EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30313031	Expression of resistance gene and prognosis of chemotherapy in primary epithelial ovarian cancer.	Medicine (Baltimore)	2018 Oct	Yang F	doi: 10.1097/MD.0000000000012364.
18200595	Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia.	Cytometry B Clin Cytom	2008 May	de Figueiredo-Pontes LL	doi: 10.1002/cyto.b.20403.
17178862	Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein.	Cancer Res	2006 Dec 15	Minaguchi T	-
15379935	Increased expression of lung resistance-related protein in lower grade urothelial carcinoma of the renal pelvis and ureter.	Int J Urol	2004 Sep	Kong CZ	-
21344396	p53 Suppresses lung resistance-related protein expression through Y-box binding protein 1 in the MCF-7 breast tumor cell line.	J Cell Physiol	2011 Dec	Tian B	doi: 10.1002/jcp.22700.
19660100	Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression.	Radiat Oncol	2009 Aug 6	Lara PC	doi: 10.1186/1748-717X-4-29.
12622134	Major vault protein/lung resistance-related protein (MVP/LRP) expression in nervous system tumors.	Brain Tumor Pathol	2002	Sasaki T	-
21793937	The expression and significance of MRP1, LRP, TOPOIIβ, and BCL2 in tongue squamous cell carcinoma.	J Oral Pathol Med	2012 Feb	Zhang B	doi: 10.1111/j.1600-0714.2011.01066.x
19472297	Age associated high level of major vault protein is p53 dependent.	Cell Biochem Funct	2009 Jul	An HJ	doi: 10.1002/cbf.1571.
22117969	Lung resistance protein and multidrug resistance protein in non-small cell lung cancer and their clinical significance.	J Int Med Res	2011	Chen ZJ	-
19080004	[Correlations of EGFR and LRP to chemotherapy resistance and prognosis of ovarian cancer].	Ai Zheng	2008 Dec	Zhang J	-
22235652	[The structure of cellular vaults, their role in the normal cell and in the multidrug resistance of cancer].	Postepy Biochem	2011	Szaflarski W	-
26632382	Concomitance of P-gp/LRP Expression with EGFR Mutations in Exons 19 and 21 in Non-Small Cell Lung Cancers.	Yonsei Med J	2016 Jan	Wei H	doi: 10.3349/ymj.2016.57.1.50.
26754263	Association between single-nucleotide polymorphisms in DNA double-strand break repair genes and prostate cancer aggressiveness in the Spanish population.	Prostate Cancer Prostatic Dis	2016 Mar	Henr??quez-Hern??ndez LA	doi: 10.1038/pcan.2015.63
27706681	Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.	Genet Mol Res	2016 Sep 2	Jiang YQ	doi: 10.4238/gmr.15038336.
23178631	The effect of TRAIL on the expression of multidrug resistant genes MDR1, LRP and GST-?? in drug-resistant gastric cancer cell SGC7901/VCR.	Hepatogastroenterology	2012 Nov-Dec	Zhang KG	doi: 10.5754/hge11850.
12576456	RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.	Clin Cancer Res	2003 Feb	Burger H	-
19875192	Association of expression of MRP1, BCRP, LRP and ERCC1 with outcome of patients with locally advanced non-small cell lung cancer who received neoadjuvant chemotherapy.	Lung Cancer	2010 Jul	Li J	doi: 10.1016/j.lungcan.2009.09.013
24997994	Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.	Mol Cell Proteomics	2015 Jan	Pasillas MP	doi: 10.1074/mcp.M114.037697
27817195	Mechanisms underlying lung resistance-related protein (LRP)-mediated doxorubicin resistance of non-small cell lung cancer cells.	Chin J Physiol	2016 Dec 31	Chen YL	-
28551640	vPARP Adjusts MVP Expression in Drug-resistant Cell Lines in Conjunction with MDR Proteins.	Anticancer Res	2017 Jun	Wojtowicz K	-
27664836	Search for KPNA7 cargo proteins in human cells reveals MVP and ZNF414 as novel regulators of cancer cell growth.	Biochim Biophys Acta Mol Basis Dis	2017 Jan	Vuorinen EM	doi: 10.1016/j.bbadis.2016.09.015

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr16	29842075	Missense_Mutation	NA	D533N	0.15
