EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24113381GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts.Biochem Biophys Res Commun2013 Nov 1Peng Ydoi: 10.1016/j.bbrc.2013.09.108
23759331Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth.J Surg Res2013 NovKuo LJdoi: 10.1016/j.jss.2013.05.020
19713465GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib.Blood2009 Oct 29Kern Jdoi: 10.1182/blood-2009-03-209668
28038917A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells.Exp Cell Res2017 Feb 1Wang Ydoi: 10.1016/j.yexcr.2016.12.017
28629783GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages.Cell Signal2017 SepZhang Ldoi: 10.1016/j.cellsig.2017.06.008
16182273Overexpression of glucose-regulated protein 78 in colon cancer.Clin Chim Acta2006 FebXing X-
24977433GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling.Oncotarget2014 Jul 30Li Z-
24048331Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.Clin Cancer Res2013 Dec 15Liu Rdoi: 10.1158/1078-0432.CCR-13-1106
15778089Expression of stress response protein glucose regulated protein-78 mediated by c-Myb.Int J Biochem Cell Biol2005 JunRamsay RG-
22613557Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells.FEBS J2012 JulSokolowska Idoi: 10.1111/j.1742-4658.2012.08641.x
24795528Involvement of PAR-4 in cannabinoid-dependent sensitization of osteosarcoma cells to TRAIL-induced apoptosis.Int J Biol Sci2014 Apr 8Notaro Adoi: 10.7150/ijbs.8337
11719466Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade.Cancer Res2001 Nov 15Song MS-
20651985Differential influence of anticancer treatments and angiogenesis on the seric titer of autoantibody used as tumor and metastasis biomarker.Neoplasia2010 JulDefresne F-
19838160Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma.Mod Pathol2010 JanPapalas JAdoi: 10.1038/modpathol.2009.152
18331622Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus.BMC Cancer2008 Mar 10Langer Rdoi: 10.1186/1471-2407-8-70.
23085757miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.Oncogene2013 Sep 26Su SFdoi: 10.1038/onc.2012.483
20497865Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.J Formos Med Assoc2010 MayHuang TTdoi: 10.1016/S0929-6646(10)60060-5.
28618969Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer.Tumour Biol2017 JunRanjan Adoi: 10.1177/1010428317705517.
28601093Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma.BMC Cancer2017 Jun 10Yip CWdoi: 10.1186/s12885-017-3399-x.
28854502Prognostic role of BiP/GRP78 expression as ER stress in patients with gastric adenocarcinoma.Cancer Biomark2017 Sep 7Ogawa Hdoi: 10.3233/CBM-170062.
29066620Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.J Biol Chem2017 Dec 22Al-Hashimi AAdoi: 10.1074/jbc.M117.799908
24526410GRP78 mediates cell growth and invasiveness in endometrial cancer.J Cell Physiol2014 OctCal?? Gdoi: 10.1002/jcp.24578.
20605795Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.J Biol Chem2010 Sep 10Al-Hashimi AAdoi: 10.1074/jbc.M110.119107
26045166KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.Cancer Res2015 Aug 1Kang JMdoi: 10.1158/0008-5472.CAN-14-3751
25194164Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling.Carcinogenesis2014 NovWang Ndoi: 10.1093/carcin/bgu187
24756776Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78.Oncol Rep2014 JunLi Wdoi: 10.3892/or.2014.3147
16472112Stress induction of GRP78/BiP and its role in cancer.Curr Mol Med2006 FebLi J-
2845796817beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation.J Steroid Biochem Mol Biol2017 JulXu Ddoi: 10.1016/j.jsbmb.2017.04.009
28258248CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells.Biosci Rep2017 Apr 10Deying Wdoi: 10.1042/BSR20160470
27016417Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device.Oncotarget2016 May 3Yu Tdoi: 10.18632/oncotarget.8232.
29178343PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.Cancer Sci2018 FebMoriya Cdoi: 10.1111/cas.13458
27815359Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.Clin Cancer Res2017 May 15Dadey DYAdoi: 10.1158/1078-0432.CCR-16-1935
28245171miR-181a Inhibits Cervical Cancer Development via Downregulating GRP78.Oncol Res2017 Sep 21Luo Cdoi: 10.3727/096504017X14867268787969
