelX59_splice0.82
LUSCchr1820966970Missense_MutationNAS1100C0.14
MESOchr1820992855Frame_Shift_DelNAQ656Rfs*40.51
MESOchr1821042613Missense_MutationnovelE258K0.3
OVchr1820970507Splice_SitenovelX885_splice0.19
OVchr18209506883'UTRnovel0.63
OVchr18209506893'UTRnovel0.63
OVchr1820970367Missense_MutationnovelK934T0.05
OVchr1821020209In_Frame_DelnovelQ425_K434del0.13
PAADchr1821028841Frame_Shift_DelnovelI383Ffs*130.17
PAADchr1821008124Missense_MutationnovelR494I0.17
PAADchr1821042146Missense_MutationnovelD304N0.04
PAADchr1821045437Missense_MutationnovelL149F0.1
PAADchr1820982824Missense_MutationnovelR833K0.12
PRADchr1821045367Missense_MutationNAE172G0.6
PRADchr1821110877In_Frame_InsnovelF11dup0.28
PRADchr1820966985Missense_MutationNAL1095S0.08
PRADchr1820953646SilentnovelT1331T0.41
PRADchr1820982798SilentnovelL842L0.54
READchr1821049180Missense_MutationNAK109I0.58
READchr1821006467Missense_Mutationrs141266099R590Q0.23
READchr1820991312SilentnovelL669L0.07
READchr18209512123'UTRnovel0.29
READchr1820967027Missense_MutationNAA1081D0.28
READchr1820970451Missense_MutationnovelR906Q0.34
READchr1821110834Missense_MutationNAN26T0.29
READchr1820967909Missense_MutationNAR1012Q0.43
READchr1820970405Missense_MutationNAK921N0.37
READchr1820991305Missense_MutationNAD672Y0.09
READchr1821006360Missense_MutationnovelD626Y0.04
READchr1821049219Missense_MutationNAK96T0.4
READchr1820967772Nonsense_MutationnovelE1058*0.2
READchr1820953724Missense_MutationNAQ1305H0.11
READchr1820970405Missense_MutationNAK921N0.33
READchr1821070558Missense_MutationNAK50T0.09
SARCchr1820987014Missense_MutationnovelD747G0.3
SARCchr1820955046Splice_SitenovelX1198_splice0.08
SKCMchr1821006563Nonsense_MutationNAS558*0.24
SKCMchr1820954843Missense_MutationNAH1265Y0.28
SKCMchr1820959858Missense_MutationNAS1165F0.2
SKCMchr1820954836Missense_MutationNAK1267M0.3
SKCMchr1821015476Silentrs150844243T455T0.2
SKCMchr1821015477Missense_MutationnovelT455I0.2
SKCMchr1821028836Missense_MutationnovelP384L0.43
SKCMchr1821028837Missense_MutationnovelP384S0.42
SKCMchr1820959875SilentNAK1159K0.22
SKCMchr1820953612Missense_MutationNAR1343W0.36
SKCMchr1820953613SilentNAF1342F0.35
SKCMchr1820984399Missense_MutationNAL814S0.46
SKCMchr1820970362Missense_MutationNAH936Y0.51
SKCMchr1821049216Missense_MutationNAS97F0.71
SKCMchr1821008111SilentNAY498Y0.24
SKCMchr1821042641SilentNAS248S0.4
SKCMchr1821045351SilentNAF177F0.21
STADchr1821049143Frame_Shift_InsNAW122Lfs*250.48
STADchr1821049814Missense_MutationnovelV81A0.19
STADchr1820953718Frame_Shift_Delrs752898741K1307Nfs*30.43
STADchr1821006592Missense_MutationNAE548D0.25
STADchr1821049143Frame_Shift_DelnovelW122Gfs*310.29
STADchr1821042613Nonsense_MutationNAE258*0.34
STADchr1821049779Splice_SiteNAX92_splice0.31
STADchr1821042685Missense_MutationNAA234T0.21
STADchr1820959900Frame_Shift_DelnovelL1151Cfs*200.18
STADchr1821045324In_Frame_InsnovelA185_L186insF0.13
STADchr1821006696Splice_Regionnovel0.32
STADchr1820953718Frame_Shift_DelnovelK1307Mfs*110.37
STADchr1820991283Nonsense_MutationnovelS679*0.09
STADchr1820967758Missense_MutationNAM1062I0.09
STADchr1820984358Missense_MutationNAL828F0.37
STADchr1820982822Nonsense_MutationNAG834*0.16
STADchr1821045461Frame_Shift_DelnovelY141Mfs*120.25
STADchr1820953718Frame_Shift_Delrs752898741K1307Nfs*30.52