BLCA	chr16	29845923	Silent	novel	L694L	0.26
BLCA	chr16	29844593	Missense_Mutation	NA	V579L	0.6
BLCA	chr16	29841595	Splice_Site	NA	X398_splice	0.24
BLCA	chr16	29845954	Missense_Mutation	novel	E705Q	0.2
BLCA	chr16	29841638	Missense_Mutation	NA	E412K	0.51
BLCA	chr16	29841638	Missense_Mutation	NA	E412K	0.35
BLCA	chr16	29844614	Missense_Mutation	novel	V586F	0.38
BLCA	chr16	29847383	Nonsense_Mutation	novel	Q818*	0.2
BLCA	chr16	29842082	Missense_Mutation	novel	A535V	0.18
BRCA	chr16	29833999	Missense_Mutation	novel	Q170H	0.15
BRCA	chr16	29841799	Silent	rs774680750	N465N	0.38
BRCA	chr16	29840354	Silent	NA	P362P	0.25
BRCA	chr16	29833846	Silent	rs777830582	F145F	0.31
BRCA	chr16	29836796	Nonsense_Mutation	NA	W249*	0.14
CESC	chr16	29834017	Silent	novel	L176L	0.48
CESC	chr16	29847948	Missense_Mutation	NA	Q881E	0.11
CESC	chr16	29844870	Missense_Mutation	novel	A671V	0.22
CESC	chr16	29830559	Missense_Mutation	novel	E4K	0.42
CHOL	chr16	29844578	Missense_Mutation	novel	A574S	0.1
COAD	chr16	29844685	Silent	rs113018337	S609S	0.15
COAD	chr16	29833995	Frame_Shift_Del	novel	*R169Sfs23**	0.32
COAD	chr16	29835752	Missense_Mutation	novel	F209Y	0.08
COAD	chr16	29840289	Nonsense_Mutation	novel	E341*	0.24
COAD	chr16	29844605	Missense_Mutation	rs763449040	V583M	0.42
COAD	chr16	29841928	Missense_Mutation	NA	P484S	0.12
COAD	chr16	29830997	Missense_Mutation	rs142974213	R82Q	0.76
COAD	chr16	29833846	Silent	rs777830582	F145F	0.15
COAD	chr16	29834024	Missense_Mutation	rs746050112	R179C	0.14
COAD	chr16	29846239	Silent	rs761767691	S740S	0.11
COAD	chr16	29833762	Silent	NA	P117P	0.49
COAD	chr16	29844653	Missense_Mutation	novel	I599V	0.32
COAD	chr16	29847231	Missense_Mutation	novel	E767A	0.52
COAD	chr16	29848019	3'UTR	novel		0.12
COAD	chr16	29830910	Missense_Mutation	NA	V53A	0.05
COAD	chr16	29841770	Missense_Mutation	rs114581451	R456C	0.36
COAD	chr16	29830911	Frame_Shift_Del	NA	*P55Hfs69**	0.36
COAD	chr16	29844656	Missense_Mutation	rs779418542	R600C	0.47
COAD	chr16	29846197	Silent	rs139422591	A726A	0.26
ESCA	chr16	29846191	Silent	rs749354165	A724A	0.36
ESCA	chr16	29834043	Missense_Mutation	rs769471740	R185Q	0.25
ESCA	chr16	29844583	Silent	rs372666702	I575I	0.3
ESCA	chr16	29844815	Missense_Mutation	novel	A653T	0.25
GBM	chr16	29836803	Missense_Mutation	novel	T252A	0.21
GBM	chr16	29831017	Missense_Mutation	rs765084274	E89K	0.21
GBM	chr16	29834025	Missense_Mutation	rs758642200	R179H	0.23
GBM	chr16	29842023	Silent	novel	C515C	0.35
GBM	chr16	29833804	Missense_Mutation	novel	D131E	0.11	Vault
GBM	chr16	29835781	Missense_Mutation	rs145238038	V219I	0.7
GBM	chr16	29844657	Missense_Mutation	NA	R600H	0.2
GBM	chr16	29844627	Missense_Mutation	novel	D590A	0.07
HNSC	chr16	29847385	Splice_Region	novel	Q818Q	0.3
HNSC	chr16	29833779	In_Frame_Ins	novel	L123_K124insVFLWLP	0.05	Vault
HNSC	chr16	29833846	Silent	rs777830582	F145F	0.49
HNSC	chr16	29841757	Silent	rs778668067	P451P	0.39
KIRC	chr16	29847228	Missense_Mutation	rs3815823	R766Q	0.35
KIRC	chr16	29841791	Missense_Mutation	NA	P463T	0.09
KIRC	chr16	29830476	Intron	novel		0.38
KIRC	chr16	29847281	Missense_Mutation	rs200956879	A784T	0.3
KIRP	chr16	29836798	Missense_Mutation	NA	L250R	0.07
LIHC	chr16	29836787	Silent	novel	G246G	0.38
LIHC	chr16	29847312	Missense_Mutation	rs555637285	K794T	0.12
LIHC	chr16	29836730	Silent	novel	L227L	0.24
LIHC	chr16	29835702	Splice_Site	novel	X193_splice	0.27
LIHC	chr16	29847914	Silent	novel	G869G	0.4
LIHC	chr16	29836913	Silent	rs765833197	V288V	0.19
LIHC	chr16	29830489	Intron	novel		0.36
LUAD	chr16	29845873	Missense_Mutation	NA	Q678E	0.11
LUAD	chr16	29830960	Nonsense_Mutation	novel	Q70*	0.06
LUAD	chr16	29836780	Missense_Mutation	NA	R244L	0.4
