EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22914783	Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancer.	J Natl Cancer Inst	2012 Oct 3	Yuan SS	doi: 10.1093/jnci/djs355
25788520	FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis.	Hum Mol Genet	2015 Jun 15	Huang YL	doi: 10.1093/hmg/ddv102
17932350	Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.	Cancer Epidemiol Biomarkers Prev	2007 Oct	Hsu HM	-
25310185	MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.	PLoS One	2014 Oct 13	Pavelitz T	doi: 10.1371/journal.pone.0108483
19714462	Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.	Breast Cancer Res Treat	2010 May	Loizidou MA	doi: 10.1007/s10549-009-0518-7
18256278	A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.	Mol Biol Cell	2008 Apr	Wen Q	doi: 10.1091/mbc.E07-09-0975
24625413	Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours.	Oncotarget	2014 Feb 28	Martin RM	-
23912341	Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.	Hum Mol Genet	2013 Dec 20	Regal JA	doi: 10.1093/hmg/ddt368
23046361	Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic recombination 11 homolog) predict treatment-specific outcome of localised invasive bladder cancer.	BJU Int	2012 Dec	Laurberg JR	doi: 10.1111/j.1464-410X.2012.11564.x
20843819	MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.	Cancer Res	2010 Sep 15	Choudhury A	doi: 10.1158/0008-5472.CAN-10-1202.
28133604	Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses.	Biomed Res Int	2017	Yang CH	doi: 10.1155/2017/2563910
24894818	Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.	Breast Cancer Res	2014 Jun 3	Damiola F	doi: 10.1186/bcr3669.
24079363	The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.	Mol Cancer	2013 Sep 30	Zi??kowska-Suchanek I	doi: 10.1186/1476-4598-12-113.
18830935	RAD50/MRE11/NBS1 proteins in relation to tumour development and prognosis in patients with microsatellite stable colorectal cancer.	Histol Histopathol	2008 Dec	Gao J	doi: 10.14670/HH-23.1495.
20164540	Analysis of the expression of human tumor antigens in ovarian cancer tissues.	Cancer Biomark	2010	Ali-Fehmi R	doi: 10.3233/CBM-2009-0117.
27798884	High Expression of MRE11-RAD50-NBS1 Is Associated with Poor Prognosis and Chemoresistance in Gastric Cancer.	Anticancer Res	2016 Oct	Altan B	-
18553220	DNA-repair genetic polymorphisms and risk of breast cancer in Cyprus.	Breast Cancer Res Treat	2009 Jun	Loizidou MA	doi: 10.1007/s10549-008-0084-4
15319296	MRE11 expression is impaired in gastric cancer with microsatellite instability.	Carcinogenesis	2004 Dec	Ottini L	-
24623370	Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer.	Ann Oncol	2014 Apr	Teo MT	doi: 10.1093/annonc/mdu014
24752797	Development of serous ovarian cancer is associated with the expression of homologous recombination pathway proteins.	Pathol Oncol Res	2014 Oct	Ye Q	doi: 10.1007/s12253-014-9776-8
20682289	Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells.	Biochem Biophys Res Commun	2010 Sep 3	Kavitha CV	doi: 10.1016/j.bbrc.2010.07.117
11850399	Human MRE11 is inactivated in mismatch repair-deficient cancers.	EMBO Rep	2002 Mar	Giannini G	-
20956948	PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation.	Oncogene	2011 Feb 24	Deng R	doi: 10.1038/onc.2010.467
19383352	Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.	Mol Oncol	2008 Dec	Bartkova J	doi: 10.1016/j.molonc.2008.09.007
28073364	Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.	BMC Cancer	2017 Jan 10	Brandt S	doi: 10.1186/s12885-016-3026-2.
26735576	Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.	Oncotarget	2016 Apr 26	Naccarati A	doi: 10.18632/oncotarget.6804.
30176843	Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis.	BMC Cancer	2018 Sep 3	Ho V	doi: 10.1186/s12885-018-4776-9.
