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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
12820320Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.Anticancer Res2003 Mar-AprSchneider J-
12820312Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.Anticancer Res2003 Mar-AprHardt PD-
22864959Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer.Cancer2013 Feb 1Dhar DKdoi: 10.1002/cncr.27611
19820423Comparison of plasma Tu-M2-PK and CA19-9 in pancreatic cancer.Pancreas2010 MarJoergensen MTdoi: 10.1097/MPA.0b013e3181bae8ab.
25070887Pyruvate kinase M2 in blood circulation facilitates tumor growth by promoting angiogenesis.J Biol Chem2014 Sep 12Li Ldoi: 10.1074/jbc.M114.576934
17406361Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients.Br J Cancer2007 May 7Haug U-
27573352TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer.Int J Oncol2016 SepLiang Fdoi: 10.3892/ijo.2016.3599
29394289Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2.PLoS One2018 Feb 2Shankar Babu Mdoi: 10.1371/journal.pone.0191419
25818238MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer.Cancer Lett2015 Jul 10Taniguchi Kdoi: 10.1016/j.canlet.2015.03.026
18789002Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.Biochem J2009 Jan 1Thangaraju Mdoi: 10.1042/BJ20081132.
15996096Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.Biochemistry2005 Jul 12Dombrauckas JD-
26926077Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer.Sci Rep2016 Mar 1Huang Ldoi: 10.1038/srep22449.
22627140Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.Biochem Biophys Res Commun2012 Jun 22Kwon OHdoi: 10.1016/j.bbrc.2012.05.063
25649613Knockdown of PKM2 Enhances Radiosensitivity of Non-small cell Lung Cancer.Cell Biochem Biophys2015 SepWang Sdoi: 10.1007/s12013-015-0567-y.
23267074M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.Proc Natl Acad Sci U S A2013 Jan 8Cort??s-Cros Mdoi: 10.1073/pnas.1212780110
27014756Correlation between Faecal Tumour M2 Pyruvate Kinase and Colonoscopy for the Detection of Adenomatous Neoplasia in a Secondary Care Cohort.J Gastrointestin Liver Dis2016 MarBond ADdoi: 10.15403/jgld.2014.1121.251.m2p.
26092770KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma.Angiogenesis2015 OctMa Tdoi: 10.1007/s10456-015-9475-4
24658033HSP40 interacts with pyruvate kinase M2 and regulates glycolysis and cell proliferation in tumor cells.PLoS One2014 Mar 21Huang Ldoi: 10.1371/journal.pone.0092949
26787900SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.Proc Natl Acad Sci U S A2016 Feb 2Bhardwaj Adoi: 10.1073/pnas.1520045113
22271574Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression.J Exp Med2012 Feb 13Goldberg MSdoi: 10.1084/jem.20111487
26500118PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma.Dig Dis Sci2016 MarLi Cdoi: 10.1007/s10620-015-3931-2
24120138PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.Cell2013 Oct 10Israelsen WJdoi: 10.1016/j.cell.2013.09.025.
28346425CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma.Oncogene2017 Jul 20Shang Ydoi: 10.1038/onc.2017.31
28869444Plasma TuM2-PK correlates with tumor size, CRP and CA 15-3 in metastatic breast carcinomas; short versus long term follow up study of the Egyptian breast cancer patients.Cancer Biomark2017 Aug 23El-Abd Edoi: 10.3233/CBM-160482.
28067230Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.Nat Commun2017 Jan 9Wei Ydoi: 10.1038/ncomms14041.
30257458The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells.Int J Mol Sci2018 Sep 25Kurihara-Shimomura Mdoi: 10.3390/ijms19102907.
