EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24113381	GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts.	Biochem Biophys Res Commun	2013 Nov 1	Peng Y	doi: 10.1016/j.bbrc.2013.09.108
23759331	Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth.	J Surg Res	2013 Nov	Kuo LJ	doi: 10.1016/j.jss.2013.05.020
19713465	GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib.	Blood	2009 Oct 29	Kern J	doi: 10.1182/blood-2009-03-209668
28038917	A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells.	Exp Cell Res	2017 Feb 1	Wang Y	doi: 10.1016/j.yexcr.2016.12.017
28629783	GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages.	Cell Signal	2017 Sep	Zhang L	doi: 10.1016/j.cellsig.2017.06.008
16182273	Overexpression of glucose-regulated protein 78 in colon cancer.	Clin Chim Acta	2006 Feb	Xing X	-
24977433	GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling.	Oncotarget	2014 Jul 30	Li Z	-
24048331	Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.	Clin Cancer Res	2013 Dec 15	Liu R	doi: 10.1158/1078-0432.CCR-13-1106
15778089	Expression of stress response protein glucose regulated protein-78 mediated by c-Myb.	Int J Biochem Cell Biol	2005 Jun	Ramsay RG	-
22613557	Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells.	FEBS J	2012 Jul	Sokolowska I	doi: 10.1111/j.1742-4658.2012.08641.x
24795528	Involvement of PAR-4 in cannabinoid-dependent sensitization of osteosarcoma cells to TRAIL-induced apoptosis.	Int J Biol Sci	2014 Apr 8	Notaro A	doi: 10.7150/ijbs.8337
11719466	Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade.	Cancer Res	2001 Nov 15	Song MS	-
20651985	Differential influence of anticancer treatments and angiogenesis on the seric titer of autoantibody used as tumor and metastasis biomarker.	Neoplasia	2010 Jul	Defresne F	-
19838160	Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma.	Mod Pathol	2010 Jan	Papalas JA	doi: 10.1038/modpathol.2009.152
18331622	Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus.	BMC Cancer	2008 Mar 10	Langer R	doi: 10.1186/1471-2407-8-70.
23085757	miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.	Oncogene	2013 Sep 26	Su SF	doi: 10.1038/onc.2012.483
20497865	Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.	J Formos Med Assoc	2010 May	Huang TT	doi: 10.1016/S0929-6646(10)60060-5.
28618969	Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer.	Tumour Biol	2017 Jun	Ranjan A	doi: 10.1177/1010428317705517.
28601093	Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma.	BMC Cancer	2017 Jun 10	Yip CW	doi: 10.1186/s12885-017-3399-x.
28854502	Prognostic role of BiP/GRP78 expression as ER stress in patients with gastric adenocarcinoma.	Cancer Biomark	2017 Sep 7	Ogawa H	doi: 10.3233/CBM-170062.
29066620	Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.	J Biol Chem	2017 Dec 22	Al-Hashimi AA	doi: 10.1074/jbc.M117.799908
24526410	GRP78 mediates cell growth and invasiveness in endometrial cancer.	J Cell Physiol	2014 Oct	Cal?? G	doi: 10.1002/jcp.24578.
20605795	Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.	J Biol Chem	2010 Sep 10	Al-Hashimi AA	doi: 10.1074/jbc.M110.119107
26045166	KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.	Cancer Res	2015 Aug 1	Kang JM	doi: 10.1158/0008-5472.CAN-14-3751
25194164	Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling.	Carcinogenesis	2014 Nov	Wang N	doi: 10.1093/carcin/bgu187
24756776	Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78.	Oncol Rep	2014 Jun	Li W	doi: 10.3892/or.2014.3147
16472112	Stress induction of GRP78/BiP and its role in cancer.	Curr Mol Med	2006 Feb	Li J	-
28457968	17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation.	J Steroid Biochem Mol Biol	2017 Jul	Xu D	doi: 10.1016/j.jsbmb.2017.04.009
28258248	CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells.	Biosci Rep	2017 Apr 10	Deying W	doi: 10.1042/BSR20160470
27016417	Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device.	Oncotarget	2016 May 3	Yu T	doi: 10.18632/oncotarget.8232.
29178343	PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.	Cancer Sci	2018 Feb	Moriya C	doi: 10.1111/cas.13458
27815359	Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.	Clin Cancer Res	2017 May 15	Dadey DYA	doi: 10.1158/1078-0432.CCR-16-1935
28245171	miR-181a Inhibits Cervical Cancer Development via Downregulating GRP78.	Oncol Res	2017 Sep 21	Luo C	doi: 10.3727/096504017X14867268787969
16912197	BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis.	Cancer Res	2006 Aug 15	Gupta P	-
23056589	An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer.	PLoS One	2012	Sethi G	doi: 10.1371/journal.pone.0047086
23200913	The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival.	Gynecol Oncol	2013 Mar	Matsuo K	doi: 10.1016/j.ygyno.2012.11.024
21056970	Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.	J Biol Chem	2011 Jan 14	Misra UK	doi: 10.1074/jbc.M110.129767
17640713	Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.	Hum Pathol	2007 Oct	Daneshmand S	-
22564965	Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK.	Oncotarget	2012 Apr	Kandala PK	-
25212833	E1A-mediated inhibition of HSPA5 suppresses cell migration and invasion in triple-negative breast cancer.	Ann Surg Oncol	2015 Mar	Chen HA	doi: 10.1245/s10434-014-4061-3
25338653	Knockdown of glucose-regulated protein 78/binding immunoglobulin heavy chain protein expression by asymmetric small interfering RNA induces apoptosis in prostate cancer cells and attenuates migratory capability.	Mol Med Rep	2015 Jan	Lu T	doi: 10.3892/mmr.2014.2737
25081541	Reversed expression of GRIM-1 and GRP78 in human non-small cell lung cancer.	Hum Pathol	2014 Sep	Wu HM	doi: 10.1016/j.humpath.2014.04.023
