EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
12384782	ELAC2 and prostate cancer risk in Afro-Caribbeans of Tobago.	Hum Genet	2002 Oct	Shea PR	-
14504198	Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study.	Cancer Epidemiol Biomarkers Prev	2003 Sep	Stanford JL	-
11175785	A candidate prostate cancer susceptibility gene at chromosome 17p.	Nat Genet	2001 Feb	Tavtigian SV	-
16114055	Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma.	Prostate	2006 Jan 1	Noonan-Wheeler FC	-
18375959	Sequence variants of elaC homolog 2 (Escherichia coli) (ELAC2) gene and susceptibility to prostate cancer in the Health Professionals Follow-Up Study.	Carcinogenesis	2008 May	Chen YC	doi: 10.1093/carcin/bgn081
18767027	Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases.	Prostate	2008 Dec 1	Robbins CM	doi: 10.1002/pros.20841.
12522685	Association of common missense changes in ELAC2 ( HPC2) with prostate cancer in a Japanese case-control series.	J Hum Genet	2002	Fujiwara H	-
16636667	ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells.	Oncogene	2006 Sep 14	Noda D	-
12949798	Ser217Leu polymorphism of the HPC2/ELAC2 gene associated with prostatic cancer risk in Japanese men.	Int J Cancer	2003 Nov 1	Takahashi H	-
20231859	ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case-control studies.	Prostate Cancer Prostatic Dis	2010 Sep	Xu B	doi: 10.1038/pcan.2010.6
12783937	ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer.	J Natl Cancer Inst	2003 Jun 4	Severi G	-
14625808	HPC2/ELAC2 gene variants associated with incident prostate cancer.	J Hum Genet	2003	Adler D	-
12515253	Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer.	Am J Hum Genet	2002 Dec	Camp NJ	-
20086112	Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.	Cancer Epidemiol Biomarkers Prev	2010 Feb	Beuten J	doi: 10.1158/1055-9965.EPI-09-0864

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr17	13002573	Silent	novel	G362G	0.04
BLCA	chr17	12993709	Missense_Mutation	NA	G744E	0.11
BLCA	chr17	13010659	Missense_Mutation	novel	R231K	0.64
BLCA	chr17	12996499	Intron	novel		0.42
BLCA	chr17	12992794	3'UTR	novel		0.5
BRCA	chr17	13010650	Missense_Mutation	novel	V234A	0.06
BRCA	chr17	12993738	Silent	NA	L734L	0.3
BRCA	chr17	13002342	Silent	novel	L412L	0.54
BRCA	chr17	13010658	Silent	NA	R231R	0.43
BRCA	chr17	13003968	Intron	novel		0.5
BRCA	chr17	12998454	Missense_Mutation	NA	P493L	0.45
BRCA	chr17	13000179	Missense_Mutation	rs749460308	A467V	0.17
BRCA	chr17	12993744	Silent	NA	V732V	0.51
BRCA	chr17	12993746	Missense_Mutation	novel	V732L	0.19
CESC	chr17	13000325	Intron	novel		0.8
CESC	chr17	12996676	Silent	rs202041978	T510T	0.17
CESC	chr17	13003586	Intron	novel		0.45
CESC	chr17	13005023	Missense_Mutation	novel	I317V	0.14
CESC	chr17	12995794	Missense_Mutation	novel	L573F	0.19
CESC	chr17	13000342	Intron	novel		0.63
CHOL	chr17	13000307	Intron	novel		0.21
COAD	chr17	12993762	Silent	NA	S726S	0.34
COAD	chr17	13016894	Missense_Mutation	novel	R112P	0.22
COAD	chr17	13003695	Intron	novel		0.5
COAD	chr17	13002505	Missense_Mutation	novel	I385T	0.38
COAD	chr17	13011696	Missense_Mutation	novel	E216K	0.28
COAD	chr17	12993825	Silent	rs755866051	T705T	0.33
COAD	chr17	12993720	Silent	rs140626107	S740S	0.13
COAD	chr17	12992927	Missense_Mutation	rs148819805	R791Q	0.41
COAD	chr17	12998500	Missense_Mutation	novel	S478G	0.31
COAD	chr17	13011769	In_Frame_Del	NA	R191del	0.23
COAD	chr17	13000226	Silent	rs776280164	L451L	0.2
COAD	chr17	12992980	Silent	rs550032568	G773G	0.36