16912197BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis.Cancer Res2006 Aug 15Gupta P-
23056589An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer.PLoS One2012Sethi Gdoi: 10.1371/journal.pone.0047086
23200913The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival.Gynecol Oncol2013 MarMatsuo Kdoi: 10.1016/j.ygyno.2012.11.024
21056970Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.J Biol Chem2011 Jan 14Misra UKdoi: 10.1074/jbc.M110.129767
17640713Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.Hum Pathol2007 OctDaneshmand S-
22564965Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK.Oncotarget2012 AprKandala PK-
25212833E1A-mediated inhibition of HSPA5 suppresses cell migration and invasion in triple-negative breast cancer.Ann Surg Oncol2015 MarChen HAdoi: 10.1245/s10434-014-4061-3
25338653Knockdown of glucose-regulated protein 78/binding immunoglobulin heavy chain protein expression by asymmetric small interfering RNA induces apoptosis in prostate cancer cells and attenuates migratory capability.Mol Med Rep2015 JanLu Tdoi: 10.3892/mmr.2014.2737
25081541Reversed expression of GRIM-1 and GRP78 in human non-small cell lung cancer.Hum Pathol2014 SepWu HMdoi: 10.1016/j.humpath.2014.04.023
20473863GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy.Int J Cancer2011 Feb 1Lee Edoi: 10.1002/ijc.25370.
19674193Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response.J Cell Mol Med2009 SepWang Jdoi: 10.1111/j.1582-4934.2009.00873.x
23922175Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression.Tumour Biol2014 JanWu CTdoi: 10.1007/s13277-013-1024-4
17062670Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer.Clin Cancer Res2006 Oct 15Pootrakul L-
18192872Down-regulation of molecular chaperone 78-kd glucose-regulated protein/immunoglobulin-binding protein expression involved in enhancement of human RS cell mutability.Pancreas2008 JanHirano Jdoi: 10.1097/mpa.0b013e31814dadf5.
16543232Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.J Biol Chem2006 May 12Misra UK-
27822448Intraperitoneal Fat through GRP78: A Risk Factor for Endometrial Cancer.Anal Cell Pathol (Amst)2016Ciortea R-
24853418HKH40A downregulates GRP78/BiP expression in cancer cells.Cell Death Dis2014 May 22Kosakowska-Cholody Tdoi: 10.1038/cddis.2014.203.
22297694Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer.Mol Biol Rep2012 JunSun Qdoi: 10.1007/s11033-012-1500-8.
25669168Glucose-regulated protein 78 mediates the anticancer efficacy of shikonin in hormone-refractory prostate cancer cells.Tumour Biol2015 JulKuo LJdoi: 10.1007/s13277-015-3157-0
25333575Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress.Oncol Rep2014 DecJiang Xdoi: 10.3892/or.2014.3533
21516372Survivin-mediated cancer cell migration through GRP78 and epithelial-mesenchymal transition (EMT) marker expression in Mahlavu cells.Ann Surg Oncol2012 JanTai CJdoi: 10.1245/s10434-011-1692-5
24002052GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line.Oncol Rep2013 NovLi Bdoi: 10.3892/or.2013.2710
15949590Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance.Lung Cancer2005 JulUramoto H-
18268478A new tumor-specific variant of GRP78 as target for antibody-based therapy.Lab Invest2008 AprRauschert Ndoi: 10.1038/labinvest.2008.2
19626590Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3.Int J Cancer2010 Apr 1Tanimoto Rdoi: 10.1002/ijc.24764.
25973748Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3.PLoS One2015 May 14Yao Xdoi: 10.1371/journal.pone.0125634
25360516Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells.Oncotarget2014 Nov 30Raiter A-
22146569Endoplasmic reticulum stress is activated in endometrial adenocarcinoma.Gynecol Oncol2012 AprBifulco Gdoi: 10.1016/j.ygyno.2011.11.045
23280503AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers.Int J Cancer2013 JulGray MJdoi: 10.1002/ijc.27994
22801219IGFBP-3 sensitizes antiestrogen-resistant breast cancer cells through interaction with GRP78.Cancer Lett2012 Dec 28Li Cdoi: 10.1016/j.canlet.2012.07.004
25227822GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling.Asian Pac J Cancer Prev2014Fu R-
22689054GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.Oncogene2013 Apr 11Li Ndoi: 10.1038/onc.2012.212