20473863	GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy.	Int J Cancer	2011 Feb 1	Lee E	doi: 10.1002/ijc.25370.
19674193	Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response.	J Cell Mol Med	2009 Sep	Wang J	doi: 10.1111/j.1582-4934.2009.00873.x
23922175	Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression.	Tumour Biol	2014 Jan	Wu CT	doi: 10.1007/s13277-013-1024-4
17062670	Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer.	Clin Cancer Res	2006 Oct 15	Pootrakul L	-
18192872	Down-regulation of molecular chaperone 78-kd glucose-regulated protein/immunoglobulin-binding protein expression involved in enhancement of human RS cell mutability.	Pancreas	2008 Jan	Hirano J	doi: 10.1097/mpa.0b013e31814dadf5.
16543232	Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.	J Biol Chem	2006 May 12	Misra UK	-
27822448	Intraperitoneal Fat through GRP78: A Risk Factor for Endometrial Cancer.	Anal Cell Pathol (Amst)	2016	Ciortea R	-
24853418	HKH40A downregulates GRP78/BiP expression in cancer cells.	Cell Death Dis	2014 May 22	Kosakowska-Cholody T	doi: 10.1038/cddis.2014.203.
22297694	Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer.	Mol Biol Rep	2012 Jun	Sun Q	doi: 10.1007/s11033-012-1500-8.
25669168	Glucose-regulated protein 78 mediates the anticancer efficacy of shikonin in hormone-refractory prostate cancer cells.	Tumour Biol	2015 Jul	Kuo LJ	doi: 10.1007/s13277-015-3157-0
25333575	Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress.	Oncol Rep	2014 Dec	Jiang X	doi: 10.3892/or.2014.3533
21516372	Survivin-mediated cancer cell migration through GRP78 and epithelial-mesenchymal transition (EMT) marker expression in Mahlavu cells.	Ann Surg Oncol	2012 Jan	Tai CJ	doi: 10.1245/s10434-011-1692-5
24002052	GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line.	Oncol Rep	2013 Nov	Li B	doi: 10.3892/or.2013.2710
15949590	Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance.	Lung Cancer	2005 Jul	Uramoto H	-
18268478	A new tumor-specific variant of GRP78 as target for antibody-based therapy.	Lab Invest	2008 Apr	Rauschert N	doi: 10.1038/labinvest.2008.2
19626590	Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3.	Int J Cancer	2010 Apr 1	Tanimoto R	doi: 10.1002/ijc.24764.
25973748	Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3.	PLoS One	2015 May 14	Yao X	doi: 10.1371/journal.pone.0125634
25360516	Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells.	Oncotarget	2014 Nov 30	Raiter A	-
22146569	Endoplasmic reticulum stress is activated in endometrial adenocarcinoma.	Gynecol Oncol	2012 Apr	Bifulco G	doi: 10.1016/j.ygyno.2011.11.045
23280503	AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers.	Int J Cancer	2013 Jul	Gray MJ	doi: 10.1002/ijc.27994
22801219	IGFBP-3 sensitizes antiestrogen-resistant breast cancer cells through interaction with GRP78.	Cancer Lett	2012 Dec 28	Li C	doi: 10.1016/j.canlet.2012.07.004
25227822	GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling.	Asian Pac J Cancer Prev	2014	Fu R	-
22689054	GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.	Oncogene	2013 Apr 11	Li N	doi: 10.1038/onc.2012.212
23818965	Polymorphisms of glucose-regulated protein 78 and risk of colorectal cancer: a case-control study in southwest China.	PLoS One	2013 Jun 20	Zhang D	doi: 10.1371/journal.pone.0066791
24244613	Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production.	PLoS One	2013 Nov 11	Zhang Y	doi: 10.1371/journal.pone.0080071
25301734	De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells.	Oncotarget	2014 Nov 15	Chang YW	-
24781973	The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer.	Breast Cancer Res Treat	2014 Jun	Zheng YZ	doi: 10.1007/s10549-014-2967-x
20204278	Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer.	Oncol Rep	2010 Apr	Tsunemi S	-
22945507	Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity.	Cell Oncol (Dordr)	2012 Oct	Hardy B	-
20672702	[The role of GRP78 on the resistance to cisplatin in SPCA-1 cell line].	Zhongguo Fei Ai Za Zhi	2010 Jan	Wu J	doi: 10.3779/j.issn.1009-3419.2010.01.07.
