This domain is always found to the amino terminal side of PF00293. This domain is specific to mRNA decapping protein 2 and this region has been termed Box A . Removal of the cap structure is catalysed by the Dcp1-Dcp2 complex .
This presumed domain is always found to the N-terminal side of the NUDIX hydrolase domain INTERPRO. This domain appears to be specific to mRNA decapping protein 2 (DCP2) SWISSPROT and its close homologues. This region has been termed Box A [PUBMED:12218187].
She M, Decker CJ, Chen N, Tumati S, Parker R, Song H; , Nat Struct Mol Biol. 2006;13:63-70.: Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. PUBMED:16341225 EPMC:16341225.