22824010Emerging roles of PKM2 in cell metabolism and cancer progression.Trends Endocrinol Metab2012 NovLuo Wdoi: 10.1016/j.tem.2012.06.010
25732087Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells.Biochem Biophys Res Commun2015 Apr 3Yang Pdoi: 10.1016/j.bbrc.2015.02.112
26493994PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway.Tumour Biol2016 MarZhao Zdoi: 10.1007/s13277-015-4121-8
23846818Aberrant overexpression of pyruvate kinase M2 is associated with aggressive tumor features and the BRAF mutation in papillary thyroid cancer.J Clin Endocrinol Metab2013 SepFeng Cdoi: 10.1210/jc.2012-4258
17414054Diagnostic and prognostic value of plasma tumor M2 pyruvate kinase in periampullary cancer: evidence for a novel biological marker of adverse prognosis.Pancreas2007 AprGoonetilleke KS-
22807066Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells.IUBMB Life2012 SepZhou CFdoi: 10.1002/iub.1066
22052977Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.Science2011 Dec 2Anastasiou Ddoi: 10.1126/science.1211485
28259998Enhanced expression of PKM2 associates with the biological properties of cancer stem cells from A549 human lung cancer cells.Oncol Rep2017 AprGuo CYdoi: 10.3892/or.2017.5438
29540198Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer.World J Surg Oncol2018 Mar 14Bandara IAdoi: 10.1186/s12957-018-1360-3.
29514980Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma.J Biol Chem2018 Apr 27Zhao Xdoi: 10.1074/jbc.RA117.000100
25233397PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer.Br J Cancer2014 Oct 28Papadaki Cdoi: 10.1038/bjc.2014.492
25703326Regulatory circuit of PKM2/NF-??B/miR-148a/152-modulated tumor angiogenesis and cancer progression.Oncogene2015 OctXu Qdoi: 10.1038/onc.2015.6
26158845The Diagnostic Accuracy of the M2 Pyruvate Kinase Quick Stool Test--A Rapid Office Based Assay Test for the Detection of Colorectal Cancer.PLoS One2015 Jul 9Sithambaram Sdoi: 10.1371/journal.pone.0131616
26506517The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells.Oncotarget2015 Nov 10Liang YCdoi: 10.18632/oncotarget.5710.
26183399Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.Oncotarget2015 Sep 15Giannoni E-
25661370Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture.Biomed Pharmacother2015 FebDong Tdoi: 10.1016/j.biopha.2014.12.010
23793810PKM2 and ACVR 1C are prognostic markers for poor prognosis of gallbladder cancer.Clin Transl Oncol2014 FebLi Jdoi: 10.1007/s12094-013-1063-8
26702927The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.Oncotarget2015 Dec 29Altuntas Sdoi: 10.18632/oncotarget.6759.
27012213PKM1 is involved in resistance to anti-cancer drugs.Biochem Biophys Res Commun2016 Apr 22Taniguchi Kdoi: 10.1016/j.bbrc.2016.03.074
23086999SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions.Science2012 Nov 23Keller KEdoi: 10.1126/science.1224409
26405201Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor.Nucleic Acids Res2016 Jan 29Matsuda Sdoi: 10.1093/nar/gkv967
25313085Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.Proc Natl Acad Sci U S A2014 Oct 28Hamabe Adoi: 10.1073/pnas.1407717111
24077665Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers.Oncotarget2014 Sep 30Desai S-
20332442Tumor-specific correlation of tumor M2 pyruvate kinase in pre-invasive, invasive and recurrent cervical cancer.Anticancer Res2010 FebLandt S-
24508027PKM2 contributes to cancer metabolism.Cancer Lett2015 Jan 28Wong Ndoi: 10.1016/j.canlet.2014.01.031
26464675Overexpression of metabolic markers HK1 and PKM2 contributes to lymphatic metastasis and adverse prognosis in Chinese gastric cancer.Int J Clin Exp Pathol2015 Aug 1Gao Y-
