EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
16491129The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.Oncogene2006 Jun 1Moniaux N-
26282204Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.Biochem Biophys Res Commun2015 Oct 2Zhi Xdoi: 10.1016/j.bbrc.2015.08.017
25003666Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells.Br J Cancer2014 Jul 29Vaz APdoi: 10.1038/bjc.2014.152
22046413Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.PLoS One2011Dey Pdoi: 10.1371/journal.pone.0026926
28122356hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells.Oncotarget2017 Feb 28Karmakar Sdoi: 10.18632/oncotarget.14775.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1939386121Missense_MutationNAG489A0.11
BLCAchr1939386203In_Frame_InsnovelE461_D462insK0.49
BLCAchr1939389674SilentNAL86L0.07
BLCAchr1939386023Missense_MutationNAD522N0.14
BLCAchr1939389506Missense_Mutationrs200763809E111D0.19
BLCAchr1939386758Missense_MutationNAS343L0.21
BRCAchr19393859323'UTRNA0.25
BRCAchr1939386719Missense_MutationNAM356T0.2
BRCAchr1939390160Missense_MutationnovelS27T0.08
BRCAchr19393859773'UTRnovel0.2
BRCAchr1939390264Nonsense_MutationNAE25*0.23
CESCchr19393908885'UTRnovel0.32
CESCchr1939389671Missense_MutationNAI87M0.3
CESCchr1939389161Missense_MutationNAE167K0.28
CESCchr1939386353Missense_MutationNAE412Q0.18
CESCchr1939386566Missense_MutationNAR367W0.36
COADchr1939386266Missense_MutationnovelE441Q0.31
COADchr1939388772Missense_MutationnovelA244T0.09
COADchr1939388974Missense_MutationNAE203D0.16
COADchr1939389134Missense_MutationNAI176L0.36
COADchr1939389132SilentNAI176I0.48
COADchr1939390141Missense_MutationnovelV33A0.37
COADchr1939388394Missense_MutationnovelY311H0.1
COADchr1939388604SilentnovelR271R0.15
COADchr1939386721SilentNAD355D0.4
COADchr1939388834Missense_MutationnovelF223S0.09
ESCAchr19393909535'UTRnovel0.13
GBMchr1939386314SilentnovelR425R0.08
GBMchr1939386162Missense_MutationnovelQ475H0.06
GBMchr1939389161Nonsense_MutationnovelE167*0.47
GBMchr1939386698Missense_MutationnovelA363V0.08
GBMchr1939388955Missense_MutationnovelD210Y0.51
GBMchr1939386329Missense_Mutationrs200627106R420W0.78
GBMchr1939386208Missense_MutationnovelS460Y0.05
GBMchr1939386297SilentnovelD430D0.09
GBMchr1939386331Missense_MutationnovelE419V0.11
GBMchr1939388849Missense_MutationnovelC218Y0.08
HNSCchr1939388632Missense_MutationnovelL262Q0.22
HNSCchr1939386326Frame_Shift_DelnovelE421Rfs*1370.13
HNSCchr1939390072Missense_MutationnovelN56S0.06
HNSCchr1939388767Missense_MutationnovelM245I0.28
HNSCchr1939389167Nonsense_MutationnovelE165*0.23
HNSCchr1939389330Missense_MutationnovelS138F0.16
HNSCchr1939389734SilentnovelL66L0.16
KIRCchr1939389722Missense_MutationNAH70Q0.15
KIRCchr1939389716Silentrs778687735H72H0.36
KIRPchr1939388669Missense_MutationNAM250V0.19
LGGchr1939389755SilentnovelV59V0.3
LUADchr1939390071Splice_RegionnovelN56N0.04
LUADchr1939386023Missense_MutationNAD522N0.18
LUADchr1939390136Missense_MutationnovelY35H0.15
LUADchr1939386182Missense_MutationNAE469K0.37
LUADchr1939388435Missense_MutationNAW297L0.32
LUSCchr1939386518Missense_MutationnovelE383Q0.06
LUSCchr1939386058Missense_Mutationrs778486153S510L0.12
LUSCchr1939386323Nonsense_MutationnovelE422*0.08
OVchr1939389172Missense_MutationnovelF163C0.07
OVchr1939389488Missense_MutationnovelS117R0.1
