EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20843712	Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer.	Urol Oncol	2012 Jul-Aug	Chiyomaru T	doi: 10.1016/j.urolonc.2010.05.008
16430883	Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells.	Exp Cell Res	2006 Apr 15	Grunewald TG	-
19155088	LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma.	J Hepatol	2009 Mar	Wang B	doi: 10.1016/j.jhep.2008.10.025
28404954	Upregulation of the long non-coding RNA PVT1 promotes esophageal squamous cell carcinoma progression by acting as a molecular sponge of miR-203 and LASP1.	Oncotarget	2017 May 23	Li PD	doi: 10.18632/oncotarget.15878.
28982387	MiR-203a-3p suppresses cell proliferation and metastasis through inhibiting LASP1 in nasopharyngeal carcinoma.	J Exp Clin Cancer Res	2017 Oct 5	Jiang N	doi: 10.1186/s13046-017-0604-3.
21215099	[Impact of LASP-1 expression on proliferation and tumorigenesis of human colorectal cancer cell line SW480].	Zhonghua Bing Li Xue Za Zhi	2010 Dec	Zhao L	-
24990592	LASP-1 promotes tumor proliferation and metastasis and is an independent unfavorable prognostic factor in gastric cancer.	J Cancer Res Clin Oncol	2014 Nov	Zheng J	doi: 10.1007/s00432-014-1759-3
28621232	Paving the path for invasion: The polyedric role of LASP1 in cancer.	Tumour Biol	2017 Jun	Ruggieri V	doi: 10.1177/1010428317705757.
27938497	Silencing of LIM and SH3 Protein 1 (LASP-1) Inhibits Thyroid Cancer Cell Proliferation and Invasion.	Oncol Res	2017 Jul 5	Gao W	doi: 10.3727/096504016X14785415155643
29207145	MicroRNA-133a acts as a tumour suppressor in breast cancer through targeting LASP1.	Oncol Rep	2018 Feb	Sui Y	doi: 10.3892/or.2017.6114
26797416	LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway.	Cancer Lett	2016 Mar 28	Li Z	doi: 10.1016/j.canlet.2016.01.008
22713668	MicroRNA-203 suppresses cell proliferation and migration by targeting BIRC5 and LASP1 in human triple-negative breast cancer cells.	J Exp Clin Cancer Res	2012 Jun 19	Wang C	doi: 10.1186/1756-9966-31-58.
27840958	Suppression of LASP-1 attenuates the carcinogenesis of prostatic cancer cell lines: Key role of the NF-??B pathway.	Oncol Rep	2017 Jan	Sun W	doi: 10.3892/or.2016.5223
24955835	LIM and SH3 domain protein 1 (LASP-1) overexpression was associated with aggressive phenotype and poor prognosis in clear cell renal cell cancer.	PLoS One	2014 Jun 23	Yang F	doi: 10.1371/journal.pone.0100557
20461080	Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer.	Br J Cancer	2010 May 25	Frietsch JJ	doi: 10.1038/sj.bjc.6605685
25252758	LIM and SH3 protein 1 induces TGFβ-mediated epithelial-mesenchymal transition in human colorectal cancer by regulating S100A4 expression.	Clin Cancer Res	2014 Nov 15	Wang H	doi: 10.1158/1078-0432.CCR-14-0485
26683818	LASP-1, regulated by miR-203, promotes tumor proliferation and aggressiveness in human non-small cell lung cancer.	Exp Mol Pathol	2016 Feb	Zheng J	doi: 10.1016/j.yexmp.2015.11.031
20660701	Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1.	Gut	2010 Sep	Zhao L	doi: 10.1136/gut.2009.202739
27696291	MicroRNA-218 inhibits the proliferation, migration, and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1.	Tumour Biol	2016 Nov	Wang LL	-
24386158	Overexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancer.	PLoS One	2013 Dec 26	Shimizu F	doi: 10.1371/journal.pone.0083187
25622104	An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein.	Oncotarget	2015 Jan 1	Orth MF	-
27588391	Regulation of matrix metalloproteinases (MMPs) expression and secretion in MDA-MB-231 breast cancer cells by LIM and SH3 protein 1 (LASP1).	Oncotarget	2016 Sep 27	Endres M	doi: 10.18632/oncotarget.11720.
27156963	Loss of the 14-3-3?? is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway.	Sci Rep	2016 May 9	Shao Z	doi: 10.1038/srep25631.
27181092	LASP1-S100A11 axis promotes colorectal cancer aggressiveness by modulating TGFβ/Smad signaling.	Sci Rep	2016 May 16	Niu Y	doi: 10.1038/srep26112.