COAD	chr17	12996655	Silent	NA	G517G	0.24
COAD	chr17	12996047	Intron	novel		0.26
COAD	chr17	13005783	Silent	rs369092504	D280D	0.28
COAD	chr17	13013271	Silent	rs751671002	V165V	0.07
COAD	chr17	12993782	Missense_Mutation	NA	I720V	0.11
COAD	chr17	12992768	3'UTR	novel		0.12
COAD	chr17	12996537	Intron	novel		0.65
COAD	chr17	12992944	Silent	NA	R785R	0.32
COAD	chr17	13000230	Frame_Shift_Del	novel	*A450Gfs45**	0.12
COAD	chr17	12992765	3'UTR	novel		0.18
ESCA	chr17	12995768	Frame_Shift_Del	novel	*N582Tfs23**	0.15
ESCA	chr17	13000178	Silent	rs146858023	A467A	0.13
ESCA	chr17	12994812	Missense_Mutation	rs747446525	V661L	0.31
GBM	chr17	13005971	Missense_Mutation	novel	L249F	0.28
GBM	chr17	13000334	Intron	novel		0.12
GBM	chr17	13011667	Silent	novel	P225P	0.14
GBM	chr17	13002565	Frame_Shift_Ins	novel	*T365Ifs8**	0.06
GBM	chr17	12994854	Missense_Mutation	novel	H647D	0.13
GBM	chr17	12993793	Missense_Mutation	novel	N716S	0.12
GBM	chr17	13005078	Silent	novel	T298T	0.05
GBM	chr17	13006084	Intron	novel		0.19
HNSC	chr17	13013271	Silent	novel	V165V	0.33
HNSC	chr17	13005918	Splice_Region	novel		0.38
HNSC	chr17	13002360	Splice_Site	novel	X407_splice	0.25
HNSC	chr17	13011696	Missense_Mutation	novel	E216K	0.12
HNSC	chr17	13002336	Silent	novel	V414V	0.28
HNSC	chr17	13005789	Silent	novel	V278V	0.13
HNSC	chr17	12992796	3'UTR	novel		0.14
HNSC	chr17	13002499	Frame_Shift_Ins	novel	*T387Mfs63**	0.25
HNSC	chr17	13003682	Intron	novel		0.33
HNSC	chr17	13013270	Missense_Mutation	rs766783415	R166W	0.34
KICH	chr17	12992945	Missense_Mutation	novel	R785Q	0.83
KICH	chr17	12995026	Silent	novel	E615E	0.04
KIRC	chr17	12992746	3'UTR	novel		0.27
KIRC	chr17	13002356	Missense_Mutation	NA	E408K	0.4
KIRC	chr17	13016902	Silent	NA	F109F	0.32
KIRP	chr17	12994873	Silent	rs753389017	C640C	0.49
LAML	chr17	13003968	Intron	novel		0.63
LAML	chr17	13003968	Intron	novel		0.5
LGG	chr17	12994838	Missense_Mutation	rs761881914	A652V	0.19
LGG	chr17	13005036	Silent	novel	P312P	0.11
LIHC	chr17	13003556	Silent	novel	D334D	0.35
LIHC	chr17	13015821	Missense_Mutation	novel	T127A	0.13
LIHC	chr17	13017944	Missense_Mutation	novel	W2R	0.17
LIHC	chr17	13002352	Missense_Mutation	NA	G409D	0.56
LIHC	chr17	13002283	Missense_Mutation	novel	E432V	0.5
LIHC	chr17	12992985	Missense_Mutation	NA	A772P	0.8
LIHC	chr17	13017985	5'UTR	novel		0.31
LIHC	chr17	12994494	Missense_Mutation	novel	A680V	0.13
LUAD	chr17	13002356	Missense_Mutation	NA	E408K	0.08
LUAD	chr17	13011772	Missense_Mutation	novel	R190S	0.08
LUAD	chr17	13000320	Intron	novel		0.13
LUAD	chr17	13002292	Missense_Mutation	NA	P429R	0.09
LUAD	chr17	13002295	Missense_Mutation	NA	R428L	0.29
LUSC	chr17	13002352	Missense_Mutation	novel	G409V	0.81
LUSC	chr17	12993774	Silent	NA	L722L	0.44
LUSC	chr17	12994487	Silent	novel	L682L	0.16
LUSC	chr17	13013204	Splice_Region	novel		0.2
LUSC	chr17	13002464	Frame_Shift_Del	novel	*L399Cfs49**	0.24
LUSC	chr17	13002503	Missense_Mutation	NA	Q386E	0.14
LUSC	chr17	13005001	Missense_Mutation	NA	A324V	0.22
LUSC	chr17	13000387	Intron	novel		0.24
MESO	chr17	12996652	Missense_Mutation	novel	E518D	0.3
OV	chr17	13003568	Frame_Shift_Ins	novel	*G331Rfs34**	0.18
OV	chr17	12992944	Silent	NA	R785R	0.23
OV	chr17	13005814	Missense_Mutation	novel	A270D	0.07
OV	chr17	13017741	Missense_Mutation	novel	D69E	0.25
PAAD	chr17	13000230	Missense_Mutation	rs759926685	A450V	0.17
PAAD	chr17	13005808	Missense_Mutation	novel	A272D	0.19
PAAD	chr17	13006052	Intron	novel		0.2
PRAD	chr17	13015797	Nonsense_Mutation	novel	*K135Vfs7**	0.1
PRAD	chr17	13000307	Intron	novel		0.49
