Caenorhabditis_elegansFamily: MRP-S23 Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
mrps-23
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Introduction

Pfam

MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs [1]. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system [2]. MRP-S23 is significantly up-regulated in uterine cancer cells [3].

InterPro

This entry represents a domain found in both the mitochondrial ribosomal 23S and 25S proteins. The function of this conserved region is not known.

Reference

  1. Koc EC, Burkhart W, Blackburn K, Moseley A, Koc H, Spremulli LL; , J Biol Chem 2000;275:32585-32591.: A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. PUBMED:10938081 EPMC:10938081 .

  2. O'Brien TW; , IUBMB Life. 2003;55:505-513.: Properties of human mitochondrial ribosomes. PUBMED:14658756 EPMC:14658756 .

  3. Lyng H, Brovig RS, Svendsrud DH, Holm R, Kaalhus O, Knutstad K, Oksefjell H, Sundfor K, Kristensen GB, Stokke T; , BMC Genomics. 2006;7:268.: Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer. PUBMED:17054779 EPMC:17054779.