OVchr1939386208Missense_MutationnovelS460Y0.13
OVchr1939386039Missense_MutationnovelS516R0.14
OVchr1939389007Missense_MutationnovelQ192H0.15
OVchr1939386571Missense_MutationnovelE365G0.05
OVchr1939386561Missense_MutationnovelK368N0.04
OVchr1939386399Missense_MutationnovelE396D0.06
OVchr1939390153Missense_MutationnovelV29G0.74
OVchr1939388617Missense_MutationNAT267M0.03
OVchr19393909855'UTRnovel0.13
PAADchr1939388772Missense_MutationnovelA244T0.18
PAADchr1939389659SilentnovelT91T0.21
PRADchr1939389316Missense_MutationnovelR143C0.1
PRADchr1939389349Nonsense_Mutationrs775209420R132*0.3
PRADchr1939388616Silentrs143167089T267T0.18
READchr1939386757SilentnovelS343S0.47
READchr1939388424Missense_MutationNAN301H0.27
READchr1939390106Missense_MutationnovelD45N0.35
READchr1939390861Missense_MutationnovelA2T0.11
SARCchr1939389667Missense_MutationnovelP89S0.22
SKCMchr1939389137Nonsense_MutationnovelQ175*0.36
SKCMchr1939389138SilentnovelS174S0.35
SKCMchr1939390098SilentnovelK47K0.49
SKCMchr1939386778SilentNAR336R0.41
SKCMchr1939388950Missense_MutationnovelF211L0.45
SKCMchr1939386182Nonsense_MutationNAE469*0.24
SKCMchr1939386538Missense_Mutationrs761456502P376L0.33
SKCMchr1939389514Missense_MutationNAE109K0.27
SKCMchr1939389296SilentNAE149E0.2
SKCMchr1939388564Missense_MutationNAD285N0.41
STADchr1939388677Splice_SiteNAX247_splice0.28
STADchr1939389336Missense_MutationnovelY136C0.4
STADchr1939388762In_Frame_DelnovelI246_R247delinsM0.16
STADchr1939390265SilentnovelP24P0.32
STADchr19393859603'UTRnovel0.15
STADchr1939386234SilentNAE451E0.18
STADchr1939390286SilentNAP17P0.43
STADchr1939388791Silentrs547127898A237A0.12
TGCTchr1939389379Nonsense_Mutationrs757357536Q122*0.38
UCECchr1939388823Missense_MutationnovelP227T0.2
UCECchr1939389368SilentNAA125A0.31
UCECchr1939388846Missense_MutationnovelA219V0.45
UCECchr1939386565Missense_Mutationrs372480955R367Q0.44
UCECchr1939386770Missense_MutationnovelA339D0.14
UCECchr1939388599Missense_Mutationrs754420217R273Q0.4
UCECchr1939390275Missense_MutationnovelR21Q0.09
UCECchr19393859693'UTRnovel0.38
UCECchr1939386266Missense_Mutationrs201740690E441K0.29
UCECchr1939390833Missense_MutationNAR11L0.14
UCECchr1939386173Nonsense_MutationNAG472*0.41
UCECchr1939386201Silentrs777154167D462D0.12
UCECchr1939388845SilentnovelA219A0.21
UCECchr1939386056Missense_MutationnovelA511T0.32
UCECchr1939388366Missense_Mutationrs745419714G320E0.33
UCECchr1939389348Missense_MutationnovelR132Q0.45
UCECchr1939386364Missense_MutationnovelG408D0.31
UCECchr1939389161Nonsense_MutationnovelE167*0.6
UCECchr1939389710SilentNAL74L0.14
UCECchr1939388981Missense_Mutationrs751010774P201L0.35
UCECchr1939386156SilentnovelG477G0.36
UCECchr19393859123'UTRnovel0.5
UCECchr1939386506Nonsense_MutationnovelE387*0.41
UCECchr1939389099SilentnovelQ187Q0.38
UCECchr1939389524Missense_MutationNAE105D0.25
UCECchr1939386726Missense_MutationNAR354W0.08
UCECchr1939389340Nonsense_MutationnovelE135*0.42
UCECchr1939386276Silentrs145049661D437D0.31
UCECchr1939388605Missense_Mutationrs747480050R271Q0.3
UCECchr1939386090Silentrs371726994S499S0.17
UCECchr1939386506Nonsense_MutationnovelE387*0.44
UCECchr1939386223Missense_MutationnovelG455D0.41
UCECchr1939386725Missense_MutationnovelR354Q0.36
UCECchr1939389679Missense_MutationNAD85N0.26
UCECchr19393909235'UTRnovel0.26