READ	chr17	13005949	Missense_Mutation	rs777491508	L257F	0.42
READ	chr17	12996366	Intron	novel		0.31
SARC	chr17	13014497	Splice_Site	novel	X145_splice	0.33
SARC	chr17	12995725	Missense_Mutation	novel	Q596K	0.05
SARC	chr17	13003514	Frame_Shift_Del	novel	*V348Afs16**	0.44
SKCM	chr17	12992819	Silent	rs533278704	*827*	0.57
SKCM	chr17	13000339	Intron	novel		0.25
SKCM	chr17	13015800	Missense_Mutation	NA	P134S	0.34
SKCM	chr17	12993743	Missense_Mutation	rs758585863	P733S	0.41
SKCM	chr17	12995021	Missense_Mutation	NA	S617F	0.55
SKCM	chr17	12995015	Missense_Mutation	NA	P619L	0.37
SKCM	chr17	12998476	Missense_Mutation	NA	L486F	0.12
SKCM	chr17	13005068	Missense_Mutation	NA	P302S	0.44
SKCM	chr17	13002345	Silent	rs745763181	T411T	0.13
SKCM	chr17	13000211	Silent	NA	F456F	0.32
SKCM	chr17	12995055	Missense_Mutation	NA	P606S	0.3
SKCM	chr17	12992946	Missense_Mutation	NA	R785W	0.19
SKCM	chr17	12996467	Intron	novel		0.53
SKCM	chr17	13017714	Silent	novel	S78S	0.33
SKCM	chr17	13017715	Missense_Mutation	novel	S78F	0.35	Lactamase_B_4
SKCM	chr17	13000210	Nonsense_Mutation	NA	Q457*	0.26
SKCM	chr17	12994802	Missense_Mutation	NA	S664F	0.25
SKCM	chr17	12995789	Silent	rs770617287	H574H	0.33
SKCM	chr17	12998483	Silent	NA	I483I	0.2
SKCM	chr17	13000185	Missense_Mutation	NA	R465K	0.58
SKCM	chr17	12994770	Missense_Mutation	NA	R675W	0.29
SKCM	chr17	12992936	Missense_Mutation	rs567494102	R788Q	0.23
STAD	chr17	12994434	Missense_Mutation	NA	K700T	0.09
STAD	chr17	13005783	Silent	rs369092504	D280D	0.15
STAD	chr17	12994805	Missense_Mutation	novel	Y663C	0.34
STAD	chr17	13006108	Intron	novel		0.27
STAD	chr17	13000229	Silent	rs375565327	A450A	0.17
STAD	chr17	12992895	Missense_Mutation	rs147779718	G802S	0.3
STAD	chr17	12992759	3'UTR	novel		0.19
STAD	chr17	13006070	Intron	NA		0.3
STAD	chr17	13006070	Intron	NA		0.52
STAD	chr17	13003700	Intron	novel		0.43
STAD	chr17	13003523	Silent	novel	P345P	0.49
STAD	chr17	12996453	Intron	novel		0.34
STAD	chr17	13005754	Missense_Mutation	NA	E290G	0.31
STAD	chr17	13002329	Missense_Mutation	novel	V417L	0.17
TGCT	chr17	13017768	Silent	rs370459638	L60L	0.2
UCEC	chr17	13006070	Intron	NA		0.57
UCEC	chr17	13002515	Missense_Mutation	NA	S382G	0.32
UCEC	chr17	13000178	Silent	rs146858023	A467A	0.23
UCEC	chr17	12998502	Missense_Mutation	NA	R477I	0.31
UCEC	chr17	12995009	Missense_Mutation	novel	V621A	0.3
UCEC	chr17	13006070	Intron	NA		0.49
UCEC	chr17	13003567	Nonsense_Mutation	novel	G331*	0.41
UCEC	chr17	12992759	3'UTR	novel		0.23
UCEC	chr17	12996461	Intron	novel		0.19
UCEC	chr17	12998476	Missense_Mutation	novel	L486I	0.09
UCEC	chr17	13006105	Intron	novel		0.32
UCEC	chr17	12992759	3'UTR	novel		0.43
UCEC	chr17	12994505	Splice_Site	novel	X677_splice	0.03
UCEC	chr17	13006130	Intron	NA		0.2
UCEC	chr17	12993792	Silent	rs759078534	N716N	0.23
UCEC	chr17	13011760	Missense_Mutation	novel	H194Q	0.21
UCEC	chr17	12994877	Missense_Mutation	novel	T639I	0.15
UCEC	chr17	12996548	Missense_Mutation	rs755904309	T553M	0.38
UCEC	chr17	13003661	Intron	novel		0.56
UCEC	chr17	12992754	3'UTR	novel		0.2
UCEC	chr17	12992960	Missense_Mutation	novel	E780G	0.17
UCEC	chr17	13014484	Missense_Mutation	rs779607134	E149K	0.15
UCEC	chr17	13005814	Missense_Mutation	rs111531241	A270V	0.43
UCEC	chr17	13005818	Missense_Mutation	novel	A269T	0.25
UCEC	chr17	12996514	Intron	novel		0.44
UCEC	chr17	13006099	Intron	novel		1
UCEC	chr17	12995759	Silent	rs372108840	L584L	0.5
UCEC	chr17	13005809	Missense_Mutation	rs765353090	A272T	0.12
UCEC	chr17	12993792	Silent	rs759078534	N716N	0.41
