EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
17158449TAK1-dependent signaling requires functional interaction with TAB2/TAB3.J Biol Chem2007 Feb 9Besse A-
22660635The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.Nat Med2012 JulZhu Sdoi: 10.1038/nm.2815.
27992601A Novel Functional Domain of Tab2 Involved in the Interaction with Estrogen Receptor Alpha in Breast Cancer Cells.PLoS One2016 Dec 19Reineri Sdoi: 10.1371/journal.pone.0168639

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr6149378211Missense_MutationNAG99V0.1
BLCAchr61493699945'UTRnovel0.18
BLCAchr6149379102Missense_MutationNAG396A0.19
BLCAchr6149409701Missense_MutationNAE688D0.25
BLCAchr6149379484SilentNAL523L0.51
BLCAchr6149379269Nonsense_MutationNAR452*0.31
BLCAchr6149397639Missense_MutationnovelL547F0.16
BLCAchr6149379042Missense_Mutationrs760538795T376M0.28
BLCAchr6149378919Missense_MutationNAR335T0.41
BLCAchr6149397736Frame_Shift_InsnovelR579Sfs*120.04
BLCAchr6149397737In_Frame_InsnovelR579_S580insNKNL0.04
BRCAchr6149378222Frame_Shift_InsnovelT104Nfs*50.24
BRCAchr6149378843Missense_MutationNAS310G0.13
BRCAchr61494098703'UTRnovel0.3
BRCAchr61494113303'UTRnovel0.23
BRCAchr6149378269Silentrs148722166N118N0.39
BRCAchr61494104403'UTRnovel0.27
CESCchr6149398053Missense_MutationNAQ617E0.19
CESCchr61494110163'UTRnovel0.39
CESCchr6149379156Missense_Mutationrs775633022G414A0.21
CESCchr6149378433Missense_MutationNAR173T0.61
CESCchr61494111623'UTRnovel0.38
COADchr61493699285'UTRnovel0.76
COADchr6149399105Splice_RegionnovelG620G0.25
COADchr6149370032Frame_Shift_DelnovelL13Yfs*480.43
COADchr6149378928Missense_MutationNAS338Y0.34
COADchr6149378248Missense_MutationnovelQ111H0.07
COADchr6149379060Missense_Mutationrs532837920R382H0.32
COADchr6149378661Missense_MutationNAQ249R0.41
COADchr6149378288Missense_Mutationrs374508964E125K0.19
COADchr6149378840Missense_MutationnovelH309N0.06
COADchr6149397720Nonsense_MutationNAR574*0.21
COADchr6149379319Silentrs138678250V468V0.33
COADchr6149379387Missense_MutationnovelL491R0.14
COADchr6149398047Missense_MutationnovelL615I0.05
COADchr6149409684Missense_MutationNAR683C0.35
COADchr61494098563'UTRnovel0.17
COADchr6149378542Missense_MutationnovelQ209H0.21
GBMchr6149378679Missense_Mutationrs748656776P255L0.1
GBMchr6149379328SilentnovelN471N0.08
GBMchr6149378275Silentrs765640727E120E0.74
GBMchr6149409596Silentrs111920140K653K0.38
HNSCchr6149379255Missense_MutationnovelS447F0.25
HNSCchr6149370046Nonsense_MutationnovelR17*0.1
HNSCchr6149378814Missense_MutationnovelS300L0.1
HNSCchr6149398027Missense_Mutationrs746984589C608Y0.26
KIRCchr6149378735Frame_Shift_InsnovelN274Ifs*300.2
KIRCchr6149370059Missense_MutationNAP21R0.65
LGGchr6149378763Missense_MutationnovelV283G0.12
LGGchr6149397639Missense_MutationnovelL547F0.36
LIHCchr6149379433SilentnovelL506L0.3
LIHCchr6149378467Frame_Shift_InsnovelI185Nfs*60.35
LUADchr6149409576Splice_SiteNAX647_splice0.18
LUADchr6149379491Nonsense_MutationNAG526*0.29
LUADchr6149378874Missense_MutationNAG320V0.27
LUADchr6149379020Missense_MutationnovelI369V0.11
LUADchr6149379169Silentrs371956282A418A0.23
LUADchr6149378473Missense_MutationNAQ186H0.4
LUADchr6149409630Missense_MutationnovelG665R0.18
LUADchr61494097293'UTRrs7559177620.33
LUADchr6149378840Missense_MutationNAH309D0.2
LUSCchr6149379470Missense_MutationnovelE519K0.27
LUSCchr6149379295Silentrs150699204T460T0.25
LUSCchr6149378827SilentNAS304S0.49
LUSCchr6149378847Missense_MutationnovelQ311R0.17
LUSCchr6149397684Missense_MutationnovelK562E0.25
OVchr6149378238Missense_MutationnovelS108T0.04
OVchr6149379057Missense_MutationnovelS381F0.04
PAADchr6149378706Missense_MutationnovelP264H0.17
PCPGchr6149397737Missense_MutationnovelR579S0.05
PRADchr6149378821In_Frame_DelnovelS304_S310del0.13
PRADchr6149378685Missense_MutationnovelT257I0.4
PRADchr6149379133SilentNAT406T0.37
READchr6149378526Missense_MutationNAV204E0.41
READchr6149370070Missense_Mutationrs747627781E25K0.44
SKCMchr6149378430Missense_MutationNAP172L0.29
SKCMchr6149378315Missense_MutationnovelP134S0.42