STADchr1820986950Missense_MutationNAE768D0.22
STADchr1821008070Missense_MutationNAV512A0.25
STADchr1820984491SilentNAR783R0.1
STADchr1820955226Missense_MutationnovelP1178S0.23
STADchr1820953718Frame_Shift_Delrs752898741K1307Nfs*30.42
STADchr1820984395SilentNAL815L0.32
STADchr1821006591Nonsense_MutationNAE549*0.25
STADchr1820959868Missense_MutationNAS1162P0.11
STADchr1821042171Missense_MutationNAN295K0.08
THCAchr1820991260Frame_Shift_InsnovelE687Ffs*100.05
THYMchr18209509313'UTRnovel0.34
UCECchr18209512123'UTRnovel0.28
UCECchr18209513793'UTRnovel0.11
UCECchr1820953650Missense_MutationNAR1330Q0.36
UCECchr1820959886Missense_Mutationrs747883475E1156K0.21
UCECchr1820967019Nonsense_MutationNAE1084*0.35
UCECchr1820992934Missense_MutationNAR630Q0.25
UCECchr1820959869Missense_MutationnovelQ1161H0.43
UCECchr1820967909Missense_MutationNAR1012Q0.13
UCECchr18211115205'UTRnovel0.25
UCECchr18211110365'UTRnovel0.4
UCECchr1820967909Missense_MutationNAR1012Q0.36
UCECchr1821023648Missense_MutationNAR415I0.35
UCECchr1820959885Missense_MutationnovelE1156A0.3
UCECchr1821028920Missense_MutationnovelV356A0.27
UCECchr18209509313'UTRnovel0.46
UCECchr18209509313'UTRnovel0.39
UCECchr1820953718Frame_Shift_Delrs752898741K1307Nfs*30.46
UCECchr1821045315SilentnovelI189I0.81
UCECchr1821006591Nonsense_MutationNAE549*0.49
UCECchr1820967757Nonsense_MutationnovelQ1063*0.36
UCECchr18209510993'UTRnovel0.4
UCECchr18209512073'UTRnovel0.33
UCECchr1820955041SilentnovelL1199L0.27
UCECchr18211109155'UTRnovel0.48
UCECchr18211116885'UTRnovel0.55
UCECchr1820970511Missense_MutationnovelE886A0.33
UCECchr1820979959Nonsense_MutationnovelE869*0.15
UCECchr1820967935Frame_Shift_InsnovelL1006Ifs*40.04
UCECchr1820992920Nonsense_MutationNAQ635*0.22
UCECchr1821039473Splice_RegionNAD350D0.16
UCECchr1820953718Frame_Shift_Delrs752898741K1307Nfs*30.41
UCECchr1820953598Missense_MutationNAK1347N0.26
UCECchr1820991242Missense_MutationNAV693L0.21
UCECchr1821006467Missense_Mutationrs141266099R590Q0.33
UCECchr1821039522Missense_MutationNAR334Q0.23
UCECchr1821049863Missense_Mutationrs763280401K65E0.25
UCECchr1821039535Nonsense_MutationnovelE330*0.2
UCECchr1820980003Missense_MutationnovelT854R0.1
UCECchr1820984353Splice_Regionrs372187123T829T0.45
UCECchr1821008129Missense_MutationnovelQ492H0.45
UCECchr1820960196SilentnovelI1121I0.46
UCECchr1820959903Frame_Shift_InsNAI1150Nfs*50.43
UCECchr1820953650Missense_MutationNAR1330Q0.36
UCECchr1820967904Missense_MutationNAD1014Y0.29
UCECchr1820979993Missense_MutationnovelK857N0.07
UCECchr1821006467Missense_Mutationrs141266099R590Q0.09
UCECchr1821023648Missense_MutationNAR415I0.35
UCECchr1820967904Missense_MutationNAD1014Y0.37
UCECchr1820968861Splice_SitenovelX972_splice0.32
UCECchr1820992934Missense_MutationNAR630Q0.4
UCECchr1821006467Missense_Mutationrs141266099R590Q0.13
UCECchr1821006591Nonsense_MutationNAE549*0.4
UCECchr1821110836SilentnovelV25V0.15
UCECchr1820966962Missense_MutationnovelV1103I0.38
UCECchr1821049195Missense_MutationnovelM104R0.39
UCECchr1820982803Missense_MutationNAR840Q0.47
UCECchr1821028831Missense_MutationnovelA386P0.06
UCECchr1820967912Missense_MutationnovelN1011T0.4
UCECchr1820979994Missense_MutationnovelK857T0.14
UCECchr1820992934Missense_MutationNAR630Q0.18
UCECchr18209509163'UTRnovel0.38
UCECchr1821015445Nonsense_MutationNAE466*0.47