29138807	Role of LASP-1, a novel SOX9 transcriptional target, in the progression of lung cancer.	Int J Oncol	2018 Jan	Shi J	doi: 10.3892/ijo.2017.4201

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr17	38914323	Splice_Site	novel	X120_splice	0.24
BLCA	chr17	38914351	Silent	novel	K128K	0.46
BLCA	chr17	38870160	5'UTR	novel		0.23
BLCA	chr17	38890502	Nonsense_Mutation	rs776937950	Q83*	0.15
BLCA	chr17	38918698	Missense_Mutation	novel	D236N	0.47
BLCA	chr17	38870117	5'UTR	novel		0.45
BLCA	chr17	38870208	Missense_Mutation	NA	R7G	0.54
BRCA	chr17	38898488	Missense_Mutation	NA	R109K	0.19
BRCA	chr17	38898520	Splice_Site	novel	X119_splice	0.13
BRCA	chr17	38918642	Missense_Mutation	NA	D217A	0.32
BRCA	chr17	38915041	Splice_Site	novel	X170_splice	0.75
BRCA	chr17	38870134	5'UTR	novel		1
CESC	chr17	38921226	3'UTR	novel		0.12
CESC	chr17	38920856	3'UTR	novel		0.42
CESC	chr17	38920972	3'UTR	novel		0.39
CESC	chr17	38878106	Missense_Mutation	NA	F30L	0.16
CESC	chr17	38914369	Silent	rs755621366	S134S	0.07
COAD	chr17	38878180	Missense_Mutation	NA	A55V	0.58
COAD	chr17	38918806	3'UTR	novel		0.13
COAD	chr17	38918703	Silent	rs746197131	D237D	0.24
COAD	chr17	38914411	Silent	rs147575335	D148D	0.63
COAD	chr17	38918822	3'UTR	rs775926173		0.33
ESCA	chr17	38920342	3'UTR	novel		0.27
ESCA	chr17	38918692	Nonsense_Mutation	novel	Q234*	0.12
HNSC	chr17	38870185	5'UTR	novel		0.15
HNSC	chr17	38915129	Missense_Mutation	novel	A199S	0.29
HNSC	chr17	38918781	3'UTR	novel		0.36
KIRC	chr17	38918844	3'UTR	rs547870741		0.14
KIRC	chr17	38870145	5'UTR	novel		0.28
KIRP	chr17	38914475	Missense_Mutation	NA	V170I	0.51
KIRP	chr17	38898589	Intron	novel		0.19
LGG	chr17	38870084	5'UTR	novel		0.27
LIHC	chr17	38918635	Missense_Mutation	novel	A215T	0.27
LIHC	chr17	38870169	5'UTR	novel		0.37
LUAD	chr17	38915072	Missense_Mutation	NA	A180S	0.16
LUAD	chr17	38918753	Frame_Shift_Ins	novel	*A255Lfs50**	0.16
LUAD	chr17	38890448	Missense_Mutation	novel	V65L	0.29
LUAD	chr17	38878130	Silent	NA	T38T	0.18
LUAD	chr17	38918658	Silent	rs754654518	S222S	0.1
LUAD	chr17	38918694	Silent	novel	Q234Q	0.07
LUAD	chr17	38918733	Silent	novel	T247T	0.16
LUSC	chr17	38870239	Missense_Mutation	novel	K17M	0.18
MESO	chr17	38918743	Missense_Mutation	novel	G251R	0.37
MESO	chr17	38898890	Intron	novel		0.31
OV	chr17	38915130	Missense_Mutation	novel	A199D	0.21
PRAD	chr17	38918638	Missense_Mutation	NA	A216T	0.27
PRAD	chr17	38918649	Silent	novel	D219D	0.19
READ	chr17	38918703	Silent	rs746197131	D237D	0.16
SARC	chr17	38918608	Missense_Mutation	NA	R206W	0.74
SKCM	chr17	38870188	5'UTR	novel		0.16
SKCM	chr17	38870189	5'UTR	rs769364894		0.15
SKCM	chr17	38890468	Silent	novel	N71N	0.2
SKCM	chr17	38890469	Missense_Mutation	novel	L72F	0.21
SKCM	chr17	38914460	Missense_Mutation	NA	P165S	0.27
STAD	chr17	38918750	Missense_Mutation	novel	L253P	0.3
STAD	chr17	38918788	3'UTR	rs375330746		0.24
UCEC	chr17	38898475	Missense_Mutation	novel	P105S	0.2
UCEC	chr17	38918641	Missense_Mutation	NA	D217N	0.36
UCEC	chr17	38918788	3'UTR	rs375330746		0.36
UCEC	chr17	38918965	3'UTR	novel		0.27
UCEC	chr17	38920658	3'UTR	novel		0.43
UCEC	chr17	38915143	Silent	NA	G203G	0.44
UCEC	chr17	38920779	3'UTR	novel		0.19
UCEC	chr17	38878142	Missense_Mutation	novel	K42N	0.09
UCEC	chr17	38870253	Missense_Mutation	novel	D22N	0.44
UCEC	chr17	38878127	Missense_Mutation	novel	M37I	0.1
UCEC	chr17	38898630	Intron	novel		0.24
UCEC	chr17	38919011	3'UTR	novel		0.58
UCEC	chr17	38921452	3'UTR	novel		0.29
UCEC	chr17	38915068	Silent	rs569544434	P178P	0.36
UCEC	chr17	38918822	3'UTR	rs775926173		0.5
UCEC	chr17	38920669	3'UTR	novel		0.49
UCEC	chr17	38920968	3'UTR	novel		0.32
UCEC	chr17	38918879	3'UTR	rs779136869		0.44
UCEC	chr17	38890473	Missense_Mutation	novel	R73H	0.16
UCEC	chr17	38921177	3'UTR	novel		0.38
UCEC	chr17	38918822	3'UTR	rs775926173		0.35
