EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25542233The effect of benzyl isothiocyanate and its computer-aided design derivants targeting alkylglycerone phosphate synthase on the inhibition of human glioma U87MG cell line.Tumour Biol2015 MayZhu Ydoi: 10.1007/s13277-014-2986-6
24815474Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines.Asian Pac J Cancer Prev2014Zhu Y-
23980144Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity.Proc Natl Acad Sci U S A2013 Sep 10Benjamin DIdoi: 10.1073/pnas.1310894110

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr2177420352Missense_MutationnovelG115V0.39
BLCAchr2177499639Nonsense_MutationnovelQ462*0.23
BLCAchr2177482096Missense_MutationNAI381M0.16
BLCAchr2177434354SilentnovelP126P0.43
BLCAchr2177513883Nonsense_MutationnovelQ558*0.8
BLCAchr2177538113Missense_MutationNAS632C0.28
BLCAchr2177497747SilentNAK448K0.67
BLCAchr21775382753'UTRnovel0.39
BLCAchr2177436843Missense_MutationnovelS174L0.06
BRCAchr21775382273'UTRrs7807911580.51
BRCAchr21775384073'UTRnovel0.3
BRCAchr2177437020Missense_MutationNAM201I0.09
BRCAchr2177393004Missense_MutationnovelT72M0.24
BRCAchr2177436782Missense_MutationNAD154N0.18
BRCAchr21775384123'UTRnovel0.23
CESCchr2177461985Missense_MutationnovelM321I0.46
CESCchr21775382143'UTRnovel0.26
CESCchr2177440964Splice_SitenovelX213_splice0.36
CESCchr2177436881Missense_MutationNAH187Y0.23
CESCchr2177497697Missense_MutationNAL432V0.29
CESCchr2177505564Missense_MutationnovelA512T0.5
CHOLchr21775382063'UTRnovel0.63
COADchr2177462012Missense_MutationNAE330D0.39
COADchr2177445603Missense_MutationnovelT283S0.09
COADchr2177497719Frame_Shift_DelnovelF440Lfs*80.24
COADchr2177434378SilentNAN134N0.39
COADchr21775382143'UTRnovel0.44
COADchr21775382143'UTRnovel0.4
COADchr2177538077Missense_MutationNAG620D0.13
COADchr21775382273'UTRnovel0.19
COADchr21775382273'UTRrs7807911580.47
COADchr2177436867Missense_MutationNAR182Q0.06
COADchr2177462006SilentnovelN328N0.07
ESCAchr2177461971Missense_Mutationrs375775258R317C0.15
ESCAchr2177440997Missense_MutationnovelL224V0.29
ESCAchr2177434388Missense_MutationnovelV138L0.11
ESCAchr2177468503Missense_MutationnovelH362Y0.37
GBMchr2177436843Nonsense_MutationNAS174*0.4
HNSCchr2177437028Missense_MutationNAR204L0.31
HNSCchr2177461896Frame_Shift_DelnovelE293Kfs*180.47
HNSCchr2177523766Missense_MutationnovelI606V0.23
HNSCchr2177420292Missense_MutationnovelG95V0.25
HNSCchr2177436855Missense_MutationnovelE178A0.07
KIRCchr2177461938Missense_MutationNAE306Q0.35
KIRCchr2177521344Nonsense_MutationnovelL592Nfs*30.05
KIRPchr2177437028Missense_MutationNAR204L0.04
KIRPchr2177436770Missense_MutationNAL150V0.06
KIRPchr2177393019Missense_MutationNAA77V0.58
LGGchr2177461950Missense_MutationnovelV310I0.15
LGGchr2177521312Missense_MutationNAF581V0.34
LIHCchr2177505564Missense_MutationnovelA512T0.36
LIHCchr2177392795SilentnovelA2A0.44
LIHCchr21773927705'UTRnovel0.16
LUADchr2177513823Missense_MutationNAV538L0.24
LUADchr2177441034Missense_MutationnovelG236V0.15
LUADchr2177392794Missense_MutationnovelA2E0.6
LUADchr2177445594Missense_MutationNAA280S0.11
LUADchr2177461973Silentrs146526791R317R0.07
LUADchr2177497766Splice_SitenovelX454_splice0.33
LUADchr2177513906Splice_RegionnovelC565C0.27
LUADchr2177538093SilentNAQ625Q0.07
LUADchr2177437053Splice_RegionnovelP212P0.29
LUSCchr2177521365Frame_Shift_DelnovelE599Gfs*40.09
LUSCchr21775382443'UTRnovel0.38
LUSCchr2177505517Missense_MutationnovelA496G0.09
LUSCchr2177505526Missense_MutationnovelD499G0.48
LUSCchr2177482119Missense_MutationNAK389T0.09
LUSCchr2177538144SilentnovelV642V0.16
