EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22914783Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancer.J Natl Cancer Inst2012 Oct 3Yuan SSdoi: 10.1093/jnci/djs355
25788520FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis.Hum Mol Genet2015 Jun 15Huang YLdoi: 10.1093/hmg/ddv102
17932350Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.Cancer Epidemiol Biomarkers Prev2007 OctHsu HM-
25310185MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.PLoS One2014 Oct 13Pavelitz Tdoi: 10.1371/journal.pone.0108483
19714462Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.Breast Cancer Res Treat2010 MayLoizidou MAdoi: 10.1007/s10549-009-0518-7
18256278A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.Mol Biol Cell2008 AprWen Qdoi: 10.1091/mbc.E07-09-0975
24625413Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours.Oncotarget2014 Feb 28Martin RM-
23912341Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.Hum Mol Genet2013 Dec 20Regal JAdoi: 10.1093/hmg/ddt368
23046361Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic recombination 11 homolog) predict treatment-specific outcome of localised invasive bladder cancer.BJU Int2012 DecLaurberg JRdoi: 10.1111/j.1464-410X.2012.11564.x
20843819MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.Cancer Res2010 Sep 15Choudhury Adoi: 10.1158/0008-5472.CAN-10-1202.
28133604Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses.Biomed Res Int2017Yang CHdoi: 10.1155/2017/2563910
24894818Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.Breast Cancer Res2014 Jun 3Damiola Fdoi: 10.1186/bcr3669.
24079363The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.Mol Cancer2013 Sep 30Zi??kowska-Suchanek Idoi: 10.1186/1476-4598-12-113.
18830935RAD50/MRE11/NBS1 proteins in relation to tumour development and prognosis in patients with microsatellite stable colorectal cancer.Histol Histopathol2008 DecGao Jdoi: 10.14670/HH-23.1495.
20164540Analysis of the expression of human tumor antigens in ovarian cancer tissues.Cancer Biomark2010Ali-Fehmi Rdoi: 10.3233/CBM-2009-0117.
27798884High Expression of MRE11-RAD50-NBS1 Is Associated with Poor Prognosis and Chemoresistance in Gastric Cancer.Anticancer Res2016 OctAltan B-
18553220DNA-repair genetic polymorphisms and risk of breast cancer in Cyprus.Breast Cancer Res Treat2009 JunLoizidou MAdoi: 10.1007/s10549-008-0084-4
15319296MRE11 expression is impaired in gastric cancer with microsatellite instability.Carcinogenesis2004 DecOttini L-
24623370Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer.Ann Oncol2014 AprTeo MTdoi: 10.1093/annonc/mdu014
24752797Development of serous ovarian cancer is associated with the expression of homologous recombination pathway proteins.Pathol Oncol Res2014 OctYe Qdoi: 10.1007/s12253-014-9776-8
20682289Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells.Biochem Biophys Res Commun2010 Sep 3Kavitha CVdoi: 10.1016/j.bbrc.2010.07.117
11850399Human MRE11 is inactivated in mismatch repair-deficient cancers.EMBO Rep2002 MarGiannini G-
20956948PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation.Oncogene2011 Feb 24Deng Rdoi: 10.1038/onc.2010.467
19383352Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.Mol Oncol2008 DecBartkova Jdoi: 10.1016/j.molonc.2008.09.007
28073364Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.BMC Cancer2017 Jan 10Brandt Sdoi: 10.1186/s12885-016-3026-2.
26735576Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.Oncotarget2016 Apr 26Naccarati Adoi: 10.18632/oncotarget.6804.
30176843Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis.BMC Cancer2018 Sep 3Ho Vdoi: 10.1186/s12885-018-4776-9.
29678143Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population.BMC Cancer2018 Apr 20Podralska Mdoi: 10.1186/s12885-018-4360-3.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1194467860Missense_Mutationrs757492041R351C0.21