UCEC	chr17	13002345	Silent	rs745763181	T411T	0.47
UCEC	chr17	13003540	Missense_Mutation	novel	V340M	0.47
UCEC	chr17	13016891	Missense_Mutation	novel	M113T	0.12
UCEC	chr17	12994849	Silent	novel	A648A	0.4
UCEC	chr17	12992766	3'UTR	rs540886198		0.41
UCEC	chr17	13003527	Missense_Mutation	novel	A344V	0.59
UCEC	chr17	13011691	Silent	rs201530031	S217S	0.07
UCEC	chr17	13005775	Missense_Mutation	novel	S283I	0.16
UCEC	chr17	13011740	Missense_Mutation	novel	E201A	0.29
UCEC	chr17	13000202	Silent	NA	S459S	0.23
UCEC	chr17	13005755	Nonsense_Mutation	novel	E290*	0.08
UCEC	chr17	12998454	Missense_Mutation	NA	P493L	0.41
UCEC	chr17	12992883	Missense_Mutation	NA	G806R	0.57
UCEC	chr17	13005067	Missense_Mutation	NA	P302H	0.27
UCEC	chr17	12992937	Missense_Mutation	rs749996506	R788W	0.35
UCEC	chr17	13002464	Missense_Mutation	NA	L399M	0.06
UCEC	chr17	12993014	Missense_Mutation	NA	K762T	0.2
UCEC	chr17	13006046	Intron	novel		0.4
UCEC	chr17	12998443	Nonsense_Mutation	rs550032922	R497*	0.43
UCEC	chr17	12992800	3'UTR	novel		0.35
UCEC	chr17	12994843	Silent	novel	G650G	0.28
UCEC	chr17	12996372	Intron	novel		0.19
UCEC	chr17	13005992	Intron	novel		0.05
UCEC	chr17	12995755	Missense_Mutation	novel	A586T	0.52
UCEC	chr17	13000307	Intron	novel		0.28
UCEC	chr17	12993825	Silent	rs755866051	T705T	0.37
UCEC	chr17	12998442	Missense_Mutation	rs531523727	R497Q	0.37
UCEC	chr17	13000297	Intron	novel		0.34
UCEC	chr17	13011751	Nonsense_Mutation	novel	W197*	0.39
UCEC	chr17	12992722	3'UTR	novel		0.33
UCEC	chr17	12992974	Silent	rs775479429	I775I	0.41
UCS	chr17	12994426	Frame_Shift_Del	novel	*H702Qfs46**	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1667	0.18166
ESCA	DEL	0.4022	0.074408
READ	DEL	0.6727	0.077076
SARC	AMP	0.3502	9.3248e-17
THCA	DEL	0.014	0.221
UCEC	DEL	0.2505	0.00043918
UCS	DEL	0.7143	0.044844

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.014	Kaplan-Meier Survival Analysis
UCS	0.023	Kaplan-Meier Survival Analysis
SKCM	0.0025	Kaplan-Meier Survival Analysis
BRCA	0.037	Kaplan-Meier Survival Analysis
KIRP	0.0055	Kaplan-Meier Survival Analysis
PAAD	0.0037	Kaplan-Meier Survival Analysis
BLCA	0.038	Kaplan-Meier Survival Analysis
LAML	0.0057	Kaplan-Meier Survival Analysis
UCEC	0.0042	Kaplan-Meier Survival Analysis
UVM	0.00089	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000006744 (Gene tree)
Gene ID: 60528
Gene Symbol: ELAC2
Alias: FLJ10530|HPC2
Full Name: elaC ribonuclease Z 2
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 26,576 bases
Position: chr17:12,991,612-13,018,187
Accession: 14198
Summary: The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000477482	Lactamase_B_4	PF13691.6	7.3e-17	1	1
ENSP00000405223	Lactamase_B_4	PF13691.6	4.7e-16	1	1
ENSP00000337445	Lactamase_B_4	PF13691.6	5.2e-16	1	1
ENSP00000379291	Lactamase_B_4	PF13691.6	8.5e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17671357	The structure of the flexible arm of Thermotoga maritima tRNase Z differs from those of homologous enzymes.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2007 Aug 1	Ishii R	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000578071	ELAC2-212	579	-	ENSP00000477482	158 (aa)	-	V9GZ72
ENST00000476042	ELAC2-206	428	-	ENSP00000463884	45 (aa)	-	J3QQT1
ENST00000426905	ELAC2-203	2671	XM_024450854	ENSP00000405223	786 (aa)	XP_024306622	Q9BQ52
ENST00000480891	ELAC2-207	2737	-	-	- (aa)	-	-
ENST00000583371	ELAC2-217	479	-	ENSP00000464358	122 (aa)	-	J3QRS2
ENST00000584650	ELAC2-218	2087	-	ENSP00000463740	626 (aa)	-	E7ES68