24492614Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner.J Biol Chem2014 Mar 21Iqbal MAdoi: 10.1074/jbc.M113.515742
25411978PKM2 gene regulates the behavior of pancreatic cancer cells via mitogen-activated protein kinase pathways.Mol Med Rep2015 MarFeng Jdoi: 10.3892/mmr.2014.2990
19754967Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia.BMC Cancer2009 Sep 15Aloysius MMdoi: 10.1186/1471-2407-9-327.
20847263Evidence for an alternative glycolytic pathway in rapidly proliferating cells.Science2010 Sep 17Vander Heiden MGdoi: 10.1126/science.1188015.
26140362Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.Oncotarget2015 Sep 15Goswami MT-
21325052Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.Proc Natl Acad Sci U S A2011 Mar 8Sun Qdoi: 10.1073/pnas.1014769108
20592362The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer.Anticancer Res2010 MayBenesch C-
25576919Co-expression of PKM2 and TRIM35 predicts survival and recurrence in hepatocellular carcinoma.Oncotarget2015 Feb 10Chen Z-
25041845PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells.Cell Signal2014 NovWu Hdoi: 10.1016/j.cellsig.2014.07.024
26876154Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1.Sci Rep2016 Feb 15He CLdoi: 10.1038/srep21524.
25708858Regulation of pyruvate kinase isozyme M2 is mediated by the ubiquitin-specific protease 20.Int J Oncol2015 MayKim SRdoi: 10.3892/ijo.2015.2901
26617865Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value.Int J Clin Exp Pathol2015 Sep 1Cui R-
23212076Dual roles of PKM2 in cancer metabolism.Acta Biochim Biophys Sin (Shanghai)2013 JanWu Sdoi: 10.1093/abbs/gms106
26715276Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.Tumour Biol2016 JunDong Tdoi: 10.1007/s13277-015-4729-8
25964202Cosilencing of PKM-2 and MDR-1 Sensitizes Multidrug-Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer.Mol Cancer Ther2015 JulTalekar Mdoi: 10.1158/1535-7163.MCT-15-0100
18337815Pyruvate kinase M2 is a phosphotyrosine-binding protein.Nature2008 Mar 13Christofk HRdoi: 10.1038/nature06667.
26339369Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer.Int J Clin Exp Pathol2015 Jul 1Lin Y-
24795025SAICAR binding activates PKM2 protein kinase activity.Cancer Discov2014 May-doi: 10.1158/2159-8290.CD-RW2014-062
25444918Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo.Cancer Lett2015 Jan 28Meng MBdoi: 10.1016/j.canlet.2014.11.016
23071357Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.Clin Cancer Res2012 Oct 15Tamada Mdoi: 10.1158/1078-0432.CCR-12-0859.
24626155Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms.PLoS One2014 Mar 13Liu Jdoi: 10.1371/journal.pone.0091606
22236875Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.Cancer Biol Ther2011 Dec 15Chiavarina Bdoi: 10.4161/cbt.12.12.18703
12820337Plasma levels of HER-2/neu, tumor type M2 pyruvate kinase and its tyrosine-phosphorylated metabolite in advanced breast cancer.Anticancer Res2003 Mar-AprL??ftner D-
20082317Quantitative proteome analysis of multidrug resistance in human ovarian cancer cell line.J Cell Biochem2010 Mar 1Li SLdoi: 10.1002/jcb.22413.
23130662Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology.J Drug Target2013 FebShashni Bdoi: 10.3109/1061186X.2012.736998
21620138Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.Cell2011 May 27Luo Wdoi: 10.1016/j.cell.2011.03.054.
24747424Pyruvate kinase M2 and cancer: an updated assessment.FEBS Lett2014 Aug 19Iqbal MAdoi: 10.1016/j.febslet.2014.04.011
24884829Changes in PKM2 associate with prostate cancer progression.Cancer Invest2014 AugWong Ndoi: 10.3109/07357907.2014.919306