25546329	GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease.	J Cell Physiol	2015 Jul	Booth L	doi: 10.1002/jcp.24919.
26530532	Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer.	Sci Rep	2015 Nov 4	Niu Z	doi: 10.1038/srep16067.
19212831	Upregulation of GRP78 and GRP94 and its function in chemotherapy resistance to VP-16 in human lung cancer cell line SK-MES-1.	Cancer Invest	2009 May	Zhang L	doi: 10.1080/07357900802527239.
25673690	Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface.	J Biol Chem	2015 Mar 27	Tsai YL	doi: 10.1074/jbc.M114.618736
23318453	Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78.	Oncogene	2013 Oct 10	Tsai HY	doi: 10.1038/onc.2012.514
28202509	Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.	Cancer Res	2017 Apr 15	Qian Y	doi: 10.1158/0008-5472.CAN-16-1595
27012209	Glucose regulated protein 78 (GRP78) inhibits apoptosis and attentinutes chemosensitivity of gemcitabine in breast cancer cell via AKT/mitochondrial apoptotic pathway.	Biochem Biophys Res Commun	2016 Jun 3	Xie J	doi: 10.1016/j.bbrc.2016.03.002
27130664	The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis.	Cancer Lett	2016 Jul 10	Kuang XY	doi: 10.1016/j.canlet.2016.04.035
28720068	Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells.	Tumour Biol	2017 Jul	Wang J	doi: 10.1177/1010428317716689.
28110670	GALNT6 Stabilizes GRP78 Protein by O-glycosylation and Enhances its Activity to Suppress Apoptosis Under Stress Condition.	Neoplasia	2017 Jan	Lin J	doi: 10.1016/j.neo.2016.11.007.
28645527	Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.	J Steroid Biochem Mol Biol	2017 Sep	Wang XQ	doi: 10.1016/j.jsbmb.2017.06.009
28739722	GRP78 Participates in PCA3-regulated Prostate Cancer Progression.	Anticancer Res	2017 Aug	Lin C	-
28423613	Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells.	Oncotarget	2017 Mar 21	Li R	doi: 10.18632/oncotarget.15223.
28157699	Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.	Oncotarget	2017 Mar 28	La X	doi: 10.18632/oncotarget.14959.
28394345	CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer.	Oncogene	2017 Aug 17	Zoni E	doi: 10.1038/onc.2017.87
27791469	New anti-cancer molecules targeting HSPA5/BIP to induce endoplasmic reticulum stress, autophagy and apoptosis.	Autophagy	2017 Jan 2	Cerezo M	doi: 10.1080/15548627.2016.1246107
27034162	FOXM1 promotes invasion and migration of colorectal cancer cells partially dependent on HSPA5 transactivation.	Oncotarget	2016 May 3	Luo X	doi: 10.18632/oncotarget.8419.
27845899	Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway.	Oncotarget	2016 Dec 13	Yang H	doi: 10.18632/oncotarget.13272.
27713511	Cell surface GRP78 as a biomarker and target for suppressing glioma cells.	Sci Rep	2016 Oct 7	Kang BR	doi: 10.1038/srep34922.
29368272	Concomitant high expression of ERα36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior.	Cell Oncol (Dordr)	2018 Jun	Dai YJ	doi: 10.1007/s13402-017-0368-y
29323121	The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness.	Sci Rep	2018 Jan 11	Chen HY	doi: 10.1038/s41598-017-14604-5.
29024602	Knockdown of CEMIP suppresses proliferation and induces apoptosis in colorectal cancer cells: downregulation of GRP78 and attenuation of unfolded protein response.	Biochem Cell Biol	2018 Jun	Liang G	doi: 10.1139/bcb-2017-0151
29260979	HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer.	Autophagy	2018	Kim SY	doi: 10.1080/15548627.2017.1414126

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr9	125236694	Missense_Mutation	novel	K621N	0.06
BLCA	chr9	125240733	Silent	NA	I99I	0.27
BLCA	chr9	125237116	Missense_Mutation	novel	T481A	0.37
BLCA	chr9	125236621	Missense_Mutation	novel	E646Q	0.2
BLCA	chr9	125241166	5'UTR	novel		0.38
BLCA	chr9	125241103	Silent	rs201266003	A8A	0.56
BLCA	chr9	125237014	Missense_Mutation	NA	D515H	0.21
BLCA	chr9	125238154	Silent	novel	I463I	0.24
