This domain is involved in pre-rRNA processing . It has has been shown to be required either for nucleolar retention or correct assembly of the box C/D snoRNP in Saccharomyces cerevisiae .
Proteins containing the PIH1 domain include kintoun, Saccharomyces cerevisiae PIH1 (protein interacting with Hsp90 1, also known as Nop17) and PIH1 domain-containing proteins.
Gonzales FA, Zanchin NI, Luz JS, Oliveira CC; , J Mol Biol 2005;346:437-455.: Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in Pre-rRNA processing. PUBMED:15670595 EPMC:15670595 .
Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C;, Structure. 2014;22:805-818.: Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1. PUBMED:24794838 EPMC:24794838.