LUAD	chr16	29847847	Missense_Mutation	novel	G847V	0.41
LUAD	chr16	29833793	Missense_Mutation	NA	D128H	0.22	Vault
LUAD	chr16	29847985	Missense_Mutation	novel	R893P	0.39
LUAD	chr16	29834026	Silent	NA	R179R	0.18
LUAD	chr16	29833967	Missense_Mutation	novel	V160L	0.15
LUSC	chr16	29834025	Missense_Mutation	rs758642200	R179H	0.44
LUSC	chr16	29840198	Silent	rs770847927	L310L	0.26
LUSC	chr16	29847867	Missense_Mutation	rs766972215	E854K	0.42
LUSC	chr16	29841952	Missense_Mutation	novel	E492K	0.6
LUSC	chr16	29844539	Missense_Mutation	NA	L561F	0.44
LUSC	chr16	29836894	Missense_Mutation	novel	C282F	0.28
LUSC	chr16	29841785	Missense_Mutation	novel	R461S	0.17
LUSC	chr16	29834130	Intron	novel		0.36
LUSC	chr16	29836780	Missense_Mutation	NA	R244L	0.17
MESO	chr16	29833960	Silent	novel	V157V	0.05
MESO	chr16	29833961	Nonsense_Mutation	novel	E158*	0.05
OV	chr16	29844521	Missense_Mutation	novel	P555S	0.16
OV	chr16	29841834	Missense_Mutation	rs748570854	R477Q	0.2
OV	chr16	29845885	Missense_Mutation	novel	Q682K	0.07
OV	chr16	29847784	Missense_Mutation	novel	G826V	0.08
OV	chr16	29836815	Missense_Mutation	NA	T256A	0.14
PAAD	chr16	29841638	Missense_Mutation	NA	E412K	0.16
PAAD	chr16	29836786	Missense_Mutation	novel	G246V	0.08
PAAD	chr16	29831002	Missense_Mutation	rs146114293	R84C	0.19
PAAD	chr16	29841924	Silent	rs748325373	F482F	0.2
PRAD	chr16	29841695	Frame_Shift_Ins	novel	*Q431Rfs120**	0.15
PRAD	chr16	29830898	Missense_Mutation	rs560872333	R49H	0.4
PRAD	chr16	29836740	Missense_Mutation	novel	A231T	0.32
PRAD	chr16	29842017	Silent	rs578151102	A513A	0.46
SARC	chr16	29841623	Missense_Mutation	novel	M407V	0.14
SKCM	chr16	29831044	Missense_Mutation	rs754544174	P98S	0.52
SKCM	chr16	29836786	Missense_Mutation	novel	G246E	0.36
SKCM	chr16	29836754	Silent	NA	F235F	0.26
SKCM	chr16	29830627	Silent	NA	S26S	0.45
SKCM	chr16	29841758	Missense_Mutation	rs372484922	R452W	0.48
SKCM	chr16	29847778	Missense_Mutation	rs781429024	S824F	0.2
SKCM	chr16	29847873	Nonsense_Mutation	NA	Q856*	0.12
SKCM	chr16	29847925	Missense_Mutation	rs111546502	S873F	0.43
SKCM	chr16	29835722	Missense_Mutation	NA	T199I	0.2
SKCM	chr16	29841929	Missense_Mutation	novel	P484L	0.2
SKCM	chr16	29840203	Missense_Mutation	NA	P312L	0.15
SKCM	chr16	29834002	Silent	novel	N171N	0.28
SKCM	chr16	29831044	Missense_Mutation	rs754544174	P98S	0.5
SKCM	chr16	29845867	Missense_Mutation	NA	E676K	0.38
SKCM	chr16	29841975	Silent	NA	S499S	0.23
SKCM	chr16	29841755	Missense_Mutation	NA	P451S	0.2
SKCM	chr16	29830598	Missense_Mutation	NA	H17Y	0.4
SKCM	chr16	29847954	Missense_Mutation	novel	P883S	0.59
SKCM	chr16	29830960	Nonsense_Mutation	novel	Q70*	0.39
SKCM	chr16	29842066	Missense_Mutation	rs769739441	E530K	0.35
SKCM	chr16	29835787	Missense_Mutation	rs762222128	L221F	0.27
SKCM	chr16	29830627	Silent	NA	S26S	0.36
SKCM	chr16	29844656	Missense_Mutation	rs779418542	R600C	0.38
STAD	chr16	29847296	Missense_Mutation	NA	E789K	0.15
STAD	chr16	29841745	Missense_Mutation	NA	Q447H	0.13
STAD	chr16	29835734	Missense_Mutation	rs755247776	A203V	0.33
STAD	chr16	29830579	Frame_Shift_Del	novel	*P12Hfs40**	0.24
STAD	chr16	29845896	Silent	rs149725123	R685R	0.47
STAD	chr16	29834030	Nonsense_Mutation	novel	E181*	0.3
STAD	chr16	29844657	Missense_Mutation	NA	R600H	0.32
STAD	chr16	29841921	Silent	NA	V481V	0.14
STAD	chr16	29830497	Intron	novel		0.3
STAD	chr16	29841942	Silent	rs537113581	S488S	0.25
STAD	chr16	29834047	Silent	rs772883962	D186D	0.21
STAD	chr16	29834012	Missense_Mutation	rs753938190	R175W	0.32
STAD	chr16	29835723	Silent	rs766590067	T199T	0.3
STAD	chr16	29847195	Splice_Site	novel	X756_splice	0.25
STAD	chr16	29844775	Silent	rs747731704	D639D	0.16
STAD	chr16	29836949	Silent	rs747145264	R300R	0.12
STAD	chr16	29841973	Missense_Mutation	NA	S499P	0.16