23818965Polymorphisms of glucose-regulated protein 78 and risk of colorectal cancer: a case-control study in southwest China.PLoS One2013 Jun 20Zhang Ddoi: 10.1371/journal.pone.0066791
24244613Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production.PLoS One2013 Nov 11Zhang Ydoi: 10.1371/journal.pone.0080071
25301734De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells.Oncotarget2014 Nov 15Chang YW-
24781973The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer.Breast Cancer Res Treat2014 JunZheng YZdoi: 10.1007/s10549-014-2967-x
20204278Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer.Oncol Rep2010 AprTsunemi S-
22945507Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity.Cell Oncol (Dordr)2012 OctHardy B-
20672702[The role of GRP78 on the resistance to cisplatin in SPCA-1 cell line].Zhongguo Fei Ai Za Zhi2010 JanWu Jdoi: 10.3779/j.issn.1009-3419.2010.01.07.
25546329GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease.J Cell Physiol2015 JulBooth Ldoi: 10.1002/jcp.24919.
26530532Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer.Sci Rep2015 Nov 4Niu Zdoi: 10.1038/srep16067.
19212831Upregulation of GRP78 and GRP94 and its function in chemotherapy resistance to VP-16 in human lung cancer cell line SK-MES-1.Cancer Invest2009 MayZhang Ldoi: 10.1080/07357900802527239.
25673690Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface.J Biol Chem2015 Mar 27Tsai YLdoi: 10.1074/jbc.M114.618736
23318453Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78.Oncogene2013 Oct 10Tsai HYdoi: 10.1038/onc.2012.514
28202509Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.Cancer Res2017 Apr 15Qian Ydoi: 10.1158/0008-5472.CAN-16-1595
27012209Glucose regulated protein 78 (GRP78) inhibits apoptosis and attentinutes chemosensitivity of gemcitabine in breast cancer cell via AKT/mitochondrial apoptotic pathway.Biochem Biophys Res Commun2016 Jun 3Xie Jdoi: 10.1016/j.bbrc.2016.03.002
27130664The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis.Cancer Lett2016 Jul 10Kuang XYdoi: 10.1016/j.canlet.2016.04.035
28720068Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells.Tumour Biol2017 JulWang Jdoi: 10.1177/1010428317716689.
28110670GALNT6 Stabilizes GRP78 Protein by O-glycosylation and Enhances its Activity to Suppress Apoptosis Under Stress Condition.Neoplasia2017 JanLin Jdoi: 10.1016/j.neo.2016.11.007.
28645527Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.J Steroid Biochem Mol Biol2017 SepWang XQdoi: 10.1016/j.jsbmb.2017.06.009
28739722GRP78 Participates in PCA3-regulated Prostate Cancer Progression.Anticancer Res2017 AugLin C-
28423613Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells.Oncotarget2017 Mar 21Li Rdoi: 10.18632/oncotarget.15223.
28157699Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.Oncotarget2017 Mar 28La Xdoi: 10.18632/oncotarget.14959.
28394345CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer.Oncogene2017 Aug 17Zoni Edoi: 10.1038/onc.2017.87
27791469New anti-cancer molecules targeting HSPA5/BIP to induce endoplasmic reticulum stress, autophagy and apoptosis.Autophagy2017 Jan 2Cerezo Mdoi: 10.1080/15548627.2016.1246107
27034162FOXM1 promotes invasion and migration of colorectal cancer cells partially dependent on HSPA5 transactivation.Oncotarget2016 May 3Luo Xdoi: 10.18632/oncotarget.8419.
27845899Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway.Oncotarget2016 Dec 13Yang Hdoi: 10.18632/oncotarget.13272.
27713511Cell surface GRP78 as a biomarker and target for suppressing glioma cells.Sci Rep2016 Oct 7Kang BRdoi: 10.1038/srep34922.
29368272Concomitant high expression of ERα36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior.Cell Oncol (Dordr)2018 JunDai YJdoi: 10.1007/s13402-017-0368-y
29323121The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness.Sci Rep2018 Jan 11Chen HYdoi: 10.1038/s41598-017-14604-5.
29024602Knockdown of CEMIP suppresses proliferation and induces apoptosis in colorectal cancer cells: downregulation of GRP78 and attenuation of unfolded protein response.Biochem Cell Biol2018 JunLiang Gdoi: 10.1139/bcb-2017-0151
29260979HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer.Autophagy2018Kim SYdoi: 10.1080/15548627.2017.1414126