29678143	Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population.	BMC Cancer	2018 Apr 20	Podralska M	doi: 10.1186/s12885-018-4360-3.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	94467860	Missense_Mutation	rs757492041	R351C	0.21
BLCA	chr11	94470597	Silent	novel	H297H	0.23
BLCA	chr11	94479720	Missense_Mutation	novel	S119L	0.25
BLCA	chr11	94461024	Missense_Mutation	rs587782457	N413S	0.33
BLCA	chr11	94447329	Missense_Mutation	novel	S558F	0.5
BLCA	chr11	94464141	Silent	novel	F399F	0.12
BLCA	chr11	94467865	Missense_Mutation	NA	R349L	0.5
BLCA	chr11	94420081	3'UTR	novel		0.38
BRCA	chr11	94456332	Missense_Mutation	rs761458720	R503C	0.55
BRCA	chr11	94476296	Missense_Mutation	NA	Q218K	0.38
BRCA	chr11	94464133	Missense_Mutation	NA	R402K	0.16
BRCA	chr11	94460975	Silent	NA	V429V	0.55
CESC	chr11	94464218	Missense_Mutation	novel	E374Q	0.45
CESC	chr11	94456332	Missense_Mutation	rs761458720	R503C	0.61
CESC	chr11	94437181	Nonsense_Mutation	novel	S641*	0.07
CESC	chr11	94490898	Nonsense_Mutation	novel	A30*	0.2
CESC	chr11	94459510	Silent	NA	E466E	0.4
CESC	chr11	94470536	Missense_Mutation	novel	P318A	0.27
COAD	chr11	94420042	3'UTR	novel		0.23
COAD	chr11	94456318	Silent	NA	T507T	0.28
COAD	chr11	94447287	Missense_Mutation	rs200085146	R572Q	0.27
COAD	chr11	94471711	Silent	NA	D236D	0.45
COAD	chr11	94464158	Missense_Mutation	NA	D394Y	0.08
COAD	chr11	94447245	Missense_Mutation	rs753717905	S586L	0.21
COAD	chr11	94445828	Missense_Mutation	NA	N617H	0.25
COAD	chr11	94486009	Missense_Mutation	rs779269083	E77K	0.21
COAD	chr11	94490835	Missense_Mutation	NA	E51K	0.24
COAD	chr11	94467811	Splice_Site	NA	X366_splice	0.3
COAD	chr11	94471742	Nonsense_Mutation	novel	*T226Ifs2**	0.04
COAD	chr11	94490898	Nonsense_Mutation	novel	A30*	0.04
COAD	chr11	94470524	Frame_Shift_Ins	NA	N322*	0.14
ESCA	chr11	94492882	5'UTR	novel		0.08
GBM	chr11	94459523	Missense_Mutation	NA	V462E	0.06
GBM	chr11	94467821	Nonsense_Mutation	rs371077728	R364*	0.22
GBM	chr11	94478799	Missense_Mutation	novel	E160D	0.45
GBM	chr11	94466561	Intron	novel		0.48
GBM	chr11	94459460	Missense_Mutation	rs587781378	R483Q	0.35
HNSC	chr11	94445869	Missense_Mutation	novel	T603I	0.05
HNSC	chr11	94490895	Missense_Mutation	novel	V31I	0.26
HNSC	chr11	94445854	Nonsense_Mutation	novel	S608*	0.25
KIRC	chr11	94485956	Silent	NA	L94L	0.23
KIRC	chr11	94435852	Silent	rs772019392	T658T	0.26
KIRP	chr11	94490856	Missense_Mutation	NA	L44V	0.37
KIRP	chr11	94492792	Missense_Mutation	novel	A4S	0.1
LAML	chr11	94459479	Missense_Mutation	NA	Q477E	0.35
LGG	chr11	94467820	Missense_Mutation	rs140528613	R364Q	0.45
LGG	chr11	94490842	Missense_Mutation	novel	Q48H	0.32
LUAD	chr11	94447427	Missense_Mutation	NA	R525S	0.56
LUAD	chr11	94435857	Missense_Mutation	novel	P657T	0.18
LUAD	chr11	94479710	Silent	NA	V122V	0.28
LUAD	chr11	94464236	Missense_Mutation	novel	D368Y	0.38
LUAD	chr11	94476332	Missense_Mutation	NA	D206Y	0.08
LUAD	chr11	94464240	Splice_Site	novel	X367_splice	0.28
LUAD	chr11	94471711	Missense_Mutation	novel	D236E	0.23
LUAD	chr11	94467868	Missense_Mutation	NA	E348V	0.39
LUAD	chr11	94492866	5'UTR	novel		0.38
LUAD	chr11	94466570	Intron	novel		0.12
LUAD	chr11	94486081	Missense_Mutation	NA	D53Y	0.09
LUAD	chr11	94459551	Missense_Mutation	novel	G453W	0.24