27040384Tanshinone ??A inhibits human esophageal cancer cell growth through miR-122-mediated PKM2 down-regulation.Arch Biochem Biophys2016 May 15Zhang HSdoi: 10.1016/j.abb.2016.03.031
28347237Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment.Tumour Biol2017 MarZou Kdoi: 10.1177/1010428317695962.
28641694[MiR-133b Affect the Proliferation and Drug Sensitivity in A549 Lung Cancer Stem Cells by Targeting PKM2].Zhongguo Fei Ai Za Zhi2017 Jun 20Mi Ydoi: 10.3779/j.issn.1009-3419.2017.06.02.
28393220Metformin increases sensitivity of osteosarcoma stem cells to cisplatin by inhibiting expression of PKM2.Int J Oncol2017 MayShang Ddoi: 10.3892/ijo.2017.3950
27197174SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.Cancer Res2016 Jul 1Park SHdoi: 10.1158/0008-5472.CAN-15-2498
27385486Mutant p53 and mTOR/PKM2 regulation in cancer cells.IUBMB Life2016 SepDando Idoi: 10.1002/iub.1534
28418088RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells.Mol Carcinog2017 NovZhou Cdoi: 10.1002/mc.22663
27683215Limited Clinical Significance of Dimeric Form of Pyruvate Kinase as a Diagnostic and Prognostic Biomarker in Non-small Cell Lung Cancer.Adv Exp Med Biol2017Rzechonek Adoi: 10.1007/5584_2016_92.
28994148LincRNA-p21 suppresses development of human prostate cancer through inhibition of PKM2.Cell Prolif2017 DecWang Xdoi: 10.1111/cpr.12395
29032577Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer.Cancer Sci2017 DecKitayama Kdoi: 10.1111/cas.13421
28543190Effects of shRNA-Mediated Silencing of PKM2 Gene on Aerobic Glycolysis, Cell Migration, Cell Invasion, and Apoptosis in Colorectal Cancer Cells.J Cell Biochem2017 DecYan XLdoi: 10.1002/jcb.26148
27989750The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition.Free Radic Biol Med2016 DecBrandi Jdoi: 10.1016/j.freeradbiomed.2016.10.499
29277786Correlation of Pyruvate Kinase M2 Expression with Clinicopathological Data in Ovarian Cancer.Anticancer Res2018 JanKobierzycki C-
27911861Pyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysis.Oncotarget2017 Jan 3Zhu Hdoi: 10.18632/oncotarget.13703.
29225125Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.Arch Biochem Biophys2018 Jan 15Shimada Ndoi: 10.1016/j.abb.2017.12.008
28415668MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in cervical cancer.Oncotarget2017 Apr 25Guo Mdoi: 10.18632/oncotarget.15999.
28380434iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer.Oncotarget2017 May 16Li Ldoi: 10.18632/oncotarget.16523.
27283076Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.Sci Rep2016 Jun 10Lu Wdoi: 10.1038/srep26351.
29094170miR-361-5p modulates metabolism and autophagy via the Sp1-mediated regulation of PKM2 in prostate cancer.Oncol Rep2017 SepLing Zdoi: 10.3892/or.2017.5852
29229835O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect.Proc Natl Acad Sci U S A2017 Dec 26Wang Ydoi: 10.1073/pnas.1704145115
29619774Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells.Dig Dis Sci2018 JulMasamune Adoi: 10.1007/s10620-018-5051-2
29752805Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.Med Sci Monit2018 May 12Zheng Bdoi: 10.12659/MSM.907490.
30249877Pyruvate kinase M2 inhibits the progression of bladder cancer by targeting MAKP pathway.J Cancer Res Ther2018 SepZhu Qdoi: 10.4103/0973-1482.187302.
30279379SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells.Int J Mol Sci2018 Oct 2Kuranaga Ydoi: 10.3390/ijms19103012.
29408265Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress.Cancer Lett2018 May 1Yang YCdoi: 10.1016/j.canlet.2018.01.075