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr9125236694Missense_MutationnovelK621N0.06
BLCAchr9125240733SilentNAI99I0.27
BLCAchr9125237116Missense_MutationnovelT481A0.37
BLCAchr9125236621Missense_MutationnovelE646Q0.2
BLCAchr91252411665'UTRnovel0.38
BLCAchr9125241103Silentrs201266003A8A0.56
BLCAchr9125237014Missense_MutationNAD515H0.21
BLCAchr9125238154SilentnovelI463I0.24
BLCAchr9125239072Missense_MutationnovelR289W0.07
BLCAchr9125236879Missense_MutationnovelD560H0.7
BLCAchr9125237053Missense_MutationnovelE502Q0.71
BLCAchr9125236921Missense_MutationnovelE546K0.35
BLCAchr9125236951Missense_MutationnovelE536K0.26
BLCAchr9125238795Missense_MutationnovelQ343H0.37
BLCAchr9125238952Missense_MutationnovelE329Q0.26
BRCAchr9125239050Missense_MutationnovelK296T0.09
BRCAchr9125239528SilentNAT166T0.34
BRCAchr9125239139SilentnovelF266F0.09
BRCAchr9125240819Missense_MutationNAE71K0.19
BRCAchr9125237017Missense_MutationNAE514Q0.41
BRCAchr9125239054Frame_Shift_DelNAA295Pfs*280.26
BRCAchr91252365263'UTRnovel0.29
BRCAchr9125240250Missense_MutationNAK138N0.15
BRCAchr9125240269Missense_Mutationrs191087735I132T0.62
BRCAchr9125236962Missense_Mutationrs368840257R532H0.2
CESCchr9125240909Splice_SitenovelX41_splice0.25
CESCchr9125238966Missense_Mutationrs762582529R324Q0.38
COADchr91252365083'UTRnovel0.38
COADchr9125236845Missense_MutationNAS571Y0.42
COADchr9125236992Frame_Shift_DelNAN522Ifs*120.36
COADchr9125239007SilentNAE310E0.41
COADchr9125239288Frame_Shift_DelNAE217Rfs*760.2
GBMchr9125238161Missense_MutationnovelV461A0.09
GBMchr9125237047Missense_MutationnovelD504Y0.18
GBMchr9125240687SilentnovelL115L0.28
GBMchr9125236819Missense_MutationnovelE580K0.14
HNSCchr9125237078SilentnovelG493G0.25
HNSCchr9125236693Missense_MutationnovelE622K0.4
HNSCchr9125236729Missense_MutationnovelD610N0.12
HNSCchr9125240298Missense_MutationnovelK122N0.12
HNSCchr9125240901SilentnovelG43G0.06
KIRCchr9125236696Missense_Mutationrs773627521K621E0.28
KIRCchr9125239075Missense_MutationNAL288V0.2
KIRPchr9125239175Silentrs747075001G254G0.12
LAMLchr9125241044Missense_MutationnovelG28V0.06
LAMLchr9125240842Missense_MutationnovelP63Q0.21
LIHCchr9125239270Missense_MutationNAF223V0.53
LIHCchr9125240822Missense_MutationNAP70T0.27
LUADchr9125238294Missense_MutationNAL417F0.19
LUADchr9125238742Missense_MutationnovelL361H0.11
LUADchr9125238670Missense_MutationNAS385C0.61
LUSCchr9125239247Silentrs770209845F230F0.23
LUSCchr9125238684Missense_MutationNAN380K0.05
LUSCchr91252412715'UTRnovel0.77
LUSCchr9125239328SilentnovelT203T0.49
LUSCchr9125239002Missense_MutationNAF312S0.28
OVchr9125238795Missense_MutationNAQ343H0.23
OVchr9125238267Missense_MutationNAI426F0.17
OVchr9125240796Nonsense_MutationnovelD78Efs*90.04
OVchr9125236715Missense_MutationNAE614D0.17
OVchr9125236634SilentNAP641P0.19
OVchr91252364003'UTRnovel0.29
PAADchr9125238635Missense_MutationnovelG397S0.24
PAADchr9125238647Missense_Mutationrs200526775A393T0.15
PAADchr9125239108Missense_MutationnovelD277Y0.15
PAADchr9125239246Missense_MutationnovelD231N0.11
