Caenorhabditis_elegansFamily: U5_2-snRNA_bdg Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
prp-8
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Introduction

Pfam

The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [2].

InterPro

The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [PUBMED:16431982]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [PUBMED:16431982].

Reference

  1. Grainger RJ, Beggs JD; , RNA. 2005;11:533-557.: Prp8 protein: at the heart of the spliceosome. PUBMED:15840809 EPMC:15840809 .

  2. Turner IA, Norman CM, Churcher MJ, Newman AJ; , RNA. 2006;12:375-386.: Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome. PUBMED:16431982 EPMC:16431982.