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1572209764Missense_MutationnovelW158C0.43
BLCAchr1572208634Nonsense_MutationnovelE275*0.13
BLCAchr1572202542Missense_MutationnovelD407H0.36
BLCAchr1572200570Missense_Mutationrs756647275L465M0.21
BLCAchr1572206808Missense_MutationNAD354N0.56
BLCAchr1572203038Intronnovel0.15
BRCAchr1572199735Missense_Mutationrs747511396K504R0.27
BRCAchr1572207164Missense_MutationNAC317Y0.25
CESCchr1572218970Missense_MutationnovelR43P0.15
CESCchr1572208679Missense_MutationnovelE260Q0.11
CESCchr15721994103'UTRnovel0.11
CESCchr1572229635Intronrs5509479200.28
CESCchr1572199708Missense_MutationnovelT513I0.4
CESCchr1572200489Missense_MutationNAF492I0.34
CESCchr15722311535'UTRnovel0.24
CESCchr1572210424Missense_MutationNAD101N0.29
CESCchr1572199740Silentrs771602110F502F0.12
COADchr1572207254Missense_MutationNAS287I0.18
COADchr1572208753Missense_MutationnovelQ235R0.16
COADchr1572209671Splice_SiteNAX189_splice0.46
COADchr1572202471SilentnovelV430V0.3
COADchr1572218978SilentnovelI40I0.32
COADchr1572219041Silentrs774838196H19H0.28
COADchr1572202522Silentrs559983009A413A0.35
COADchr1572203131Intronnovel0.08
COADchr1572209685Missense_MutationNAV185M0.25
COADchr1572210471Missense_Mutationrs772455998A85V0.21
ESCAchr1572209818SilentnovelL140L0.42
GBMchr1572209683SilentnovelV185V0.07
GBMchr1572208761SilentnovelG232G0.05
GBMchr1572202525SilentNAT412T0.24
GBMchr1572206774Missense_MutationnovelT365I0.08
GBMchr1572206742Missense_Mutationrs770540884R376C0.44
GBMchr1572219086SilentnovelP4P0.05
HNSCchr1572208792Missense_Mutationrs143294717S222L0.32
HNSCchr1572210413Silentrs779591275L104L0.58
HNSCchr15722191055'UTRnovel0.18
HNSCchr1572207270Missense_MutationnovelE282K0.25
HNSCchr1572217476Missense_MutationnovelT60M0.16
KIRPchr1572210454Missense_MutationnovelV91M0.42
KIRPchr1572206766Missense_MutationNAG368R0.11
LAMLchr1572208763Missense_MutationnovelG232R0.18
LAMLchr1572210409Missense_MutationnovelR106W0.14
LUADchr1572203080IntronNA0.57
LUADchr1572203141Intronnovel0.14
LUADchr1572206843Missense_MutationnovelR342L0.11
LUADchr1572207204Nonsense_MutationNAE304*0.09
LUADchr1572218961Missense_MutationNAG46V0.47
LUADchr1572209836SilentnovelL134L0.11
LUADchr1572210473Missense_MutationnovelH84Q0.29
LUADchr1572203105IntronNA0.15
LUSCchr1572200564Missense_Mutationrs746373368R467C0.38
LUSCchr1572209691Missense_MutationnovelL183F0.38
LUSCchr1572210458Missense_MutationnovelK89N0.32
LUSCchr1572209856Missense_MutationNAG128S0.21
LUSCchr1572199690Missense_MutationnovelS519F0.3
LUSCchr1572206741Missense_MutationNAR376L0.38
LUSCchr1572199667Missense_MutationnovelV527L0.35
LUSCchr1572210368SilentnovelI119I0.32
LUSCchr1572207157SilentnovelR319R0.22
LUSCchr1572207264Frame_Shift_InsnovelL284Sfs*130.11
LUSCchr1572206819Missense_MutationnovelN350S0.15
LUSCchr1572202535Nonsense_MutationnovelT409delinsIRME*NPPP0.09
MESOchr1572218943Splice_SitenovelX52_splice0.29
OVchr1572203141Intronnovel0.08
OVchr1572208628Missense_MutationNAV277I0.06
PAADchr1572208746SilentnovelV237V0.09
PCPGchr1572203071Intronnovel0.07
READchr1572207184SilentnovelQ310Q0.23
READchr1572208644Silentrs778442082I271I0.35
READchr1572207194Missense_MutationnovelF307C0.15
SKCMchr1572208881SilentnovelF192F0.2
SKCMchr15721996283'UTRnovel0.22
SKCMchr1572200579Nonsense_MutationNAQ462*0.07