BLCA	chr9	125239072	Missense_Mutation	novel	R289W	0.07
BLCA	chr9	125236879	Missense_Mutation	novel	D560H	0.7
BLCA	chr9	125237053	Missense_Mutation	novel	E502Q	0.71
BLCA	chr9	125236921	Missense_Mutation	novel	E546K	0.35
BLCA	chr9	125236951	Missense_Mutation	novel	E536K	0.26
BLCA	chr9	125238795	Missense_Mutation	novel	Q343H	0.37
BLCA	chr9	125238952	Missense_Mutation	novel	E329Q	0.26
BRCA	chr9	125239050	Missense_Mutation	novel	K296T	0.09
BRCA	chr9	125239528	Silent	NA	T166T	0.34
BRCA	chr9	125239139	Silent	novel	F266F	0.09
BRCA	chr9	125240819	Missense_Mutation	NA	E71K	0.19
BRCA	chr9	125237017	Missense_Mutation	NA	E514Q	0.41
BRCA	chr9	125239054	Frame_Shift_Del	NA	*A295Pfs28**	0.26
BRCA	chr9	125236526	3'UTR	novel		0.29
BRCA	chr9	125240250	Missense_Mutation	NA	K138N	0.15
BRCA	chr9	125240269	Missense_Mutation	rs191087735	I132T	0.62
BRCA	chr9	125236962	Missense_Mutation	rs368840257	R532H	0.2
CESC	chr9	125240909	Splice_Site	novel	X41_splice	0.25
CESC	chr9	125238966	Missense_Mutation	rs762582529	R324Q	0.38
COAD	chr9	125236508	3'UTR	novel		0.38
COAD	chr9	125236845	Missense_Mutation	NA	S571Y	0.42
COAD	chr9	125236992	Frame_Shift_Del	NA	*N522Ifs12**	0.36
COAD	chr9	125239007	Silent	NA	E310E	0.41
COAD	chr9	125239288	Frame_Shift_Del	NA	*E217Rfs76**	0.2
GBM	chr9	125238161	Missense_Mutation	novel	V461A	0.09
GBM	chr9	125237047	Missense_Mutation	novel	D504Y	0.18
GBM	chr9	125240687	Silent	novel	L115L	0.28
GBM	chr9	125236819	Missense_Mutation	novel	E580K	0.14
HNSC	chr9	125237078	Silent	novel	G493G	0.25
HNSC	chr9	125236693	Missense_Mutation	novel	E622K	0.4
HNSC	chr9	125236729	Missense_Mutation	novel	D610N	0.12
HNSC	chr9	125240298	Missense_Mutation	novel	K122N	0.12
HNSC	chr9	125240901	Silent	novel	G43G	0.06
KIRC	chr9	125236696	Missense_Mutation	rs773627521	K621E	0.28
KIRC	chr9	125239075	Missense_Mutation	NA	L288V	0.2
KIRP	chr9	125239175	Silent	rs747075001	G254G	0.12
LAML	chr9	125241044	Missense_Mutation	novel	G28V	0.06
LAML	chr9	125240842	Missense_Mutation	novel	P63Q	0.21
LIHC	chr9	125239270	Missense_Mutation	NA	F223V	0.53
LIHC	chr9	125240822	Missense_Mutation	NA	P70T	0.27
LUAD	chr9	125238294	Missense_Mutation	NA	L417F	0.19
LUAD	chr9	125238742	Missense_Mutation	novel	L361H	0.11
LUAD	chr9	125238670	Missense_Mutation	NA	S385C	0.61
LUSC	chr9	125239247	Silent	rs770209845	F230F	0.23
LUSC	chr9	125238684	Missense_Mutation	NA	N380K	0.05
LUSC	chr9	125241271	5'UTR	novel		0.77
LUSC	chr9	125239328	Silent	novel	T203T	0.49
LUSC	chr9	125239002	Missense_Mutation	NA	F312S	0.28
OV	chr9	125238795	Missense_Mutation	NA	Q343H	0.23
OV	chr9	125238267	Missense_Mutation	NA	I426F	0.17
OV	chr9	125240796	Nonsense_Mutation	novel	*D78Efs9**	0.04
OV	chr9	125236715	Missense_Mutation	NA	E614D	0.17
OV	chr9	125236634	Silent	NA	P641P	0.19
OV	chr9	125236400	3'UTR	novel		0.29
PAAD	chr9	125238635	Missense_Mutation	novel	G397S	0.24
PAAD	chr9	125238647	Missense_Mutation	rs200526775	A393T	0.15
PAAD	chr9	125239108	Missense_Mutation	novel	D277Y	0.15
PAAD	chr9	125239246	Missense_Mutation	novel	D231N	0.11
PRAD	chr9	125240835	Frame_Shift_Del	novel	*Y65Cfs6**	0.31
READ	chr9	125236703	Silent	rs759041468	A618A	0.27
READ	chr9	125241237	5'UTR	novel		0.29
READ	chr9	125238988	Missense_Mutation	novel	D317Y	0.05
READ	chr9	125239108	Missense_Mutation	novel	D277Y	0.36
READ	chr9	125236948	Nonsense_Mutation	NA	E537*	0.33
SKCM	chr9	125238172	Missense_Mutation	NA	N457K	0.22
SKCM	chr9	125241116	Missense_Mutation	rs774479903	S4F	0.41
SKCM	chr9	125236678	Missense_Mutation	NA	V627I	0.22
SKCM	chr9	125238640	Missense_Mutation	NA	A395V	0.07
SKCM	chr9	125238230	Missense_Mutation	novel	P438L	0.4
SKCM	chr9	125238231	Missense_Mutation	novel	P438S	0.38
SKCM	chr9	125237000	Silent	rs151232464	G519G	0.29
SKCM	chr9	125240192	Missense_Mutation	NA	E158K	0.17
STAD	chr9	125236955	Silent	novel	T534T	0.04
STAD	chr9	125239288	Frame_Shift_Del	NA	*E217Rfs76**	0.17