STAD	chr16	29831008	Missense_Mutation	rs754161146	A86T	0.23
THYM	chr16	29836895	Silent	rs761735258	C282C	0.08
UCEC	chr16	29841799	Silent	rs774680750	N465N	0.42
UCEC	chr16	29833785	Missense_Mutation	NA	A125V	0.25	Vault
UCEC	chr16	29830918	Missense_Mutation	rs141230585	R56C	0.4
UCEC	chr16	29847976	Missense_Mutation	novel	P890L	0.16
UCEC	chr16	29844623	Missense_Mutation	NA	D589N	0.38
UCEC	chr16	29844627	Missense_Mutation	novel	D590G	0.38
UCEC	chr16	29840358	Missense_Mutation	novel	E364K	0.37
UCEC	chr16	29841943	Missense_Mutation	novel	L489M	0.38
UCEC	chr16	29836857	Missense_Mutation	novel	V270I	0.18
UCEC	chr16	29840380	Missense_Mutation	novel	V371A	0.4
UCEC	chr16	29841740	Missense_Mutation	novel	L446F	0.4
UCEC	chr16	29844690	Missense_Mutation	novel	A611V	0.39
UCEC	chr16	29844870	Missense_Mutation	novel	A671V	0.58
UCEC	chr16	29833769	Missense_Mutation	NA	A120T	0.25	Vault
UCEC	chr16	29841788	Missense_Mutation	rs776161545	V462M	0.31
UCEC	chr16	29842012	Missense_Mutation	rs140949055	R512C	0.13
UCEC	chr16	29845879	Missense_Mutation	NA	L680M	0.21
UCEC	chr16	29844845	Missense_Mutation	rs758260116	E663K	0.2
UCEC	chr16	29847841	Missense_Mutation	NA	A845V	0.23
UCEC	chr16	29840346	Missense_Mutation	rs150899988	R360C	0.56
UCEC	chr16	29841942	Silent	rs537113581	S488S	0.46
UCEC	chr16	29845945	Missense_Mutation	novel	A702S	0.36
UCEC	chr16	29830911	Frame_Shift_Del	NA	*P55Hfs69**	0.23
UCEC	chr16	29841638	Missense_Mutation	NA	E412K	0.45
UCEC	chr16	29842012	Missense_Mutation	rs140949055	R512C	0.33
UCEC	chr16	29844660	Missense_Mutation	novel	T601I	0.34
UCEC	chr16	29830658	Missense_Mutation	NA	R37W	0.3
UCEC	chr16	29842013	Missense_Mutation	rs745924270	R512H	0.3
UCEC	chr16	29846190	Missense_Mutation	rs772703096	A724V	0.29
UCEC	chr16	29830529	5'UTR	novel		0.42
UCEC	chr16	29844873	Missense_Mutation	NA	A672V	0.39
UCEC	chr16	29830579	Frame_Shift_Del	novel	*P12Hfs40**	0.36
UCEC	chr16	29846274	Missense_Mutation	novel	A752V	0.21
UCEC	chr16	29847984	Missense_Mutation	rs34437030	R893C	0.57
UCEC	chr16	29836780	Missense_Mutation	rs561716536	R244H	0.33
UCEC	chr16	29841599	Missense_Mutation	rs758676231	R399C	0.42
UCEC	chr16	29841740	Missense_Mutation	NA	L446I	0.31
UCEC	chr16	29830528	5'UTR	novel		0.39
UCEC	chr16	29833786	Silent	rs760234729	A125A	0.42
UCEC	chr16	29835728	Missense_Mutation	novel	V201A	0.07
UCEC	chr16	29841754	Silent	rs756859817	A450A	0.19
UCEC	chr16	29830911	Frame_Shift_Del	NA	*P55Hfs69**	0.2
UCEC	chr16	29848018	3'UTR	novel		0.36
UCEC	chr16	29836834	Missense_Mutation	NA	D262V	0.5
UCEC	chr16	29830658	Missense_Mutation	NA	R37W	0.55
UCEC	chr16	29844656	Missense_Mutation	rs779418542	R600C	0.43
UCEC	chr16	29842065	Silent	novel	I529I	0.2
UCEC	chr16	29845973	Missense_Mutation	novel	A711V	0.46
UCEC	chr16	29834011	Silent	novel	L174L	0.26
UCEC	chr16	29834043	Missense_Mutation	rs769471740	R185Q	0.3
UCEC	chr16	29842070	Missense_Mutation	rs773178461	T531M	0.55
UCEC	chr16	29846205	Missense_Mutation	rs562114790	R729H	0.45
UCEC	chr16	29831029	Missense_Mutation	novel	A93T	0.33
UCEC	chr16	29844556	Missense_Mutation	novel	D566E	0.38
UCEC	chr16	29845948	Missense_Mutation	novel	R703C	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.0556	0.23475
LUAD	AMP	0.2461	0.20955

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0086	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
SKCM	0.0011	Kaplan-Meier Survival Analysis
LUSC	0.021	Kaplan-Meier Survival Analysis
BRCA	0.012	Kaplan-Meier Survival Analysis
KIRP	0.00083	Kaplan-Meier Survival Analysis
PAAD	0.017	Kaplan-Meier Survival Analysis
BLCA	0.04	Kaplan-Meier Survival Analysis
LAML	0.00012	Kaplan-Meier Survival Analysis
KICH	0.034	Kaplan-Meier Survival Analysis
LIHC	0.042	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.03	Kaplan-Meier Survival Analysis