PRADchr9125240835Frame_Shift_DelnovelY65Cfs*60.31
READchr9125236703Silentrs759041468A618A0.27
READchr91252412375'UTRnovel0.29
READchr9125238988Missense_MutationnovelD317Y0.05
READchr9125239108Missense_MutationnovelD277Y0.36
READchr9125236948Nonsense_MutationNAE537*0.33
SKCMchr9125238172Missense_MutationNAN457K0.22
SKCMchr9125241116Missense_Mutationrs774479903S4F0.41
SKCMchr9125236678Missense_MutationNAV627I0.22
SKCMchr9125238640Missense_MutationNAA395V0.07
SKCMchr9125238230Missense_MutationnovelP438L0.4
SKCMchr9125238231Missense_MutationnovelP438S0.38
SKCMchr9125237000Silentrs151232464G519G0.29
SKCMchr9125240192Missense_MutationNAE158K0.17
STADchr9125236955SilentnovelT534T0.04
STADchr9125239288Frame_Shift_DelNAE217Rfs*760.17
STADchr9125236778SilentNAT593T0.14
STADchr9125236640SilentNAG639G0.23
STADchr9125239031SilentnovelQ302Q0.38
STADchr91252364833'UTRnovel0.6
STADchr9125238230Missense_MutationnovelP438Q0.28
STADchr9125241013SilentNAT38T0.36
STADchr9125239306Missense_MutationNAL211M0.1
TGCTchr9125236765Missense_MutationnovelV598I0.11
TGCTchr91252412955'UTRnovel0.36
THCAchr9125237081SilentNAR492R0.14
THCAchr9125239034SilentNAS301S0.59
THCAchr9125236696Missense_Mutationrs773627521K621E0.43
UCECchr9125239506Missense_MutationNAA174T0.3
UCECchr9125240308Missense_MutationnovelV119A0.32
UCECchr9125236838Missense_MutationNAK573N0.41
UCECchr9125238156Missense_Mutationrs200465691I463V0.38
UCECchr9125237037Missense_MutationnovelG507D0.29
UCECchr9125239115SilentnovelT274T0.46
UCECchr9125236657Missense_MutationnovelL634I0.37
UCECchr91252412215'UTRnovel0.67
UCECchr91252364423'UTRnovel0.41
UCECchr9125238664Missense_MutationNAG387D0.08
UCECchr9125236885Missense_Mutationrs762500054R558C0.37
UCECchr9125236927Missense_MutationnovelD544Y0.07
UCECchr91252364003'UTRnovel0.47
UCECchr91252364013'UTRnovel0.33
UCECchr9125236650Missense_MutationnovelG636E0.2
UCECchr9125240741Missense_MutationnovelR97W0.22
UCECchr9125240756Missense_MutationNAV92I0.55
UCECchr9125239218Missense_MutationNAG240D0.41
UCECchr91252363633'UTRnovel0.38
UCECchr91252362613'UTRnovel0.44
UCECchr9125239332Splice_SitenovelX202_splice0.38
UCECchr9125240298Missense_MutationnovelK122N0.35
UCECchr9125238230Missense_MutationnovelP438Q0.2
UCECchr91252362163'UTRnovel0.41
UCECchr91252364013'UTRnovel0.33
UCECchr91252362613'UTRnovel0.27
UCECchr9125238205Missense_MutationnovelK446N0.32
UCECchr9125237069Missense_MutationnovelQ496H0.4
UCECchr9125238596Missense_MutationNAD410Y0.23
UCECchr9125238181SilentnovelA454A0.17
UCECchr9125239246Missense_MutationnovelD231N0.19
UCECchr9125239308Missense_MutationnovelG210D0.12
UCECchr91252365603'UTRnovel0.42
UCECchr91252365483'UTRnovel0.33
UCECchr9125237124Missense_MutationnovelL478P0.33
UCECchr9125238768Missense_MutationnovelK352N0.23
UCECchr9125241024Missense_MutationnovelL35M0.5
UCECchr9125238974SilentnovelT321T0.29
UCECchr9125239455Missense_MutationnovelA191T0.07
UCECchr9125238775Missense_MutationnovelD350A0.05
UCECchr9125239461Missense_MutationNAT189P0.3
UCECchr9125241021Missense_MutationnovelG36R0.28
UCSchr9125240742SilentnovelK96K0.36