LUAD	chr11	94479744	Missense_Mutation	NA	Y111S	0.28
LUAD	chr11	94447263	Missense_Mutation	novel	R580K	0.37
LUAD	chr11	94456329	Missense_Mutation	novel	F504V	0.5
LUAD	chr11	94464125	Missense_Mutation	novel	K405E	0.33
LUAD	chr11	94420169	Missense_Mutation	novel	D695Y	0.19
LUSC	chr11	94447256	Silent	rs778762259	Q582Q	0.04
LUSC	chr11	94467850	Missense_Mutation	novel	N354I	0.25
LUSC	chr11	94447314	Missense_Mutation	NA	S563L	0.07
LUSC	chr11	94479735	Missense_Mutation	novel	G114A	0.21
LUSC	chr11	94467863	Nonsense_Mutation	rs781140391	E350*	0.17
OV	chr11	94459583	Splice_Site	NA	X443_splice	0.37
OV	chr11	94460992	Missense_Mutation	novel	G424R	0.08
OV	chr11	94476351	Silent	NA	T199T	0.15
PAAD	chr11	94459416	Missense_Mutation	rs564511708	D498N	0.16
READ	chr11	94490928	Missense_Mutation	novel	D20Y	0.31
READ	chr11	94420158	Missense_Mutation	novel	M698I	0.42
READ	chr11	94437199	Missense_Mutation	novel	V635A	0.48
READ	chr11	94456334	Missense_Mutation	rs767097795	R502H	0.38
READ	chr11	94466493	Intron	rs144419972		0.43
READ	chr11	94490928	Missense_Mutation	novel	D20Y	0.38
SKCM	chr11	94471708	Silent	NA	F237F	0.42
SKCM	chr11	94447314	Missense_Mutation	NA	S563L	0.28
SKCM	chr11	94456307	Frame_Shift_Del	rs765800560	*N511Ifs13**	0.4
SKCM	chr11	94420166	Missense_Mutation	NA	P696S	0.07
SKCM	chr11	94492842	5'UTR	novel		0.35
SKCM	chr11	94429953	Silent	NA	S676S	0.36
SKCM	chr11	94492704	Intron	novel		0.53
SKCM	chr11	94435872	Missense_Mutation	NA	E652K	0.16
SKCM	chr11	94471601	Missense_Mutation	rs143400546	S273F	0.38
SKCM	chr11	94459417	Silent	rs199634245	I497I	0.23
SKCM	chr11	94471635	Frame_Shift_Del	novel	*Y262Ifs19**	0.12
SKCM	chr11	94476360	Missense_Mutation	novel	K196N	0.22
SKCM	chr11	94492759	Intron	novel		0.43
STAD	chr11	94456307	Frame_Shift_Del	rs765800560	*N511Ifs13**	0.24
STAD	chr11	94447373	Silent	NA	D543D	0.17
STAD	chr11	94467821	Nonsense_Mutation	rs371077728	R364*	0.25
STAD	chr11	94464154	Missense_Mutation	NA	I395T	0.12
STAD	chr11	94492848	5'UTR	novel		0.12
STAD	chr11	94466525	Intron	novel		0.4
STAD	chr11	94478818	Missense_Mutation	novel	G154E	0.1
STAD	chr11	94456307	Frame_Shift_Del	rs765800560	*N511Ifs13**	0.44
STAD	chr11	94456307	Frame_Shift_Del	rs765800560	*N511Ifs13**	0.31
THCA	chr11	94490898	Frame_Shift_Ins	novel	*A30Sfs7**	0.12
THCA	chr11	94490900	Nonsense_Mutation	novel	*D29delinsVYY**	0.12
THCA	chr11	94490898	In_Frame_Ins	novel	D29_A30insIQ	0.14
UCEC	chr11	94478830	Missense_Mutation	NA	V150A	0.28
UCEC	chr11	94459530	Nonsense_Mutation	NA	E460*	0.33
UCEC	chr11	94492663	Intron	novel		0.07
UCEC	chr11	94429938	Silent	NA	S681S	0.24
UCEC	chr11	94464175	Missense_Mutation	rs587780134	R388Q	0.27
UCEC	chr11	94459428	Missense_Mutation	rs104895016	E494K	0.39
UCEC	chr11	94420105	3'UTR	novel		0.42
UCEC	chr11	94471656	Missense_Mutation	NA	K255E	0.46
UCEC	chr11	94490943	Missense_Mutation	NA	I15L	0.19
UCEC	chr11	94461017	Silent	novel	G415G	0.46
UCEC	chr11	94419880	3'UTR	novel		0.09
UCEC	chr11	94456307	Frame_Shift_Del	rs765800560	*N511Ifs13**	0.46
UCEC	chr11	94466526	Intron	novel		0.38
UCEC	chr11	94490878	Silent	rs763003456	T36T	0.39
UCEC	chr11	94467814	Missense_Mutation	rs773968042	R366Q	0.26
UCEC	chr11	94492643	Intron	novel		0.3
UCEC	chr11	94464158	Missense_Mutation	NA	D394Y	0.3