BLCAchr1194470597SilentnovelH297H0.23
BLCAchr1194479720Missense_MutationnovelS119L0.25
BLCAchr1194461024Missense_Mutationrs587782457N413S0.33
BLCAchr1194447329Missense_MutationnovelS558F0.5
BLCAchr1194464141SilentnovelF399F0.12
BLCAchr1194467865Missense_MutationNAR349L0.5
BLCAchr11944200813'UTRnovel0.38
BRCAchr1194456332Missense_Mutationrs761458720R503C0.55
BRCAchr1194476296Missense_MutationNAQ218K0.38
BRCAchr1194464133Missense_MutationNAR402K0.16
BRCAchr1194460975SilentNAV429V0.55
CESCchr1194464218Missense_MutationnovelE374Q0.45
CESCchr1194456332Missense_Mutationrs761458720R503C0.61
CESCchr1194437181Nonsense_MutationnovelS641*0.07
CESCchr1194490898Nonsense_MutationnovelA30*0.2
CESCchr1194459510SilentNAE466E0.4
CESCchr1194470536Missense_MutationnovelP318A0.27
COADchr11944200423'UTRnovel0.23
COADchr1194456318SilentNAT507T0.28
COADchr1194447287Missense_Mutationrs200085146R572Q0.27
COADchr1194471711SilentNAD236D0.45
COADchr1194464158Missense_MutationNAD394Y0.08
COADchr1194447245Missense_Mutationrs753717905S586L0.21
COADchr1194445828Missense_MutationNAN617H0.25
COADchr1194486009Missense_Mutationrs779269083E77K0.21
COADchr1194490835Missense_MutationNAE51K0.24
COADchr1194467811Splice_SiteNAX366_splice0.3
COADchr1194471742Nonsense_MutationnovelT226Ifs*20.04
COADchr1194490898Nonsense_MutationnovelA30*0.04
COADchr1194470524Frame_Shift_InsNAN322*0.14
ESCAchr11944928825'UTRnovel0.08
GBMchr1194459523Missense_MutationNAV462E0.06
GBMchr1194467821Nonsense_Mutationrs371077728R364*0.22
GBMchr1194478799Missense_MutationnovelE160D0.45
GBMchr1194466561Intronnovel0.48
GBMchr1194459460Missense_Mutationrs587781378R483Q0.35
HNSCchr1194445869Missense_MutationnovelT603I0.05
HNSCchr1194490895Missense_MutationnovelV31I0.26
HNSCchr1194445854Nonsense_MutationnovelS608*0.25
KIRCchr1194485956SilentNAL94L0.23
KIRCchr1194435852Silentrs772019392T658T0.26
KIRPchr1194490856Missense_MutationNAL44V0.37
KIRPchr1194492792Missense_MutationnovelA4S0.1
LAMLchr1194459479Missense_MutationNAQ477E0.35
LGGchr1194467820Missense_Mutationrs140528613R364Q0.45
LGGchr1194490842Missense_MutationnovelQ48H0.32
LUADchr1194447427Missense_MutationNAR525S0.56
LUADchr1194435857Missense_MutationnovelP657T0.18
LUADchr1194479710SilentNAV122V0.28
LUADchr1194464236Missense_MutationnovelD368Y0.38
LUADchr1194476332Missense_MutationNAD206Y0.08
LUADchr1194464240Splice_SitenovelX367_splice0.28
LUADchr1194471711Missense_MutationnovelD236E0.23
LUADchr1194467868Missense_MutationNAE348V0.39
LUADchr11944928665'UTRnovel0.38
LUADchr1194466570Intronnovel0.12
LUADchr1194486081Missense_MutationNAD53Y0.09
LUADchr1194459551Missense_MutationnovelG453W0.24
LUADchr1194479744Missense_MutationNAY111S0.28
LUADchr1194447263Missense_MutationnovelR580K0.37
LUADchr1194456329Missense_MutationnovelF504V0.5
LUADchr1194464125Missense_MutationnovelK405E0.33
LUADchr1194420169Missense_MutationnovelD695Y0.19
LUSCchr1194447256Silentrs778762259Q582Q0.04
LUSCchr1194467850Missense_MutationnovelN354I0.25
LUSCchr1194447314Missense_MutationNAS563L0.07
LUSCchr1194479735Missense_MutationnovelG114A0.21
LUSCchr1194467863Nonsense_Mutationrs781140391E350*0.17
OVchr1194459583Splice_SiteNAX443_splice0.37
OVchr1194460992Missense_MutationnovelG424R0.08
OVchr1194476351SilentNAT199T0.15
PAADchr1194459416Missense_Mutationrs564511708D498N0.16
READchr1194490928Missense_MutationnovelD20Y0.31
READchr1194420158Missense_MutationnovelM698I0.42
READchr1194437199Missense_MutationnovelV635A0.48
READchr1194456334Missense_Mutationrs767097795R502H0.38
READchr1194466493Intronrs1444199720.43
READchr1194490928Missense_MutationnovelD20Y0.38
SKCMchr1194471708SilentNAF237F0.42
SKCMchr1194447314Missense_MutationNAS563L0.28
SKCMchr1194456307Frame_Shift_Delrs765800560N511Ifs*130.4
SKCMchr1194420166Missense_MutationNAP696S0.07
SKCMchr11944928425'UTRnovel0.35
SKCMchr1194429953SilentNAS676S0.36
SKCMchr1194492704Intronnovel0.53