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.44440.067545
LAMLDEL0.00520.24147
LGGAMP0.05460.21332
LIHCDEL0.25410.12467
PRADAMP0.07930.059049
THCADEL0.04010.24038
THYMDEL0.01630.022012
UCSDEL0.58930.089783

Survival Analysis
CancerP-value Q-value
SARC0.002

Kaplan-Meier Survival Analysis

ACC0.0031

Kaplan-Meier Survival Analysis

HNSC0.0018

Kaplan-Meier Survival Analysis

LUSC0.041

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

BLCA0.013

Kaplan-Meier Survival Analysis

CESC0.0011

Kaplan-Meier Survival Analysis

UCEC0.028

Kaplan-Meier Survival Analysis

GBM0.0012

Kaplan-Meier Survival Analysis

LIHC0.0045

Kaplan-Meier Survival Analysis

LGG0.0048

Kaplan-Meier Survival Analysis

CHOL0.042

Kaplan-Meier Survival Analysis

UVM0.00012

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000044574 (Gene tree)
Gene ID
3309
Gene Symbol
HSPA5
Alias
BiP|GRP78
Full Name
heat shock protein family A (Hsp70) member 5
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
6,540 bases
Position
chr9:125,234,848-125,241,387
Accession
5238
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
11359930Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.Mol Biol Cell2001 MayWaelter S-
28407361Influence of Tanshinone IIA on apoptosis of human esophageal carcinoma Eca-109 cells and its molecular mechanism.Thorac Cancer2017 JulZhang Ydoi: 10.1111/1759-7714.12441
25415248Advanced glycation end products upregulate the endoplasmic reticulum stress in human periodontal ligament cells.J Periodontol2015 MarXu Jdoi: 10.1902/jop.2014.140446
26802109The Nrf2 Activator Vinylsulfone Reduces High Glucose-Induced Neural Tube Defects by Suppressing Cellular Stress and Apoptosis.Reprod Sci2016 AugDong Ddoi: 10.1177/1933719115625846
30973085Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.Neurol Res2019 JulMostafa DGdoi: 10.1080/01616412.2019.1596206
17400804Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies.J Endocrinol2007 AprTsunekawa S-
2895472cDNA cloning of the immunoglobulin heavy chain binding protein.Proc Natl Acad Sci U S A1988 AprHaas IG-
10939522The efficiency of different IRESs (internal ribosomes entry site) in monocistronic mRNAS.Mol Biol Rep2000 MarAttal J-
23403503The Molecular Chaperone GRP78/BiP in the Development of Chemoresistance: Mechanism and Possible Treatment.Front Pharmacol2013 Feb 11Roller Cdoi: 10.3389/fphar.2013.00010
18842681Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells.Carcinogenesis2009 FebJiang CCdoi: 10.1093/carcin/bgn220
22853733Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment.J Biomed Sci2012 Aug 1Mahfoudh-Boussaid Adoi: 10.1186/1423-0127-19-71.
22226148Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine.J Biomed Sci2012 Jan 8Liu GLdoi: 10.1186/1423-0127-19-4.
22127699Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response.Arthritis Rheum2011 DecZeng Ldoi: 10.1002/art.30593.
20924496Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress.Evid Based Complement Alternat Med2011Zhang Rdoi: 10.1155/2011/231938
20473228Endoplasmic reticulum stress markers and ubiquitin-proteasome pathway activity in response to a 200-km run.Med Sci Sports Exerc2011 JanKim HJdoi: 10.1249/MSS.0b013e3181e4c5d1.
28253590[Activation of endoplasmic reticulum stress and its effect on osteogenic differentiation induced by micropit/nanotube topography].Zhonghua Kou Qiang Yi Xue Za Zhi2017 Feb 9Shi MQdoi: 10.3760/cma.j.issn.1002-0098.2017.02.015.
25187414Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine-induced atherosclerosis.Acta Biochim Biophys Sin (Shanghai)2014 OctYang Xdoi: 10.1093/abbs/gmu081
25111690Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes.Lab Invest2014 OctChoi YJdoi: 10.1038/labinvest.2014.98
24515801The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells.Mol Cancer Res2014 AprLee SOdoi: 10.1158/1541-7786.MCR-13-0567
26497095Transcriptome analysis of the unfolded protein response in hemocytes of Litopenaeus vannamei.Fish Shellfish Immunol2016 JulChen YHdoi: 10.1016/j.fsi.2015.10.027
27293989Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress.Am J Cancer Res2016 May 1Bu X-
26453010Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects.Biochem Biophys Res Commun2015 Nov 13Zhong Jdoi: 10.1016/j.bbrc.2015.10.024
29233047RNAi of Grp78 may disturb the fusion of ICR mouse palate cultured in vitro.Hum Exp Toxicol2018 FebRen Cdoi: 10.1177/0960327117692132
30556250Long noncoding RNA MEG3 inhibits breast cancer growth via upregulating endoplasmic reticulum stress and activating NF-kB and p53.J Cell Biochem2019 AprZhang Ydoi: 10.1002/jcb.27982
30606992Protective Effects of Alpha-Lipoic Acid on Glutamate-Induced Cytotoxicity in C6 Glioma Cells.Biol Pharm Bull2019Park Edoi: 10.1248/bpb.b18-00603.
30770792Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress.Cell Death Dis2019 Feb 15Abhari BAdoi: 10.1038/s41419-019-1381-z.
