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At least one member, Noc2p from yeast, is required for a late step in 60S subunit export from the nucleus . It has also been shown to co-precipitate with Nug1p, a nuclear GTPase also required for ribosome nucleus export . This family was formerly known as UPF0120.
In Saccharomyces cerevisiae, Noc2 forms a nucleolar complex with Mak21 that binds to 90S and 66S pre-ribosomes. It also forms a nuclear complex with Noc3 that binds to 66S pre-ribosomes [PUBMED:11371346]. Both complexes mediate intranuclear transport of ribosomal precursors [PUBMED:11371346].
Bassler J, Grandi P, Gadal O, Lessmann T, Petfalski E, Tollervey D, Lechner J, Hurt E; , Mol Cell 2001;8:517-529.: Identification of a 60S preribosomal particle that is closely linked to nuclear export. PUBMED:11583615 EPMC:11583615 .
Milkereit P, Gadal O, Podtelejnikov A, Trumtel S, Gas N, Petfalski E, Tollervey D, Mann M, Hurt E, Tschochner H; , Cell 2001;105:499-509.: Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. PUBMED:11371346 EPMC:11371346.