UCEC	chr11	94460944	Missense_Mutation	rs773469981	A440T	0.17
UCEC	chr11	94456307	Frame_Shift_Del	rs765800560	*N511Ifs13**	0.27
UCEC	chr11	94419880	3'UTR	novel		0.09
UCEC	chr11	94471679	Frame_Shift_Ins	novel	*H247Lfs6**	0.1
UCEC	chr11	94471680	Frame_Shift_Ins	novel	*H247Ffs7**	0.1
UCEC	chr11	94478792	Missense_Mutation	novel	D163Y	0.18
UCEC	chr11	94492709	Intron	rs770546313		0.43
UCEC	chr11	94470635	Missense_Mutation	NA	G285C	0.15
UCEC	chr11	94478876	Missense_Mutation	novel	A135T	0.17
UCEC	chr11	94490862	Nonsense_Mutation	novel	E42*	0.09
UCEC	chr11	94456335	Missense_Mutation	rs186333183	R502C	0.27
UCEC	chr11	94464208	Missense_Mutation	novel	S377N	0.5
UCEC	chr11	94490891	Missense_Mutation	novel	R32K	0.31
UCEC	chr11	94486009	Missense_Mutation	rs779269083	E77K	0.44
UCEC	chr11	94419958	3'UTR	novel		0.45
UCEC	chr11	94420129	Missense_Mutation	novel	R708I	0.32
UCEC	chr11	94459417	Silent	rs199634245	I497I	0.27
UCEC	chr11	94478765	Nonsense_Mutation	novel	G172*	0.47
UCEC	chr11	94459417	Silent	rs199634245	I497I	0.44
UCEC	chr11	94445867	Missense_Mutation	rs750926542	R604C	0.35
UCEC	chr11	94459530	Nonsense_Mutation	NA	E460*	0.09
UCEC	chr11	94492761	Intron	novel		0.38
UCEC	chr11	94420141	Missense_Mutation	novel	R704K	0.19
UCEC	chr11	94435884	Nonsense_Mutation	novel	E648*	0.34
UCEC	chr11	94460933	Splice_Region	novel		0.21
UCEC	chr11	94470569	Missense_Mutation	novel	F307L	0.15
UCEC	chr11	94490883	Missense_Mutation	novel	D35Y	0.39
UCEC	chr11	94447290	Missense_Mutation	novel	G571D	0.23
UCEC	chr11	94461031	Nonsense_Mutation	novel	E411*	0.28
UCEC	chr11	94470474	Missense_Mutation	novel	E338D	0.39
UCEC	chr11	94445840	Missense_Mutation	novel	S613P	0.57
UCEC	chr11	94476376	Missense_Mutation	rs746932208	R191Q	0.53
UCEC	chr11	94419991	3'UTR	novel		0.73
UCEC	chr11	94459428	Missense_Mutation	rs104895016	E494K	0.15
UCEC	chr11	94476350	Missense_Mutation	novel	M200L	0.16
UCEC	chr11	94492881	5'UTR	novel		0.34
UCEC	chr11	94476385	Frame_Shift_Ins	novel	*R188Kfs9**	0.48
UCEC	chr11	94456307	Frame_Shift_Del	rs765800560	*N511Ifs13**	0.32
UCEC	chr11	94470525	Frame_Shift_Del	novel	*F321Lfs8**	0.23
UCEC	chr11	94429938	Silent	NA	S681S	0.25
UCEC	chr11	94459503	Missense_Mutation	novel	A469T	0.19
UCEC	chr11	94456307	Frame_Shift_Del	rs765800560	*N511Ifs13**	0.43
UCEC	chr11	94466540	Intron	novel		0.24
UCEC	chr11	94479676	Frame_Shift_Ins	novel	*G134Wfs32**	0.35
UCEC	chr11	94447296	Missense_Mutation	novel	G569E	0.33
UCEC	chr11	94459503	Missense_Mutation	novel	A469T	0.26
UCEC	chr11	94476385	Missense_Mutation	novel	R188K	0.45
UCS	chr11	94445830	Missense_Mutation	novel	R616I	0.37
UCS	chr11	94490878	Silent	rs763003456	T36T	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1467	0.018342
LUSC	DEL	0.2236	0.00011543
TGCT	DEL	0.74	0.21504
UCS	DEL	0.3929	0.061343

Survival Analysis

Cancer	P-value	Q-value
THYM	0.004	Kaplan-Meier Survival Analysis
SARC	0.047	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
HNSC	0.047	Kaplan-Meier Survival Analysis
SKCM	0.048	Kaplan-Meier Survival Analysis
PRAD	0.0095	Kaplan-Meier Survival Analysis
BRCA	0.018	Kaplan-Meier Survival Analysis
PAAD	0.018	Kaplan-Meier Survival Analysis
BLCA	0.026	Kaplan-Meier Survival Analysis
READ	0.0001	Kaplan-Meier Survival Analysis
KICH	0.025	Kaplan-Meier Survival Analysis