UVM	0.00079	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000013364 (Gene tree)
Gene ID: 9961
Gene Symbol: MVP
Alias: LRP|VAULT1
Full Name: major vault protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 27,646 bases
Position: chr16:29,820,394-29,848,039
Accession: 7531
RBP type: canonical RBP
Summary: This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000349977	Vault	PF01505.18	5.5e-57	1	4
ENSP00000349977	Vault	PF01505.18	5.5e-57	2	4
ENSP00000349977	Vault	PF01505.18	5.5e-57	3	4
ENSP00000349977	Vault	PF01505.18	5.5e-57	4	4
ENSP00000378760	Vault	PF01505.18	5.5e-57	1	4
ENSP00000378760	Vault	PF01505.18	5.5e-57	2	4
ENSP00000378760	Vault	PF01505.18	5.5e-57	3	4
ENSP00000378760	Vault	PF01505.18	5.5e-57	4	4
ENSP00000455819	Vault	PF01505.18	4.5e-31	1	2
ENSP00000455819	Vault	PF01505.18	4.5e-31	2	2
ENSP00000456291	Vault	PF01505.18	2.2e-11	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23820674	Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells.	Int J Mol Med	2013 Sep	Tajitsu Y	doi: 10.3892/ijmm.2013.1428

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000570061	MVP-217	674	-	-	- (aa)	-	-
ENST00000566859	MVP-213	589	-	ENSP00000455741	81 (aa)	-	H3BQE7
ENST00000395353	MVP-202	2925	-	ENSP00000378760	893 (aa)	-	Q14764
ENST00000563558	MVP-206	548	-	ENSP00000454825	144 (aa)	-	H3BNF6
ENST00000566554	MVP-212	811	-	-	- (aa)	-	-
ENST00000563915	MVP-207	854	-	ENSP00000455819	220 (aa)	-	H3BQK6
ENST00000565830	MVP-209	557	-	-	- (aa)	-	-
ENST00000569887	MVP-216	549	-	ENSP00000455532	39 (aa)	-	H3BPZ2
ENST00000568068	MVP-214	561	-	-	- (aa)	-	-
ENST00000629059	MVP-219	120	-	ENSP00000486166	39 (aa)	-	H3BPZ2
ENST00000562463	MVP-203	525	-	ENSP00000457734	57 (aa)	-	H3BUP3
ENST00000570234	MVP-218	658	-	ENSP00000456291	148 (aa)	-	H3BRL2
ENST00000357402	MVP-201	2870	-	ENSP00000349977	893 (aa)	-	Q14764
ENST00000563096	MVP-204	546	-	-	- (aa)	-	-
ENST00000566252	MVP-211	408	-	ENSP00000457685	107 (aa)	-	H3BUK7
ENST00000563123	MVP-205	575	-	ENSP00000458583	61 (aa)	-	I3L155
ENST00000566066	MVP-210	548	-	ENSP00000455186	94 (aa)	-	H3BP76
ENST00000565164	MVP-208	211	-	ENSP00000454819	42 (aa)	-	H3BNF2
ENST00000569612	MVP-215	2091	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000013364's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000013364's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000013364	MVP	96	86.842	ENSAPOG00000008671	mvp	98	69.381	Acanthochromis_polyacanthus
ENSG00000013364	MVP	100	97.619	ENSAMEG00000014878	MVP	100	92.022	Ailuropoda_melanoleuca
ENSG00000013364	MVP	98	86.842	ENSACIG00000024427	mvp	98	70.877	Amphilophus_citrinellus
ENSG00000013364	MVP	62	69.120	ENSAOCG00000021379	mvp	96	69.686	Amphiprion_ocellaris
ENSG00000013364	MVP	94	76.136	ENSAOCG00000016534	mvp	73	72.391	Amphiprion_ocellaris
ENSG00000013364	MVP	96	86.842	ENSAPEG00000007015	mvp	98	69.575	Amphiprion_percula
ENSG00000013364	MVP	98	86.842	ENSATEG00000017429	mvp	99	68.942	Anabas_testudineus
ENSG00000013364	MVP	89	81.481	ENSAPLG00000010706	MVP	92	70.000	Anas_platyrhynchos
ENSG00000013364	MVP	90	92.105	ENSACAG00000014742	MVP	97	72.973	Anolis_carolinensis
ENSG00000013364	MVP	100	100.000	ENSANAG00000025785	MVP	99	96.413	Aotus_nancymaae
ENSG00000013364	MVP	98	84.211	ENSACLG00000016512	mvp	98	68.304	Astatotilapia_calliptera
ENSG00000013364	MVP	99	84.615	ENSAMXG00000039149	mvp	98	69.781	Astyanax_mexicanus
ENSG00000013364	MVP	100	92.857	ENSBTAG00000007952	MVP	100	90.225	Bos_taurus
ENSG00000013364	MVP	100	98.182	ENSCJAG00000007166	MVP	99	96.749	Callithrix_jacchus
ENSG00000013364	MVP	100	95.327	ENSCAFG00000016970	MVP	100	91.348	Canis_familiaris
ENSG00000013364	MVP	100	97.619	ENSCAFG00020017730	MVP	100	91.461	Canis_lupus_dingo