STAD	chr9	125236778	Silent	NA	T593T	0.14
STAD	chr9	125236640	Silent	NA	G639G	0.23
STAD	chr9	125239031	Silent	novel	Q302Q	0.38
STAD	chr9	125236483	3'UTR	novel		0.6
STAD	chr9	125238230	Missense_Mutation	novel	P438Q	0.28
STAD	chr9	125241013	Silent	NA	T38T	0.36
STAD	chr9	125239306	Missense_Mutation	NA	L211M	0.1
TGCT	chr9	125236765	Missense_Mutation	novel	V598I	0.11
TGCT	chr9	125241295	5'UTR	novel		0.36
THCA	chr9	125237081	Silent	NA	R492R	0.14
THCA	chr9	125239034	Silent	NA	S301S	0.59
THCA	chr9	125236696	Missense_Mutation	rs773627521	K621E	0.43
UCEC	chr9	125239506	Missense_Mutation	NA	A174T	0.3
UCEC	chr9	125240308	Missense_Mutation	novel	V119A	0.32
UCEC	chr9	125236838	Missense_Mutation	NA	K573N	0.41
UCEC	chr9	125238156	Missense_Mutation	rs200465691	I463V	0.38
UCEC	chr9	125237037	Missense_Mutation	novel	G507D	0.29
UCEC	chr9	125239115	Silent	novel	T274T	0.46
UCEC	chr9	125236657	Missense_Mutation	novel	L634I	0.37
UCEC	chr9	125241221	5'UTR	novel		0.67
UCEC	chr9	125236442	3'UTR	novel		0.41
UCEC	chr9	125238664	Missense_Mutation	NA	G387D	0.08
UCEC	chr9	125236885	Missense_Mutation	rs762500054	R558C	0.37
UCEC	chr9	125236927	Missense_Mutation	novel	D544Y	0.07
UCEC	chr9	125236400	3'UTR	novel		0.47
UCEC	chr9	125236401	3'UTR	novel		0.33
UCEC	chr9	125236650	Missense_Mutation	novel	G636E	0.2
UCEC	chr9	125240741	Missense_Mutation	novel	R97W	0.22
UCEC	chr9	125240756	Missense_Mutation	NA	V92I	0.55
UCEC	chr9	125239218	Missense_Mutation	NA	G240D	0.41
UCEC	chr9	125236363	3'UTR	novel		0.38
UCEC	chr9	125236261	3'UTR	novel		0.44
UCEC	chr9	125239332	Splice_Site	novel	X202_splice	0.38
UCEC	chr9	125240298	Missense_Mutation	novel	K122N	0.35
UCEC	chr9	125238230	Missense_Mutation	novel	P438Q	0.2
UCEC	chr9	125236216	3'UTR	novel		0.41
UCEC	chr9	125236401	3'UTR	novel		0.33
UCEC	chr9	125236261	3'UTR	novel		0.27
UCEC	chr9	125238205	Missense_Mutation	novel	K446N	0.32
UCEC	chr9	125237069	Missense_Mutation	novel	Q496H	0.4
UCEC	chr9	125238596	Missense_Mutation	NA	D410Y	0.23
UCEC	chr9	125238181	Silent	novel	A454A	0.17
UCEC	chr9	125239246	Missense_Mutation	novel	D231N	0.19
UCEC	chr9	125239308	Missense_Mutation	novel	G210D	0.12
UCEC	chr9	125236560	3'UTR	novel		0.42
UCEC	chr9	125236548	3'UTR	novel		0.33
UCEC	chr9	125237124	Missense_Mutation	novel	L478P	0.33
UCEC	chr9	125238768	Missense_Mutation	novel	K352N	0.23
UCEC	chr9	125241024	Missense_Mutation	novel	L35M	0.5
UCEC	chr9	125238974	Silent	novel	T321T	0.29
UCEC	chr9	125239455	Missense_Mutation	novel	A191T	0.07
UCEC	chr9	125238775	Missense_Mutation	novel	D350A	0.05
UCEC	chr9	125239461	Missense_Mutation	NA	T189P	0.3
UCEC	chr9	125241021	Missense_Mutation	novel	G36R	0.28
UCS	chr9	125240742	Silent	novel	K96K	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.4444	0.067545
LAML	DEL	0.0052	0.24147
LGG	AMP	0.0546	0.21332
LIHC	DEL	0.2541	0.12467
PRAD	AMP	0.0793	0.059049
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCS	DEL	0.5893	0.089783

Survival Analysis

Cancer	P-value	Q-value
SARC	0.002	Kaplan-Meier Survival Analysis
ACC	0.0031	Kaplan-Meier Survival Analysis
HNSC	0.0018	Kaplan-Meier Survival Analysis
LUSC	0.041	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.013	Kaplan-Meier Survival Analysis
CESC	0.0011	Kaplan-Meier Survival Analysis
UCEC	0.028	Kaplan-Meier Survival Analysis
GBM	0.0012	Kaplan-Meier Survival Analysis
LIHC	0.0045	Kaplan-Meier Survival Analysis
LGG	0.0048	Kaplan-Meier Survival Analysis
CHOL	0.042	Kaplan-Meier Survival Analysis
UVM	0.00012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000044574 (Gene tree)
Gene ID: 3309
Gene Symbol: HSPA5
Alias: BiP|GRP78
Full Name: heat shock protein family A (Hsp70) member 5
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 6,540 bases
Position: chr9:125,234,848-125,241,387
Accession: 5238
Summary: The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11359930	Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.	Mol Biol Cell	2001 May	Waelter S	-