LIHC	0.00089	Kaplan-Meier Survival Analysis
LGG	0.0062	Kaplan-Meier Survival Analysis
CHOL	0.02	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000020922 (Gene tree)
Gene ID: 4361
Gene Symbol: MRE11
Alias: ATLD|MRE11A
Full Name: MRE11 homolog, double strand break repair nuclease
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 96,608 bases
Position: chr11:94,415,578-94,512,185
Accession: 7230
Summary: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27708105	Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.	Science	2016 Sep 30	Kanakkanthara A	-
12007281	Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas.	Pathobiology	2001	Matsutani N	-
26358508	Arabidopsis TAF1 is an MRE11-interacting protein required for resistance to genotoxic stress and viability of the male gametophyte.	Plant J	2015 Nov	Waterworth WM	doi: 10.1111/tpj.13020

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000407439	MRE11-204	2684	-	ENSP00000385614	711 (aa)	-	P49959
ENST00000535120	MRE11-205	234	-	-	- (aa)	-	-
ENST00000540013	MRE11-209	1212	-	ENSP00000440986	221 (aa)	-	F5GXT0
ENST00000536144	MRE11-206	619	-	-	- (aa)	-	-
ENST00000393241	MRE11-203	2604	XM_006718842	ENSP00000376933	707 (aa)	XP_006718905	F8W7U8
ENST00000541157	MRE11-210	594	-	-	- (aa)	-	-
ENST00000323929	MRE11-201	6897	XM_005274008	ENSP00000325863	708 (aa)	XP_005274065	P49959
ENST00000536754	MRE11-207	572	-	ENSP00000439511	127 (aa)	-	F5H256
ENST00000323977	MRE11-202	2588	-	ENSP00000326094	680 (aa)	-	P49959
ENST00000538923	MRE11-208	558	-	ENSP00000442809	111 (aa)	-	F5H742

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03440	Homologous recombination	KEGG
hsa03450	Non-homologous end-joining	KEGG
hsa04218	Cellular senescence	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000020922	Hip	5.05582542858084E-7	17903296
ENSG00000020922	Hip	6.41468097372212E-7	17903296
ENSG00000020922	Hip	3.85985440793942E-6	17903296
ENSG00000020922	Platelet Function Tests	5.2600000E-006	-

Protein-Protein Interaction (PPI)

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Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	9705271.	IDA	Function
GO:0000019	regulation of mitotic recombination	8530104.	TAS	Process
GO:0000723	telomere maintenance	21873635.	IBA	Process
GO:0000724	double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:0000724	double-strand break repair via homologous recombination	29670289.	IDA	Process
GO:0000724	double-strand break repair via homologous recombination	-	TAS	Process
GO:0000729	DNA double-strand break processing	-	TAS	Process
GO:0000781	chromosome, telomeric region	15149599.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000784	nuclear chromosome, telomeric region	21873635.	IBA	Component
GO:0000784	nuclear chromosome, telomeric region	10811102.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	24270157.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	-	ISS	Component
GO:0003677	DNA binding	15790808.	IDA	Function
GO:0003690	double-stranded DNA binding	10802669.	TAS	Function
GO:0004003	ATP-dependent DNA helicase activity	15790808.	IMP	Function
GO:0004518	nuclease activity	15790808.	TAS	Function
GO:0004520	endodeoxyribonuclease activity	9705271.	IDA	Function
