EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24854846	RECQL1 plays an important role in the development of tongue squamous cell carcinoma.	Cell Physiol Biochem	2014	Tao J	doi: 10.1159/000358721
25483193	Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.	Cell Cycle	2014	Li XL	doi: 10.4161/cc.29419.
17953710	Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase.	Cancer Sci	2008 Jan	Futami K	-
25945795	Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer.	PLoS Genet	2015 May 6	Sun J	doi: 10.1371/journal.pgen.1005228
27832498	Analysis of a RECQL splicing mutation, c.1667_1667+3delAGTA, in breast cancer patients and controls from Central Europe.	Fam Cancer	2017 Apr	Bogdanova N	doi: 10.1007/s10689-016-9944-y.
23951333	RECQL1 DNA repair helicase: a potential therapeutic target and a proliferative marker against ovarian cancer.	PLoS One	2013 Aug 9	Sanada S	doi: 10.1371/journal.pone.0072820
25424877	The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer.	J Ovarian Res	2014 Nov 26	Matsushita Y	doi: 10.1186/s13048-014-0107-1.
26387136	RECQL: a DNA helicase in breast cancer.	Oncotarget	2015 Sep 29	Akbari MR	doi: 10.18632/oncotarget.5452.
20198302	RecQL1 DNA repair helicase: A potential tumor marker and therapeutic target against hepatocellular carcinoma.	Int J Mol Med	2010 Apr	Futami K	-
21752281	The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.	Mol Cancer	2011 Jul 13	Mendoza-Maldonado R	doi: 10.1186/1476-4598-10-83.
23601052	Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D.	Mol Cancer	2013 Apr 22	Lu X	doi: 10.1186/1476-4598-12-29.
27565844	Effects of RECQ1 helicase silencing on non-small cell lung cancer cells.	Biomed Pharmacother	2016 Oct	Li L	doi: 10.1016/j.biopha.2016.07.053
26725729	RECQ1 A159C Polymorphism Is Associated With Overall Survival of Patients With Resected Pancreatic Cancer: A Replication Study in NRG Oncology Radiation Therapy Oncology Group 9704.	Int J Radiat Oncol Biol Phys	2016 Mar 1	Li D	doi: 10.1016/j.ijrobp.2015.10.062
25915596	Germline RECQL mutations are associated with breast cancer susceptibility.	Nat Genet	2015 Jun	Cybulski C	doi: 10.1038/ng.3284
26125302	RECQL: a new breast cancer susceptibility gene.	Cell Cycle	2015	Banerjee T	doi: 10.1080/15384101.2015.1066539.
27125668	Germline RECQL mutations in high risk Chinese breast cancer patients.	Breast Cancer Res Treat	2016 Jun	Kwong A	doi: 10.1007/s10549-016-3784-1
29341116	Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer.	Int J Cancer	2018 Jun 1	Tervasmki A	doi: 10.1002/ijc.31259
29351780	FANCM and RECQL genetic variants and breast cancer susceptibility: relevance to South Poland and West Ukraine.	BMC Med Genet	2018 Jan 19	Nguyen-Dumont T	doi: 10.1186/s12881-018-0524-x.
29914420	Low expression of RECQL is associated with poor prognosis in Chinese breast cancer patients.	BMC Cancer	2018 Jun 18	Xu H	doi: 10.1186/s12885-018-4585-1.