SKCMchr1572217414Missense_MutationNAH81Y0.3
SKCMchr1572210405Missense_MutationNAP107L0.92
SKCMchr1572209856Missense_MutationNAG128S0.15
SKCMchr15721996033'UTRnovel0.42
SKCMchr1572210410SilentNAY105Y0.27
SKCMchr1572208704SilentnovelV251V0.13
SKCMchr1572209689SilentNAL183L0.37
SKCMchr1572219093Missense_Mutationrs752256480S2L0.1
SKCMchr1572219063Missense_MutationNAF12Y0.24
SKCMchr1572202624Splice_Regionnovel0.25
SKCMchr1572208759Missense_MutationnovelV233A0.29
STADchr1572207262SilentnovelL284L0.11
STADchr1572219004Missense_Mutationrs776788433R32C0.41
STADchr1572209726Missense_MutationnovelG171D0.18
STADchr1572208791Silentrs11558356S222S0.25
STADchr1572206743SilentNAV375V0.59
STADchr1572209807Missense_Mutationrs771478196L144P0.05
STADchr1572200564Missense_Mutationrs746373368R467C0.29
STADchr1572219092Silentrs764776324S2S0.32
STADchr1572208871Missense_MutationnovelE196K0.15
STADchr1572219053SilentnovelT15T0.48
STADchr1572202521Missense_MutationNAV414M0.43
STADchr1572206852Missense_Mutationrs2959910R339H0.21
STADchr1572218952Missense_MutationNAC49Y0.13
STADchr1572207157SilentnovelR319R0.29
STADchr1572202481Missense_MutationNAA427V0.27
STADchr1572210450Missense_MutationnovelR92H0.17
THCAchr1572203180IntronNA0.06
THCAchr1572202568Missense_MutationnovelL398H0.15
UCECchr1572208644Silentrs778442082I271I0.32
UCECchr1572207265SilentnovelI283I0.13
UCECchr1572228655Intronnovel0.27
UCECchr1572229616Intronnovel0.31
UCECchr1572208872SilentnovelT195T0.1
UCECchr1572200623Missense_MutationnovelR447H0.44
UCECchr1572207222Missense_MutationnovelG298C0.43
UCECchr1572208822Missense_MutationnovelP212H0.47
UCECchr1572219092Silentrs764776324S2S0.28
UCECchr1572208659Missense_MutationNAK266N0.21
UCECchr1572203159Intronnovel0.19
UCECchr1572206800SilentnovelA356A0.14
UCECchr1572218941Splice_Regionrs782708970.18
UCECchr1572199700Missense_Mutationrs753992080R516C0.5
UCECchr1572210408Missense_Mutationrs755468302R106Q0.36
UCECchr1572203182Intronrs1995992460.45
UCECchr1572199654Missense_Mutationrs371099168P531L0.43
UCECchr1572208887Silentrs766883191A190A0.57
UCECchr1572229557Intronrs7965535570.51
UCECchr1572207168Missense_Mutationrs147956260R316W0.34
UCECchr1572208732Missense_Mutationrs751885485A242V0.51
UCECchr1572200546Missense_MutationnovelL473M0.32
UCECchr1572203130Intronrs5642921590.16
UCECchr1572202613Missense_MutationnovelR383H0.46
UCECchr1572219003Missense_Mutationrs771046142R32H0.43
UCECchr1572202542Missense_MutationNAD407N0.28
UCECchr1572219081Missense_MutationnovelS6T0.54
UCECchr15721993273'UTRnovel0.15
UCECchr1572202524Missense_Mutationrs377014720A413T0.14
UCECchr1572208776Missense_MutationnovelQ227H0.41
UCECchr1572229663Intronnovel0.35
UCECchr1572200616SilentnovelP449P0.44
UCECchr1572200599Missense_Mutationrs772885059R455Q0.25
UCECchr1572229562Intronnovel0.31
UCECchr1572219092Silentrs764776324S2S0.41
UCECchr1572217475Silentrs747898479T60T0.42
UCECchr1572210470SilentnovelA85A0.31
UCECchr1572210451Missense_Mutationrs763971278R92C0.36
UCECchr1572217491Missense_MutationNAS55F0.36
UCECchr1572208853Missense_MutationnovelS202P0.31
UCSchr1572200546SilentnovelL473L0.5
UCSchr1572206844Missense_MutationnovelR342W0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LGGAMP0.01360.19963
PAADAMP0.06520.20695
PAADDEL0.10870.13216