SKCMchr1194435872Missense_MutationNAE652K0.16
SKCMchr1194471601Missense_Mutationrs143400546S273F0.38
SKCMchr1194459417Silentrs199634245I497I0.23
SKCMchr1194471635Frame_Shift_DelnovelY262Ifs*190.12
SKCMchr1194476360Missense_MutationnovelK196N0.22
SKCMchr1194492759Intronnovel0.43
STADchr1194456307Frame_Shift_Delrs765800560N511Ifs*130.24
STADchr1194447373SilentNAD543D0.17
STADchr1194467821Nonsense_Mutationrs371077728R364*0.25
STADchr1194464154Missense_MutationNAI395T0.12
STADchr11944928485'UTRnovel0.12
STADchr1194466525Intronnovel0.4
STADchr1194478818Missense_MutationnovelG154E0.1
STADchr1194456307Frame_Shift_Delrs765800560N511Ifs*130.44
STADchr1194456307Frame_Shift_Delrs765800560N511Ifs*130.31
THCAchr1194490898Frame_Shift_InsnovelA30Sfs*70.12
THCAchr1194490900Nonsense_MutationnovelD29delinsVY*Y0.12
THCAchr1194490898In_Frame_InsnovelD29_A30insIQ0.14
UCECchr1194478830Missense_MutationNAV150A0.28
UCECchr1194459530Nonsense_MutationNAE460*0.33
UCECchr1194492663Intronnovel0.07
UCECchr1194429938SilentNAS681S0.24
UCECchr1194464175Missense_Mutationrs587780134R388Q0.27
UCECchr1194459428Missense_Mutationrs104895016E494K0.39
UCECchr11944201053'UTRnovel0.42
UCECchr1194471656Missense_MutationNAK255E0.46
UCECchr1194490943Missense_MutationNAI15L0.19
UCECchr1194461017SilentnovelG415G0.46
UCECchr11944198803'UTRnovel0.09
UCECchr1194456307Frame_Shift_Delrs765800560N511Ifs*130.46
UCECchr1194466526Intronnovel0.38
UCECchr1194490878Silentrs763003456T36T0.39
UCECchr1194467814Missense_Mutationrs773968042R366Q0.26
UCECchr1194492643Intronnovel0.3
UCECchr1194464158Missense_MutationNAD394Y0.3
UCECchr1194460944Missense_Mutationrs773469981A440T0.17
UCECchr1194456307Frame_Shift_Delrs765800560N511Ifs*130.27
UCECchr11944198803'UTRnovel0.09
UCECchr1194471679Frame_Shift_InsnovelH247Lfs*60.1
UCECchr1194471680Frame_Shift_InsnovelH247Ffs*70.1
UCECchr1194478792Missense_MutationnovelD163Y0.18
UCECchr1194492709Intronrs7705463130.43
UCECchr1194470635Missense_MutationNAG285C0.15
UCECchr1194478876Missense_MutationnovelA135T0.17
UCECchr1194490862Nonsense_MutationnovelE42*0.09
UCECchr1194456335Missense_Mutationrs186333183R502C0.27
UCECchr1194464208Missense_MutationnovelS377N0.5
UCECchr1194490891Missense_MutationnovelR32K0.31
UCECchr1194486009Missense_Mutationrs779269083E77K0.44
UCECchr11944199583'UTRnovel0.45
UCECchr1194420129Missense_MutationnovelR708I0.32
UCECchr1194459417Silentrs199634245I497I0.27
UCECchr1194478765Nonsense_MutationnovelG172*0.47
UCECchr1194459417Silentrs199634245I497I0.44
UCECchr1194445867Missense_Mutationrs750926542R604C0.35
UCECchr1194459530Nonsense_MutationNAE460*0.09
UCECchr1194492761Intronnovel0.38
UCECchr1194420141Missense_MutationnovelR704K0.19
UCECchr1194435884Nonsense_MutationnovelE648*0.34
UCECchr1194460933Splice_Regionnovel0.21
UCECchr1194470569Missense_MutationnovelF307L0.15
UCECchr1194490883Missense_MutationnovelD35Y0.39
UCECchr1194447290Missense_MutationnovelG571D0.23
UCECchr1194461031Nonsense_MutationnovelE411*0.28
UCECchr1194470474Missense_MutationnovelE338D0.39
UCECchr1194445840Missense_MutationnovelS613P0.57
UCECchr1194476376Missense_Mutationrs746932208R191Q0.53
UCECchr11944199913'UTRnovel0.73
UCECchr1194459428Missense_Mutationrs104895016E494K0.15
UCECchr1194476350Missense_MutationnovelM200L0.16
UCECchr11944928815'UTRnovel0.34
UCECchr1194476385Frame_Shift_InsnovelR188Kfs*90.48
UCECchr1194456307Frame_Shift_Delrs765800560N511Ifs*130.32
UCECchr1194470525Frame_Shift_DelnovelF321Lfs*80.23
UCECchr1194429938SilentNAS681S0.25
UCECchr1194459503Missense_MutationnovelA469T0.19
UCECchr1194456307Frame_Shift_Delrs765800560N511Ifs*130.43
UCECchr1194466540Intronnovel0.24
UCECchr1194479676Frame_Shift_InsnovelG134Wfs*320.35
UCECchr1194447296Missense_MutationnovelG569E0.33
UCECchr1194459503Missense_MutationnovelA469T0.26
UCECchr1194476385Missense_MutationnovelR188K0.45
UCSchr1194445830Missense_MutationnovelR616I0.37
UCSchr1194490878Silentrs763003456T36T0.27