30224651	Mutations in RECQL are not associated with breast cancer risk in an Australian population.	Nat Genet	2018 Oct	Li N	doi: 10.1038/s41588-018-0206-9.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	21471077	Silent	novel	A563A	0.43
BLCA	chr12	21471480	Missense_Mutation	NA	R539G	0.18
BLCA	chr12	21483453	Missense_Mutation	novel	Y208F	0.17
BLCA	chr12	21471604	Silent	NA	I497I	0.06
BLCA	chr12	21471604	Missense_Mutation	novel	I497M	0.13
BLCA	chr12	21471542	Missense_Mutation	NA	S518F	0.09
BLCA	chr12	21499582	5'UTR	novel		0.43
BLCA	chr12	21474934	Missense_Mutation	NA	G421E	0.67
BRCA	chr12	21471492	Missense_Mutation	NA	P535S	0.28
BRCA	chr12	21486560	Silent	NA	L140L	0.52
BRCA	chr12	21474884	Nonsense_Mutation	novel	Q438*	0.04
BRCA	chr12	21477813	Missense_Mutation	NA	L286Q	0.52
BRCA	chr12	21470206	Silent	rs763894040	I646I	0.18
BRCA	chr12	21471601	Missense_Mutation	novel	K498N	0.09
BRCA	chr12	21477856	Nonsense_Mutation	novel	E272*	0.05
BRCA	chr12	21477857	Frame_Shift_Ins	novel	*E272Lfs5**	0.07
CESC	chr12	21490352	Missense_Mutation	NA	D81Y	0.37
CESC	chr12	21471101	Splice_Region	novel		0.17
CESC	chr12	21476939	Silent	NA	L307L	0.31
CESC	chr12	21471514	Silent	rs774747023	L527L	0.11
CESC	chr12	21486510	Missense_Mutation	rs766866319	S157L	0.19
COAD	chr12	21475493	Missense_Mutation	novel	N397K	0.45
COAD	chr12	21490197	Splice_Site	NA	X132_splice	0.48
COAD	chr12	21475471	Missense_Mutation	NA	A405T	0.28
COAD	chr12	21499610	5'UTR	novel		0.24
COAD	chr12	21477928	Missense_Mutation	rs202110155	A248T	0.24
COAD	chr12	21476927	Silent	NA	R311R	0.32
COAD	chr12	21475467	Splice_Site	rs199622367	X406_splice	0.28
ESCA	chr12	21470303	Frame_Shift_Del	novel	*K614Rfs46**	0.35
ESCA	chr12	21474962	Missense_Mutation	novel	A412T	0.6
ESCA	chr12	21477929	Silent	rs148490073	N247N	0.37
ESCA	chr12	21474841	Missense_Mutation	rs577044266	K452R	0.8
ESCA	chr12	21483524	Missense_Mutation	novel	L184F	0.13
GBM	chr12	21491633	Missense_Mutation	novel	E34Q	0.17
GBM	chr12	21490200	Splice_Region	rs781458665	D131D	0.3
GBM	chr12	21476965	Missense_Mutation	novel	D299Y	0.18
GBM	chr12	21499565	Silent	novel	A2A	0.06
HNSC	chr12	21473603	Silent	novel	V465V	0.19
HNSC	chr12	21471051	Frame_Shift_Ins	novel	*I572Kfs2**	0.17
HNSC	chr12	21476959	Missense_Mutation	novel	I301V	0.29
HNSC	chr12	21471466	Silent	novel	E543E	0.2
HNSC	chr12	21475678	Nonsense_Mutation	novel	Q366*	0.43
HNSC	chr12	21476939	Silent	NA	L307L	0.09
HNSC	chr12	21477820	Missense_Mutation	novel	P284S	0.25
HNSC	chr12	21473620	Missense_Mutation	novel	Q460E	0.24
KIRC	chr12	21471069	Nonsense_Mutation	novel	*T566delinsINKLIA*	0.05
KIRP	chr12	21470211	Missense_Mutation	NA	K645Q	0.63
LAML	chr12	21483574	Missense_Mutation	novel	E168K	0.18
LAML	chr12	21483538	Missense_Mutation	novel	K180E	0.12
LAML	chr12	21490346	Silent	novel	L83L	0.07
LGG	chr12	21491605	Missense_Mutation	novel	T43I	0.09
LIHC	chr12	21477944	Silent	NA	K242K	0.06
LIHC	chr12	21490276	Missense_Mutation	NA	G106A	0.18	ResIII
LIHC	chr12	21490276	Missense_Mutation	NA	G106A	0.94	ResIII
LIHC	chr12	21491697	Silent	NA	D12D	0.28
LUAD	chr12	21491663	Nonsense_Mutation	novel	Q24*	0.23
LUAD	chr12	21499561	Missense_Mutation	NA	V4F	0.09
LUAD	chr12	21499600	5'UTR	novel		0.14
LUAD	chr12	21483400	Nonsense_Mutation	novel	Q226*	0.09
LUAD	chr12	21471566	Missense_Mutation	novel	L510P	0.1
LUAD	chr12	21490227	Nonsense_Mutation	novel	C122*	0.25	ResIII
LUAD	chr12	21483445	Missense_Mutation	NA	R211W	0.42
