Caenorhabditis_elegansFamily: Surp Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
prp-21
-
swp-1
-
C07H6.4
-

Introduction

Pfam

This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding [1].

InterPro

SWAP is derived from the Suppressor-of-White-APricot splicing regulator from Drosophila melanogaster. The domain is found in regulators responsible for pervasive, nonsex-specific alternative pre-mRNA splicing characteristics and has been found in splicing regulatory proteins [PUBMED:8206918]. These ancient, conserved SWAP proteins share a colinearly arrayed series of novel sequence motifs [PUBMED:7971282].

Reference

  1. Denhez F, Lafyatis R; , J Biol Chem. 1994;269:16170-16179.: Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot. PUBMED:8206918 EPMC:8206918.