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This is a family of endoribonucleases involved in RNA biosynthesis which has been named XendoU in Xenopus laevis. XendoU is a U-specific metal dependent enzyme that produces products with a 2'-3' cyclic phosphate termini.
This entry represents the EndoU endoribonucleases mostly from eukaryotes. The founding member XendoU is a uridylate-specific, divalent cation-dependent enzyme that produces molecules with 2',3'-cyclic phosphate ends [PUBMED:15755742, PUBMED:16895992]. The human Endou, known as PP11, has endoribonuclease activity with placental tissue specificity [PUBMED:18936097, PUBMED:28610924].