LUAD	chr12	21483467	Frame_Shift_Ins	novel	*R203Sfs4**	0.07
LUAD	chr12	21483468	Nonsense_Mutation	novel	R203delinsM*	0.07
LUSC	chr12	21490269	Missense_Mutation	NA	E108D	0.19	ResIII
LUSC	chr12	21477927	Missense_Mutation	novel	A248E	0.57
LUSC	chr12	21486584	Splice_Region	novel	G132G	0.1
LUSC	chr12	21483425	Silent	novel	A217A	0.3
LUSC	chr12	21483511	Missense_Mutation	novel	V189L	0.09
LUSC	chr12	21491608	Missense_Mutation	NA	L42P	0.34
LUSC	chr12	21483411	Missense_Mutation	novel	H222R	0.17
OV	chr12	21471062	Silent	NA	S568S	0.23
OV	chr12	21490215	Silent	NA	P126P	0.31
OV	chr12	21473582	Missense_Mutation	rs755294309	N472K	0.12
PAAD	chr12	21491609	Missense_Mutation	novel	L42M	0.15
PAAD	chr12	21471487	Silent	novel	T536T	0.21
PAAD	chr12	21491534	Missense_Mutation	rs754016839	A67T	0.19
PRAD	chr12	21477910	Missense_Mutation	rs200538229	T254A	0.38
PRAD	chr12	21473603	Silent	novel	V465V	0.08
READ	chr12	21471447	Missense_Mutation	novel	L550V	0.09
READ	chr12	21477928	Missense_Mutation	rs202110155	A248T	0.32
SKCM	chr12	21483433	Missense_Mutation	rs376839517	R215G	0.51
SKCM	chr12	21471077	Silent	NA	A563A	0.29
SKCM	chr12	21486564	Missense_Mutation	novel	P139L	0.2
SKCM	chr12	21499562	Silent	rs745666008	S3S	0.24
SKCM	chr12	21483443	Silent	NA	R211R	0.32
SKCM	chr12	21490373	Missense_Mutation	NA	P74S	0.19
SKCM	chr12	21483412	Missense_Mutation	NA	H222Y	0.14
SKCM	chr12	21486581	Frame_Shift_Del	novel	*F133Lfs8**	0.26
STAD	chr12	21491647	Missense_Mutation	rs145067169	T29M	0.25
STAD	chr12	21477881	Silent	novel	T263T	0.18
STAD	chr12	21477928	Missense_Mutation	rs202110155	A248T	0.37
STAD	chr12	21471552	Silent	novel	L515L	0.09
STAD	chr12	21483445	Missense_Mutation	NA	R211G	0.1
STAD	chr12	21499600	5'UTR	novel		0.18
STAD	chr12	21475577	Silent	rs774173984	V369V	0.09
STAD	chr12	21473634	Missense_Mutation	NA	R455L	0.62
STAD	chr12	21491613	Frame_Shift_Del	rs745659712	*V41Sfs2**	0.41
STAD	chr12	21474903	Silent	NA	V431V	0.28
STAD	chr12	21491613	Silent	NA	K40K	0.17
STAD	chr12	21470222	Missense_Mutation	NA	A641D	0.12
STAD	chr12	21471040	Missense_Mutation	NA	A576T	0.22
STAD	chr12	21486574	Missense_Mutation	rs138278747	V136I	0.5
THYM	chr12	21490369	Missense_Mutation	novel	W75L	0.11
UCEC	chr12	21483381	Missense_Mutation	NA	R232I	0.29
UCEC	chr12	21471463	Silent	NA	K544K	0.3
UCEC	chr12	21471062	Silent	rs2417989	S568S	0.46
UCEC	chr12	21490379	Splice_Site	NA	X72_splice	0.33
UCEC	chr12	21491640	Silent	novel	R31R	0.06
UCEC	chr12	21475467	Splice_Site	NA	X406_splice	0.25
UCEC	chr12	21499572	5'UTR	novel		0.32
UCEC	chr12	21470209	Missense_Mutation	NA	K645N	0.36
UCEC	chr12	21471049	Nonsense_Mutation	novel	G573*	0.4
UCEC	chr12	21471507	Missense_Mutation	rs768793126	A530T	0.35
UCEC	chr12	21471450	Missense_Mutation	novel	F549L	0.4
UCEC	chr12	21499612	5'UTR	novel		0.33
UCEC	chr12	21486536	Missense_Mutation	novel	L148F	0.49
UCEC	chr12	21499610	5'UTR	novel		0.53
UCEC	chr12	21473599	Missense_Mutation	novel	N467H	0.13
UCEC	chr12	21477928	Missense_Mutation	rs202110155	A248T	0.2
UCEC	chr12	21477889	Missense_Mutation	rs761204305	V261I	0.3
UCEC	chr12	21473639	Silent	novel	C453C	0.32
UCEC	chr12	21471551	Missense_Mutation	novel	L515R	0.4
UCEC	chr12	21470222	Missense_Mutation	NA	A641D	0.22
UCEC	chr12	21470206	Silent	rs763894040	I646I	0.29
UCEC	chr12	21475720	Missense_Mutation	novel	D352Y	0.21
UCEC	chr12	21470961	Splice_Region	novel		0.47