ENSG00000013364	MVP	100	95.238	ENSCHIG00000007963	MVP	100	90.337	Capra_hircus
ENSG00000013364	MVP	100	95.745	ENSTSYG00000004093	MVP	100	91.732	Carlito_syrichta
ENSG00000013364	MVP	100	88.095	ENSCAPG00000015186	MVP	99	84.607	Cavia_aperea
ENSG00000013364	MVP	100	88.095	ENSCPOG00000007374	MVP	99	89.895	Cavia_porcellus
ENSG00000013364	MVP	100	96.818	ENSCCAG00000026419	-	95	95.704	Cebus_capucinus
ENSG00000013364	MVP	100	98.649	ENSCCAG00000033828	-	100	96.386	Cebus_capucinus
ENSG00000013364	MVP	100	100.000	ENSCATG00000036298	MVP	100	94.513	Cercocebus_atys
ENSG00000013364	MVP	100	90.476	ENSCLAG00000011381	MVP	99	88.652	Chinchilla_lanigera
ENSG00000013364	MVP	100	100.000	ENSCSAG00000006120	MVP	99	99.215	Chlorocebus_sabaeus
ENSG00000013364	MVP	95	87.500	ENSCPBG00000012775	-	97	76.842	Chrysemys_picta_bellii
ENSG00000013364	MVP	100	76.316	ENSCING00000012198	-	98	64.603	Ciona_intestinalis
ENSG00000013364	MVP	100	100.000	ENSCANG00000041427	MVP	100	79.162	Colobus_angolensis_palliatus
ENSG00000013364	MVP	100	97.619	ENSCGRG00001015253	Mvp	99	92.065	Cricetulus_griseus_chok1gshd
ENSG00000013364	MVP	100	97.619	ENSCGRG00000006655	Mvp	99	92.065	Cricetulus_griseus_crigri
ENSG00000013364	MVP	96	86.486	ENSCSEG00000008233	mvp	95	68.046	Cynoglossus_semilaevis
ENSG00000013364	MVP	96	82.051	ENSCVAG00000014286	mvp	97	69.045	Cyprinodon_variegatus
ENSG00000013364	MVP	96	89.189	ENSDARG00000021242	mvp	97	69.778	Danio_rerio
ENSG00000013364	MVP	100	95.238	ENSDNOG00000040061	MVP	100	90.568	Dasypus_novemcinctus
ENSG00000013364	MVP	100	92.857	ENSDORG00000007996	Mvp	100	89.741	Dipodomys_ordii
ENSG00000013364	MVP	97	91.667	ENSETEG00000004009	MVP	91	82.748	Echinops_telfairi
ENSG00000013364	MVP	87	62.420	ENSEBUG00000003566	-	98	62.420	Eptatretus_burgeri
ENSG00000013364	MVP	100	73.810	ENSEBUG00000016025	-	94	63.212	Eptatretus_burgeri
ENSG00000013364	MVP	100	73.810	ENSEBUG00000002336	-	92	65.000	Eptatretus_burgeri
ENSG00000013364	MVP	100	95.270	ENSEASG00005013194	MVP	98	94.042	Equus_asinus_asinus
ENSG00000013364	MVP	100	94.595	ENSECAG00000025091	MVP	100	91.910	Equus_caballus
ENSG00000013364	MVP	100	97.619	ENSEEUG00000015545	MVP	80	92.739	Erinaceus_europaeus
ENSG00000013364	MVP	99	86.842	ENSELUG00000024149	mvp	100	67.995	Esox_lucius
ENSG00000013364	MVP	100	98.131	ENSFCAG00000014153	MVP	100	92.472	Felis_catus
ENSG00000013364	MVP	100	92.857	ENSFDAG00000007611	MVP	99	87.456	Fukomys_damarensis
ENSG00000013364	MVP	100	73.810	ENSFHEG00000022085	mvp	98	70.025	Fundulus_heteroclitus
ENSG00000013364	MVP	94	77.273	ENSGMOG00000018225	mvp	99	75.349	Gadus_morhua
ENSG00000013364	MVP	89	83.333	ENSGALG00000040471	MVP	99	68.845	Gallus_gallus
ENSG00000013364	MVP	100	82.051	ENSGAFG00000020182	mvp	99	67.162	Gambusia_affinis
ENSG00000013364	MVP	93	79.487	ENSGACG00000015023	mvp	99	66.161	Gasterosteus_aculeatus
ENSG00000013364	MVP	89	81.481	ENSGAGG00000018515	MVP	99	71.817	Gopherus_agassizii
ENSG00000013364	MVP	100	100.000	ENSGGOG00000015603	MVP	100	99.888	Gorilla_gorilla
ENSG00000013364	MVP	98	84.211	ENSHBUG00000019312	mvp	98	69.829	Haplochromis_burtoni
ENSG00000013364	MVP	100	95.238	ENSHGLG00000019034	MVP	99	88.453	Heterocephalus_glaber_female
ENSG00000013364	MVP	100	95.238	ENSHGLG00100017258	MVP	99	68.627	Heterocephalus_glaber_male
ENSG00000013364	MVP	96	81.579	ENSHCOG00000002602	mvp	97	69.124	Hippocampus_comes
ENSG00000013364	MVP	99	84.211	ENSIPUG00000002045	mvp	98	70.104	Ictalurus_punctatus
ENSG00000013364	MVP	100	93.919	ENSSTOG00000001480	MVP	99	84.049	Ictidomys_tridecemlineatus
ENSG00000013364	MVP	100	95.238	ENSJJAG00000015211	Mvp	99	90.341	Jaculus_jaculus
ENSG00000013364	MVP	100	79.487	ENSKMAG00000009170	mvp	98	67.394	Kryptolebias_marmoratus