28407361	Influence of Tanshinone IIA on apoptosis of human esophageal carcinoma Eca-109 cells and its molecular mechanism.	Thorac Cancer	2017 Jul	Zhang Y	doi: 10.1111/1759-7714.12441
25415248	Advanced glycation end products upregulate the endoplasmic reticulum stress in human periodontal ligament cells.	J Periodontol	2015 Mar	Xu J	doi: 10.1902/jop.2014.140446
26802109	The Nrf2 Activator Vinylsulfone Reduces High Glucose-Induced Neural Tube Defects by Suppressing Cellular Stress and Apoptosis.	Reprod Sci	2016 Aug	Dong D	doi: 10.1177/1933719115625846
30973085	Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.	Neurol Res	2019 Jul	Mostafa DG	doi: 10.1080/01616412.2019.1596206
17400804	Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies.	J Endocrinol	2007 Apr	Tsunekawa S	-
2895472	cDNA cloning of the immunoglobulin heavy chain binding protein.	Proc Natl Acad Sci U S A	1988 Apr	Haas IG	-
10939522	The efficiency of different IRESs (internal ribosomes entry site) in monocistronic mRNAS.	Mol Biol Rep	2000 Mar	Attal J	-
23403503	The Molecular Chaperone GRP78/BiP in the Development of Chemoresistance: Mechanism and Possible Treatment.	Front Pharmacol	2013 Feb 11	Roller C	doi: 10.3389/fphar.2013.00010
18842681	Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells.	Carcinogenesis	2009 Feb	Jiang CC	doi: 10.1093/carcin/bgn220
22853733	Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment.	J Biomed Sci	2012 Aug 1	Mahfoudh-Boussaid A	doi: 10.1186/1423-0127-19-71.
22226148	Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine.	J Biomed Sci	2012 Jan 8	Liu GL	doi: 10.1186/1423-0127-19-4.
22127699	Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response.	Arthritis Rheum	2011 Dec	Zeng L	doi: 10.1002/art.30593.
20924496	Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress.	Evid Based Complement Alternat Med	2011	Zhang R	doi: 10.1155/2011/231938
20473228	Endoplasmic reticulum stress markers and ubiquitin-proteasome pathway activity in response to a 200-km run.	Med Sci Sports Exerc	2011 Jan	Kim HJ	doi: 10.1249/MSS.0b013e3181e4c5d1.
28253590	[Activation of endoplasmic reticulum stress and its effect on osteogenic differentiation induced by micropit/nanotube topography].	Zhonghua Kou Qiang Yi Xue Za Zhi	2017 Feb 9	Shi MQ	doi: 10.3760/cma.j.issn.1002-0098.2017.02.015.
25187414	Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine-induced atherosclerosis.	Acta Biochim Biophys Sin (Shanghai)	2014 Oct	Yang X	doi: 10.1093/abbs/gmu081
25111690	Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes.	Lab Invest	2014 Oct	Choi YJ	doi: 10.1038/labinvest.2014.98
24515801	The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells.	Mol Cancer Res	2014 Apr	Lee SO	doi: 10.1158/1541-7786.MCR-13-0567
26497095	Transcriptome analysis of the unfolded protein response in hemocytes of Litopenaeus vannamei.	Fish Shellfish Immunol	2016 Jul	Chen YH	doi: 10.1016/j.fsi.2015.10.027
27293989	Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress.	Am J Cancer Res	2016 May 1	Bu X	-
26453010	Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects.	Biochem Biophys Res Commun	2015 Nov 13	Zhong J	doi: 10.1016/j.bbrc.2015.10.024
29233047	RNAi of Grp78 may disturb the fusion of ICR mouse palate cultured in vitro.	Hum Exp Toxicol	2018 Feb	Ren C	doi: 10.1177/0960327117692132
30556250	Long noncoding RNA MEG3 inhibits breast cancer growth via upregulating endoplasmic reticulum stress and activating NF-kB and p53.	J Cell Biochem	2019 Apr	Zhang Y	doi: 10.1002/jcb.27982
30606992	Protective Effects of Alpha-Lipoic Acid on Glutamate-Induced Cytotoxicity in C6 Glioma Cells.	Biol Pharm Bull	2019	Park E	doi: 10.1248/bpb.b18-00603.
30770792	Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress.	Cell Death Dis	2019 Feb 15	Abhari BA	doi: 10.1038/s41419-019-1381-z.