UCEC	chr12	21474855	Silent	novel	C447C	0.29
UCEC	chr12	21491611	Missense_Mutation	novel	V41A	0.45
UCEC	chr12	21491535	Silent	rs754948157	A66A	0.43
UCEC	chr12	21499616	Splice_Site	rs756434860		0.34
UCEC	chr12	21474894	Missense_Mutation	novel	N434K	0.15
UCEC	chr12	21477940	Nonsense_Mutation	NA	Q244*	0.32
UCEC	chr12	21471062	Silent	rs2417989	S568S	0.27
UCEC	chr12	21499561	Missense_Mutation	rs201737130	V4I	0.31
UCEC	chr12	21483527	Silent	NA	E183E	0.3
UCEC	chr12	21491582	Nonsense_Mutation	novel	E51*	0.14
UCEC	chr12	21475476	Missense_Mutation	NA	G403E	0.24
UCEC	chr12	21483534	Frame_Shift_Del	novel	*N181Tfs4**	0.32
UCEC	chr12	21483407	Nonsense_Mutation	novel	C223*	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0833	0.11856
PAAD	DEL	0.1087	0.0019175
READ	DEL	0.103	0.064633
TGCT	AMP	0.9467	1.4729e-22
THYM	AMP	0.0325	0.24554

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0057	Kaplan-Meier Survival Analysis
SARC	0.047	Kaplan-Meier Survival Analysis
MESO	0.0018	Kaplan-Meier Survival Analysis
ACC	0.017	Kaplan-Meier Survival Analysis
UCS	0.021	Kaplan-Meier Survival Analysis
SKCM	0.0015	Kaplan-Meier Survival Analysis
PRAD	0.0082	Kaplan-Meier Survival Analysis
BRCA	0.023	Kaplan-Meier Survival Analysis
PAAD	0.0046	Kaplan-Meier Survival Analysis
BLCA	0.02	Kaplan-Meier Survival Analysis
CESC	0.025	Kaplan-Meier Survival Analysis
LAML	0.048	Kaplan-Meier Survival Analysis
LIHC	0.0072	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.002	Kaplan-Meier Survival Analysis
UVM	0.0023	Kaplan-Meier Survival Analysis
OV	0.0075	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000004700 (Gene tree)
Gene ID: 5965
Gene Symbol: RECQL
Alias: RecQ1|RecQL1
Full Name: RecQ like helicase
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 32,760 bases
Position: chr12:21,468,910-21,501,669
Accession: 9948
Summary: The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. The encoded protein is involved in the processing of Holliday junctions, the suppression of sister chromatid exchanges, telomere maintenance, and is required for genotoxic stress resistance. Defects in this gene have been associated with several types of cancer. [provided by RefSeq, Jan 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000395449	ResIII	PF04851.15	1.6e-06	1	1
ENSP00000416739	ResIII	PF04851.15	1.6e-06	1	1
ENSP00000395449	DEAD	PF00270.29	7.2e-17	1	1
ENSP00000416739	DEAD	PF00270.29	7.2e-17	1	1
ENSP00000379400	DEAD	PF00270.29	6.5e-12	1	1
ENSP00000318727	DEAD	PF00270.29	9.4e-12	1	1
ENSP00000445555	DEAD	PF00270.29	1.1e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18448429	The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.	J Biol Chem	2008 Jun 27	Popuri V	doi: 10.1074/jbc.M709749200

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000536240	RECQL-205	565	-	ENSP00000439069	106 (aa)	-	F5H3W0
ENST00000421138	RECQL-203	2572	-	ENSP00000395449	649 (aa)	-	P46063
ENST00000314748	RECQL-201	1054	-	ENSP00000318727	199 (aa)	-	F8WA66
ENST00000444129	RECQL-204	3702	XM_005253461	ENSP00000416739	649 (aa)	XP_005253518	P46063
ENST00000396093	RECQL-202	932	-	ENSP00000379400	211 (aa)	-	F8WD97
ENST00000539672	RECQL-207	579	-	ENSP00000440700	72 (aa)	-	F5GYB7
ENST00000542432	RECQL-208	600	-	ENSP00000445555	131 (aa)	-	F5H2L2
ENST00000536964	RECQL-206	578	-	ENSP00000446036	96 (aa)	-	F5H4P4

Gene Model