ENSG00000013364	MVP	96	86.842	ENSLBEG00000012831	mvp	98	67.384	Labrus_bergylta
ENSG00000013364	MVP	99	84.211	ENSLACG00000006862	MVP	98	70.657	Latimeria_chalumnae
ENSG00000013364	MVP	100	88.636	ENSLAFG00000005520	-	100	86.458	Loxodonta_africana
ENSG00000013364	MVP	100	100.000	ENSMFAG00000032090	MVP	100	99.440	Macaca_fascicularis
ENSG00000013364	MVP	100	100.000	ENSMMUG00000016422	MVP	100	99.328	Macaca_mulatta
ENSG00000013364	MVP	100	100.000	ENSMNEG00000039450	MVP	100	98.992	Macaca_nemestrina
ENSG00000013364	MVP	100	100.000	ENSMLEG00000036661	MVP	100	99.328	Mandrillus_leucophaeus
ENSG00000013364	MVP	98	86.842	ENSMAMG00000017792	mvp	98	68.686	Mastacembelus_armatus
ENSG00000013364	MVP	98	84.211	ENSMZEG00005002831	mvp	98	69.829	Maylandia_zebra
ENSG00000013364	MVP	93	79.487	ENSMGAG00000003200	MVP	96	74.257	Meleagris_gallopavo
ENSG00000013364	MVP	100	97.619	ENSMAUG00000009864	Mvp	99	92.299	Mesocricetus_auratus
ENSG00000013364	MVP	100	97.619	ENSMICG00000010206	MVP	99	93.274	Microcebus_murinus
ENSG00000013364	MVP	100	97.619	ENSMOCG00000021967	Mvp	99	92.182	Microtus_ochrogaster
ENSG00000013364	MVP	96	86.842	ENSMMOG00000012669	mvp	97	66.706	Mola_mola
ENSG00000013364	MVP	96	85.315	ENSMODG00000015756	MVP	94	84.155	Monodelphis_domestica
ENSG00000013364	MVP	100	86.842	ENSMALG00000019911	mvp	96	69.825	Monopterus_albus
ENSG00000013364	MVP	100	97.619	MGP_CAROLIEiJ_G0030478	Mvp	99	91.949	Mus_caroli
ENSG00000013364	MVP	100	97.619	ENSMUSG00000030681	Mvp	99	91.832	Mus_musculus
ENSG00000013364	MVP	100	97.619	MGP_PahariEiJ_G0013688	Mvp	99	92.065	Mus_pahari
ENSG00000013364	MVP	100	97.619	MGP_SPRETEiJ_G0031592	Mvp	99	91.715	Mus_spretus
ENSG00000013364	MVP	100	97.619	ENSMPUG00000012462	MVP	89	91.685	Mustela_putorius_furo
ENSG00000013364	MVP	100	97.619	ENSMLUG00000012898	MVP	100	81.159	Myotis_lucifugus
ENSG00000013364	MVP	100	97.619	ENSNGAG00000012766	Mvp	99	90.136	Nannospalax_galili
ENSG00000013364	MVP	100	100.000	ENSNLEG00000007564	-	100	74.132	Nomascus_leucogenys
ENSG00000013364	MVP	91	85.926	ENSMEUG00000014942	MVP	90	85.475	Notamacropus_eugenii
ENSG00000013364	MVP	100	95.238	ENSOPRG00000009511	MVP	100	89.574	Ochotona_princeps
ENSG00000013364	MVP	100	88.095	ENSODEG00000015812	MVP	99	80.377	Octodon_degus
ENSG00000013364	MVP	98	86.842	ENSONIG00000009362	mvp	99	70.526	Oreochromis_niloticus
ENSG00000013364	MVP	100	88.095	ENSOANG00000007170	MVP	98	82.807	Ornithorhynchus_anatinus
ENSG00000013364	MVP	100	97.619	ENSOCUG00000008668	MVP	100	90.787	Oryctolagus_cuniculus
ENSG00000013364	MVP	99	82.051	ENSORLG00000019976	mvp	99	66.667	Oryzias_latipes
ENSG00000013364	MVP	100	82.051	ENSORLG00020000633	mvp	100	68.750	Oryzias_latipes_hni
ENSG00000013364	MVP	99	82.051	ENSOMEG00000020196	mvp	99	67.691	Oryzias_melastigma
ENSG00000013364	MVP	100	96.818	ENSOGAG00000010511	MVP	99	89.586	Otolemur_garnettii
ENSG00000013364	MVP	100	95.238	ENSOARG00000005356	MVP	100	90.022	Ovis_aries
ENSG00000013364	MVP	100	100.000	ENSPPAG00000036492	MVP	100	95.521	Pan_paniscus
ENSG00000013364	MVP	100	100.000	ENSPTRG00000007971	MVP	100	100.000	Pan_troglodytes
ENSG00000013364	MVP	100	100.000	ENSPANG00000016369	MVP	100	99.328	Papio_anubis
ENSG00000013364	MVP	98	81.579	ENSPKIG00000018322	mvp	99	63.850	Paramormyrops_kingsleyae
ENSG00000013364	MVP	100	86.842	ENSPMGG00000006617	mvp	99	68.488	Periophthalmus_magnuspinnatus
ENSG00000013364	MVP	98	97.561	ENSPEMG00000000532	Mvp	99	91.472	Peromyscus_maniculatus_bairdii
ENSG00000013364	MVP	96	88.811	ENSPCIG00000025128	MVP	94	84.525	Phascolarctos_cinereus
ENSG00000013364	MVP	100	82.051	ENSPFOG00000009770	mvp	98	67.506	Poecilia_formosa
ENSG00000013364	MVP	51	69.048	ENSPLAG00000016176	mvp	82	58.857	Poecilia_latipinna
ENSG00000013364	MVP	100	73.810	ENSPLAG00000016028	mvp	92	67.797	Poecilia_latipinna