8385931	Intracellular Ca2+ stores of rat cerebellum: heterogeneity within and distinction from endoplasmic reticulum.	Biochem J	1993 Apr 1	Nori A	-
19549899	Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1.	Cancer Res	2009 Jul 1	McFarland BC	doi: 10.1158/0008-5472.CAN-08-4841
23354132	Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria.	Int J Oncol	2013 Mar	Lee SK	doi: 10.3892/ijo.2013.1792
21750018	Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes.	Exp Biol Med (Maywood)	2011 Sep	Tang L	doi: 10.1258/ebm.2011.010400
28360534	Involvement of endoplasmic reticulum stress in formalin-induced pain is attenuated by 4-phenylbutyric acid.	J Pain Res	2017 Mar 20	Zhou F	doi: 10.2147/JPR.S125805
27844183	Evaluation and Treatment of Endoplasmic Reticulum (ER) Stress in Right Ventricular Dysfunction during Monocrotaline-Induced Rat Pulmonary Arterial Hypertension.	Cardiovasc Drugs Ther	2016 Dec	Wang JJ	-
25434873	Carbon monoxide offers neuroprotection from hippocampal cell damage induced by recurrent febrile seizures through the PERK-activated ER stress pathway.	Neurosci Lett	2015 Jan 12	Han Y	doi: 10.1016/j.neulet.2014.11.040
24522478	Role of unfolded protein response in affecting osteoblast differentiation induced by fluoride.	Biol Trace Elem Res	2014 Apr	Li XN	doi: 10.1007/s12011-014-9897-7
24453024	Role of endoplasmic reticulum stress via the PERK signaling pathway in brain injury from status epilepticus.	J Mol Neurosci	2014 Aug	Chen J	doi: 10.1007/s12031-014-0236-4
28070992	Molecular signal networks and regulating mechanisms of the unfolded protein response.	J Zhejiang Univ Sci B	2017 Jan	Gong J	doi: 10.1631/jzus.B1600043.
27809414	Salidroside protects against homocysteine-induced injury in human umbilical vein endothelial cells via the regulation of endoplasmic reticulum stress.	Cardiovasc Ther	2017 Feb	Zhu L	doi: 10.1111/1755-5922.12234.
27830010	Glutaminase inhibitor compound 968 inhibits cell proliferation and sensitizes paclitaxel in ovarian cancer.	Am J Transl Res	2016 Oct 15	Yuan L	-
26935620	Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress.	Int J Mol Med	2016 Apr	He J	doi: 10.3892/ijmm.2016.2509
26916916	Attenuation of Endoplasmic Reticulum Stress-Mediated Liver Damage by Mulberry Leaf Diet in Streptozotocin-Induced Diabetic Rats.	Am J Chin Med	2016	Afrin R	doi: 10.1142/S0192415X16500063.
26693693	Lipopolysaccharide Activates the Unfolded Protein Response in Human Periodontal Ligament Fibroblasts.	J Periodontol	2016 May	Wang Y	doi: 10.1902/jop.2015.150413
25873533	CRH knockout inhibits the murine innate immune responses in association with endoplasmic reticulum stress after thermal injury.	Surgery	2015 Jul	Yang C	doi: 10.1016/j.surg.2015.01.024
30505248	Endoplasmic Reticulum Stress Is Involved in Baicalin Protection on Chondrocytes From Patients With Osteoarthritis.	Dose Response	2018 Nov 25	Cao J	doi: 10.1177/1559325818810636
30513588	The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner.	Cells	2018 Nov 30	Roest G	doi: 10.3390/cells7120239.
30981813	The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response.	Biochim Biophys Acta Mol Basis Dis	2019 Sep 1	Merlot AM	doi: 10.1016/j.bbadis.2019.04.007

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000324460	HSPA5-201	3908	-	ENSP00000324173	654 (aa)	-	P11021

Gene Model

Click here to download ENSG00000044574's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03060	Protein export	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04612	Antigen processing and presentation	KEGG
hsa04918	Thyroid hormone synthesis	KEGG
hsa05020	Prion diseases	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000044574	Platelet Function Tests	2.0793200E-005	-
ENSG00000044574	Platelet Function Tests	4.8557778E-006	-
ENSG00000044574	Platelet Function Tests	4.9138553E-006	-
ENSG00000044574	Platelet Function Tests	4.7551428E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000044574's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000044574	HSPA5	100	98.624	ENSMUSG00000026864	Hspa5	99	98.624	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001554	luteolysis	-	IEA	Process
GO:0005509	calcium ion binding	16130169.	TAS	Function
GO:0005515	protein binding	11907036.18064632.18264092.18502753.18923428.18923430.19632185.20335166.20477988.21445305.22613557.22689054.22735594.22796945.23220234.23349634.23769672.23990668.24189400.25601083.26496610.26551274.27238082.30021884.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11943137.	IMP	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	22689054.	IDA	Component
GO:0005739	mitochondrion	22689054.	IDA	Component
GO:0005783	endoplasmic reticulum	16223484.	IDA	Component
GO:0005783	endoplasmic reticulum	11943137.	IMP	Component
GO:0005783	endoplasmic reticulum	16130169.	TAS	Component
GO:0005788	endoplasmic reticulum lumen	21873635.	IBA	Component
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005790	smooth endoplasmic reticulum	-	IEA	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	15308636.	IDA	Component