GO:0004520	endodeoxyribonuclease activity	-	TAS	Function
GO:0005515	protein binding	12419185.15916964.16377563.17428914.17500065.17500595.17612497.18583988.18716619.19234442.19609304.21052091.22078559.22157895.24529708.24534091.24651726.25558984.25772236.26807646.27568553.28834754.29670289.	IPI	Function
GO:0005634	nucleus	10802669.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005657	replication fork	29290612.	IDA	Component
GO:0005737	cytoplasm	25468996.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006281	DNA repair	9705271.9931460.	TAS	Process
GO:0006302	double-strand break repair	10612394.	TAS	Process
GO:0006303	double-strand break repair via nonhomologous end joining	21873635.	IBA	Process
GO:0006303	double-strand break repair via nonhomologous end joining	9651580.	IDA	Process
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0006310	DNA recombination	9705271.	TAS	Process
GO:0006974	cellular response to DNA damage stimulus	17500065.29670289.	IDA	Process
GO:0007004	telomere maintenance via telomerase	9705271.9931460.	TAS	Process
GO:0007062	sister chromatid cohesion	15917200.	IMP	Process
GO:0007095	mitotic G2 DNA damage checkpoint	21873635.	IBA	Process
GO:0007129	synapsis	-	IEA	Process
GO:0007131	reciprocal meiotic recombination	8530104.9931460.	TAS	Process
GO:0008022	protein C-terminus binding	9590181.	IPI	Function
GO:0008283	cell proliferation	-	IEA	Process
GO:0008296	3'-5'-exodeoxyribonuclease activity	21873635.	IBA	Function
GO:0008408	3'-5' exonuclease activity	21873635.	IBA	Function
GO:0008408	3'-5' exonuclease activity	9651580.9705271.	IDA	Function
GO:0008409	5'-3' exonuclease activity	29670289.	IDA	Function
GO:0016032	viral process	-	IEA	Process
GO:0016605	PML body	10811102.	IDA	Component
GO:0016605	PML body	-	ISS	Component
GO:0030145	manganese ion binding	-	IEA	Function
GO:0030870	Mre11 complex	19151086.	IDA	Component
GO:0030870	Mre11 complex	15790808.	NAS	Component
GO:0030870	Mre11 complex	27918544.	TAS	Component
GO:0031573	intra-S DNA damage checkpoint	21873635.	IBA	Process
GO:0031860	telomeric 3' overhang formation	16374507.	IMP	Process
GO:0031954	positive regulation of protein autophosphorylation	15790808.	IDA	Process
GO:0032206	positive regulation of telomere maintenance	16374507.	IMP	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0032508	DNA duplex unwinding	15790808.	IMP	Process
GO:0032876	negative regulation of DNA endoreduplication	15917200.	IMP	Process
GO:0033674	positive regulation of kinase activity	15790808.	IDA	Process
GO:0035861	site of double-strand break	15916964.	IDA	Component
GO:0042138	meiotic DNA double-strand break formation	21873635.	IBA	Process
GO:0042802	identical protein binding	22078559.	IPI	Function
GO:0043066	negative regulation of apoptotic process	16374507.	IMP	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0097552	mitochondrial double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:0110025	DNA strand resection involved in replication fork processing	29670289.	IDA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process

EuRBPDB

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Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Gene Ontology

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