Click here to download ENSG00000004700's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000004700	Platelet Function Tests	4.5900000E-006	-
ENSG00000004700	Platelet Function Tests	4.2000000E-006	-
ENSG00000004700	Platelet Function Tests	5.2400000E-006	-
ENSG00000004700	Platelet Function Tests	4.8200000E-006	-
ENSG00000004700	Platelet Function Tests	2.0700000E-006	-
ENSG00000004700	Platelet Function Tests	1.7800000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000004700's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000004700	RECQL	65	58.696	ENSAPOG00000021194	-	84	50.222	Acanthochromis_polyacanthus
ENSG00000004700	RECQL	100	88.136	ENSAMEG00000016233	RECQL	100	88.136	Ailuropoda_melanoleuca
ENSG00000004700	RECQL	90	59.696	ENSACIG00000020781	recql	93	60.034	Amphilophus_citrinellus
ENSG00000004700	RECQL	95	56.704	ENSAOCG00000010244	recql	97	56.866	Amphiprion_ocellaris
ENSG00000004700	RECQL	95	55.784	ENSAPEG00000002040	recql	98	56.101	Amphiprion_percula
ENSG00000004700	RECQL	96	57.143	ENSATEG00000023342	recql	98	57.346	Anabas_testudineus
ENSG00000004700	RECQL	97	74.146	ENSAPLG00000003404	RECQL	99	73.292	Anas_platyrhynchos
ENSG00000004700	RECQL	99	74.619	ENSACAG00000017383	RECQL	99	80.266	Anolis_carolinensis
ENSG00000004700	RECQL	100	96.682	ENSANAG00000035372	RECQL	99	97.222	Aotus_nancymaae
ENSG00000004700	RECQL	90	59.729	ENSACLG00000021416	recql	98	54.312	Astatotilapia_calliptera
ENSG00000004700	RECQL	98	57.121	ENSAMXG00000014249	recql	98	57.121	Astyanax_mexicanus
ENSG00000004700	RECQL	100	92.417	ENSBTAG00000021083	RECQL	100	90.447	Bos_taurus
ENSG00000004700	RECQL	98	44.898	WBGene00019334	K02F3.12	97	45.172	Caenorhabditis_elegans
ENSG00000004700	RECQL	100	96.682	ENSCJAG00000044420	RECQL	100	96.610	Callithrix_jacchus
ENSG00000004700	RECQL	100	88.626	ENSCAFG00000012221	RECQL	100	88.290	Canis_familiaris
ENSG00000004700	RECQL	100	88.626	ENSCAFG00020007872	RECQL	100	88.290	Canis_lupus_dingo
ENSG00000004700	RECQL	100	91.943	ENSCHIG00000024281	RECQL	100	89.676	Capra_hircus
ENSG00000004700	RECQL	100	94.313	ENSTSYG00000009224	RECQL	100	93.066	Carlito_syrichta
ENSG00000004700	RECQL	100	91.943	ENSCPOG00000024644	RECQL	99	89.676	Cavia_porcellus
ENSG00000004700	RECQL	100	97.072	ENSCCAG00000028085	RECQL	100	97.072	Cebus_capucinus
ENSG00000004700	RECQL	100	98.921	ENSCATG00000036038	RECQL	100	98.921	Cercocebus_atys
ENSG00000004700	RECQL	100	89.573	ENSCLAG00000014618	RECQL	100	89.368	Chinchilla_lanigera
ENSG00000004700	RECQL	100	98.613	ENSCSAG00000007974	RECQL	100	98.613	Chlorocebus_sabaeus
ENSG00000004700	RECQL	100	88.550	ENSCHOG00000002452	RECQL	90	89.820	Choloepus_hoffmanni
ENSG00000004700	RECQL	100	76.884	ENSCPBG00000009109	RECQL	97	75.851	Chrysemys_picta_bellii
ENSG00000004700	RECQL	95	44.231	ENSCING00000004012	-	92	46.691	Ciona_intestinalis
ENSG00000004700	RECQL	95	42.328	ENSCSAVG00000011052	-	89	45.543	Ciona_savignyi
ENSG00000004700	RECQL	100	98.767	ENSCANG00000035259	RECQL	100	98.767	Colobus_angolensis_palliatus
ENSG00000004700	RECQL	100	88.945	ENSCGRG00001015141	Recql	100	87.057	Cricetulus_griseus_chok1gshd
ENSG00000004700	RECQL	100	88.945	ENSCGRG00000003545	Recql	100	87.057	Cricetulus_griseus_crigri
ENSG00000004700	RECQL	94	56.240	ENSCSEG00000015932	recql	94	57.550	Cynoglossus_semilaevis
ENSG00000004700	RECQL	96	56.938	ENSCVAG00000014613	recql	93	60.204	Cyprinodon_variegatus
ENSG00000004700	RECQL	100	53.171	ENSDARG00000007175	recql	97	57.372	Danio_rerio