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.14670.018342
LUSCDEL0.22360.00011543
TGCTDEL0.740.21504
UCSDEL0.39290.061343

Survival Analysis
CancerP-value Q-value
THYM0.004

Kaplan-Meier Survival Analysis

SARC0.047

Kaplan-Meier Survival Analysis

ACC0.00018

Kaplan-Meier Survival Analysis

HNSC0.047

Kaplan-Meier Survival Analysis

SKCM0.048

Kaplan-Meier Survival Analysis

PRAD0.0095

Kaplan-Meier Survival Analysis

BRCA0.018

Kaplan-Meier Survival Analysis

PAAD0.018

Kaplan-Meier Survival Analysis

BLCA0.026

Kaplan-Meier Survival Analysis

READ0.0001

Kaplan-Meier Survival Analysis

KICH0.025

Kaplan-Meier Survival Analysis

LIHC0.00089

Kaplan-Meier Survival Analysis

LGG0.0062

Kaplan-Meier Survival Analysis

CHOL0.02

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000020922 (Gene tree)
Gene ID
4361
Gene Symbol
MRE11
Alias
ATLD|MRE11A
Full Name
MRE11 homolog, double strand break repair nuclease
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
96,608 bases
Position
chr11:94,415,578-94,512,185
Accession
7230
RBP type
non-canonical RBP
Summary
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
27708105Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.Science2016 Sep 30Kanakkanthara A-
12007281Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas.Pathobiology2001Matsutani N-
26358508Arabidopsis TAF1 is an MRE11-interacting protein required for resistance to genotoxic stress and viability of the male gametophyte.Plant J2015 NovWaterworth WMdoi: 10.1111/tpj.13020
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000407439MRE11-2042684-ENSP00000385614711 (aa)-P49959
ENST00000535120MRE11-205234--- (aa)--
ENST00000540013MRE11-2091212-ENSP00000440986221 (aa)-F5GXT0
ENST00000536144MRE11-206619--- (aa)--
ENST00000393241MRE11-2032604XM_006718842ENSP00000376933707 (aa)XP_006718905F8W7U8
ENST00000541157MRE11-210594--- (aa)--
ENST00000323929MRE11-2016897XM_005274008ENSP00000325863708 (aa)XP_005274065P49959
ENST00000536754MRE11-207572-ENSP00000439511127 (aa)-F5H256
ENST00000323977MRE11-2022588-ENSP00000326094680 (aa)-P49959
ENST00000538923MRE11-208558-ENSP00000442809111 (aa)-F5H742
Gene Model
Click here to download ENSG00000020922's gene model file
Pathways
Pathway IDPathway NameSource
hsa03440Homologous recombinationKEGG
hsa03450Non-homologous end-joiningKEGG
hsa04218Cellular senescenceKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000020922Hip5.05582542858084E-717903296
ENSG00000020922Hip6.41468097372212E-717903296
ENSG00000020922Hip3.85985440793942E-617903296
ENSG00000020922Platelet Function Tests5.2600000E-006-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000020922's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000014single-stranded DNA endodeoxyribonuclease activity9705271.IDAFunction
GO:0000019regulation of mitotic recombination8530104.TASProcess
GO:0000723telomere maintenance21873635.IBAProcess
GO:0000724double-strand break repair via homologous recombination21873635.IBAProcess
GO:0000724double-strand break repair via homologous recombination29670289.IDAProcess
GO:0000724double-strand break repair via homologous recombination-TASProcess
GO:0000729DNA double-strand break processing-TASProcess
GO:0000781chromosome, telomeric region15149599.IDAComponent
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0000784nuclear chromosome, telomeric region21873635.IBAComponent
GO:0000784nuclear chromosome, telomeric region10811102.IDAComponent