8385931Intracellular Ca2+ stores of rat cerebellum: heterogeneity within and distinction from endoplasmic reticulum.Biochem J1993 Apr 1Nori A-
19549899Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1.Cancer Res2009 Jul 1McFarland BCdoi: 10.1158/0008-5472.CAN-08-4841
23354132Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria.Int J Oncol2013 MarLee SKdoi: 10.3892/ijo.2013.1792
21750018Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes.Exp Biol Med (Maywood)2011 SepTang Ldoi: 10.1258/ebm.2011.010400
28360534Involvement of endoplasmic reticulum stress in formalin-induced pain is attenuated by 4-phenylbutyric acid.J Pain Res2017 Mar 20Zhou Fdoi: 10.2147/JPR.S125805
27844183Evaluation and Treatment of Endoplasmic Reticulum (ER) Stress in Right Ventricular Dysfunction during Monocrotaline-Induced Rat Pulmonary Arterial Hypertension.Cardiovasc Drugs Ther2016 DecWang JJ-
25434873Carbon monoxide offers neuroprotection from hippocampal cell damage induced by recurrent febrile seizures through the PERK-activated ER stress pathway.Neurosci Lett2015 Jan 12Han Ydoi: 10.1016/j.neulet.2014.11.040
24522478Role of unfolded protein response in affecting osteoblast differentiation induced by fluoride.Biol Trace Elem Res2014 AprLi XNdoi: 10.1007/s12011-014-9897-7
24453024Role of endoplasmic reticulum stress via the PERK signaling pathway in brain injury from status epilepticus.J Mol Neurosci2014 AugChen Jdoi: 10.1007/s12031-014-0236-4
28070992Molecular signal networks and regulating mechanisms of the unfolded protein response.J Zhejiang Univ Sci B2017 JanGong Jdoi: 10.1631/jzus.B1600043.
27809414Salidroside protects against homocysteine-induced injury in human umbilical vein endothelial cells via the regulation of endoplasmic reticulum stress.Cardiovasc Ther2017 FebZhu Ldoi: 10.1111/1755-5922.12234.
27830010Glutaminase inhibitor compound 968 inhibits cell proliferation and sensitizes paclitaxel in ovarian cancer.Am J Transl Res2016 Oct 15Yuan L-
26935620Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress.Int J Mol Med2016 AprHe Jdoi: 10.3892/ijmm.2016.2509
26916916Attenuation of Endoplasmic Reticulum Stress-Mediated Liver Damage by Mulberry Leaf Diet in Streptozotocin-Induced Diabetic Rats.Am J Chin Med2016Afrin Rdoi: 10.1142/S0192415X16500063.
26693693Lipopolysaccharide Activates the Unfolded Protein Response in Human Periodontal Ligament Fibroblasts.J Periodontol2016 MayWang Ydoi: 10.1902/jop.2015.150413
25873533CRH knockout inhibits the murine innate immune responses in association with endoplasmic reticulum stress after thermal injury.Surgery2015 JulYang Cdoi: 10.1016/j.surg.2015.01.024
30505248Endoplasmic Reticulum Stress Is Involved in Baicalin Protection on Chondrocytes From Patients With Osteoarthritis.Dose Response2018 Nov 25Cao Jdoi: 10.1177/1559325818810636
30513588The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner.Cells2018 Nov 30Roest Gdoi: 10.3390/cells7120239.
30981813The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response.Biochim Biophys Acta Mol Basis Dis2019 Sep 1Merlot AMdoi: 10.1016/j.bbadis.2019.04.007
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000324460HSPA5-2013908-ENSP00000324173654 (aa)-P11021
Gene Model
Click here to download ENSG00000044574's gene model file
Pathways
Pathway IDPathway NameSource
hsa03060Protein exportKEGG
hsa04141Protein processing in endoplasmic reticulumKEGG
hsa04612Antigen processing and presentationKEGG
hsa04918Thyroid hormone synthesisKEGG
hsa05020Prion diseasesKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000044574Platelet Function Tests2.0793200E-005-
ENSG00000044574Platelet Function Tests4.8557778E-006-
ENSG00000044574Platelet Function Tests4.9138553E-006-
ENSG00000044574Platelet Function Tests4.7551428E-006-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000044574's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000044574HSPA510098.624ENSMUSG00000026864Hspa59998.624Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001554luteolysis-IEAProcess
GO:0005509calcium ion binding16130169.TASFunction
GO:0005515protein binding11907036.18064632.18264092.18502753.18923428.18923430.19632185.20335166.20477988.21445305.22613557.22689054.22735594.22796945.23220234.23349634.23769672.23990668.24189400.25601083.26496610.26551274.27238082.30021884.IPIFunction
GO:0005524ATP binding21873635.IBAFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus11943137.IMPComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm22689054.IDAComponent
GO:0005739mitochondrion22689054.IDAComponent
GO:0005783endoplasmic reticulum16223484.IDAComponent
GO:0005783endoplasmic reticulum11943137.IMPComponent
GO:0005783endoplasmic reticulum16130169.TASComponent
GO:0005788endoplasmic reticulum lumen21873635.IBAComponent
GO:0005788endoplasmic reticulum lumen-TASComponent
GO:0005789endoplasmic reticulum membrane-TASComponent
GO:0005790smooth endoplasmic reticulum-IEAComponent