Survival Analysis
CancerP-value Q-value
THYM0.03

Kaplan-Meier Survival Analysis

MESO0.0013

Kaplan-Meier Survival Analysis

HNSC0.00076

Kaplan-Meier Survival Analysis

COAD0.0099

Kaplan-Meier Survival Analysis

PAAD0.0011

Kaplan-Meier Survival Analysis

BLCA0.011

Kaplan-Meier Survival Analysis

CESC0.0026

Kaplan-Meier Survival Analysis

LAML0.00051

Kaplan-Meier Survival Analysis

LIHC0.00012

Kaplan-Meier Survival Analysis

LUAD0.00063

Kaplan-Meier Survival Analysis

UVM0.0013

Kaplan-Meier Survival Analysis

OV0.016

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000067225 (Gene tree)
Gene ID
5315
Gene Symbol
PKM
Alias
THBP1|OIP3|PK3|PKM2
Full Name
pyruvate kinase M1/2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
32,794 bases
Position
chr15:72,199,029-72,231,822
Accession
9021
RBP type
non-canonical RBP
Summary
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
29805711Antagonistic role of GSK3 isoforms in glioma survival.J Cancer2018 Apr 24Vashishtha Vdoi: 10.7150/jca.21248
26874904PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.Int J Cancer2016 Jul 1Mukherjee Jdoi: 10.1002/ijc.30041
28575669The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.Cell2017 Jun 1Simsek Ddoi: 10.1016/j.cell.2017.05.022.
29344170Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer.Oncol Lett2017 DecSun Ydoi: 10.3892/ol.2017.7085
28086949NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase.J Hematol Oncol2017 Jan 13Gu Zdoi: 10.1186/s13045-017-0392-4.
30368881PKM2 promotes glucose metabolism through a let-7a-5p/Stat3/hnRNP-A1 regulatory feedback loop in breast cancer cells.J Cell Biochem2019 AprYao Adoi: 10.1002/jcb.27947
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000568883PKM-2221863-ENSP00000456100366 (aa)-H3BR70
ENST00000449901PKM-2042526-ENSP00000403365516 (aa)-P14618
ENST00000565154PKM-2152004-ENSP00000455901531 (aa)-P14618
ENST00000564440PKM-2123016--- (aa)--
ENST00000335181PKM-2022318XM_005254443ENSP00000334983531 (aa)XP_005254500P14618
ENST00000562784PKM-206529--- (aa)--
ENST00000319622PKM-2012717XM_017022313ENSP00000320171531 (aa)XP_016877802P14618
ENST00000389093PKM-2032279-ENSP00000373745457 (aa)-B4DNK4
ENST00000564993PKM-213663--- (aa)--
ENST00000563986PKM-209825--- (aa)--
ENST00000567087PKM-218550-ENSP00000456984151 (aa)-H3BT25
ENST00000566809PKM-217560-ENSP0000045742082 (aa)-H3BU13
ENST00000569050PKM-223457-ENSP0000045466851 (aa)-H3BN34
ENST00000568743PKM-221580--- (aa)--
ENST00000570166PKM-225626--- (aa)--
ENST00000562997PKM-207582-ENSP00000457830162 (aa)-H3BUW1
ENST00000564276PKM-211753--- (aa)--
ENST00000565143PKM-2142301--- (aa)--
ENST00000569857PKM-2241355-ENSP00000455584281 (aa)-H3BQ34
ENST00000561609PKM-2051568-ENSP00000457253485 (aa)-H3BTN5
ENST00000564178PKM-210554-ENSP00000457198168 (aa)-H3BTJ2
ENST00000565184PKM-2162503-ENSP00000455736531 (aa)-P14618
ENST00000563275PKM-208699--- (aa)--
ENST00000567118PKM-2192254-ENSP0000045600469 (aa)-H3BQZ3
ENST00000568459PKM-2201806-ENSP00000456970531 (aa)-P14618
Gene Model
Click here to download ENSG00000067225's gene model file
Pathways
Pathway IDPathway NameSource
hsa00010Glycolysis / GluconeogenesisKEGG
hsa00230Purine metabolismKEGG
hsa00620Pyruvate metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa01200Carbon metabolismKEGG
