RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z and binds to a nuclear exoribonuclease . It is required for 5.8S rRNA processing . Profile-profile comparison tools demonstrate this to be a PD-(D/E)XK nuclease, with a full set of canonical active site signature motifs characteristic to the PD-(D/E)XK nuclease superfamily .
Xue Y, Bai X, Lee I, Kallstrom G, Ho J, Brown J, Stevens A, Johnson AW; , Mol Cell Biol. 2000;20:4006-4015.: Saccharomyces cerevisiae RAI1 (YGL246c) is homologous to human DOM3Z and encodes a protein that binds the nuclear exoribonuclease Rat1p. PUBMED:10805743 EPMC:10805743 .
Xiang S, Cooper-Morgan A, Jiao X, Kiledjian M, Manley JL, Tong L;, Nature. 2009;458:784-788.: Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. PUBMED:19194460 EPMC:19194460.