LUSCchr2177442473Missense_MutationnovelD259V0.28
LUSCchr21775382463'UTRnovel0.26
LUSCchr2177420351Frame_Shift_DelnovelR117Gfs*220.1
LUSCchr2177523782Missense_MutationnovelG611V0.13
MESOchr2177434381SilentnovelT135T0.24
OVchr21775382273'UTRrs7807911580.47
OVchr2177437027SilentNAR204R0.12
PRADchr2177538099SilentnovelL627L0.21
PRADchr2177521308SilentnovelF579F0.29
PRADchr2177493158Missense_Mutationrs144444120P415L0.38
READchr2177499709Frame_Shift_Insnovel0.06
READchr2177493186SilentnovelK424K0.52
READchr2177437028Missense_MutationNAR204Q0.43
SKCMchr2177508004Missense_MutationNAS527F0.21
SKCMchr2177499632SilentnovelD459D0.32
SKCMchr2177499675Missense_MutationnovelR474C0.35
SKCMchr2177436991Missense_MutationnovelH192Y0.16
SKCMchr2177461978Missense_MutationNAS319L0.16
SKCMchr2177434404Missense_MutationNAK143T0.65
SKCMchr2177482062Missense_MutationNAT370I0.23
SKCMchr2177508021Missense_MutationnovelP533S0.23
SKCMchr2177521268Splice_SiteNAX566_splice0.16
SKCMchr2177521269Splice_RegionnovelR566R0.16
STADchr2177499685Missense_MutationNAV477A0.29
STADchr2177441015Missense_MutationNAL230I0.15
STADchr21775382143'UTRnovel0.24
STADchr21775382273'UTRrs7807911580.54
STADchr21775382143'UTRnovel0.14
STADchr2177497719Frame_Shift_DelnovelF440Lfs*80.16
STADchr2177521335Silentrs772375722I588I0.06
STADchr2177434362Missense_MutationnovelK129T0.34
STADchr21775382273'UTRnovel0.26
STADchr2177523807Splice_SitenovelX619_splice0.34
STADchr2177521351Missense_Mutationrs764836897V594I0.16
STADchr2177521284Silentrs773126499Y571Y0.51
THCAchr2177420358Nonsense_MutationnovelY118Kfs*40.09
THYMchr2177497722Missense_MutationnovelF440S0.06
UCECchr21775384203'UTRnovel0.8
UCECchr21775383193'UTRnovel0.38
UCECchr2177482079Nonsense_MutationNAE376*0.31
UCECchr2177445550Missense_MutationNAR265Q0.35
UCECchr2177538166Missense_MutationNAN650D0.29
UCECchr2177482082Missense_MutationnovelA377T0.45
UCECchr21775381983'UTRrs7621953510.52
UCECchr2177434327Splice_RegionnovelR117R0.31
UCECchr2177436773Missense_MutationnovelN151H0.48
UCECchr21775381983'UTRrs7621953510.36
UCECchr2177499721Missense_MutationnovelA489V0.43
UCECchr2177420359Splice_SitenovelX117_splice0.09
UCECchr21775383043'UTRnovel0.38
UCECchr2177392962Missense_MutationnovelC58Y0.4
UCECchr2177521350Silentrs753841033T593T0.58
UCECchr2177445550Missense_MutationNAR265Q0.48
UCECchr2177497744Frame_Shift_DelnovelK449Sfs*150.32
UCECchr2177523752Missense_MutationnovelA601D0.41
UCECchr2177437028Missense_MutationNAR204Q0.35
UCECchr2177442486Missense_MutationnovelM263I0.38
UCECchr2177437020Missense_MutationNAM201I0.44
UCECchr2177482064Missense_MutationnovelL371I0.4
UCECchr2177461893Missense_MutationnovelL291F0.41
UCECchr2177497750Missense_MutationnovelK449N0.14
UCECchr2177493200Splice_SitenovelX429_splice0.27
UCECchr2177499690Nonsense_MutationnovelQ479*0.33
UCECchr2177497748Missense_MutationnovelK449E0.35
UCECchr2177499675Missense_MutationnovelR474C0.53
UCECchr2177523748Missense_MutationnovelA600T0.35
UCECchr2177436830Missense_MutationnovelE170K0.19
UCECchr2177505574Missense_MutationnovelR515Q0.09
UCECchr2177513829Missense_MutationNAL540I0.44
UCECchr2177436769SilentNAS149S0.25
UCECchr2177521284Silentrs773126499Y571Y0.06
UCECchr2177523769Frame_Shift_InsNAA608Cfs*20.43
UCECchr2177499727Missense_MutationNAF491C0.15
UCECchr2177445545Splice_SiteNAX264_splice0.33
UCECchr2177437027Nonsense_MutationnovelR204*0.39
UCECchr2177513847Nonsense_MutationnovelE546*0.43
UCECchr21775382893'UTRnovel0.28
UCECchr2177445550Missense_MutationNAR265Q0.42
UCECchr21775382473'UTRnovel0.5
UCECchr2177523805Missense_MutationnovelV619L0.38