ENSG00000004700	RECQL	100	91.457	ENSDNOG00000013557	RECQL	99	93.555	Dasypus_novemcinctus
ENSG00000004700	RECQL	99	85.577	ENSDORG00000015884	Recql	100	83.234	Dipodomys_ordii
ENSG00000004700	RECQL	92	83.333	ENSETEG00000018325	-	63	79.355	Echinops_telfairi
ENSG00000004700	RECQL	97	86.010	ENSETEG00000018631	-	99	79.439	Echinops_telfairi
ENSG00000004700	RECQL	99	86.357	ENSEASG00005014041	RECQL	95	91.463	Equus_asinus_asinus
ENSG00000004700	RECQL	100	88.906	ENSECAG00000024762	RECQL	87	88.906	Equus_caballus
ENSG00000004700	RECQL	94	58.654	ENSELUG00000011528	recql	96	58.654	Esox_lucius
ENSG00000004700	RECQL	100	88.598	ENSFCAG00000030888	RECQL	99	88.598	Felis_catus
ENSG00000004700	RECQL	96	72.134	ENSFALG00000002635	RECQL	98	72.134	Ficedula_albicollis
ENSG00000004700	RECQL	100	90.521	ENSFDAG00000019693	RECQL	100	89.831	Fukomys_damarensis
ENSG00000004700	RECQL	99	56.682	ENSFHEG00000014563	recql	99	57.323	Fundulus_heteroclitus
ENSG00000004700	RECQL	78	58.777	ENSGMOG00000010504	recql	100	58.777	Gadus_morhua
ENSG00000004700	RECQL	100	73.869	ENSGALG00000013174	RECQL	98	73.035	Gallus_gallus
ENSG00000004700	RECQL	99	49.309	ENSGACG00000001005	recql	97	57.461	Gasterosteus_aculeatus
ENSG00000004700	RECQL	100	77.725	ENSGAGG00000025428	RECQL	97	76.161	Gopherus_agassizii
ENSG00000004700	RECQL	100	99.230	ENSGGOG00000010985	RECQL	100	99.230	Gorilla_gorilla
ENSG00000004700	RECQL	95	57.166	ENSHBUG00000001341	recql	98	57.166	Haplochromis_burtoni
ENSG00000004700	RECQL	100	92.417	ENSHGLG00000009712	RECQL	100	89.676	Heterocephalus_glaber_female
ENSG00000004700	RECQL	99	91.827	ENSHGLG00100015306	RECQL	100	89.319	Heterocephalus_glaber_male
ENSG00000004700	RECQL	95	58.911	ENSHCOG00000012735	recql	97	58.871	Hippocampus_comes
ENSG00000004700	RECQL	100	55.024	ENSIPUG00000024092	recql	99	54.136	Ictalurus_punctatus
ENSG00000004700	RECQL	95	92.000	ENSSTOG00000006328	RECQL	100	86.936	Ictidomys_tridecemlineatus
ENSG00000004700	RECQL	98	91.262	ENSJJAG00000017339	Recql	100	84.341	Jaculus_jaculus
ENSG00000004700	RECQL	97	53.905	ENSKMAG00000011232	recql	97	55.063	Kryptolebias_marmoratus
ENSG00000004700	RECQL	98	55.538	ENSLBEG00000023652	recql	98	55.846	Labrus_bergylta
ENSG00000004700	RECQL	100	70.854	ENSLACG00000011482	RECQL	93	72.120	Latimeria_chalumnae
ENSG00000004700	RECQL	100	57.286	ENSLOCG00000015393	recql	97	54.545	Lepisosteus_oculatus
ENSG00000004700	RECQL	99	90.994	ENSLAFG00000000963	RECQL	99	90.994	Loxodonta_africana
ENSG00000004700	RECQL	100	99.076	ENSMFAG00000031470	RECQL	100	99.076	Macaca_fascicularis
ENSG00000004700	RECQL	100	99.076	ENSMMUG00000010857	RECQL	100	99.076	Macaca_mulatta
ENSG00000004700	RECQL	100	99.076	ENSMNEG00000031827	RECQL	100	99.076	Macaca_nemestrina
ENSG00000004700	RECQL	100	98.611	ENSMLEG00000039659	RECQL	99	98.998	Mandrillus_leucophaeus
ENSG00000004700	RECQL	92	57.261	ENSMAMG00000023289	recql	94	57.261	Mastacembelus_armatus
ENSG00000004700	RECQL	95	57.166	ENSMZEG00005016027	recql	98	57.166	Maylandia_zebra
ENSG00000004700	RECQL	100	73.367	ENSMGAG00000013629	RECQL	98	73.538	Meleagris_gallopavo
ENSG00000004700	RECQL	100	88.442	ENSMAUG00000010642	Recql	99	89.270	Mesocricetus_auratus
ENSG00000004700	RECQL	100	91.469	ENSMICG00000002664	RECQL	100	90.293	Microcebus_murinus
ENSG00000004700	RECQL	100	84.422	ENSMOCG00000007093	Recql	100	83.385	Microtus_ochrogaster
ENSG00000004700	RECQL	96	52.469	ENSMMOG00000007279	recql	99	53.042	Mola_mola