UCECchr1821042577Missense_MutationNAE270K0.32
UCECchr1820955011Missense_MutationNAD1209Y0.28
UCECchr1820967034Nonsense_MutationNAQ1079*0.51
UCECchr1821023633Missense_MutationnovelA420V0.28
UCECchr18209505923'UTRnovel0.57
UCECchr1820967912Missense_MutationnovelN1011I0.3
UCECchr1820969137Missense_MutationnovelE964D0.48
UCECchr1820991321Missense_Mutationrs770190015K666N0.22
UCECchr1821039477Missense_MutationnovelR349Q0.38
UCECchr1821049847Nonsense_MutationnovelR70Lfs*60.05
UCECchr18209500893'UTRnovel0.3
UCECchr18209507133'UTRnovel0.5
UCECchr1820953650Missense_MutationNAR1330Q0.35
UCECchr1820959886Missense_Mutationrs747883475E1156K0.4
UCECchr1821049194Missense_MutationnovelM104I0.48
UCECchr18209504963'UTRnovel0.35
UCECchr1820953603Missense_MutationnovelV1346L0.21
UCECchr1820953596Frame_Shift_DelnovelN1348Ifs*760.37
UCECchr1820954866Frame_Shift_DelNAP1257Lfs*30.28
UCECchr1820970381Frame_Shift_DelnovelQ929Rfs*50.27
UCECchr18209509753'UTRnovel0.29
UCECchr1820967909Missense_MutationNAR1012Q0.2
UCECchr1820984428Missense_MutationnovelE804D0.16
UCECchr1821042134Nonsense_MutationnovelE308*0.15
UCECchr18209509313'UTRnovel0.82
UCECchr18211109915'UTRnovel0.44
UCECchr18209509313'UTRnovel0.54
UCECchr18209500993'UTRnovel0.24
UCECchr1821023648Missense_MutationNAR415I0.37
UCECchr1821049847Missense_MutationNAR70Q0.17
UCECchr18209511213'UTRnovel0.29
UCECchr1821070609Missense_MutationnovelG33E0.33
UCECchr18209501793'UTRnovel0.29
UCECchr18209511213'UTRnovel0.45
UCECchr1820970385Missense_MutationnovelR928I0.31
UCECchr1820968788Missense_MutationNAR996Q0.3
UCECchr1821006591Missense_MutationnovelE549K0.43
UCECchr1820953718Frame_Shift_Delrs752898741K1307Nfs*30.42
UCECchr1821015449Missense_MutationnovelM464I0.4
UCECchr1821044111Missense_MutationnovelK222N0.25
UCECchr1821028915Missense_Mutationrs569522637D358N0.26
UCECchr1820991235Missense_MutationnovelK695T0.1
UCECchr1821042577Nonsense_MutationnovelE270*0.19
UCECchr18209504093'UTRnovel0.13
UCECchr1821008124Missense_MutationnovelR494I0.22
UCECchr1821028779Missense_Mutationrs374052961R403H0.38
UCECchr1820953646SilentnovelT1331T0.05
UCECchr1820959904Frame_Shift_DelnovelI1150Ffs*210.11
UCECchr1821028825Missense_MutationNAV388I0.27
UCECchr1821045442Missense_Mutationrs755247871R147H0.1
UCECchr1821049121Missense_MutationNAA129T0.37
UCECchr1820954865Frame_Shift_InsnovelA1258Cfs*100.3
UCECchr18209507293'UTRnovel0.4
UCECchr1820984376Nonsense_MutationNAE822*0.44
UCECchr1820986954Missense_MutationNAD767G0.37
UCECchr1821015445Nonsense_MutationNAE466*0.43
UCECchr18209509313'UTRnovel0.6
UCECchr18209509313'UTRnovel0.53
UCECchr1820959904Frame_Shift_DelnovelI1150Ffs*210.47
UCECchr1820984437Frame_Shift_DelnovelG802Vfs*20.26
UCECchr1821042134Nonsense_MutationnovelE308*0.19
UCECchr1821049847Missense_MutationNAR70Q0.05
UCECchr1821039532Nonsense_MutationNAE331*0.06
UCECchr1821049862Missense_MutationNAK65I0.22
UCECchr1820953635Missense_MutationnovelR1335I0.19
UCECchr1820991233Missense_MutationnovelA696S0.21
UCECchr1821006396Nonsense_MutationnovelR614*0.12
UCECchr18209509313'UTRnovel0.58
UCECchr18209512113'UTRrs2005476040.41
UCECchr1820979951Frame_Shift_InsNAN871Kfs*140.21
UCECchr1821042626SilentnovelG253G0.09
UCECchr1820966981Silentrs757035057D1096D0.33
UCECchr1820967904Missense_MutationNAD1014Y0.34

