EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18280813Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.Biochim Biophys Acta2008 AprGolden Tdoi: 10.1016/j.bbadis.2008.01.004
24327656The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.J Biol Chem2014 Jan 31Connarn JNdoi: 10.1074/jbc.M113.519421
28534961Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells.Int J Oncol2017 JulChen Mdoi: 10.3892/ijo.2017.3997
30280322Interactions of cantharidin-like inhibitors with human protein phosphatase-5 in a Mg2+ system: molecular dynamics and quantum calculations.J Mol Model2018 Oct 2Assis LCdoi: 10.1007/s00894-018-3837-y.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1946353912Missense_MutationnovelI96F0.46
BLCAchr1946388576SilentnovelR400R0.08
BLCAchr1946387522Intronnovel0.59
BLCAchr1946390124Missense_MutationnovelT477S0.47
BLCAchr1946387193Silentrs371076132F335F0.56
BLCAchr1946353868Missense_Mutationrs776101874A81V0.6
BLCAchr19463470475'UTRnovel0.5
BLCAchr1946388725Missense_MutationnovelN450S0.09
BLCAchr1946387124Missense_MutationnovelI312M0.14
BLCAchr1946390287Missense_MutationnovelH481Y0.57
BLCAchr1946388698Missense_Mutationrs753540087R441H0.24
BRCAchr1946383379Intronnovel0.31
BRCAchr1946375675Missense_MutationNAQ145H0.13
BRCAchr1946387166SilentNAQ326Q0.12
BRCAchr1946390080Missense_MutationNAI462T0.38
BRCAchr1946383425SilentNAV216V0.27
BRCAchr1946387418Missense_MutationNAR367Q0.27
BRCAchr1946353745Splice_Regionnovel0.2
BRCAchr1946388690Silentrs752596841H438H0.26
CESCchr1946347172Missense_MutationNAK26E0.53
CESCchr1946353964Missense_Mutationrs749045957R113Q0.23
CESCchr1946384906Nonsense_MutationnovelR301*0.06
CESCchr1946383862Missense_MutationNAS261L0.1
CESCchr1946387172SilentNAY328Y0.35
CESCchr1946387435Nonsense_MutationnovelR373*0.42
CESCchr1946390103Missense_MutationnovelR470W0.33
CESCchr19463907783'UTRnovel0.56
CESCchr1946375669SilentnovelV143V0.31
CHOLchr1946388682Missense_MutationnovelV436M0.42
COADchr1946353837Missense_MutationNAA71T0.19
COADchr1946387133SilentNAF315F0.42
COADchr1946353765Missense_MutationNAA47T0.27
COADchr1946375696Silentrs775576018I152I0.36
COADchr1946347135Frame_Shift_Insrs766639242R16Pfs*70.32
COADchr1946387429Missense_MutationNAR371W0.31
COADchr1946390104Missense_Mutationrs148346594R470Q0.3
COADchr1946376500Missense_MutationNAT187A0.4
COADchr1946347136Frame_Shift_DelNAR16Gfs*100.35
COADchr1946353765Missense_MutationNAA47T0.24
COADchr1946387193Silentrs371076132F335F0.11
COADchr1946390308Missense_MutationnovelA488T0.08
COADchr1946383866SilentnovelE262E0.24
COADchr1946387101Missense_MutationnovelE305K0.34
DLBCchr1946375702SilentNAG154G0.6
GBMchr1946387442In_Frame_InsnovelP375_P376insITTS0.17
GBMchr1946387444Frame_Shift_InsnovelP376Hfs*80.05
GBMchr1946387499Intronnovel0.55
GBMchr1946375604Missense_MutationnovelV122M0.12
HNSCchr1946353829Missense_MutationnovelR68L0.25
HNSCchr1946376566Missense_MutationnovelA209T0.18
HNSCchr1946388621Missense_MutationnovelL415F0.14
HNSCchr1946387499Intronnovel0.43
HNSCchr1946388658Missense_MutationNAE428K0.21
HNSCchr1946376562SilentnovelK207K0.31
KIRCchr1946384879Missense_MutationnovelL292V0.08
KIRPchr1946384862Missense_MutationnovelL286H0.23
KIRPchr1946388225Intronnovel0.38
LIHCchr1946390319SilentnovelN491N0.26
LIHCchr19463903643'UTRnovel0.26
LIHCchr1946347203Missense_MutationNAN36S0.17
LIHCchr1946353984Missense_MutationNAE120Q0.19
LIHCchr1946390130Missense_MutationnovelV479L0.26
LIHCchr1946388415Missense_MutationnovelM381I0.35