hsa01230Biosynthesis of amino acidsKEGG
hsa04922Glucagon signaling pathwayKEGG
hsa04930Type II diabetes mellitusKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05203Viral carcinogenesisKEGG
hsa05230Central carbon metabolism in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000067225S-(3-hydroxypropyl)cysteine N-acetate9E-626053186
ENSG00000067225Smoking9E-626053186
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000067225rs1139209241572206596?3-hydroxypropylmercapturic acid levels in smokers26053186[NR] unit increase1.0445EFO_0004318|EFO_0007014
ENSG00000067225rs80237031572211718?Morning person30595370EFO_0008328
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000067225's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000067225PKM9668.293FBgn0267385PyK9965.949Drosophila_melanogaster
ENSG00000067225PKM10097.938ENSMUSG00000032294Pkm10097.845Mus_musculus
ENSG00000067225PKM8955.077YAL038WCDC199652.041Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000287magnesium ion binding-IEAFunction
GO:0001666response to hypoxia-IEAProcess
GO:0001889liver development-IEAProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0004743pyruvate kinase activity21873635.IBAFunction
GO:0004743pyruvate kinase activity20005212.IDAFunction
GO:0004743pyruvate kinase activity2040271.2813362.2854097.TASFunction
GO:0005515protein binding12620389.17500595.17620599.18191611.18298799.18519040.21044950.21620138.21725354.22056988.25241761.27199445.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus17308100.18191611.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm18298799.IDAComponent
GO:0005739mitochondrion20833797.HDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol2813362.NASComponent
GO:0005829cytosol-TASComponent
GO:0005929cilium-IEAComponent
GO:0006096glycolytic process21873635.IBAProcess
GO:0007584response to nutrient-IEAProcess
GO:0009629response to gravity-IEAProcess
GO:0012501programmed cell death17308100.IDAProcess
GO:0014870response to muscle inactivity-IEAProcess
GO:0016301kinase activity-IEAFunction
GO:0023026MHC class II protein complex binding20458337.HDAFunction
GO:0030955potassium ion binding-IEAFunction
GO:0031100animal organ regeneration-IEAProcess
GO:0031982vesicle19190083.HDAComponent
GO:0032869cellular response to insulin stimulus21873635.IBAProcess
GO:0034774secretory granule lumen-TASComponent
GO:0042802identical protein binding-IEAFunction
GO:0043312neutrophil degranulation-TASProcess
GO:0043403skeletal muscle tissue regeneration-IEAProcess
GO:0043531ADP binding-IEAFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0051289protein homotetramerization-IEAProcess
GO:0061621canonical glycolysis-TASProcess
GO:0062023collagen-containing extracellular matrix23658023.HDAComponent
GO:0070062extracellular exosome11487543.12519789.19056867.19199708.20458337.21362503.23533145.HDAComponent
GO:0070324thyroid hormone binding-IEAFunction
GO:1902912pyruvate kinase complex-IEAComponent
GO:1903561extracellular vesicle24769233.HDAComponent
GO:1903672positive regulation of sprouting angiogenesis27199445.IMPProcess
GO:1904813ficolin-1-rich granule lumen-TASComponent
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