ENST00000609345	ELAC2-220	849	-	-	- (aa)	-	-
ENST00000484122	ELAC2-208	3738	-	-	- (aa)	-	-
ENST00000487229	ELAC2-209	2452	-	-	- (aa)	-	-
ENST00000578991	ELAC2-214	550	-	-	- (aa)	-	-
ENST00000580504	ELAC2-215	579	-	ENSP00000463594	148 (aa)	-	J3QLK4
ENST00000578104	ELAC2-213	664	-	-	- (aa)	-	-
ENST00000609757	ELAC2-221	588	-	ENSP00000477093	124 (aa)	-	V9GYU5
ENST00000338034	ELAC2-201	3148	XM_024450850	ENSP00000337445	826 (aa)	XP_024306618	Q9BQ52
ENST00000465825	ELAC2-205	2793	-	-	- (aa)	-	-
ENST00000446899	ELAC2-204	858	-	ENSP00000406192	286 (aa)	-	H7C2I4
ENST00000581499	ELAC2-216	581	-	ENSP00000463321	132 (aa)	-	J3QL08
ENST00000609101	ELAC2-219	866	-	ENSP00000477044	242 (aa)	-	V9GYS7
ENST00000492559	ELAC2-211	615	-	-	- (aa)	-	-
ENST00000491478	ELAC2-210	758	-	-	- (aa)	-	-
ENST00000395962	ELAC2-202	2924	XM_024450856	ENSP00000379291	807 (aa)	XP_024306624	G5E9D5

Gene Model

Click here to download ENSG00000006744's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000006744	Respiratory Function Tests	8.12171927270868E-6	17903307
ENSG00000006744	Echocardiography	6.71965115106588E-5	17903301
ENSG00000006744	Echocardiography	8.85489686242025E-5	17903301
ENSG00000006744	Walking	2.68096320554501E-5	17903295
ENSG00000006744	Walking	2.68096320554501E-5	17903295
ENSG00000006744	Hemoglobin A, Glycosylated	6.4100000E-005	19875614
ENSG00000006744	Cholesterol, LDL	1.998e-005	19060910
ENSG00000006744	Blood Glucose	6.6180000E-005	-
ENSG00000006744	Insulin	7.7770000E-005	-
ENSG00000006744	Eosinophils	8.6130000E-005	-
ENSG00000006744	Urine	6.8608935E-006	-
ENSG00000006744	Platelet Function Tests	3.4412900E-005	-
ENSG00000006744	Platelet Function Tests	6.3700000E-006	-
ENSG00000006744	Platelet Function Tests	1.4100700E-005	-
ENSG00000006744	Platelet Function Tests	1.9399300E-005	-
ENSG00000006744	Platelet Function Tests	2.2059100E-005	-
ENSG00000006744	Platelet Function Tests	1.3946857E-006	-
ENSG00000006744	Platelet Function Tests	3.4246273E-007	-
ENSG00000006744	Child Development Disorders, Pervasive	9.8872000E-006	-
ENSG00000006744	Child Development Disorders, Pervasive	1.6597000E-005	-
ENSG00000006744	Autistic Disorder	3.5512000E-005	-
ENSG00000006744	Child Development Disorders, Pervasive	4.7196000E-005	-
ENSG00000006744	Autistic Disorder	9.3941000E-006	-
ENSG00000006744	Autistic Disorder	2.4899000E-005	-
ENSG00000006744	Autistic Disorder	1.5212000E-005	-
ENSG00000006744	Substance-Related Disorders	2E-6	22823124
ENSG00000006744	Agranulocytosis	5E-6	27400856
ENSG00000006744	Clozapine	5E-6	27400856
ENSG00000006744	Schizophrenia	5E-6	27400856
ENSG00000006744	Schizophrenia	2E-6	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000006744	rs9908102	17	12993236	T	Schizophrenia	26198764	[NR]	1.05	EFO_0000692

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000006744's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000006744	ELAC2	98	61.345	ENSAPOG00000002563	elac2	91	59.728	Acanthochromis_polyacanthus
ENSG00000006744	ELAC2	99	85.950	ENSAMEG00000010418	ELAC2	100	79.493	Ailuropoda_melanoleuca
ENSG00000006744	ELAC2	83	68.702	ENSACIG00000010330	elac2	78	64.539	Amphilophus_citrinellus
ENSG00000006744	ELAC2	98	63.866	ENSAOCG00000003756	elac2	91	59.144	Amphiprion_ocellaris
ENSG00000006744	ELAC2	98	63.866	ENSAPEG00000019425	elac2	92	58.625	Amphiprion_percula
ENSG00000006744	ELAC2	100	57.255	ENSATEG00000020251	elac2	90	59.795	Anabas_testudineus
ENSG00000006744	ELAC2	96	70.085	ENSACAG00000017398	ELAC2	93	66.456	Anolis_carolinensis