ENSG00000004700	RECQL	97	87.255	ENSMODG00000017805	RECQL	99	83.410	Monodelphis_domestica
ENSG00000004700	RECQL	91	57.807	ENSMALG00000004415	recql	93	57.807	Monopterus_albus
ENSG00000004700	RECQL	100	87.940	MGP_CAROLIEiJ_G0029030	Recql	100	86.228	Mus_caroli
ENSG00000004700	RECQL	100	87.940	ENSMUSG00000030243	Recql	100	86.228	Mus_musculus
ENSG00000004700	RECQL	100	89.447	MGP_PahariEiJ_G0022791	Recql	100	88.024	Mus_pahari
ENSG00000004700	RECQL	100	87.437	MGP_SPRETEiJ_G0030085	Recql	100	86.228	Mus_spretus
ENSG00000004700	RECQL	100	89.573	ENSMPUG00000000202	RECQL	100	88.923	Mustela_putorius_furo
ENSG00000004700	RECQL	100	90.293	ENSMLUG00000005741	RECQL	100	90.293	Myotis_lucifugus
ENSG00000004700	RECQL	100	81.061	ENSNGAG00000020417	-	98	71.121	Nannospalax_galili
ENSG00000004700	RECQL	100	90.995	ENSNGAG00000010997	-	100	86.903	Nannospalax_galili
ENSG00000004700	RECQL	90	59.797	ENSNBRG00000020825	recql	98	57.075	Neolamprologus_brichardi
ENSG00000004700	RECQL	100	100.000	ENSNLEG00000004797	RECQL	100	99.538	Nomascus_leucogenys
ENSG00000004700	RECQL	100	92.462	ENSOPRG00000007493	RECQL	100	90.985	Ochotona_princeps
ENSG00000004700	RECQL	97	90.244	ENSODEG00000010240	RECQL	100	89.088	Octodon_degus
ENSG00000004700	RECQL	96	56.556	ENSONIG00000001694	recql	98	56.556	Oreochromis_niloticus
ENSG00000004700	RECQL	64	48.905	ENSOANG00000021930	-	100	48.094	Ornithorhynchus_anatinus
ENSG00000004700	RECQL	100	91.943	ENSOCUG00000008787	RECQL	100	90.293	Oryctolagus_cuniculus
ENSG00000004700	RECQL	99	49.550	ENSORLG00000012853	recql	94	54.531	Oryzias_latipes
ENSG00000004700	RECQL	99	49.550	ENSORLG00020020245	recql	93	57.383	Oryzias_latipes_hni
ENSG00000004700	RECQL	99	49.550	ENSORLG00015018708	recql	93	57.383	Oryzias_latipes_hsok
ENSG00000004700	RECQL	94	56.090	ENSOMEG00000019484	recql	94	57.973	Oryzias_melastigma
ENSG00000004700	RECQL	99	92.558	ENSOGAG00000004754	RECQL	99	92.558	Otolemur_garnettii
ENSG00000004700	RECQL	100	91.943	ENSOARG00000020343	RECQL	100	89.985	Ovis_aries
ENSG00000004700	RECQL	100	95.692	ENSPPAG00000030306	RECQL	99	95.692	Pan_paniscus
ENSG00000004700	RECQL	100	89.060	ENSPPRG00000010371	RECQL	99	89.060	Panthera_pardus
ENSG00000004700	RECQL	100	89.060	ENSPTIG00000008593	RECQL	100	89.060	Panthera_tigris_altaica
ENSG00000004700	RECQL	100	100.000	ENSPTRG00000004758	RECQL	99	99.231	Pan_troglodytes
ENSG00000004700	RECQL	100	98.767	ENSPANG00000003394	RECQL	100	98.767	Papio_anubis
ENSG00000004700	RECQL	96	56.651	ENSPKIG00000008072	recql	95	57.305	Paramormyrops_kingsleyae
ENSG00000004700	RECQL	100	75.879	ENSPSIG00000002979	RECQL	96	75.617	Pelodiscus_sinensis
ENSG00000004700	RECQL	99	51.598	ENSPMGG00000011010	recql	92	57.119	Periophthalmus_magnuspinnatus
ENSG00000004700	RECQL	100	89.000	ENSPEMG00000016418	Recql	100	87.538	Peromyscus_maniculatus_bairdii
ENSG00000004700	RECQL	100	57.073	ENSPMAG00000005495	recql	98	57.454	Petromyzon_marinus
ENSG00000004700	RECQL	100	84.925	ENSPCIG00000022452	RECQL	99	83.155	Phascolarctos_cinereus
ENSG00000004700	RECQL	96	55.189	ENSPFOG00000000940	recql	90	58.883	Poecilia_formosa
ENSG00000004700	RECQL	96	55.189	ENSPLAG00000006194	recql	89	58.714	Poecilia_latipinna
ENSG00000004700	RECQL	99	53.670	ENSPMEG00000013399	recql	90	58.124	Poecilia_mexicana
ENSG00000004700	RECQL	96	54.245	ENSPREG00000012991	recql	91	58.714	Poecilia_reticulata
ENSG00000004700	RECQL	100	98.921	ENSPPYG00000004352	RECQL	100	98.921	Pongo_abelii