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.11860.012962
PAADAMP0.05980.1091
PAADDEL0.03260.2014

Survival Analysis
CancerP-value Q-value
THYM0.017

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

MESO0.0002

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

UCS0.032

Kaplan-Meier Survival Analysis

HNSC0.011

Kaplan-Meier Survival Analysis

SKCM0.016

Kaplan-Meier Survival Analysis

COAD0.0062

Kaplan-Meier Survival Analysis

PAAD0.00097

Kaplan-Meier Survival Analysis

CESC0.0069

Kaplan-Meier Survival Analysis

READ0.033

Kaplan-Meier Survival Analysis

LIHC0.00017

Kaplan-Meier Survival Analysis

THCA0.014

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000018510 (Gene tree)
Gene ID
8540
Gene Symbol
AGPS
Alias
ADHAPS|ADAS|ALDHPSY|ADPS|ADAP-S
Full Name
alkylglycerone phosphate synthase
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
166,656 bases
Position
chr2:177,392,644-177,559,299
Accession
327
RBP type
non-canonical RBP
Summary
This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000460342AGPS-203576--- (aa)--
ENST00000637633AGPS-2042143-ENSP00000490844543 (aa)-A0A1B0GWA2
ENST00000409888AGPS-202815-ENSP00000386688189 (aa)-B8ZZ81
ENST00000642466AGPS-2052273-ENSP00000494433560 (aa)-A0A2R8YEL0
ENST00000264167AGPS-2017764XM_011512041ENSP00000264167658 (aa)XP_011510343O00116
Gene Model
Click here to download ENSG00000018510's gene model file
Pathways
Pathway IDPathway NameSource
hsa00565Ether lipid metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa04146PeroxisomeKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000018510Insulin5.94238606994105E-817903298
ENSG00000018510Echocardiography1.20879885520644E-517903301
ENSG00000018510Platelet Function Tests1.8342300E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000018510rs13488502177553847AAlanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)28090653[1.02-1.46]1.22EFO_0004735|EFO_0007965|EFO_0000220
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000018510's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000018510AGPS9854.426WBGene00000081ads-19653.927Caenorhabditis_elegans
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005515protein binding25416956.IPIFunction
GO:0005730nucleolus-IDAComponent
GO:0005739mitochondrion20833797.HDAComponent
GO:0005777peroxisome9553082.10415121.IDAComponent
GO:0005778peroxisomal membrane21525035.HDAComponent
GO:0005782peroxisomal matrix-TASComponent
GO:0005829cytosol-TASComponent
GO:0006625protein targeting to peroxisome-TASProcess
GO:0008609alkylglycerone-phosphate synthase activity9553082.10415121.IDAFunction
GO:0008610lipid biosynthetic process9553082.IDAProcess
GO:0008611ether lipid biosynthetic process-IEAProcess
GO:0008611ether lipid biosynthetic process-ISSProcess
GO:0008611ether lipid biosynthetic process-TASProcess
GO:0016020membrane19946888.HDAComponent
GO:0016491oxidoreductase activity-IEAFunction
GO:0055114oxidation-reduction process-IEAProcess
GO:0071949FAD binding-ISSFunction
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