EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20843712Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer.Urol Oncol2012 Jul-AugChiyomaru Tdoi: 10.1016/j.urolonc.2010.05.008
16430883Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells.Exp Cell Res2006 Apr 15Grunewald TG-
19155088LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma.J Hepatol2009 MarWang Bdoi: 10.1016/j.jhep.2008.10.025
28404954Upregulation of the long non-coding RNA PVT1 promotes esophageal squamous cell carcinoma progression by acting as a molecular sponge of miR-203 and LASP1.Oncotarget2017 May 23Li PDdoi: 10.18632/oncotarget.15878.
28982387MiR-203a-3p suppresses cell proliferation and metastasis through inhibiting LASP1 in nasopharyngeal carcinoma.J Exp Clin Cancer Res2017 Oct 5Jiang Ndoi: 10.1186/s13046-017-0604-3.
21215099[Impact of LASP-1 expression on proliferation and tumorigenesis of human colorectal cancer cell line SW480].Zhonghua Bing Li Xue Za Zhi2010 DecZhao L-
24990592LASP-1 promotes tumor proliferation and metastasis and is an independent unfavorable prognostic factor in gastric cancer.J Cancer Res Clin Oncol2014 NovZheng Jdoi: 10.1007/s00432-014-1759-3
28621232Paving the path for invasion: The polyedric role of LASP1 in cancer.Tumour Biol2017 JunRuggieri Vdoi: 10.1177/1010428317705757.
27938497Silencing of LIM and SH3 Protein 1 (LASP-1) Inhibits Thyroid Cancer Cell Proliferation and Invasion.Oncol Res2017 Jul 5Gao Wdoi: 10.3727/096504016X14785415155643
29207145MicroRNA-133a acts as a tumour suppressor in breast cancer through targeting LASP1.Oncol Rep2018 FebSui Ydoi: 10.3892/or.2017.6114
26797416LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway.Cancer Lett2016 Mar 28Li Zdoi: 10.1016/j.canlet.2016.01.008
22713668MicroRNA-203 suppresses cell proliferation and migration by targeting BIRC5 and LASP1 in human triple-negative breast cancer cells.J Exp Clin Cancer Res2012 Jun 19Wang Cdoi: 10.1186/1756-9966-31-58.
27840958Suppression of LASP-1 attenuates the carcinogenesis of prostatic cancer cell lines: Key role of the NF-??B pathway.Oncol Rep2017 JanSun Wdoi: 10.3892/or.2016.5223
24955835LIM and SH3 domain protein 1 (LASP-1) overexpression was associated with aggressive phenotype and poor prognosis in clear cell renal cell cancer.PLoS One2014 Jun 23Yang Fdoi: 10.1371/journal.pone.0100557
20461080Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer.Br J Cancer2010 May 25Frietsch JJdoi: 10.1038/sj.bjc.6605685
25252758LIM and SH3 protein 1 induces TGFβ-mediated epithelial-mesenchymal transition in human colorectal cancer by regulating S100A4 expression.Clin Cancer Res2014 Nov 15Wang Hdoi: 10.1158/1078-0432.CCR-14-0485
26683818LASP-1, regulated by miR-203, promotes tumor proliferation and aggressiveness in human non-small cell lung cancer.Exp Mol Pathol2016 FebZheng Jdoi: 10.1016/j.yexmp.2015.11.031
20660701Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1.Gut2010 SepZhao Ldoi: 10.1136/gut.2009.202739
27696291MicroRNA-218 inhibits the proliferation, migration, and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1.Tumour Biol2016 NovWang LL-
24386158Overexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancer.PLoS One2013 Dec 26Shimizu Fdoi: 10.1371/journal.pone.0083187
25622104An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein.Oncotarget2015 Jan 1Orth MF-
27588391Regulation of matrix metalloproteinases (MMPs) expression and secretion in MDA-MB-231 breast cancer cells by LIM and SH3 protein 1 (LASP1).Oncotarget2016 Sep 27Endres Mdoi: 10.18632/oncotarget.11720.
27156963Loss of the 14-3-3?? is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway.Sci Rep2016 May 9Shao Zdoi: 10.1038/srep25631.
27181092LASP1-S100A11 axis promotes colorectal cancer aggressiveness by modulating TGFβ/Smad signaling.Sci Rep2016 May 16Niu Ydoi: 10.1038/srep26112.
29138807Role of LASP-1, a novel SOX9 transcriptional target, in the progression of lung cancer.Int J Oncol2018 JanShi Jdoi: 10.3892/ijo.2017.4201