ENSG00000006744	ELAC2	100	91.730	ENSANAG00000036642	ELAC2	100	91.730	Aotus_nancymaae
ENSG00000006744	ELAC2	100	58.400	ENSACLG00000020349	elac2	91	60.758	Astatotilapia_calliptera
ENSG00000006744	ELAC2	100	81.922	ENSBTAG00000021939	ELAC2	100	81.922	Bos_taurus
ENSG00000006744	ELAC2	100	91.349	ENSCJAG00000004542	ELAC2	100	91.349	Callithrix_jacchus
ENSG00000006744	ELAC2	99	85.124	ENSCAFG00000017886	ELAC2	100	82.431	Canis_familiaris
ENSG00000006744	ELAC2	99	85.124	ENSCAFG00020000574	ELAC2	100	81.370	Canis_lupus_dingo
ENSG00000006744	ELAC2	100	78.821	ENSCHIG00000025992	ELAC2	100	78.821	Capra_hircus
ENSG00000006744	ELAC2	99	90.083	ENSTSYG00000005202	ELAC2	100	88.041	Carlito_syrichta
ENSG00000006744	ELAC2	99	84.298	ENSCPOG00000009098	ELAC2	99	80.549	Cavia_porcellus
ENSG00000006744	ELAC2	99	92.562	ENSCCAG00000036307	ELAC2	100	90.840	Cebus_capucinus
ENSG00000006744	ELAC2	100	97.581	ENSCATG00000030564	ELAC2	100	94.304	Cercocebus_atys
ENSG00000006744	ELAC2	99	85.816	ENSCLAG00000007156	ELAC2	100	81.742	Chinchilla_lanigera
ENSG00000006744	ELAC2	100	98.387	ENSCSAG00000009057	ELAC2	100	93.462	Chlorocebus_sabaeus
ENSG00000006744	ELAC2	99	68.939	ENSCPBG00000027769	ELAC2	99	66.196	Chrysemys_picta_bellii
ENSG00000006744	ELAC2	100	95.041	ENSCANG00000040743	ELAC2	100	94.148	Colobus_angolensis_palliatus
ENSG00000006744	ELAC2	100	84.800	ENSCGRG00001023086	Elac2	97	79.641	Cricetulus_griseus_chok1gshd
ENSG00000006744	ELAC2	100	83.200	ENSCGRG00000011564	Elac2	99	74.502	Cricetulus_griseus_crigri
ENSG00000006744	ELAC2	94	59.218	ENSCSEG00000020630	elac2	93	55.851	Cynoglossus_semilaevis
ENSG00000006744	ELAC2	99	59.821	ENSCVAG00000003649	elac2	99	59.821	Cyprinodon_variegatus
ENSG00000006744	ELAC2	98	58.025	ENSDARG00000034060	elac2	92	59.470	Danio_rerio
ENSG00000006744	ELAC2	100	78.512	ENSDNOG00000004242	ELAC2	99	74.486	Dasypus_novemcinctus
ENSG00000006744	ELAC2	97	84.477	ENSDORG00000005592	Elac2	98	83.196	Dipodomys_ordii
ENSG00000006744	ELAC2	94	34.110	FBgn0028426	JhI-1	95	33.543	Drosophila_melanogaster
ENSG00000006744	ELAC2	95	49.398	ENSEBUG00000011361	elac2	88	49.860	Eptatretus_burgeri
ENSG00000006744	ELAC2	99	85.950	ENSEASG00005016922	ELAC2	100	84.699	Equus_asinus_asinus
ENSG00000006744	ELAC2	98	59.220	ENSELUG00000018265	elac2	93	59.690	Esox_lucius
ENSG00000006744	ELAC2	99	85.950	ENSFCAG00000008407	ELAC2	100	82.500	Felis_catus
ENSG00000006744	ELAC2	99	86.066	ENSFDAG00000010293	ELAC2	100	80.964	Fukomys_damarensis
ENSG00000006744	ELAC2	97	63.333	ENSFHEG00000015744	elac2	88	59.735	Fundulus_heteroclitus
ENSG00000006744	ELAC2	82	67.763	ENSGMOG00000008574	elac2	94	67.763	Gadus_morhua
ENSG00000006744	ELAC2	98	62.857	ENSGALG00000001036	ELAC2	98	59.880	Gallus_gallus
ENSG00000006744	ELAC2	99	66.667	ENSGAFG00000005456	elac2	99	66.667	Gambusia_affinis
ENSG00000006744	ELAC2	99	55.556	ENSGACG00000014454	elac2	99	58.521	Gasterosteus_aculeatus
ENSG00000006744	ELAC2	100	69.697	ENSGAGG00000017133	ELAC2	93	69.895	Gopherus_agassizii
ENSG00000006744	ELAC2	100	100.000	ENSGGOG00000015850	ELAC2	100	100.000	Gorilla_gorilla
ENSG00000006744	ELAC2	100	58.400	ENSHBUG00000017777	elac2	89	59.631	Haplochromis_burtoni
ENSG00000006744	ELAC2	99	85.950	ENSHGLG00000005718	ELAC2	100	80.788	Heterocephalus_glaber_female
ENSG00000006744	ELAC2	99	85.950	ENSHGLG00100003619	ELAC2	100	80.549	Heterocephalus_glaber_male
ENSG00000006744	ELAC2	100	56.735	ENSHCOG00000006972	elac2	93	61.312	Hippocampus_comes
ENSG00000006744	ELAC2	98	57.801	ENSIPUG00000022303	elac2	89	60.705	Ictalurus_punctatus