SKCMchr6149378349Missense_Mutationrs778012324S145F0.92
SKCMchr6149399111SilentNAH622H0.44
SKCMchr6149378480Missense_Mutationrs754720551R189C0.51
SKCMchr6149370058Missense_Mutationrs756714260P21S0.5
SKCMchr6149379392Missense_MutationNAH493Y0.25
SKCMchr61494097823'UTRnovel0.29
SKCMchr6149378944SilentnovelS343S0.26
SKCMchr6149378945Missense_MutationnovelS344P0.27
SKCMchr6149378135Missense_MutationNAH74Y0.38
SKCMchr6149370057SilentNAF20F0.51
SKCMchr6149399178Missense_MutationNAP645S0.31
SKCMchr6149378832Missense_MutationnovelS306Y0.24
STADchr6149398057Missense_MutationNAA618V0.26
STADchr6149378523Missense_MutationNAP203L0.05
STADchr6149379131Missense_MutationNAT406A0.11
STADchr6149379492Missense_MutationnovelG526E0.08
STADchr6149378028Missense_MutationNAN38I0.38
STADchr61494097953'UTRnovel0.31
STADchr6149379120Missense_MutationNAR402Q0.45
TGCTchr6149378703Missense_MutationnovelN263S0.19
THYMchr61494110163'UTRnovel0.34
UCECchr6149398059Nonsense_MutationNAR619*0.33
UCECchr61494116083'UTRnovel0.42
UCECchr6149379282Missense_MutationnovelT456I0.14
UCECchr61494111963'UTRnovel0.34
UCECchr61494111383'UTRnovel0.13
UCECchr6149378224SilentnovelL103L0.17
UCECchr6149409631Missense_MutationnovelG665V0.47
UCECchr6149378928Missense_MutationNAS338Y0.49
UCECchr6149379360Missense_MutationnovelS482F0.36
UCECchr6149397760Missense_MutationnovelP587H0.38
UCECchr61494099463'UTRnovel0.43
UCECchr6149378228Missense_Mutationrs748152528H105Y0.51
UCECchr6149379087Missense_MutationnovelA391V0.18
UCECchr6149379240Missense_MutationNAA442V0.14
UCECchr6149397995Missense_MutationNAS597R0.18
UCECchr6149379165Missense_Mutationrs147099781A417V0.1
UCECchr6149378480Missense_Mutationrs754720551R189C0.2
UCECchr6149378078Missense_MutationNAY55H0.53
UCECchr61494099493'UTRnovel0.48
UCECchr6149379101Nonsense_MutationnovelG396*0.61
UCECchr61494100983'UTRnovel0.42
UCECchr6149378954Nonsense_MutationnovelR347*0.38
UCECchr6149378167SilentnovelS84S0.16
UCECchr6149378300Missense_MutationnovelA129S0.31
UCECchr6149379100SilentnovelT395T0.3
UCECchr6149379477Missense_Mutationrs768565483R521L0.32
UCECchr61494110163'UTRnovel0.33
UCECchr6149397666Frame_Shift_DelNAK557Sfs*50.48
UCECchr6149370089Missense_MutationnovelC31Y0.3
UCECchr6149379333Missense_MutationNAP473L0.34
UCECchr6149378186Nonsense_MutationNAG91*0.04
UCECchr6149378477Missense_MutationNAG188C0.38
UCECchr61494109063'UTRnovel0.55
UCECchr6149378465Missense_MutationnovelN184D0.22
UCECchr6149379140Missense_MutationnovelI409V0.41
UCECchr61494115543'UTRnovel0.33
UCECchr61494099263'UTRnovel0.23
UCECchr61494110163'UTRnovel0.35
UCECchr61494110163'UTRnovel0.3
UCECchr6149379359Missense_MutationnovelS482P0.33
UCECchr61494100883'UTRnovel0.28
UCECchr61494102323'UTRnovel0.42
UCECchr6149379236Nonsense_MutationnovelR441*0.49
UCECchr61494097543'UTRnovel0.45
UCECchr61494098813'UTRnovel0.4
UCECchr6149397724Missense_MutationNAR575M0.35
UCECchr6149379955Intronnovel0.4
UCECchr6149379031SilentNAS372S0.37
UCECchr61494105603'UTRrs5389618880.29
UCECchr61494097823'UTRnovel0.24
UCECchr61493699955'UTRnovel0.27
UCECchr6149378496Missense_MutationnovelS194Y0.05
UCECchr6149378817Missense_MutationNAS301F0.3
UCECchr6149379303Missense_MutationNAT463I0.12
UCECchr6149378169Frame_Shift_DelnovelN86Hfs*100.47
UCECchr6149378939Missense_Mutationrs761260364R342C0.23
UCECchr6149379192Missense_MutationnovelV426A0.11
UCECchr61494108883'UTRNA0.44
UCECchr6149378782SilentnovelS289S0.28
UCECchr61494108883'UTRNA0.36
UCECchr6149378919Missense_MutationnovelR335I0.06
UCECchr6149379269Nonsense_MutationNAR452*0.34
UCECchr6149378195Nonsense_MutationNAG94*0.26
UCECchr6149378087Missense_MutationnovelG58R0.28
UCECchr6149378393Missense_MutationnovelG160S0.27
UCECchr6149379955Intronnovel0.45
UCECchr61494110163'UTRnovel0.29
UCECchr61493699855'UTRrs7652418300.35
UCECchr6149378594Nonsense_MutationnovelR227*0.33
UCECchr6149378928Missense_MutationNAS338Y0.31
UCECchr6149409651Missense_Mutationrs771448294A672T0.46
UCECchr61494103453'UTRnovel0.33
UCECchr61494116043'UTRnovel0.42