ENSG00000004700	RECQL	100	85.496	ENSPCOG00000027353	RECQL	100	88.675	Propithecus_coquereli
ENSG00000004700	RECQL	93	90.728	ENSPVAG00000002457	RECQL	93	90.698	Pteropus_vampyrus
ENSG00000004700	RECQL	95	57.166	ENSPNYG00000016013	recql	98	57.166	Pundamilia_nyererei
ENSG00000004700	RECQL	99	55.878	ENSPNAG00000029317	recql	99	55.878	Pygocentrus_nattereri
ENSG00000004700	RECQL	100	82.412	ENSRNOG00000012602	Recql	99	84.980	Rattus_norvegicus
ENSG00000004700	RECQL	100	98.921	ENSRBIG00000034966	RECQL	100	98.921	Rhinopithecus_bieti
ENSG00000004700	RECQL	100	98.921	ENSRROG00000010234	RECQL	100	98.921	Rhinopithecus_roxellana
ENSG00000004700	RECQL	100	97.381	ENSSBOG00000005645	RECQL	100	97.381	Saimiri_boliviensis_boliviensis
ENSG00000004700	RECQL	100	85.427	ENSSHAG00000015815	RECQL	99	83.614	Sarcophilus_harrisii
ENSG00000004700	RECQL	99	55.814	ENSSFOG00015002537	recql	92	60.870	Scleropages_formosus
ENSG00000004700	RECQL	95	55.854	ENSSMAG00000014910	recql	98	56.013	Scophthalmus_maximus
ENSG00000004700	RECQL	95	56.013	ENSSDUG00000019205	recql	98	56.329	Seriola_dumerili
ENSG00000004700	RECQL	95	56.013	ENSSLDG00000013921	recql	98	55.975	Seriola_lalandi_dorsalis
ENSG00000004700	RECQL	78	76.471	ENSSPUG00000018613	RECQL	91	63.908	Sphenodon_punctatus
ENSG00000004700	RECQL	95	55.721	ENSSPAG00000008384	recql	98	55.873	Stegastes_partitus
ENSG00000004700	RECQL	100	90.995	ENSSSCG00000000580	RECQL	100	91.590	Sus_scrofa
ENSG00000004700	RECQL	98	71.359	ENSTGUG00000011730	RECQL	98	70.898	Taeniopygia_guttata
ENSG00000004700	RECQL	99	52.153	ENSTRUG00000000534	recql	99	57.016	Takifugu_rubripes
ENSG00000004700	RECQL	99	50.711	ENSTNIG00000007242	recql	99	54.341	Tetraodon_nigroviridis
ENSG00000004700	RECQL	99	91.667	ENSTBEG00000004653	RECQL	91	91.667	Tupaia_belangeri
ENSG00000004700	RECQL	100	87.023	ENSTTRG00000003296	RECQL	90	89.222	Tursiops_truncatus
ENSG00000004700	RECQL	100	87.982	ENSUAMG00000003261	RECQL	100	87.982	Ursus_americanus
ENSG00000004700	RECQL	100	89.214	ENSUMAG00000001523	RECQL	100	89.214	Ursus_maritimus
ENSG00000004700	RECQL	89	91.667	ENSVPAG00000007546	RECQL	89	91.667	Vicugna_pacos
ENSG00000004700	RECQL	100	89.100	ENSVVUG00000001101	RECQL	100	88.752	Vulpes_vulpes
ENSG00000004700	RECQL	79	68.093	ENSXETG00000013524	recql	99	68.217	Xenopus_tropicalis
ENSG00000004700	RECQL	94	55.662	ENSXMAG00000029316	recql	97	55.573	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000724	double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:0000733	DNA strand renaturation	19177149.	IDA	Process
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003678	DNA helicase activity	11562355.	IDA	Function
GO:0004003	ATP-dependent DNA helicase activity	7961977.	TAS	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	9168958.15886194.23396353.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005694	chromosome	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006281	DNA repair	21873635.	IBA	Process
GO:0006310	DNA recombination	21873635.	IBA	Process
GO:0009378	four-way junction helicase activity	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0032508	DNA duplex unwinding	21873635.	IBA	Process
GO:0036310	annealing helicase activity	21873635.	IBA	Function
GO:0036310	annealing helicase activity	19177149.	IDA	Function
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21873635.	IBA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.