GO:0005793endoplasmic reticulum-Golgi intermediate compartment15308636.IDAComponent
GO:0005829cytosol22689054.IDAComponent
GO:0005886plasma membrane-IEAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006983ER overload response-IEAProcess
GO:0006986response to unfolded protein21873635.IBAProcess
GO:0008180COP9 signalosome18850735.IDAComponent
GO:0009986cell surface-IEAComponent
GO:0010976positive regulation of neuron projection development-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016020membrane21873635.IBAComponent
GO:0016887ATPase activity21873635.IBAFunction
GO:0016887ATPase activity20335166.23975754.IDAFunction
GO:0016887ATPase activity-ISSFunction
GO:0019899enzyme binding23921388.IPIFunction
GO:0019904protein domain specific binding12411443.IPIFunction
GO:0021589cerebellum structural organization-IEAProcess
GO:0021680cerebellar Purkinje cell layer development-IEAProcess
GO:0021762substantia nigra development22926577.HEPProcess
GO:0030176integral component of endoplasmic reticulum membrane11181571.IDAComponent
GO:0030182neuron differentiation-IEAProcess
GO:0030335positive regulation of cell migration23990668.IMPProcess
GO:0030433ubiquitin-dependent ERAD pathway21873635.IBAProcess
GO:0030433ubiquitin-dependent ERAD pathway19816510.TASProcess
GO:0030496midbody15166316.IDAComponent
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IEAProcess
GO:0030968endoplasmic reticulum unfolded protein response21873635.IBAProcess
GO:0030968endoplasmic reticulum unfolded protein response19816510.TASProcess
GO:0031072heat shock protein binding21873635.IBAFunction
GO:0031204posttranslational protein targeting to membrane, translocation29719251.IMPProcess
GO:0031398positive regulation of protein ubiquitination-IEAProcess
GO:0031625ubiquitin protein ligase binding8666824.IPIFunction
GO:0032991protein-containing complex23349634.IDAComponent
GO:0034605cellular response to heat21873635.IBAProcess
GO:0034620cellular response to unfolded protein21873635.IBAProcess
GO:0034663endoplasmic reticulum chaperone complex21873635.IBAComponent
GO:0034663endoplasmic reticulum chaperone complex18400946.IDAComponent
GO:0034975protein folding in endoplasmic reticulum22013210.TASProcess
GO:0035437maintenance of protein localization in endoplasmic reticulum23990668.IMPProcess
GO:0035690cellular response to drug-IEAProcess
GO:0036498IRE1-mediated unfolded protein response-TASProcess
GO:0036499PERK-mediated unfolded protein response-TASProcess
GO:0036500ATF6-mediated unfolded protein response-TASProcess
GO:0042026protein refolding21873635.IBAProcess
GO:0042149cellular response to glucose starvation10085239.IDAProcess
GO:0042220response to cocaine-IEAProcess
GO:0042470melanosome-IEAComponent
GO:0042623ATPase activity, coupled21873635.IBAFunction
GO:0043022ribosome binding-IEAFunction
GO:0043066negative regulation of apoptotic process10760948.12665508.IMPProcess
GO:0043066negative regulation of apoptotic process16130169.TASProcess
GO:0043231intracellular membrane-bounded organelle22689054.IDAComponent
GO:0044183protein binding involved in protein folding21873635.IBAFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0051082unfolded protein binding21873635.IBAFunction
GO:0051082unfolded protein binding14685163.16130169.22013210.TASFunction
GO:0051085chaperone cofactor-dependent protein refolding21873635.IBAProcess
GO:0051087chaperone binding19816510.TASFunction
GO:0051402neuron apoptotic process-IEAProcess
GO:0051787misfolded protein binding21873635.IBAFunction
GO:0051787misfolded protein binding18400946.IDAFunction
GO:0060904regulation of protein folding in endoplasmic reticulum19816510.TASProcess
GO:0070062extracellular exosome19056867.19199708.20458337.HDAComponent
GO:0071236cellular response to antibiotic-IEAProcess
GO:0071277cellular response to calcium ion-IEAProcess
GO:0071287cellular response to manganese ion-IEAProcess
GO:0071320cellular response to cAMP-IEAProcess
GO:0071353cellular response to interleukin-4-IEAProcess
GO:0071480cellular response to gamma radiation-IEAProcess
GO:0090074negative regulation of protein homodimerization activity-ISSProcess
GO:0090074negative regulation of protein homodimerization activity14685163.TASProcess
GO:0097501stress response to metal ion-IEAProcess
GO:1901998toxin transport-IEAProcess
GO:1903891regulation of ATF6-mediated unfolded protein response22934019.TASProcess
GO:1903894regulation of IRE1-mediated unfolded protein response22934019.TASProcess
GO:1903895negative regulation of IRE1-mediated unfolded protein response-ISSProcess
GO:1903897regulation of PERK-mediated unfolded protein response22934019.TASProcess
GO:1904313response to methamphetamine hydrochloride-IEAProcess
GO:1990090cellular response to nerve growth factor stimulus-IEAProcess
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress14685163.TASProcess
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