ENSG00000013364	MVP	100	82.051	ENSPMEG00000009616	mvp	98	67.735	Poecilia_mexicana
ENSG00000013364	MVP	100	82.051	ENSPREG00000011953	mvp	98	67.543	Poecilia_reticulata
ENSG00000013364	MVP	100	97.619	ENSPPYG00000019352	-	99	94.619	Pongo_abelii
ENSG00000013364	MVP	100	99.545	ENSPPYG00000007257	-	98	99.419	Pongo_abelii
ENSG00000013364	MVP	100	95.238	ENSPCAG00000010750	MVP	78	92.517	Procavia_capensis
ENSG00000013364	MVP	100	95.946	ENSPCOG00000007547	MVP	99	93.498	Propithecus_coquereli
ENSG00000013364	MVP	100	95.238	ENSPVAG00000017213	MVP	99	86.756	Pteropus_vampyrus
ENSG00000013364	MVP	98	84.211	ENSPNYG00000012193	mvp	99	70.960	Pundamilia_nyererei
ENSG00000013364	MVP	99	84.615	ENSPNAG00000004713	mvp	97	69.907	Pygocentrus_nattereri
ENSG00000013364	MVP	100	97.619	ENSRNOG00000020182	Mvp	98	91.482	Rattus_norvegicus
ENSG00000013364	MVP	100	100.000	ENSRBIG00000032912	MVP	100	96.098	Rhinopithecus_bieti
ENSG00000013364	MVP	100	100.000	ENSRROG00000032290	MVP	100	99.328	Rhinopithecus_roxellana
ENSG00000013364	MVP	100	100.000	ENSSBOG00000022115	MVP	99	96.525	Saimiri_boliviensis_boliviensis
ENSG00000013364	MVP	96	89.423	ENSSHAG00000009673	MVP	98	82.884	Sarcophilus_harrisii
ENSG00000013364	MVP	98	80.488	ENSSFOG00015001397	mvp	97	68.119	Scleropages_formosus
ENSG00000013364	MVP	94	86.486	ENSSMAG00000014869	mvp	99	66.156	Scophthalmus_maximus
ENSG00000013364	MVP	98	86.842	ENSSDUG00000006071	mvp	97	69.550	Seriola_dumerili
ENSG00000013364	MVP	100	95.238	ENSSARG00000013146	-	79	92.216	Sorex_araneus
ENSG00000013364	MVP	93	94.872	ENSSPUG00000010594	MVP	99	73.357	Sphenodon_punctatus
ENSG00000013364	MVP	98	84.615	ENSSPAG00000018918	mvp	98	69.310	Stegastes_partitus
ENSG00000013364	MVP	100	97.619	ENSSSCG00000027946	MVP	100	90.111	Sus_scrofa
ENSG00000013364	MVP	99	86.842	ENSTRUG00000000022	mvp	98	69.176	Takifugu_rubripes
ENSG00000013364	MVP	100	86.842	ENSTNIG00000006502	mvp	99	68.930	Tetraodon_nigroviridis
ENSG00000013364	MVP	100	97.872	ENSTBEG00000007045	MVP	93	92.111	Tupaia_belangeri
ENSG00000013364	MVP	100	97.619	ENSTTRG00000005451	MVP	100	90.471	Tursiops_truncatus
ENSG00000013364	MVP	100	97.619	ENSUMAG00000011153	-	97	94.301	Ursus_maritimus
ENSG00000013364	MVP	100	97.619	ENSVVUG00000026093	MVP	100	91.461	Vulpes_vulpes
ENSG00000013364	MVP	89	83.333	ENSXETG00000004670	mvp	99	68.237	Xenopus_tropicalis
ENSG00000013364	MVP	100	75.510	ENSXCOG00000004286	mvp	97	67.462	Xiphophorus_couchianus
ENSG00000013364	MVP	100	75.510	ENSXMAG00000009640	mvp	98	67.277	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	15133037.16815308.18809583.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	15133037.16441665.	IDA	Component
GO:0005643	nuclear pore	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	16441665.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005856	cytoskeleton	16441665.	IDA	Component
GO:0015031	protein transport	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019901	protein kinase binding	16441665.	IPI	Function
GO:0019903	protein phosphatase binding	15133037.	IDA	Function
GO:0023057	negative regulation of signaling	16441665.	IDA	Process
GO:0031953	negative regulation of protein autophosphorylation	16441665.	IDA	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0038127	ERBB signaling pathway	15133037.	IDA	Process
GO:0042802	identical protein binding	21988832.25416956.	IPI	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0048471	perinuclear region of cytoplasm	16441665.	IDA	Component
GO:0051028	mRNA transport	-	IEA	Process
GO:0061099	negative regulation of protein tyrosine kinase activity	16441665.	IDA	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.21362503.	HDA	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.