LIHCchr1946353791Silentrs374930457I55I0.28
LIHCchr1946388164Intronnovel0.36
LIHCchr1946387431SilentNAR371R0.29
LUADchr1946353886Missense_MutationnovelR87L0.11
LUADchr1946353887SilentnovelR87R0.12
LUADchr1946375697Missense_MutationNAA153S0.31
LUADchr1946387419SilentnovelR367R0.5
LUADchr1946353869SilentnovelA81A0.29
LUADchr1946347136Frame_Shift_DelNAR16Gfs*101
LUSCchr1946390291Missense_MutationnovelP482L0.23
LUSCchr1946375741Silentrs144237776I167I0.26
MESOchr1946387621Intronnovel0.23
OVchr1946383829Missense_MutationnovelL250H0.06
OVchr1946388626Missense_MutationnovelE417V0.05
OVchr1946387189Missense_MutationnovelV334A0.3
PAADchr1946375741Silentrs144237776I167I0.11
PRADchr1946347133Frame_Shift_DelnovelE13Gfs*60.58
PRADchr1946388697Missense_Mutationrs376107784R441C0.35
READchr1946383843Missense_Mutationrs758489583E255K0.17
READchr1946387193Silentrs371076132F335F0.27
READchr1946347136Frame_Shift_DelNAR16Gfs*100.25
READchr1946383435Missense_MutationnovelL220V0.5
READchr1946353937Missense_MutationnovelA104D0.56
SARCchr1946388582SilentnovelV402V0.43
SARCchr1946376567Missense_Mutationrs199770924A209V0.27
SARCchr1946376568SilentnovelA209A0.26
SKCMchr1946375720Silentrs754692842S160S0.29
SKCMchr1946387514Intronnovel0.31
SKCMchr1946388691Missense_Mutationrs775331289G439R0.3
SKCMchr1946388692Missense_MutationnovelG439E0.3
SKCMchr1946388711SilentnovelV445V0.34
SKCMchr1946383777Splice_Regionnovel0.56
SKCMchr1946383818SilentnovelQ246Q0.16
SKCMchr1946353766Missense_MutationNAA47V0.25
SKCMchr1946388615Silentrs777439537A413A0.19
STADchr1946383797SilentNAV239V0.31
STADchr1946387185Missense_MutationNAE333K0.24
STADchr1946353919Missense_MutationNAG98D0.62
STADchr1946390097Missense_MutationNAD468N0.21
STADchr1946353983SilentNAY119Y0.13
STADchr1946353867Missense_MutationNAA81T0.3
STADchr1946388679Missense_Mutationrs767506672E435K0.1
STADchr1946387379Missense_MutationNAG354D0.26
STADchr1946376473Missense_MutationNAG178R0.25
STADchr1946347136Frame_Shift_DelNAR16Gfs*100.63
STADchr1946383851Silentrs781056485N257N0.24
UCECchr1946387429Missense_MutationNAR371W0.3
UCECchr1946383843Missense_Mutationrs758489583E255K0.32
UCECchr1946383821Silentrs762149325F247F0.36
UCECchr1946387234Missense_MutationnovelL349R0.37
UCECchr19463903723'UTRnovel0.68
UCECchr1946384828Nonsense_MutationnovelR275*0.39
UCECchr19463903563'UTRrs7522098700.42
UCECchr19463904783'UTRnovel0.1
UCECchr1946387172SilentNAY328Y0.26
UCECchr1946387502Intronnovel0.27
UCECchr19463903523'UTRrs5590377180.34
UCECchr1946375702SilentNAG154G0.5
UCECchr1946387445Missense_MutationnovelP376L0.41
UCECchr1946388714Missense_MutationnovelF446L0.33
UCECchr1946375666Silentrs372807877I142I0.39
UCECchr19463905153'UTRnovel0.14
UCECchr1946353968Silentrs770696659A114A0.43
UCECchr19463904503'UTRnovel0.55
UCECchr1946347137Missense_Mutationrs150667064P14H0.43
UCECchr1946387418Missense_MutationNAR367Q0.38
UCECchr1946390332SilentnovelL496L0.36
UCECchr1946375721Missense_Mutationrs780928951V161M0.07
UCECchr1946390323SilentNAL493L0.33
UCECchr1946387184SilentnovelS332S0.15
UCECchr1946390322Silentrs146393311T492T0.43
UCECchr1946388718Missense_MutationNAA448T0.32
UCECchr1946375721Missense_Mutationrs780928951V161M0.45
UCECchr1946388575Missense_MutationNAR400Q0.21
UCECchr1946376475SilentnovelG178G0.29
UCECchr1946347213Missense_MutationNAF39L0.34
UCECchr1946384906Nonsense_MutationnovelR301*0.1
UCECchr1946388556Missense_MutationnovelG394W0.48
UCECchr1946387396Missense_Mutationrs780293038G360S0.44