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1738914323Splice_SitenovelX120_splice0.24
BLCAchr1738914351SilentnovelK128K0.46
BLCAchr17388701605'UTRnovel0.23
BLCAchr1738890502Nonsense_Mutationrs776937950Q83*0.15
BLCAchr1738918698Missense_MutationnovelD236N0.47
BLCAchr17388701175'UTRnovel0.45
BLCAchr1738870208Missense_MutationNAR7G0.54
BRCAchr1738898488Missense_MutationNAR109K0.19
BRCAchr1738898520Splice_SitenovelX119_splice0.13
BRCAchr1738918642Missense_MutationNAD217A0.32
BRCAchr1738915041Splice_SitenovelX170_splice0.75
BRCAchr17388701345'UTRnovel1
CESCchr17389212263'UTRnovel0.12
CESCchr17389208563'UTRnovel0.42
CESCchr17389209723'UTRnovel0.39
CESCchr1738878106Missense_MutationNAF30L0.16
CESCchr1738914369Silentrs755621366S134S0.07
COADchr1738878180Missense_MutationNAA55V0.58
COADchr17389188063'UTRnovel0.13
COADchr1738918703Silentrs746197131D237D0.24
COADchr1738914411Silentrs147575335D148D0.63
COADchr17389188223'UTRrs7759261730.33
ESCAchr17389203423'UTRnovel0.27
ESCAchr1738918692Nonsense_MutationnovelQ234*0.12
HNSCchr17388701855'UTRnovel0.15
HNSCchr1738915129Missense_MutationnovelA199S0.29
HNSCchr17389187813'UTRnovel0.36
KIRCchr17389188443'UTRrs5478707410.14
KIRCchr17388701455'UTRnovel0.28
KIRPchr1738914475Missense_MutationNAV170I0.51
KIRPchr1738898589Intronnovel0.19
LGGchr17388700845'UTRnovel0.27
LIHCchr1738918635Missense_MutationnovelA215T0.27
LIHCchr17388701695'UTRnovel0.37
LUADchr1738915072Missense_MutationNAA180S0.16
LUADchr1738918753Frame_Shift_InsnovelA255Lfs*500.16
LUADchr1738890448Missense_MutationnovelV65L0.29
LUADchr1738878130SilentNAT38T0.18
LUADchr1738918658Silentrs754654518S222S0.1
LUADchr1738918694SilentnovelQ234Q0.07
LUADchr1738918733SilentnovelT247T0.16
LUSCchr1738870239Missense_MutationnovelK17M0.18
MESOchr1738918743Missense_MutationnovelG251R0.37
MESOchr1738898890Intronnovel0.31
OVchr1738915130Missense_MutationnovelA199D0.21
PRADchr1738918638Missense_MutationNAA216T0.27
PRADchr1738918649SilentnovelD219D0.19
READchr1738918703Silentrs746197131D237D0.16
SARCchr1738918608Missense_MutationNAR206W0.74
SKCMchr17388701885'UTRnovel0.16
SKCMchr17388701895'UTRrs7693648940.15
SKCMchr1738890468SilentnovelN71N0.2
SKCMchr1738890469Missense_MutationnovelL72F0.21
SKCMchr1738914460Missense_MutationNAP165S0.27
STADchr1738918750Missense_MutationnovelL253P0.3
STADchr17389187883'UTRrs3753307460.24
UCECchr1738898475Missense_MutationnovelP105S0.2
UCECchr1738918641Missense_MutationNAD217N0.36
UCECchr17389187883'UTRrs3753307460.36
UCECchr17389189653'UTRnovel0.27
UCECchr17389206583'UTRnovel0.43
UCECchr1738915143SilentNAG203G0.44
UCECchr17389207793'UTRnovel0.19
UCECchr1738878142Missense_MutationnovelK42N0.09
UCECchr1738870253Missense_MutationnovelD22N0.44
UCECchr1738878127Missense_MutationnovelM37I0.1
UCECchr1738898630Intronnovel0.24
UCECchr17389190113'UTRnovel0.58
UCECchr17389214523'UTRnovel0.29
UCECchr1738915068Silentrs569544434P178P0.36
UCECchr17389188223'UTRrs7759261730.5
UCECchr17389206693'UTRnovel0.49
UCECchr17389209683'UTRnovel0.32
UCECchr17389188793'UTRrs7791368690.44
UCECchr1738890473Missense_MutationnovelR73H0.16
UCECchr17389211773'UTRnovel0.38
UCECchr17389188223'UTRrs7759261730.35
UCECchr17389206693'UTRnovel0.35
UCECchr17389216663'UTRnovel0.5
UCECchr1738898474SilentnovelT104T0.23
UCECchr17388700095'UTRnovel0.36
UCECchr17389208073'UTRnovel0.08
UCECchr1738878180Missense_MutationNAA55V0.24
UCECchr17389189723'UTRnovel0.31
UCECchr17389188183'UTRnovel0.24
UCECchr1738878178Splice_Regionrs201222670N54N0.46
UCECchr1738918608Missense_MutationNAR206W0.16
UCECchr17389203723'UTRnovel0.28
UCECchr1738918715Silentrs374016458Y241Y0.25
UCECchr17389205323'UTRnovel0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.27780.0017784
DLBCDEL00.18166
THCADEL0.0020.221
UCSDEL0.3750.19877
UVMDEL0.03750.22482