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.04510.054726
OVAMP0.35412.2539e-28
PAADAMP0.20113.1883e-10
READDEL0.05450.23023
UCSDEL0.1250.12448

Survival Analysis
CancerP-value Q-value
KIRC0.028

Kaplan-Meier Survival Analysis

ACC0.0016

Kaplan-Meier Survival Analysis

BRCA0.017

Kaplan-Meier Survival Analysis

PAAD0.0044

Kaplan-Meier Survival Analysis

LAML0.00048

Kaplan-Meier Survival Analysis

LIHC0.018

Kaplan-Meier Survival Analysis

DLBC0.018

Kaplan-Meier Survival Analysis

LGG0.0018

Kaplan-Meier Survival Analysis

CHOL0.0015

Kaplan-Meier Survival Analysis

UVM0.00082

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000006712 (Gene tree)
Gene ID
54623
Gene Symbol
PAF1
Alias
PD2|F23149_1|FLJ11123
Full Name
PAF1 homolog, Paf1/RNA polymerase II complex component
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
5,567 bases
Position
chr19:39,385,629-39,391,195
Accession
25459
RBP type
non-canonical RBP
Summary
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23008333A role for the RNA pol II-associated PAF complex in AID-induced immune diversification.J Exp Med2012 Oct 22Willmann KLdoi: 10.1084/jem.20112145
29864419Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.Gastroenterology2018 SepNimmakayala RKdoi: 10.1053/j.gastro.2018.05.041
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000597365PAF1-206606--- (aa)--
ENST00000595379PAF1-203281-ENSP0000046974294 (aa)-M0QYC7
ENST00000598127PAF1-207558--- (aa)--
ENST00000598594PAF1-208280--- (aa)--
ENST00000595564PAF1-2041810-ENSP00000468874485 (aa)-Q8N7H5
ENST00000595797PAF1-205760--- (aa)--
ENST00000416728PAF1-2021383-ENSP00000396412288 (aa)-B4DGJ5
ENST00000221265PAF1-2012066-ENSP00000221265531 (aa)-Q8N7H5
Gene Model
Click here to download ENSG00000006712's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000006712's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-ISSProcess
GO:0000993RNA polymerase II complex binding21873635.IBAFunction
GO:0000993RNA polymerase II complex binding15923622.IDAFunction
GO:0001711endodermal cell fate commitment-ISSProcess
GO:0003682chromatin binding21873635.IBAFunction
GO:0005515protein binding15923622.16024656.16307923.19136632.19410543.20178742.20541477.21516116.22419161.25277244.25416956.26496610.29774127.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm22046413.IDAComponent
GO:0006366transcription by RNA polymerase II-TASProcess
GO:0006368transcription elongation from RNA polymerase II promoter-TASProcess
GO:0006378mRNA polyadenylation21329879.IMPProcess
GO:0010390histone monoubiquitination16307923.IDAProcess
GO:0016020membrane22046413.IDAComponent
GO:0016055Wnt signaling pathway-IEAProcess
GO:0016567protein ubiquitination-TASProcess
GO:0016584nucleosome positioning22046413.IMPProcess
GO:0016593Cdc73/Paf1 complex21873635.IBAComponent
GO:0016593Cdc73/Paf1 complex16307923.20178742.IDAComponent
GO:0019827stem cell population maintenance-IEAProcess
GO:0030054cell junction-IDAComponent
GO:0031062positive regulation of histone methylation22046413.IMPProcess
GO:0031442positive regulation of mRNA 3'-end processing21329879.IMPProcess
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter20178742.IDAProcess
GO:0033523histone H2B ubiquitination16307923.IDAProcess
GO:0034504protein localization to nucleus22046413.IMPProcess
GO:0035327transcriptionally active chromatin21873635.IBAComponent
GO:0045638negative regulation of myeloid cell differentiation20541477.IDAProcess
GO:0045944positive regulation of transcription by RNA polymerase II20178742.IDAProcess
GO:0071222cellular response to lipopolysaccharide-ISSProcess
GO:1902808positive regulation of cell cycle G1/S phase transition15923622.IMPProcess
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