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.35050.00027473
KIRCDEL0.24437.439e-11
KIRPDEL0.10420.054498
LGGDEL0.14420.0054594
MESODEL0.44830.05642
PAADDEL0.3750.11274
SARCAMP0.25685.3375e-09
SKCMDEL0.55041.5442e-06
THYMDEL0.14630.10691
UVMDEL0.2750.0054289

Survival Analysis
CancerP-value Q-value
KIRC0.0012

Kaplan-Meier Survival Analysis

SKCM0.00013

Kaplan-Meier Survival Analysis

LUSC0.0028

Kaplan-Meier Survival Analysis

BRCA0.016

Kaplan-Meier Survival Analysis

KIRP0.026

Kaplan-Meier Survival Analysis

COAD0.023

Kaplan-Meier Survival Analysis

PAAD0.035

Kaplan-Meier Survival Analysis

CESC0.013

Kaplan-Meier Survival Analysis

READ0.027

Kaplan-Meier Survival Analysis

UCEC0.0077

Kaplan-Meier Survival Analysis

OV0.039

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
Description
Ensembl ID
ENSG00000055208 (Gene tree)
Gene ID
23118
Gene Symbol
TAB2
Alias
KIAA0733|MAP3K7IP2
Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
193,690 bases
Position
chr6:149,217,924-149,411,613
Accession
17075
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
14633996Tab2 is a novel conserved RNA binding protein required for translation of the chloroplast psaB mRNA.EMBO J2003 Dec 1Dauvillee D-
15590691Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.J Biol Chem2005 Feb 25Singhirunnusorn P-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000461481TAB2-202524--- (aa)--
ENST00000367456TAB2-2014553XM_011535633ENSP00000356426693 (aa)XP_011533935Q9NYJ8
ENST00000484505TAB2-204493--- (aa)--
ENST00000606797TAB2-207677-ENSP0000047558033 (aa)-U3KQ62
ENST00000636456TAB2-2083092-ENSP00000490379409 (aa)-A0A1B0GV57
ENST00000606202TAB2-206648-ENSP00000476139130 (aa)-U3KQR0
ENST00000637181TAB2-2094230-ENSP00000490618693 (aa)-Q9NYJ8
ENST00000538427TAB2-2054240XM_017010591ENSP00000445752693 (aa)XP_016866080Q9NYJ8
ENST00000470466TAB2-2034199-ENSP00000432709536 (aa)-Q9NYJ8
Gene Model
Click here to download ENSG00000055208's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000055208rs77580806149255943GCrohn's disease26192919[1.05-1.1]1.0790637EFO_0000384
ENSG00000055208rs77580806149255943GInflammatory bowel disease26192919[1.04-1.08]1.0597305EFO_0003767
ENSG00000055208rs94853726149287738GBreast cancer22383897[1.09-1.15]1.11EFO_0000305
ENSG00000055208rs7279796149272784?Hemostatic factors and hematological phenotypes17903294EFO_0004305
ENSG00000055208rs94853726149287738GBreast cancer29059683[1.02-1.08] (Oncoarray)1.0416667EFO_0000305
ENSG00000055208rs354098916149265193CBreast cancer29059683[0.031-0.061] unit decrease0.0457EFO_0000305
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000055208's network

* RBP PPI network refers to all genes directly bind to RBP
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