Copy Number Variations (CNVs)
CancerTypeFreq Q-value

Survival Analysis
CancerP-value Q-value
THYM0.014

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.036

Kaplan-Meier Survival Analysis

MESO0.016

Kaplan-Meier Survival Analysis

ACC0.039

Kaplan-Meier Survival Analysis

SKCM0.003

Kaplan-Meier Survival Analysis

PAAD0.0099

Kaplan-Meier Survival Analysis

LGG0.014

Kaplan-Meier Survival Analysis

OV0.011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000067900 (Gene tree)
Gene ID
6093
Gene Symbol
ROCK1
Alias
p160ROCK
Full Name
Rho associated coiled-coil containing protein kinase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
164,946 bases
Position
chr18:20,946,906-21,111,851
Accession
10251
RBP type
non-canonical RBP
Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30674565MiR-144 Inhibits Tumor Growth and Metastasis in Osteosarcoma via Dual-suppressing RhoA/ROCK1 Signaling Pathway.Mol Pharmacol2019 AprLiu JLdoi: 10.1124/mol.118.114207
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000635540ROCK1-2075656-ENSP000004891851137 (aa)-A0A0U1RQV4
ENST00000584687ROCK1-205492--- (aa)--
ENST00000584875ROCK1-206616--- (aa)--
ENST00000583556ROCK1-204672--- (aa)--
ENST00000582445ROCK1-203543--- (aa)--
ENST00000399799ROCK1-2019484XM_011526137ENSP000003826971354 (aa)XP_011524439Q13464
ENST00000578051ROCK1-202584-ENSP0000046200499 (aa)-J3KRH6
Gene Model
Click here to download ENSG00000067900's gene model file
Pathways
Pathway IDPathway NameSource
hsa04022cGMP-PKG signaling pathwayKEGG
hsa04024cAMP signaling pathwayKEGG
hsa04062Chemokine signaling pathwayKEGG
hsa04071Sphingolipid signaling pathwayKEGG
hsa04270Vascular smooth muscle contractionKEGG
hsa04350TGF-beta signaling pathwayKEGG
hsa04360Axon guidanceKEGG
hsa04510Focal adhesionKEGG
hsa04530Tight junctionKEGG
hsa04611Platelet activationKEGG
hsa04670Leukocyte transendothelial migrationKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa04921Oxytocin signaling pathwayKEGG
hsa05130Pathogenic Escherichia coli infectionKEGG
hsa05131ShigellosisKEGG
hsa05132Salmonella infectionKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05205Proteoglycans in cancerKEGG
hsa05206MicroRNAs in cancerKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000067900's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000067900ROCK19965.132ENSG00000134318ROCK210094.118Homo_sapiens
ENSG00000067900ROCK17834.295ENSG00000198752CDC42BPB8852.632Homo_sapiens
ENSG00000067900ROCK16932.371ENSG00000122966CIT8343.956Homo_sapiens
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000139Golgi membrane-IEAComponent
GO:0001726ruffle-ISSComponent
GO:0003180aortic valve morphogenesis-ISSProcess
GO:0003383apical constriction-IEAProcess
GO:0004672protein kinase activity8798490.10436159.TASFunction
GO:0004674protein serine/threonine kinase activity10652353.11018042.18694941.19036714.IDAFunction
GO:0004674protein serine/threonine kinase activity27853422.NASFunction
GO:0004674protein serine/threonine kinase activity-TASFunction
GO:0005515protein binding10652353.14660612.17853893.20230755.21281639.22085929.25416956.25448675.27853422.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005576extracellular region-TASComponent
GO:0005814centriole-IEAComponent
GO:0005829cytosol-TASComponent
GO:0005856cytoskeleton-ISSComponent
GO:0005886plasma membrane-ISSComponent
GO:0006468protein phosphorylation10436159.TASProcess
GO:0006915apoptotic process-IEAProcess
GO:0006939smooth muscle contraction12778124.TASProcess
GO:0007159leukocyte cell-cell adhesion12082081.IDAProcess
GO:0007165signal transduction10436159.TASProcess
GO:0007186G protein-coupled receptor signaling pathway-TASProcess
GO:0007249I-kappaB kinase/NF-kappaB signaling25816133.IMPProcess
GO:0007266Rho protein signal transduction27160703.IGIProcess
GO:0010494cytoplasmic stress granule-ISSComponent
GO:0010506regulation of autophagy27853422.TASProcess
GO:0010508positive regulation of autophagy27853422.IGIProcess