ENSG00000006744	ELAC2	99	89.256	ENSSTOG00000006680	ELAC2	100	84.337	Ictidomys_tridecemlineatus
ENSG00000006744	ELAC2	76	54.184	ENSKMAG00000019598	elac2	99	54.321	Kryptolebias_marmoratus
ENSG00000006744	ELAC2	78	64.844	ENSKMAG00000019583	-	71	65.873	Kryptolebias_marmoratus
ENSG00000006744	ELAC2	98	55.674	ENSLBEG00000027524	elac2	89	57.935	Labrus_bergylta
ENSG00000006744	ELAC2	89	70.370	ENSLOCG00000012146	elac2	94	61.965	Lepisosteus_oculatus
ENSG00000006744	ELAC2	99	84.298	ENSLAFG00000009404	ELAC2	100	81.325	Loxodonta_africana
ENSG00000006744	ELAC2	100	97.581	ENSMFAG00000041840	ELAC2	100	94.304	Macaca_fascicularis
ENSG00000006744	ELAC2	100	97.581	ENSMMUG00000014450	ELAC2	100	94.304	Macaca_mulatta
ENSG00000006744	ELAC2	100	97.581	ENSMNEG00000044872	ELAC2	100	93.766	Macaca_nemestrina
ENSG00000006744	ELAC2	98	58.650	ENSMAMG00000019957	elac2	92	59.893	Mastacembelus_armatus
ENSG00000006744	ELAC2	100	58.400	ENSMZEG00005000530	elac2	89	59.763	Maylandia_zebra
ENSG00000006744	ELAC2	100	87.200	ENSMAUG00000019006	Elac2	100	81.146	Mesocricetus_auratus
ENSG00000006744	ELAC2	99	89.256	ENSMICG00000002428	ELAC2	100	88.086	Microcebus_murinus
ENSG00000006744	ELAC2	99	86.066	ENSMOCG00000014060	Elac2	100	81.535	Microtus_ochrogaster
ENSG00000006744	ELAC2	97	57.348	ENSMMOG00000020227	elac2	91	57.123	Mola_mola
ENSG00000006744	ELAC2	100	74.016	ENSMODG00000008064	ELAC2	98	71.270	Monodelphis_domestica
ENSG00000006744	ELAC2	98	58.771	ENSMALG00000020125	elac2	88	60.221	Monopterus_albus
ENSG00000006744	ELAC2	98	87.395	MGP_CAROLIEiJ_G0016509	Elac2	100	81.796	Mus_caroli
ENSG00000006744	ELAC2	99	88.430	ENSMUSG00000020549	Elac2	100	81.993	Mus_musculus
ENSG00000006744	ELAC2	98	88.235	MGP_PahariEiJ_G0017638	Elac2	100	81.687	Mus_pahari
ENSG00000006744	ELAC2	99	88.430	MGP_SPRETEiJ_G0017346	Elac2	100	81.753	Mus_spretus
ENSG00000006744	ELAC2	99	85.124	ENSMPUG00000003608	ELAC2	100	81.588	Mustela_putorius_furo
ENSG00000006744	ELAC2	99	83.607	ENSNGAG00000021585	Elac2	100	81.243	Nannospalax_galili
ENSG00000006744	ELAC2	73	82.759	ENSNBRG00000010410	elac2	88	72.527	Neolamprologus_brichardi
ENSG00000006744	ELAC2	100	94.937	ENSNLEG00000014599	ELAC2	100	94.937	Nomascus_leucogenys
ENSG00000006744	ELAC2	80	85.714	ENSMEUG00000000013	ELAC2	66	86.207	Notamacropus_eugenii
ENSG00000006744	ELAC2	91	86.111	ENSOPRG00000011156	ELAC2	91	84.688	Ochotona_princeps
ENSG00000006744	ELAC2	99	85.950	ENSODEG00000000449	ELAC2	100	82.892	Octodon_degus
ENSG00000006744	ELAC2	100	60.246	ENSONIG00000009569	elac2	92	60.261	Oreochromis_niloticus
ENSG00000006744	ELAC2	99	84.298	ENSOCUG00000012703	ELAC2	94	82.239	Oryctolagus_cuniculus
ENSG00000006744	ELAC2	80	73.196	ENSORLG00000001024	elac2	87	62.204	Oryzias_latipes
ENSG00000006744	ELAC2	80	74.227	ENSORLG00015008761	elac2	86	62.204	Oryzias_latipes_hsok
ENSG00000006744	ELAC2	95	61.376	ENSOMEG00000015065	elac2	93	61.017	Oryzias_melastigma
ENSG00000006744	ELAC2	99	88.430	ENSOGAG00000012628	ELAC2	100	85.135	Otolemur_garnettii
ENSG00000006744	ELAC2	95	84.483	ENSOARG00000015747	ELAC2	98	79.481	Ovis_aries
ENSG00000006744	ELAC2	100	100.000	ENSPPAG00000011633	ELAC2	100	99.367	Pan_paniscus
ENSG00000006744	ELAC2	99	85.124	ENSPPRG00000023801	ELAC2	100	82.500	Panthera_pardus
ENSG00000006744	ELAC2	100	100.000	ENSPTRG00000008788	ELAC2	100	99.367	Pan_troglodytes
ENSG00000006744	ELAC2	100	97.581	ENSPANG00000023751	ELAC2	100	93.766	Papio_anubis
ENSG00000006744	ELAC2	100	59.091	ENSPKIG00000014594	elac2	93	57.787	Paramormyrops_kingsleyae