GO:0000784nuclear chromosome, telomeric region24270157.IDAComponent
GO:0000784nuclear chromosome, telomeric region-ISSComponent
GO:0003677DNA binding15790808.IDAFunction
GO:0003690double-stranded DNA binding10802669.TASFunction
GO:0004003ATP-dependent DNA helicase activity15790808.IMPFunction
GO:0004518nuclease activity15790808.TASFunction
GO:0004520endodeoxyribonuclease activity9705271.IDAFunction
GO:0004520endodeoxyribonuclease activity-TASFunction
GO:0005515protein binding12419185.15916964.16377563.17428914.17500065.17500595.17612497.18583988.18716619.19234442.19609304.21052091.22078559.22157895.24529708.24534091.24651726.25558984.25772236.26807646.27568553.28834754.29670289.IPIFunction
GO:0005634nucleus10802669.TASComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005657replication fork29290612.IDAComponent
GO:0005737cytoplasm25468996.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006260DNA replication-TASProcess
GO:0006281DNA repair9705271.9931460.TASProcess
GO:0006302double-strand break repair10612394.TASProcess
GO:0006303double-strand break repair via nonhomologous end joining21873635.IBAProcess
GO:0006303double-strand break repair via nonhomologous end joining9651580.IDAProcess
GO:0006303double-strand break repair via nonhomologous end joining-TASProcess
GO:0006310DNA recombination9705271.TASProcess
GO:0006974cellular response to DNA damage stimulus17500065.29670289.IDAProcess
GO:0007004telomere maintenance via telomerase9705271.9931460.TASProcess
GO:0007062sister chromatid cohesion15917200.IMPProcess
GO:0007095mitotic G2 DNA damage checkpoint21873635.IBAProcess
GO:0007129synapsis-IEAProcess
GO:0007131reciprocal meiotic recombination8530104.9931460.TASProcess
GO:0008022protein C-terminus binding9590181.IPIFunction
GO:0008283cell proliferation-IEAProcess
GO:00082963'-5'-exodeoxyribonuclease activity21873635.IBAFunction
GO:00084083'-5' exonuclease activity21873635.IBAFunction
GO:00084083'-5' exonuclease activity9651580.9705271.IDAFunction
GO:00084095'-3' exonuclease activity29670289.IDAFunction
GO:0016032viral process-IEAProcess
GO:0016605PML body10811102.IDAComponent
GO:0016605PML body-ISSComponent
GO:0030145manganese ion binding-IEAFunction
GO:0030870Mre11 complex19151086.IDAComponent
GO:0030870Mre11 complex15790808.NASComponent
GO:0030870Mre11 complex27918544.TASComponent
GO:0031573intra-S DNA damage checkpoint21873635.IBAProcess
GO:0031860telomeric 3' overhang formation16374507.IMPProcess
GO:0031954positive regulation of protein autophosphorylation15790808.IDAProcess
GO:0032206positive regulation of telomere maintenance16374507.IMPProcess
GO:0032481positive regulation of type I interferon production-TASProcess
GO:0032508DNA duplex unwinding15790808.IMPProcess
GO:0032876negative regulation of DNA endoreduplication15917200.IMPProcess
GO:0033674positive regulation of kinase activity15790808.IDAProcess
GO:0035861site of double-strand break15916964.IDAComponent
GO:0042138meiotic DNA double-strand break formation21873635.IBAProcess
GO:0042802identical protein binding22078559.IPIFunction
GO:0043066negative regulation of apoptotic process16374507.IMPProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0097552mitochondrial double-strand break repair via homologous recombination21873635.IBAProcess
GO:0110025DNA strand resection involved in replication fork processing29670289.IDAProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
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