GO:0005829	cytosol	22689054.	IDA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006983	ER overload response	-	IEA	Process
GO:0006986	response to unfolded protein	21873635.	IBA	Process
GO:0008180	COP9 signalosome	18850735.	IDA	Component
GO:0009986	cell surface	-	IEA	Component
GO:0010976	positive regulation of neuron projection development	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	21873635.	IBA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0016887	ATPase activity	20335166.23975754.	IDA	Function
GO:0016887	ATPase activity	-	ISS	Function
GO:0019899	enzyme binding	23921388.	IPI	Function
GO:0019904	protein domain specific binding	12411443.	IPI	Function
GO:0021589	cerebellum structural organization	-	IEA	Process
GO:0021680	cerebellar Purkinje cell layer development	-	IEA	Process
GO:0021762	substantia nigra development	22926577.	HEP	Process
GO:0030176	integral component of endoplasmic reticulum membrane	11181571.	IDA	Component
GO:0030182	neuron differentiation	-	IEA	Process
GO:0030335	positive regulation of cell migration	23990668.	IMP	Process
GO:0030433	ubiquitin-dependent ERAD pathway	21873635.	IBA	Process
GO:0030433	ubiquitin-dependent ERAD pathway	19816510.	TAS	Process
GO:0030496	midbody	15166316.	IDA	Component
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	IEA	Process
GO:0030968	endoplasmic reticulum unfolded protein response	21873635.	IBA	Process
GO:0030968	endoplasmic reticulum unfolded protein response	19816510.	TAS	Process
GO:0031072	heat shock protein binding	21873635.	IBA	Function
GO:0031204	posttranslational protein targeting to membrane, translocation	29719251.	IMP	Process
GO:0031398	positive regulation of protein ubiquitination	-	IEA	Process
GO:0031625	ubiquitin protein ligase binding	8666824.	IPI	Function
GO:0032991	protein-containing complex	23349634.	IDA	Component
GO:0034605	cellular response to heat	21873635.	IBA	Process
GO:0034620	cellular response to unfolded protein	21873635.	IBA	Process
GO:0034663	endoplasmic reticulum chaperone complex	21873635.	IBA	Component
GO:0034663	endoplasmic reticulum chaperone complex	18400946.	IDA	Component
GO:0034975	protein folding in endoplasmic reticulum	22013210.	TAS	Process
GO:0035437	maintenance of protein localization in endoplasmic reticulum	23990668.	IMP	Process
GO:0035690	cellular response to drug	-	IEA	Process
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0036499	PERK-mediated unfolded protein response	-	TAS	Process
GO:0036500	ATF6-mediated unfolded protein response	-	TAS	Process
GO:0042026	protein refolding	21873635.	IBA	Process
GO:0042149	cellular response to glucose starvation	10085239.	IDA	Process
GO:0042220	response to cocaine	-	IEA	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042623	ATPase activity, coupled	21873635.	IBA	Function
GO:0043022	ribosome binding	-	IEA	Function
GO:0043066	negative regulation of apoptotic process	10760948.12665508.	IMP	Process
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043231	intracellular membrane-bounded organelle	22689054.	IDA	Component
GO:0044183	protein binding involved in protein folding	21873635.	IBA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0051082	unfolded protein binding	14685163.16130169.22013210.	TAS	Function
GO:0051085	chaperone cofactor-dependent protein refolding	21873635.	IBA	Process
GO:0051087	chaperone binding	19816510.	TAS	Function
GO:0051402	neuron apoptotic process	-	IEA	Process
GO:0051787	misfolded protein binding	21873635.	IBA	Function
GO:0051787	misfolded protein binding	18400946.	IDA	Function
GO:0060904	regulation of protein folding in endoplasmic reticulum	19816510.	TAS	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.	HDA	Component
GO:0071236	cellular response to antibiotic	-	IEA	Process
GO:0071277	cellular response to calcium ion	-	IEA	Process
GO:0071287	cellular response to manganese ion	-	IEA	Process
GO:0071320	cellular response to cAMP	-	IEA	Process
GO:0071353	cellular response to interleukin-4	-	IEA	Process
GO:0071480	cellular response to gamma radiation	-	IEA	Process
GO:0090074	negative regulation of protein homodimerization activity	-	ISS	Process
GO:0090074	negative regulation of protein homodimerization activity	14685163.	TAS	Process
GO:0097501	stress response to metal ion	-	IEA	Process
GO:1901998	toxin transport	-	IEA	Process
GO:1903891	regulation of ATF6-mediated unfolded protein response	22934019.	TAS	Process
GO:1903894	regulation of IRE1-mediated unfolded protein response	22934019.	TAS	Process
GO:1903895	negative regulation of IRE1-mediated unfolded protein response	-	ISS	Process
GO:1903897	regulation of PERK-mediated unfolded protein response	22934019.	TAS	Process
GO:1904313	response to methamphetamine hydrochloride	-	IEA	Process
GO:1990090	cellular response to nerve growth factor stimulus	-	IEA	Process
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	14685163.	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.