UCEC	chr17	38920669	3'UTR	novel		0.35
UCEC	chr17	38921666	3'UTR	novel		0.5
UCEC	chr17	38898474	Silent	novel	T104T	0.23
UCEC	chr17	38870009	5'UTR	novel		0.36
UCEC	chr17	38920807	3'UTR	novel		0.08
UCEC	chr17	38878180	Missense_Mutation	NA	A55V	0.24
UCEC	chr17	38918972	3'UTR	novel		0.31
UCEC	chr17	38918818	3'UTR	novel		0.24
UCEC	chr17	38878178	Splice_Region	rs201222670	N54N	0.46
UCEC	chr17	38918608	Missense_Mutation	NA	R206W	0.16
UCEC	chr17	38920372	3'UTR	novel		0.28
UCEC	chr17	38918715	Silent	rs374016458	Y241Y	0.25
UCEC	chr17	38920532	3'UTR	novel		0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2778	0.0017784
DLBC	DEL	0	0.18166
THCA	DEL	0.002	0.221
UCS	DEL	0.375	0.19877
UVM	DEL	0.0375	0.22482

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0068	Kaplan-Meier Survival Analysis
KIRC	0.0033	Kaplan-Meier Survival Analysis
SARC	0.024	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.0059	Kaplan-Meier Survival Analysis
SKCM	0.037	Kaplan-Meier Survival Analysis
LUSC	0.049	Kaplan-Meier Survival Analysis
TGCT	0.049	Kaplan-Meier Survival Analysis
PAAD	0.048	Kaplan-Meier Survival Analysis
READ	0.043	Kaplan-Meier Survival Analysis
LAML	0.02	Kaplan-Meier Survival Analysis
UCEC	0.00061	Kaplan-Meier Survival Analysis
LIHC	0.0011	Kaplan-Meier Survival Analysis
THCA	0.0027	Kaplan-Meier Survival Analysis
LUAD	0.0025	Kaplan-Meier Survival Analysis
UVM	0.026	Kaplan-Meier Survival Analysis
OV	0.013	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000002834 (Gene tree)
Gene ID: 3927
Gene Symbol: LASP1
Alias: MLN50|Lasp-1
Full Name: LIM and SH3 protein 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 51,912 bases
Position: chr17:38,869,859-38,921,770
Accession: 6513
Summary: This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000318008	LASP1-201	4109	-	ENSP00000325240	261 (aa)	-	Q14847
ENST00000579123	LASP1-206	1874	-	ENSP00000462564	105 (aa)	-	J3KSN1
ENST00000433206	LASP1-203	4023	-	ENSP00000401048	205 (aa)	-	Q14847
ENST00000585841	LASP1-209	1408	-	ENSP00000468664	71 (aa)	-	K7ESD6
ENST00000584106	LASP1-208	1167	-	-	- (aa)	-	-
ENST00000435347	LASP1-204	3492	-	ENSP00000392853	261 (aa)	-	Q14847
ENST00000419929	LASP1-202	762	-	ENSP00000391897	166 (aa)	-	C9J9W2
ENST00000443937	LASP1-205	1482	-	ENSP00000414803	91 (aa)	-	F6S2S5
ENST00000581485	LASP1-207	617	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000002834's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000002834	Child Development Disorders, Pervasive	1.4467000E-005	-
ENSG00000002834	Child Development Disorders, Pervasive	6.7000000E-005	-
ENSG00000002834	Cognition Disorders	4E-9	26252872
ENSG00000002834	Cognitive Dysfunction	4E-9	26252872

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000002834	rs140564516	17	38873719	A	Cognitive decline rate in late mild cognitive impairment	26252872	[0.34-0.67] unit increase	0.5032	HP_0100543\|EFO_0007710

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000002834's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000002834	LASP1	100	95.437	ENSMUSG00000038366	Lasp1	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005070	SH3/SH2 adaptor activity	7589475.	TAS	Function
GO:0005515	protein binding	16189514.19060904.21516116.22665060.25416956.25814554.	IPI	Function
GO:0005737	cytoplasm	25468996.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006811	ion transport	-	ISS	Process
GO:0009967	positive regulation of signal transduction	-	IEA	Process
GO:0015075	ion transmembrane transporter activity	-	ISS	Function
GO:0030864	cortical actin cytoskeleton	-	ISS	Component
GO:0034220	ion transmembrane transport	-	IEA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0051015	actin filament binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.