ENSG00000006744	ELAC2	70	75.676	ENSPMGG00000007330	elac2	90	55.994	Periophthalmus_magnuspinnatus
ENSG00000006744	ELAC2	98	86.555	ENSPEMG00000001670	Elac2	99	81.055	Peromyscus_maniculatus_bairdii
ENSG00000006744	ELAC2	100	73.770	ENSPCIG00000009347	ELAC2	99	69.249	Phascolarctos_cinereus
ENSG00000006744	ELAC2	96	64.706	ENSPFOG00000003750	elac2	93	59.974	Poecilia_formosa
ENSG00000006744	ELAC2	96	64.706	ENSPLAG00000015167	-	71	63.402	Poecilia_latipinna
ENSG00000006744	ELAC2	67	61.667	ENSPLAG00000015161	elac2	90	60.970	Poecilia_latipinna
ENSG00000006744	ELAC2	96	64.706	ENSPMEG00000023756	elac2	87	72.656	Poecilia_mexicana
ENSG00000006744	ELAC2	96	63.866	ENSPREG00000003349	elac2	88	60.400	Poecilia_reticulata
ENSG00000006744	ELAC2	100	96.565	ENSPPYG00000007997	ELAC2	100	96.565	Pongo_abelii
ENSG00000006744	ELAC2	100	87.579	ENSPCOG00000014581	ELAC2	100	87.579	Propithecus_coquereli
ENSG00000006744	ELAC2	100	68.548	ENSPVAG00000017570	ELAC2	79	84.358	Pteropus_vampyrus
ENSG00000006744	ELAC2	100	59.055	ENSPNYG00000010837	elac2	92	57.652	Pundamilia_nyererei
ENSG00000006744	ELAC2	100	62.698	ENSPNAG00000018524	elac2	89	61.427	Pygocentrus_nattereri
ENSG00000006744	ELAC2	98	85.714	ENSRNOG00000003424	Elac2	100	81.894	Rattus_norvegicus
ENSG00000006744	ELAC2	100	94.628	ENSRBIG00000021596	ELAC2	100	94.402	Rhinopithecus_bieti
ENSG00000006744	ELAC2	100	95.868	ENSRROG00000033226	ELAC2	100	94.431	Rhinopithecus_roxellana
ENSG00000006744	ELAC2	99	94.215	ENSSBOG00000016993	ELAC2	100	89.822	Saimiri_boliviensis_boliviensis
ENSG00000006744	ELAC2	96	67.521	ENSSFOG00015004103	elac2	89	58.981	Scleropages_formosus
ENSG00000006744	ELAC2	97	56.984	ENSSMAG00000012868	elac2	97	57.531	Scophthalmus_maximus
ENSG00000006744	ELAC2	98	56.028	ENSSDUG00000023129	elac2	89	59.383	Seriola_dumerili
ENSG00000006744	ELAC2	98	56.383	ENSSLDG00000005645	elac2	89	59.438	Seriola_lalandi_dorsalis
ENSG00000006744	ELAC2	98	57.042	ENSSPAG00000005674	elac2	92	60.115	Stegastes_partitus
ENSG00000006744	ELAC2	100	79.112	ENSSSCG00000028465	ELAC2	100	79.112	Sus_scrofa
ENSG00000006744	ELAC2	100	57.377	ENSTRUG00000004076	elac2	93	59.595	Takifugu_rubripes
ENSG00000006744	ELAC2	99	58.025	ENSTNIG00000011271	elac2	98	59.459	Tetraodon_nigroviridis
ENSG00000006744	ELAC2	98	84.167	ENSTTRG00000002898	ELAC2	100	76.082	Tursiops_truncatus
ENSG00000006744	ELAC2	99	85.950	ENSUMAG00000021393	ELAC2	88	77.745	Ursus_maritimus
ENSG00000006744	ELAC2	99	85.124	ENSVVUG00000029905	ELAC2	100	79.857	Vulpes_vulpes
ENSG00000006744	ELAC2	89	69.912	ENSXETG00000012596	elac2	98	58.809	Xenopus_tropicalis
ENSG00000006744	ELAC2	67	59.953	ENSXCOG00000004282	elac2	90	59.310	Xiphophorus_couchianus
ENSG00000006744	ELAC2	99	64.744	ENSXCOG00000004279	-	99	64.744	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004519	endonuclease activity	-	IEA	Function
GO:0004549	tRNA-specific ribonuclease activity	12711671.15317868.16361254.18809514.21559454.21593607.	EXP	Function
GO:0005634	nucleus	21593607.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	21593607.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0042645	mitochondrial nucleoid	-	IEA	Component
GO:0042780	tRNA 3'-end processing	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0072684	mitochondrial tRNA 3'-trailer cleavage, endonucleolytic	21873635.	IBA	Process
GO:0072684	mitochondrial tRNA 3'-trailer cleavage, endonucleolytic	21593607.	IMP	Process
GO:0090646	mitochondrial tRNA processing	-	TAS	Process

EuRBPDB

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