GO:0010613positive regulation of cardiac muscle hypertrophy28679962.IMPProcess
GO:0010628positive regulation of gene expression27853422.28679962.IMPProcess
GO:0010628positive regulation of gene expression-ISSProcess
GO:0016525negative regulation of angiogenesis19181962.IMPProcess
GO:0017049GTP-Rho binding-IEAFunction
GO:0018105peptidyl-serine phosphorylation18573880.IDAProcess
GO:0022614membrane to membrane docking12082081.IDAProcess
GO:0030027lamellipodium-ISSComponent
GO:0030036actin cytoskeleton organization10436159.TASProcess
GO:0030155regulation of cell adhesion12778124.TASProcess
GO:0030866cortical actin cytoskeleton organization25816133.IGIProcess
GO:0030866cortical actin cytoskeleton organization25816133.IMPProcess
GO:0031175neuron projection development27160703.IGIProcess
GO:0032059bleb-IEAComponent
GO:0032060bleb assembly-IEAProcess
GO:0032091negative regulation of protein binding18573880.IDAProcess
GO:0032956regulation of actin cytoskeleton organization25911094.IDAProcess
GO:0032956regulation of actin cytoskeleton organization12778124.TASProcess
GO:0034774secretory granule lumen-TASComponent
GO:0035509negative regulation of myosin-light-chain-phosphatase activity25816133.IGIProcess
GO:0035509negative regulation of myosin-light-chain-phosphatase activity25816133.IMPProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0043410positive regulation of MAPK cascade28679962.IMPProcess
GO:0043524negative regulation of neuron apoptotic process-IEAProcess
GO:0045616regulation of keratinocyte differentiation19997641.IMPProcess
GO:0045664regulation of neuron differentiation27160703.IGIProcess
GO:0046872metal ion binding-IEAFunction
GO:0048010vascular endothelial growth factor receptor signaling pathway-TASProcess
GO:0048013ephrin receptor signaling pathway-TASProcess
GO:0048156tau protein binding28386764.NASFunction
GO:0050321tau-protein kinase activity28386764.NASFunction
GO:0050900leukocyte migration12082081.IDAProcess
GO:0050901leukocyte tethering or rolling12082081.IDAProcess
GO:0051045negative regulation of membrane protein ectodomain proteolysis27853422.TASProcess
GO:0051451myoblast migration-ISSProcess
GO:0051492regulation of stress fiber assembly12778124.TASProcess
GO:0051893regulation of focal adhesion assembly12778124.TASProcess
GO:0051894positive regulation of focal adhesion assembly-ISSProcess
GO:0061157mRNA destabilization-ISSProcess
GO:0070168negative regulation of biomineral tissue development-ISSProcess
GO:0071559response to transforming growth factor beta-ISSProcess
GO:0072518Rho-dependent protein serine/threonine kinase activity18573880.IDAFunction
GO:0072659protein localization to plasma membrane25816133.IGIProcess
GO:0072659protein localization to plasma membrane25816133.IMPProcess
GO:0097746regulation of blood vessel diameter-ISSProcess
GO:0106003amyloid-beta complex27853422.IDAComponent
GO:0110061regulation of angiotensin-activated signaling pathway28679962.IMPProcess
GO:0140058neuron projection arborization27160703.IGIProcess
GO:1900223positive regulation of amyloid-beta clearance27853422.IGIProcess
GO:1900242regulation of synaptic vesicle endocytosis27160703.IGIProcess
GO:1902003regulation of amyloid-beta formation27853422.TASProcess
GO:1902430negative regulation of amyloid-beta formation24305806.27853422.IMPProcess
GO:1902992negative regulation of amyloid precursor protein catabolic process24305806.27853422.IMPProcess
GO:1903140regulation of establishment of endothelial barrier25816133.IGIProcess
GO:1903140regulation of establishment of endothelial barrier25816133.IMPProcess
GO:1903347negative regulation of bicellular tight junction assembly25816133.IGIProcess
GO:1905205positive regulation of connective tissue replacement28679962.IMPProcess
GO:1990776response to angiotensin-ISSProcess
GO:2000114regulation of establishment of cell polarity20803696.TASProcess
GO:2000145regulation of cell motility12778124.TASProcess
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