Saccharomyces_cerevisiaeFamily: Lactamase_B_4 Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
-
-

Introduction

Pfam

This is family of tRNase Z enzymes, that are closely related structurally to the Lactamase_B family members. tRNase Z is the endonuclease that is involved in tRNA 3'-end maturation through removal of the 3'-trailer sequences from tRNA precursors. The fission yeast Schizosaccharomyces pombe contains two candidate tRNase Zs encoded by two essential genes. The first, Q10155 is targeted to the nucleus and has an SV40 nuclear localisation signal at its N-terminus, consisting of four consecutive arginine and lysine residues between residues 208 and 211 (KKRK) that is critical for the NLS function. The second, P87168 is targeted to the mitochondria, with an N-terminal mitochondrial targeting signal within the first 38 residues [1].

InterPro

This domain is found in the RNase Z enzymes, which are closely related structurally to the Lactamase B family members. tRNase Z (ribonuclease Z) is the endonuclease that is involved in tRNA 3'-end maturation through removal of the 3'-trailer sequences from tRNA precursors. The fission yeast Schizosaccharomyces pombe contains two candidate tRNase Zs encoded by two essential genes. The first, Trz1, is targeted to the nucleus and has an SV40 nuclear localisation signal at its N terminus, consisting of four consecutive arginine and lysine residues between residues 208 and 211 (KKRK) that is critical for the NLS function. The second, Trz2, is targeted to the mitochondria, with an N-terminal mitochondrial targeting signal within the first 38 residues [PUBMED:21208191].

Reference

  1. Gan X, Yang J, Li J, Yu H, Dai H, Liu J, Huang Y;, Biochem J. 2011; [Epub ahead of print]: The fission yeast Schizosaccharomyces pombe has two distinct tRNase ZLs encoded by two different genes and differentially targeted to the nucleus and mitochondria. PUBMED:21208191 EPMC:21208191.