Survival Analysis
CancerP-value Q-value
THYM0.0068

Kaplan-Meier Survival Analysis

KIRC0.0033

Kaplan-Meier Survival Analysis

SARC0.024

Kaplan-Meier Survival Analysis

MESO0.00011

Kaplan-Meier Survival Analysis

HNSC0.0059

Kaplan-Meier Survival Analysis

SKCM0.037

Kaplan-Meier Survival Analysis

LUSC0.049

Kaplan-Meier Survival Analysis

TGCT0.049

Kaplan-Meier Survival Analysis

PAAD0.048

Kaplan-Meier Survival Analysis

READ0.043

Kaplan-Meier Survival Analysis

LAML0.02

Kaplan-Meier Survival Analysis

UCEC0.00061

Kaplan-Meier Survival Analysis

LIHC0.0011

Kaplan-Meier Survival Analysis

THCA0.0027

Kaplan-Meier Survival Analysis

LUAD0.0025

Kaplan-Meier Survival Analysis

UVM0.026

Kaplan-Meier Survival Analysis

OV0.013

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000002834 (Gene tree)
Gene ID
3927
Gene Symbol
LASP1
Alias
MLN50|Lasp-1
Full Name
LIM and SH3 protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
51,912 bases
Position
chr17:38,869,859-38,921,770
Accession
6513
RBP type
non-canonical RBP
Summary
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000318008LASP1-2014109-ENSP00000325240261 (aa)-Q14847
ENST00000579123LASP1-2061874-ENSP00000462564105 (aa)-J3KSN1
ENST00000433206LASP1-2034023-ENSP00000401048205 (aa)-Q14847
ENST00000585841LASP1-2091408-ENSP0000046866471 (aa)-K7ESD6
ENST00000584106LASP1-2081167--- (aa)--
ENST00000435347LASP1-2043492-ENSP00000392853261 (aa)-Q14847
ENST00000419929LASP1-202762-ENSP00000391897166 (aa)-C9J9W2
ENST00000443937LASP1-2051482-ENSP0000041480391 (aa)-F6S2S5
ENST00000581485LASP1-207617--- (aa)--
Gene Model
Click here to download ENSG00000002834's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000002834Child Development Disorders, Pervasive1.4467000E-005-
ENSG00000002834Child Development Disorders, Pervasive6.7000000E-005-
ENSG00000002834Cognition Disorders4E-926252872
ENSG00000002834Cognitive Dysfunction4E-926252872
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000002834rs1405645161738873719ACognitive decline rate in late mild cognitive impairment26252872[0.34-0.67] unit increase0.5032HP_0100543|EFO_0007710
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000002834's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000002834LASP110095.437ENSMUSG00000038366Lasp1100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005070SH3/SH2 adaptor activity7589475.TASFunction
GO:0005515protein binding16189514.19060904.21516116.22665060.25416956.25814554.IPIFunction
GO:0005737cytoplasm25468996.IDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006811ion transport-ISSProcess
GO:0009967positive regulation of signal transduction-IEAProcess
GO:0015075ion transmembrane transporter activity-ISSFunction
GO:0030864cortical actin cytoskeleton-ISSComponent
GO:0034220ion transmembrane transport-IEAProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0046872metal ion binding-IEAFunction
GO:0051015actin filament binding-IEAFunction
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