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.08810.027508
KIRPDEL0.04860.054726
LUADDEL0.251.5526e-05
LUSCDEL0.21161.1877e-06
OVDEL0.47322.441e-17
PAADDEL0.07070.035089
READDEL0.07270.23023
TGCTDEL0.28670.0046229
UCSDEL0.21430.12448

Survival Analysis
CancerP-value Q-value
SARC0.047

Kaplan-Meier Survival Analysis

MESO0.00015

Kaplan-Meier Survival Analysis

SKCM0.024

Kaplan-Meier Survival Analysis

PRAD0.026

Kaplan-Meier Survival Analysis

PAAD0.034

Kaplan-Meier Survival Analysis

CESC0.048

Kaplan-Meier Survival Analysis

LAML0.034

Kaplan-Meier Survival Analysis

UCEC0.024

Kaplan-Meier Survival Analysis

LIHC0.00041

Kaplan-Meier Survival Analysis

LGG0.00058

Kaplan-Meier Survival Analysis

THCA0.02

Kaplan-Meier Survival Analysis

LUAD0.027

Kaplan-Meier Survival Analysis

UVM0.00013

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000011485 (Gene tree)
Gene ID
5536
Gene Symbol
PPP5C
Alias
PP5|PPP5
Full Name
protein phosphatase 5 catalytic subunit
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
45,988 bases
Position
chr19:46,346,994-46,392,981
Accession
9322
RBP type
non-canonical RBP
Summary
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000491003PPP5C-208878--- (aa)--
ENST00000493347PPP5C-210431--- (aa)--
ENST00000527623PPP5C-2131215--- (aa)--
ENST00000486994PPP5C-2062209--- (aa)--
ENST00000492109PPP5C-209848--- (aa)--
ENST00000525507PPP5C-2111300--- (aa)--
ENST00000532058PPP5C-2141970--- (aa)--
ENST00000012443PPP5C-2012109XM_017026935ENSP00000012443499 (aa)XP_016882424P53041
ENST00000487483PPP5C-2074675--- (aa)--
ENST00000527193PPP5C-212548--- (aa)--
ENST00000467502PPP5C-2031235--- (aa)--
ENST00000595055PPP5C-215556--- (aa)--
ENST00000478046PPP5C-2051886-ENSP00000434329485 (aa)-H0YDU8
ENST00000467902PPP5C-204399--- (aa)--
ENST00000391919PPP5C-2021929-ENSP00000375786371 (aa)-A8MU39
Gene Model
Click here to download ENSG00000011485's gene model file
Pathways
Pathway IDPathway NameSource
hsa04010MAPK signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000011485Crohn Disease9E-1226192919
ENSG00000011485Inflammatory Bowel Diseases2E-826192919
ENSG00000011485Crohn Disease4E-728067908
ENSG00000011485Crohn Disease2E-1023128233
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000011485rs5346666771946351484TNeuroticism29255261z score increase5.523EFO_0007660
ENSG00000011485rs617470941946375732ABasophil percentage of white cells27863252[0.015-0.03] unit decrease0.02259245EFO_0007992
ENSG00000011485rs81067451946388911?Age at menopause30595370EFO_0004704
ENSG00000011485rs621361061946365128?Red blood cell count30595370EFO_0004305
ENSG00000011485rs48039361946375372?Eosinophil counts30595370EFO_0004842
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000011485's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000165MAPK cascade-TASProcess
GO:0000278mitotic cell cycle7925273.TASProcess
GO:0004721phosphoprotein phosphatase activity9383998.ISSFunction
GO:0004721phosphoprotein phosphatase activity28386764.TASFunction
GO:0004722protein serine/threonine phosphatase activity21873635.IBAFunction
GO:0004722protein serine/threonine phosphatase activity15546861.ISSFunction
GO:0004722protein serine/threonine phosphatase activity15546861.16262633.TASFunction
GO:0005515protein binding9383998.11504734.14764652.16531226.16790549.19875381.21360678.25036637.26496610.27353360.28330616.IPIFunction
GO:0005524ATP binding23184943.IDAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IEAComponent
GO:0006281DNA repair-IEAProcess
GO:0006351transcription, DNA-templated7925273.TASProcess
GO:0006470protein dephosphorylation7925273.TASProcess
GO:0008289lipid binding-IEAFunction
GO:0010288response to lead ion-ISSProcess
GO:0016791phosphatase activity15546861.IDAFunction
GO:0032991protein-containing complex23184943.IDAComponent
GO:0035970peptidyl-threonine dephosphorylation16262633.TASProcess
GO:0042802identical protein binding21360678.IPIFunction
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling12761501.HMPProcess
GO:0043231intracellular membrane-bounded organelle-IDAComponent
GO:0043531ADP binding23184943.IDAFunction
GO:0046872metal ion binding-IEAFunction
GO:0048156tau protein binding28386764.NASFunction
GO:0051879Hsp90 protein binding15713458.IPIFunction
GO:0070262peptidyl-serine dephosphorylation16262633.TASProcess
GO:0101031chaperone complex29127155.IDAComponent
GO:1904550response to arachidonic acid15546861.ISSProcess
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