Caenorhabditis_elegansFamily: eIF3_subunit Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
eif-3.J
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Introduction

Pfam

This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3). In yeast it is called Hcr1. The Saccharomyces cerevisiae protein Q05775 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p [1].

InterPro

This shows protein subunits of the eukaryotic translation initiation factor 3 J (eIF3j). It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [PUBMED:14688252, PUBMED:8995409]. In Saccharomyces cerevisiae, eIF3j has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p [PUBMED:11387228].

Reference

  1. Phan L, Schoenfeld LW, Valasek L, Nielsen KH, Hinnebusch AG; , EMBO J. 2001;20:2954-2965.: A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met. PUBMED:11387228 EPMC:11387228 .

  2. Phan L, Schoenfeld LW, Valasek L, Nielsen KH, Hinnebusch AG; , EMBO J. 2001;20:2954-2965.: A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met. PUBMED:11387228 EPMC:11387228.